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公开(公告)号：US11591404B2
公开(公告)日：2023-02-28
申请号：US16884867
申请日：2020-05-27
发明人： Jennifer Brogdon , Saar Gill , David Jonathan Glass , Saad Kenderian , Andreas Loew , Joan Mannick , Michael C. Milone , Leon Murphy , David L. Porter , Marco Ruella , Yongqiang Wang , Qilong Wu , Jiquan Zhang
IPC分类号： C07K16/28 , C07K16/24 , C12N5/0783 , A61K39/00
摘要： The invention provides compositions and methods for treating diseases associated with expression of CD123. The invention also relates to chimeric antigen receptor (CAR) specific to CD123, vectors encoding the same, and recombinant cells comprising the CD123 CAR. The invention also includes methods of administering a genetically modified cell expressing a CAR that comprises a CD123 binding domain.
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公开(公告)号：US20180044423A1
公开(公告)日：2018-02-15
申请号：US15689163
申请日：2017-08-29
发明人： Hilmar Erhard Ebersbach , Thomas Huber , Julia Jascur , Celeste Richardson , Reshma Singh , Huijuan Song , Qilong Wu , Jiquan Zhang
IPC分类号： C07K16/28 , A61K31/711 , A61K35/28 , A61K38/17 , A61K39/395 , A61K48/00 , C07K14/725 , A61K31/436 , C07K14/715 , C07K16/30 , C07K14/705 , A61K45/06 , A61K38/00 , A61K39/00
CPC分类号： C07K16/2851 , A61K31/436 , A61K31/711 , A61K35/28 , A61K38/00 , A61K38/1774 , A61K38/1793 , A61K39/39558 , A61K45/06 , A61K48/00 , A61K2039/505 , A61K2039/5156 , C07K14/7051 , C07K14/70517 , C07K14/7056 , C07K14/70578 , C07K14/7151 , C07K16/2803 , C07K16/30 , C07K16/3061 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/53 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2319/00 , C07K2319/03 , C07K2319/33 , C07K2319/70 , A61K2300/00
摘要： The invention provides compositions and methods for treating diseases associated with expression of CD33. The invention also relates to chimeric antigen receptor (CAR) specific to CD33, vectors encoding the same, and recombinant T cells comprising the CD33 CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a CD33 binding domain.
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公开(公告)号：US20230220090A1
公开(公告)日：2023-07-13
申请号：US18148807
申请日：2022-12-30
发明人： Jennifer Brogdon , Saar Gill , David Glass , Saad Kenderian , Andreas Loew , Joan Mannick , Michael C. Milone , Leon Murphy , David L. Porter , Marco Ruella , Yongqiang Wang , Qilong Wu , Jiquan Zhang
IPC分类号： C07K16/28 , A61K39/00 , C07K16/24 , C12N5/0783
CPC分类号： C07K16/2866 , A61K39/001119 , C07K16/244 , C12N5/0636 , C07K2317/622 , C07K2319/33 , A61K2039/505 , A61K2039/5156 , C07K2317/76 , C07K2317/73 , C07K2319/03 , A61K2039/507 , C07K2317/24
摘要： The invention provides compositions and methods for treating diseases associated with expression of CD123. The invention also relates to chimeric antigen receptor (CAR) specific to CD123, vectors encoding the same, and recombinant cells comprising the CD123 CAR. The invention also includes methods of administering a genetically modified cell expressing a CAR that comprises a CD123 binding domain.
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公开(公告)号：US20230052970A1
公开(公告)日：2023-02-16
申请号：US17937488
申请日：2022-10-03
发明人： Jennifer Brogdon , Hilmar Erhard Ebersbach , David Glass , Thomas Huber , Julia Jascur , Carl H. June , Jihyun Lee , Joan Mannick , Michael C. Milone , Leon Murphy , Avery D. Posey , Huijuan Song , Yongqiang Wang , Lai Wei , Qilong Wu , Qiumei Yang , Jiquan Zhang
IPC分类号： C07K16/28 , A61K35/17 , C07K16/30 , C07K14/705 , A61P35/02 , A61P35/00 , A61K48/00 , C07K14/725 , C12N15/86
摘要： The invention provides compositions and methods for treating diseases associated with expression of a tumor antigen as described herein. The invention also relates to nucleic acids comprising a truncated PGK promoter operably linked to a chimeric antigen receptor (CAR) specific to a tumor antigen as described herein, vectors encoding the same, and recombinant T cells comprising the CARs of the present invention. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises an antigen binding domain that binds to a tumor antigen as described herein.
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公开(公告)号：US20210139595A1
公开(公告)日：2021-05-13
申请号：US17083211
申请日：2020-10-28
发明人： Hilmar Erhard Ebersbach , Thomas Huber , Julia Jascur , Celeste Richardson , Reshma Singh , Huijuan Song , Qilong Wu , Jiquan Zhang
IPC分类号： C07K16/28 , A61K39/395 , A61K31/436 , C07K14/725 , C07K14/705 , C07K16/30 , A61K35/28 , A61K31/711 , A61K38/17 , A61K45/06 , C07K14/715 , A61K48/00
摘要： The invention provides compositions and methods for treating diseases associated with expression of CD33. The invention also relates to chimeric antigen receptor (CAR) specific to CD33, vectors encoding the same, and recombinant T cells comprising the CD33 CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a CD33 binding domain.
