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公开(公告)号：US20170234799A1
公开(公告)日：2017-08-17
申请号：US15431604
申请日：2017-02-13
Applicant: The Texas A&M University System
Inventor： Haley L. Marks , Gerard L. Coté , Mitchell B. Robinson , Po-Jung Huang , Jun Kameoka
CPC classification number: G01N21/658 , B01L3/502753 , B01L2300/0654 , B01L2300/0816 , B01L2300/0861 , B01L2300/088 , G01N1/34 , G01N33/48 , G01N2001/4088 , G01N2021/651
Abstract: There is a need in the point-of-care diagnostic community for an efficient and portable method for testing blood and other biological fluids that can be easily translated across multiple applications. An aspect of the invention described involves monitoring the optical properties of molecularly-mediated nanoparticle assemblies though an optically transparent and magnetically active microfluidic chip, which has recently emerged as an attractive method for biomarker detection as it is an efficient tool for monitoring the binding events that take place in a sensing assay. In one embodiment, this device is directed towards two-nanoparticle assays that rely on the assembly or disassembly of plasmonic and magnetic nanoparticles in response to a certain analyte. A further embodiment is directed to a spiral microfluidic using inertial forces to filter fluid components by size, connected to a magnetically active channel comprised of a nickel micropad array, optically transparent microchannel, and permanent magnets.
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Patent Agency Ranking
公开(公告)号：US09989471B2
公开(公告)日：2018-06-05
申请号：US15431604
申请日：2017-02-13
Applicant: The Texas A&M University System
Inventor： Haley L. Marks , Gerard L. Coté , Mitchell B. Robinson , Po-Jung Huang , Jun Kameoka
CPC classification number: G01N21/658 , B01L3/502753 , B01L2300/0654 , B01L2300/0816 , B01L2300/0861 , B01L2300/088 , G01N1/34 , G01N33/48 , G01N2001/4088 , G01N2021/651
Abstract: There is a need in the point-of-care diagnostic community for an efficient and portable method for testing blood and other biological fluids that can be easily translated across multiple applications. An aspect of the invention described involves monitoring the optical properties of molecularly-mediated nanoparticle assemblies though an optically transparent and magnetically active microfluidic chip, which has recently emerged as an attractive method for biomarker detection as it is an efficient tool for monitoring the binding events that take place in a sensing assay. In one embodiment, this device is directed towards two-nanoparticle assays that rely on the assembly or disassembly of plasmonic and magnetic nanoparticles in response to a certain analyte. A further embodiment is directed to a spiral microfluidic using inertial forces to filter fluid components by size, connected to a magnetically active channel comprised of a nickel micropad array, optically transparent microchannel, and permanent magnets.
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公开(公告)号：US20180259459A1
公开(公告)日：2018-09-13
申请号：US15975313
申请日：2018-05-09
Applicant: The Texas A&M University System
Inventor： Po-Jung Huang , Gerard L. Coté , Mitchell B. Robinson , Jun Kameoka , Haley L. Marks
CPC classification number: G01N21/658 , B01L3/502753 , B01L2300/0654 , B01L2300/0816 , B01L2300/0861 , B01L2300/088 , G01N1/34 , G01N33/54326 , G01N33/54346 , G01N33/54366 , G01N33/553 , G01N2001/4088 , G01N2021/651
Abstract: There is a need in the point-of-care diagnostic community for an efficient and portable method for testing blood and other biological fluids that can be easily translated across multiple applications. An aspect of the invention described involves monitoring the optical properties of molecularly-mediated nanoparticle assemblies though an optically transparent and magnetically active microfluidic chip, which has recently emerged as an attractive method for biomarker detection as it is an efficient tool for monitoring the binding events that take place in a sensing assay. In one embodiment, this device is directed towards two-nanoparticle assays that rely on the assembly or disassembly of plasmonic and magnetic nanoparticles in response to a certain analyte. A further embodiment is directed to a spiral microfluidic using inertial forces to filter fluid components by size, connected to a magnetically active channel comprised of a nickel micropad array, optically transparent microchannel, and permanent magnets.
