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公开(公告)号：US20230220090A1
公开(公告)日：2023-07-13
申请号：US18148807
申请日：2022-12-30
发明人： Jennifer Brogdon , Saar Gill , David Glass , Saad Kenderian , Andreas Loew , Joan Mannick , Michael C. Milone , Leon Murphy , David L. Porter , Marco Ruella , Yongqiang Wang , Qilong Wu , Jiquan Zhang
IPC分类号： C07K16/28 , A61K39/00 , C07K16/24 , C12N5/0783
CPC分类号： C07K16/2866 , A61K39/001119 , C07K16/244 , C12N5/0636 , C07K2317/622 , C07K2319/33 , A61K2039/505 , A61K2039/5156 , C07K2317/76 , C07K2317/73 , C07K2319/03 , A61K2039/507 , C07K2317/24
摘要： The invention provides compositions and methods for treating diseases associated with expression of CD123. The invention also relates to chimeric antigen receptor (CAR) specific to CD123, vectors encoding the same, and recombinant cells comprising the CD123 CAR. The invention also includes methods of administering a genetically modified cell expressing a CAR that comprises a CD123 binding domain.
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公开(公告)号：US20210347851A1
公开(公告)日：2021-11-11
申请号：US17280467
申请日：2019-09-27
发明人： Randi Isaacs , Noelle Frey , David L. Porter
IPC分类号： C07K14/705 , A61K35/17 , A61K45/06 , A61P35/02
摘要： The invention provides compositions and methods for treating cancer, e.g., hematological cancer, by administering a CD19 CAR-expressing cell as described herein, in combination with a CD22 CAR-expressing cell as described herein.
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公开(公告)号：US11591404B2
公开(公告)日：2023-02-28
申请号：US16884867
申请日：2020-05-27
发明人： Jennifer Brogdon , Saar Gill , David Jonathan Glass , Saad Kenderian , Andreas Loew , Joan Mannick , Michael C. Milone , Leon Murphy , David L. Porter , Marco Ruella , Yongqiang Wang , Qilong Wu , Jiquan Zhang
IPC分类号： C07K16/28 , C07K16/24 , C12N5/0783 , A61K39/00
摘要： The invention provides compositions and methods for treating diseases associated with expression of CD123. The invention also relates to chimeric antigen receptor (CAR) specific to CD123, vectors encoding the same, and recombinant cells comprising the CD123 CAR. The invention also includes methods of administering a genetically modified cell expressing a CAR that comprises a CD123 binding domain.
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公开(公告)号：US10357514B2
公开(公告)日：2019-07-23
申请号：US14680860
申请日：2015-04-07
发明人： Carl H. June , David L. Porter , Marcela Maus , Mariusz Wasik , Saar Gill , Joseph Fraietta , Marco Ruella , John Byrd , Jason Dubovsky , Amy Johnson , Natarajan Muthusamy , Saad Kenderian , Joan Mannick , David Glass , Leon Murphy , Jennifer Brogdon , William Raj Sellers
IPC分类号： A61K35/17 , A61K39/395 , A61K31/519 , A61K45/06 , C07K14/725 , A61K31/436 , A61K31/53 , C12N5/0783 , C07K16/28 , A61K39/00
摘要： The invention provides compositions and methods for treating diseases associated with expression of CD19, e.g., by administering a recombinant T cell comprising the CD19 CAR as described herein, in combination with a kinase inhibitor, e.g., a kinase inhibitor described herein. The invention also provides kits and compositions described herein.
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公开(公告)号：US20180140602A1
公开(公告)日：2018-05-24
申请号：US15564463
申请日：2016-04-07
申请人： Daniela Angst , John Byrd , Jason Dubovsky , Joseph A. Fraietta , Francois Gessier , Saar Gill , Amy Johnson , Carl H. June , Marcela Maus , Natarajan Muthusamy , David L. Porter , Marco Ruella , Anna Vulpetti , Mariusz Wasik , Novartis AG , The Trustees of the University of Pennsylvania
发明人： Daniela Angst , John Byrd , Jason Dubovsky , Joseph A. Fraietta , Francois Gessier , Saar Gill , Amy Johnson , Carl H. June , Marcela Maus , Natarajan Muthusamy , David L. Porter , Marco Ruella , Anna Vulpetti , Mariusz Wasik
IPC分类号： A61K31/505 , A61K35/17 , C07K16/28 , A61K31/506 , C07K16/30 , A61P35/00 , A61P35/02
CPC分类号： A61K31/505 , A61K31/506 , A61K35/17 , A61K45/06 , A61K2035/124 , A61K2039/505 , A61K2039/545 , A61P35/00 , A61P35/02 , C07K16/2803 , C07K16/30 , C07K2317/24 , C07K2317/53 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2319/02 , C07K2319/03 , C12N5/0636 , A61K2300/00
摘要： The invention provides compositions and methods for treating diseases associated with expression of CD19, e.g., by administering a recombinant T cell comprising the CD19 CAR as described herein, in combination with a BTK inhibitor, e.g., an amino pyrimidine derivative described herein. The invention also provides kits and compositions described herein.