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公开(公告)号：US09777061B2
公开(公告)日：2017-10-03
申请号：US14805236
申请日：2015-07-21
发明人： Hilmar Erhard Ebersbach , Thomas Huber , Julia Jascur , Celeste Richardson , Reshma Singh , Huijuan Song , Qilong Wu , Jiquan Zhang
IPC分类号： C12N5/071 , C12N5/16 , C07K16/28 , C07K14/705 , A61K39/395 , A61K31/436 , C07K14/725 , C07K16/30 , A61K38/17 , A61K45/06 , C07K14/715 , A61K48/00 , A61K35/28 , A61K39/00 , A61K38/00
CPC分类号： C07K16/2851 , A61K31/436 , A61K31/711 , A61K35/28 , A61K38/00 , A61K38/1774 , A61K38/1793 , A61K39/39558 , A61K45/06 , A61K48/00 , A61K2039/505 , A61K2039/5156 , C07K14/7051 , C07K14/70517 , C07K14/7056 , C07K14/70578 , C07K14/7151 , C07K16/2803 , C07K16/30 , C07K16/3061 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/53 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2319/00 , C07K2319/03 , C07K2319/33 , C07K2319/70 , A61K2300/00
摘要： The invention provides compositions and methods for treating diseases associated with expression of CD33. The invention also relates to chimeric antigen receptor (CAR) specific to CD33, vectors encoding the same, and recombinant T cells comprising the CD33 CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a CD33 binding domain.
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公开(公告)号：US20210002377A1
公开(公告)日：2021-01-07
申请号：US16884867
申请日：2020-05-27
发明人： Jennifer Brogdon , Saar Gill , David Jonathan Glass , Saad Kenderian , Andreas Loew , Joan Mannick , Michael C. Milone , Leon Murphy , David L. Porter , Marco Ruella , Yongqiang Wang , Qilong Wu , Jiquan Zhang
IPC分类号： C07K16/28 , A61K39/00 , C07K16/24 , C12N5/0783
摘要： The invention provides compositions and methods for treating diseases associated with expression of CD123. The invention also relates to chimeric antigen receptor (CAR) specific to CD123, vectors encoding the same, and recombinant cells comprising the CD123 CAR. The invention also includes methods of administering a genetically modified cell expressing a CAR that comprises a CD123 binding domain.
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公开(公告)号：US20180312595A1
公开(公告)日：2018-11-01
申请号：US15726703
申请日：2017-10-06
发明人： Jennifer Brogdon , Saar Gill , David Jonathan Glass , Saad Kenderian , Andreas Loew , Joan Mannick , Michael Milone , Leon Murphy , David L. Porter , Marco Ruella , Yongqiang Wang , Qilong Wu , Jiquan Zhang
IPC分类号： C07K16/28 , A61K39/00 , C12N5/0783 , C07K16/24
摘要： The invention provides compositions and methods for treating diseases associated with expression of CD123. The invention also relates to chimeric antigen receptor (CAR) specific to CD123, vectors encoding the same, and recombinant cells comprising the CD123 CAR. The invention also includes methods of administering a genetically modified cell expressing a CAR that comprises a CD123 binding domain.
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公开(公告)号：US11459390B2
公开(公告)日：2022-10-04
申请号：US15543688
申请日：2016-01-15
发明人： Jennifer Brogdon , Hilmar Erhard Ebersbach , David Glass , Thomas Huber , Julia Jascur , Carl H. June , Jihyun Lee , Joan Mannick , Michael C. Milone , Leon Murphy , Avery D. Posey , Huijuan Song , Yongqiang Wang , Lai Wei , Qilong Wu , Qiumei Yang , Jiquan Zhang
IPC分类号： C07K16/28 , C07K14/705 , C07K14/725 , A61K35/17 , C07K16/30 , A61P35/00 , A61P35/02 , A61K48/00 , C12N15/86 , A61K35/12
摘要： The invention provides compositions and methods for treating diseases associated with expression of a tumor antigen as described herein. The invention also relates to nucleic acids comprising a truncated PGK promoter operably linked to a chimeric antigen receptor (CAR) specific to a tumor antigen as described herein, vectors encoding the same, and recombinant T cells comprising the CARs of the present invention. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises an antigen binding domain that binds to a tumor antigen as described herein.
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公开(公告)号：US10851166B2
公开(公告)日：2020-12-01
申请号：US15689163
申请日：2017-08-29
发明人： Hilmar Erhard Ebersbach , Thomas Huber , Julia Jascur , Celeste Richardson , Reshma Singh , Huijuan Song , Qilong Wu , Jiquan Zhang
IPC分类号： C07K16/28 , C07K14/725 , C07K16/30 , A61K39/395 , A61K31/436 , C07K14/705 , A61K35/28 , A61K31/711 , A61K38/17 , A61K45/06 , C07K14/715 , A61K48/00 , A61K39/00 , A61K38/00
摘要： The invention provides compositions and methods for treating diseases associated with expression of CD33. The invention also relates to chimeric antigen receptor (CAR) specific to CD33, vectors encoding the same, and recombinant T cells comprising the CD33 CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a CD33 binding domain.
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