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4.发明申请Hydrogel Microparticles via Soft Robotics Micromold (SRM) for In Vitro Cell Culture 审中-公开水凝胶微粒通过软机器人Micromold（SRM）进行体外细胞培养公开(公告)号：US20160297131A1
公开(公告)日：2016-10-13
申请号：US15093356
申请日：2016-04-07
Applicant: THE TEXAS A&M UNIVERSITY SYSTEM
Inventor： Jun Kameoka , Po-Jung Huang , Roland Kaunas , Carl A. Gregory
IPC: B29C47/00 , A61L27/38 , A61L27/54 , B29C33/40 , G01N33/50 , B29C47/30 , B29C33/38 , A61L27/52 , A61L27/26
CPC classification number: B29C33/405 , A61L27/18 , A61L27/20 , A61L27/227 , A61L27/3813 , A61L27/3817 , A61L27/3821 , A61L27/3826 , A61L27/383 , A61L27/3834 , A61L27/52 , A61L27/54 , A61L2300/64 , B29C33/0011 , B29C33/3857 , B29C33/42 , B29C2033/385 , B29K2105/0035 , B29K2105/0061 , B29K2883/00 , B29K2995/0056 , B29L2031/753 , B33Y10/00 , B33Y80/00 , G01N33/5082 , C08L67/04
Abstract: The present invention includes a mold and a method for producing an engineered tissue construct comprising: providing a mold comprising one or more openings, the mold being at least partially elastic and the one or more openings having a pre-determined shape; and extruding through the one or more openings in the mold a biocompatible gel-forming macromer to form a hydrogel using a mechanical force sufficient to extrude the biocompatible gel-forming macromer.
Abstract translation: 本发明包括模具和用于生产工程组织结构的方法，包括：提供包括一个或多个开口的模具，所述模具至少部分地具有弹性，并且所述一个或多个开口具有预定形状; 并且通过模具中的一个或多个开口挤出生物相容性凝胶形成大分子单体，以使用足以挤出生物相容性凝胶形成大分子单体的机械力形成水凝胶。
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公开(公告)号：US20210395112A1
公开(公告)日：2021-12-23
申请号：US17297422
申请日：2019-11-27
Applicant: The Texas A&M University System
Inventor： Jun Kameoka , Po-Jung Huang , Kung-Hui Chu
Abstract: Hydrogel-based sorbents and methods for their use in collecting, concentrating, and removing environmental per- and poly-fluoroalkyl substances. In one aspect, the invention provides hydrogel-based sorbents that are effective for collecting, concentrating, and removing PFASs from an environment in which the sorbent is placed; an environment in which the sorbent is in contact with (e.g., liquid communication).
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公开(公告)号：US10520444B2
公开(公告)日：2019-12-31
申请号：US15975313
申请日：2018-05-09
Applicant: The Texas A&M University System
Inventor： Po-Jung Huang , Gerard L. Coté , Mitchell B. Robinson , Jun Kameoka , Haley L. Marks
IPC: G01J3/44 , G01N21/65 , G01N1/34 , B01L3/00 , G01N33/553 , G01N33/543 , G01N1/40
Abstract: There is a need in the point-of-care diagnostic community for an efficient and portable method for testing blood and other biological fluids that can be easily translated across multiple applications. An aspect of the invention described involves monitoring the optical properties of molecularly-mediated nanoparticle assemblies though an optically transparent and magnetically active microfluidic chip, which has recently emerged as an attractive method for biomarker detection as it is an efficient tool for monitoring the binding events that take place in a sensing assay. In one embodiment, this device is directed towards two-nanoparticle assays that rely on the assembly or disassembly of plasmonic and magnetic nanoparticles in response to a certain analyte. A further embodiment is directed to a spiral microfluidic using inertial forces to filter fluid components by size, connected to a magnetically active channel comprised of a nickel micropad array, optically transparent microchannel, and permanent magnets.
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