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公开(公告)号：US10786465B2
公开(公告)日：2020-09-29
申请号：US15748327
申请日：2016-07-27
Applicant: The Texas A&M University System
Inventor： Naga Venkata Ravi Kumar Majeti , Raghu Ganugula , Meenakshi Arora , Prabhjot Saini
Abstract: A composition comprising a nanoparticle, wherein the nanoparticle comprises a polymer/copolymer conjugated to a moiety is disclosed. A method of forming a nanostructure includes stirring poly(lactide-co-glycolide (PLGA) and 11-Ethyl-3-(dimethylaminopropyl) carbodiimide (EDC) in CH2Cl2 to create a PLGA mixture, n-boc-ethyelenediamine and N,N-Diisopropylethylamine (DIEA) are added to the PLGA mixture to create a reaction mixture. The reaction mixture is then precipitated in cold diethyl ether to form a purified polymer, which is then dried. The dried and purified polymer is then reconstituted in CH2Cl2:TFA solution and stirred under inert conditions. The product of the reconstituting step is evaporated to form a clear viscous residue that is dissolved in CH2Cl2 and then precipitated in cold ether to form a polymer. These functional polymers can encapsulate a variety of bioactives forming nanosystems improving the performance of bioactives.
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公开(公告)号：US10780175B2
公开(公告)日：2020-09-22
申请号：US15567370
申请日：2016-04-18
Applicant: The Texas A&M University System
Inventor： Naga Venkata Ravi Kumar Majeti , Prabhjot Saini , Raghu Ganugula , Meenakshi Arora
IPC: C08G63/91 , A61K31/198 , A61K31/337 , A61K31/352 , A61K31/585 , A61K47/60 , C08G63/664 , C08G63/685 , A61K47/59 , A61K47/69 , A61K9/08 , A61K31/7004 , A61K31/7068 , A61K33/24 , A61K38/06 , A61K38/13 , A61K38/28 , G01N33/58
Abstract: The present invention provides a biodegradable “precision polymer system” (poly system) and methods for preparing pharmaceutically effective “precision polymer nanosystems” (polymer nanosystem) for delivery and/or targeting of drugs or drug like compounds.
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公开(公告)号：US20180214386A1
公开(公告)日：2018-08-02
申请号：US15748327
申请日：2016-07-27
Applicant: The Texas A&M University System
Inventor： Naga Venkata Ravi Kumar Majeti , Prabhjot Saini , Raghu Ganugula , Meenakshi Arora
CPC classification number: A61K9/5192 , A61K9/5153 , A61K47/549 , A61K47/6937 , B82Y5/00 , B82Y30/00
Abstract: A composition comprising a nanoparticle, wherein the nanoparticle comprises a polymer/copolymer conjugated to a moiety is disclosed. A method of forming a nanostructure includes stirring poly(lactide-co-glycolide (PLGA) and 11-Ethyl-3-(dimethylaminopropyl) carbodiimide (EDC) in CH2Cl2 to create a PLGA mixture, n-boc-ethyelenediamine and N,N-Diisopropylethylamine (DIEA) are added to the PLGA mixture to create a reaction mixture. The reaction mixture is then precipitated in cold diethyl ether to form a purified polymer, which is then dried. The dried and purified polymer is then reconstituted in CH2Cl2:TFA solution and stirred under inert conditions. The product of the reconstituting step is evaporated to form a clear viscous residue that is dissolved in CH2Cl2 and then precipitated in cold ether to form a polymer. These functional polymers can encapsulate a variety of bioactives forming nanosystems improving the performance of bioactives.
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公开(公告)号：US20180110865A1
公开(公告)日：2018-04-26
申请号：US15567370
申请日：2016-04-18
Applicant: The Texas A&M University System
Inventor： Naga Venkata Ravi Kumar Majeti , Prabhjot Saini , Raghu Ganugula , Meenakshi Arora
IPC: A61K47/60 , C08G63/664 , C08G63/91 , A61K47/59 , A61K31/352 , A61K31/7004 , A61K38/06 , A61K31/198 , A61K31/337 , A61K33/24 , A61K31/7068 , A61K31/585 , G01N33/58 , A61K47/69 , A61K38/28 , A61K38/13 , A61K9/08
Abstract: The present invention provides a biodegradable “precision polymer system” (poly system) and methods for preparing pharmaceutically effective “precision polymer nanosystems” (polymer nanosystem) for delivery and/or targeting of drugs or drug like compounds.
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