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公开(公告)号：US10520444B2
公开(公告)日：2019-12-31
申请号：US15975313
申请日：2018-05-09
Applicant: The Texas A&M University System
Inventor： Po-Jung Huang , Gerard L. Coté , Mitchell B. Robinson , Jun Kameoka , Haley L. Marks
IPC: G01J3/44 , G01N21/65 , G01N1/34 , B01L3/00 , G01N33/553 , G01N33/543 , G01N1/40
Abstract: There is a need in the point-of-care diagnostic community for an efficient and portable method for testing blood and other biological fluids that can be easily translated across multiple applications. An aspect of the invention described involves monitoring the optical properties of molecularly-mediated nanoparticle assemblies though an optically transparent and magnetically active microfluidic chip, which has recently emerged as an attractive method for biomarker detection as it is an efficient tool for monitoring the binding events that take place in a sensing assay. In one embodiment, this device is directed towards two-nanoparticle assays that rely on the assembly or disassembly of plasmonic and magnetic nanoparticles in response to a certain analyte. A further embodiment is directed to a spiral microfluidic using inertial forces to filter fluid components by size, connected to a magnetically active channel comprised of a nickel micropad array, optically transparent microchannel, and permanent magnets.
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公开(公告)号：US20170234799A1
公开(公告)日：2017-08-17
申请号：US15431604
申请日：2017-02-13
Applicant: The Texas A&M University System
Inventor： Haley L. Marks , Gerard L. Coté , Mitchell B. Robinson , Po-Jung Huang , Jun Kameoka
CPC classification number: G01N21/658 , B01L3/502753 , B01L2300/0654 , B01L2300/0816 , B01L2300/0861 , B01L2300/088 , G01N1/34 , G01N33/48 , G01N2001/4088 , G01N2021/651
Abstract: There is a need in the point-of-care diagnostic community for an efficient and portable method for testing blood and other biological fluids that can be easily translated across multiple applications. An aspect of the invention described involves monitoring the optical properties of molecularly-mediated nanoparticle assemblies though an optically transparent and magnetically active microfluidic chip, which has recently emerged as an attractive method for biomarker detection as it is an efficient tool for monitoring the binding events that take place in a sensing assay. In one embodiment, this device is directed towards two-nanoparticle assays that rely on the assembly or disassembly of plasmonic and magnetic nanoparticles in response to a certain analyte. A further embodiment is directed to a spiral microfluidic using inertial forces to filter fluid components by size, connected to a magnetically active channel comprised of a nickel micropad array, optically transparent microchannel, and permanent magnets.
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公开(公告)号：US09989471B2
公开(公告)日：2018-06-05
申请号：US15431604
申请日：2017-02-13
Applicant: The Texas A&M University System
Inventor： Haley L. Marks , Gerard L. Coté , Mitchell B. Robinson , Po-Jung Huang , Jun Kameoka
CPC classification number: G01N21/658 , B01L3/502753 , B01L2300/0654 , B01L2300/0816 , B01L2300/0861 , B01L2300/088 , G01N1/34 , G01N33/48 , G01N2001/4088 , G01N2021/651
Abstract: There is a need in the point-of-care diagnostic community for an efficient and portable method for testing blood and other biological fluids that can be easily translated across multiple applications. An aspect of the invention described involves monitoring the optical properties of molecularly-mediated nanoparticle assemblies though an optically transparent and magnetically active microfluidic chip, which has recently emerged as an attractive method for biomarker detection as it is an efficient tool for monitoring the binding events that take place in a sensing assay. In one embodiment, this device is directed towards two-nanoparticle assays that rely on the assembly or disassembly of plasmonic and magnetic nanoparticles in response to a certain analyte. A further embodiment is directed to a spiral microfluidic using inertial forces to filter fluid components by size, connected to a magnetically active channel comprised of a nickel micropad array, optically transparent microchannel, and permanent magnets.
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公开(公告)号：US20180259459A1
公开(公告)日：2018-09-13
申请号：US15975313
申请日：2018-05-09
Applicant: The Texas A&M University System
Inventor： Po-Jung Huang , Gerard L. Coté , Mitchell B. Robinson , Jun Kameoka , Haley L. Marks
CPC classification number: G01N21/658 , B01L3/502753 , B01L2300/0654 , B01L2300/0816 , B01L2300/0861 , B01L2300/088 , G01N1/34 , G01N33/54326 , G01N33/54346 , G01N33/54366 , G01N33/553 , G01N2001/4088 , G01N2021/651
Abstract: There is a need in the point-of-care diagnostic community for an efficient and portable method for testing blood and other biological fluids that can be easily translated across multiple applications. An aspect of the invention described involves monitoring the optical properties of molecularly-mediated nanoparticle assemblies though an optically transparent and magnetically active microfluidic chip, which has recently emerged as an attractive method for biomarker detection as it is an efficient tool for monitoring the binding events that take place in a sensing assay. In one embodiment, this device is directed towards two-nanoparticle assays that rely on the assembly or disassembly of plasmonic and magnetic nanoparticles in response to a certain analyte. A further embodiment is directed to a spiral microfluidic using inertial forces to filter fluid components by size, connected to a magnetically active channel comprised of a nickel micropad array, optically transparent microchannel, and permanent magnets.
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