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公开(公告)号：US10703819B2
公开(公告)日：2020-07-07
申请号：US15726703
申请日：2017-10-06
发明人： Jennifer Brogdon , Saar Gill , David Jonathan Glass , Saad Kenderian , Andreas Loew , Joan Mannick , Michael Milone , Leon Murphy , David L. Porter , Marco Ruella , Yongqiang Wang , Qilong Wu , Jiquan Zhang
IPC分类号： C07K16/28 , A61K39/00 , C07K16/24 , C12N5/0783
摘要： The invention provides compositions and methods for treating diseases associated with expression of CD123. The invention also relates to chimeric antigen receptor (CAR) specific to CD123, vectors encoding the same, and recombinant cells comprising the CD123 CAR. The invention also includes methods of administering a genetically modified cell expressing a CAR that comprises a CD123 binding domain.
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公开(公告)号：US20210177896A1
公开(公告)日：2021-06-17
申请号：US16305728
申请日：2017-06-02
申请人： David L. Porter , Noelle Frey , Carl H. June , Simon Lacey , Fang Chen , Jan J. Melenhorst , Tetiana Taran , Karen Thudium Mueller , Patricia Wood , Yiyun Zhang , Novartis AG , The Trustees of the University of Pennsylvania
发明人： David L. Porter , Noelle Frey , Carl H. June , Simon Lacey , Fang Chen , Jan J. Melenhorst , Tetiana Taran , Karen Thudium Mueller , Patricia Wood , Yiyun Zhang
摘要： The invention provides a method of treating an adult subject having a hematological cancer, comprising administering to the subject selected dosage regimens comprising a plurality of immune effector cells expressing a CAR molecule.
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公开(公告)号：US20210002377A1
公开(公告)日：2021-01-07
申请号：US16884867
申请日：2020-05-27
发明人： Jennifer Brogdon , Saar Gill , David Jonathan Glass , Saad Kenderian , Andreas Loew , Joan Mannick , Michael C. Milone , Leon Murphy , David L. Porter , Marco Ruella , Yongqiang Wang , Qilong Wu , Jiquan Zhang
IPC分类号： C07K16/28 , A61K39/00 , C07K16/24 , C12N5/0783
摘要： The invention provides compositions and methods for treating diseases associated with expression of CD123. The invention also relates to chimeric antigen receptor (CAR) specific to CD123, vectors encoding the same, and recombinant cells comprising the CD123 CAR. The invention also includes methods of administering a genetically modified cell expressing a CAR that comprises a CD123 binding domain.
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公开(公告)号：US20190388471A1
公开(公告)日：2019-12-26
申请号：US16435257
申请日：2019-06-07
发明人： Carl H. June , David L. Porter , Marcela Maus , Mariusz Wasik , Saar Gill , Joseph A. Fraietta , Marco Ruella , John Byrd , Jason Dubovsky , Amy Johnson , Natarajan Muthusamy , Saad Kenderian , Joan Mannick , David Jonathan Glass , Leon Murphy , Jennifer Brogdon , William Raj Sellers
IPC分类号： A61K35/17 , A61K39/395 , A61K31/519 , A61K45/06 , C07K14/725 , A61K31/436 , A61K31/53 , C12N5/0783 , C07K16/28
摘要： The invention provides compositions and methods for treating diseases associated with expression of CD19, e.g., by administering a recombinant T cell comprising the CD19 CAR as described herein, in combination with a kinase inhibitor, e.g., a kinase inhibitor described herein. The invention also provides kits and compositions described herein.
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公开(公告)号：US20180312595A1
公开(公告)日：2018-11-01
申请号：US15726703
申请日：2017-10-06
发明人： Jennifer Brogdon , Saar Gill , David Jonathan Glass , Saad Kenderian , Andreas Loew , Joan Mannick , Michael Milone , Leon Murphy , David L. Porter , Marco Ruella , Yongqiang Wang , Qilong Wu , Jiquan Zhang
IPC分类号： C07K16/28 , A61K39/00 , C12N5/0783 , C07K16/24
摘要： The invention provides compositions and methods for treating diseases associated with expression of CD123. The invention also relates to chimeric antigen receptor (CAR) specific to CD123, vectors encoding the same, and recombinant cells comprising the CD123 CAR. The invention also includes methods of administering a genetically modified cell expressing a CAR that comprises a CD123 binding domain.
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