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1.发明公开公开(公告)号：US20240261388A1
公开(公告)日：2024-08-08
申请号：US18407958
申请日：2024-01-09
发明人： David Weiner , Megan Wise
IPC分类号： A61K39/21 , A61K39/00 , A61K39/02 , C07K14/005
CPC分类号： A61K39/21 , A61K39/02 , C07K14/005 , A61K2039/53 , A61K2039/54 , A61K2039/545 , C12N2740/16134 , C12N2740/16171
摘要： The present invention relates to compositions comprising two or more DNA plasmids encoding consensus and transmitted founder HIV envelope glycoproteins which expressed and induce a potent immune response.
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2.发明公开公开(公告)号：US20240115680A1
公开(公告)日：2024-04-11
申请号：US18541798
申请日：2023-12-15
申请人： The Trustees of the University of Pennsylvania , Inovio Pharmaceuticals, Inc. , The Wistar Institute of Anatomy and Biology
CPC分类号： A61K39/001102 , A61K38/1796 , A61K39/0011 , A61P35/00 , C07K14/723 , A61K2039/5256 , A61K2039/53 , A61K2039/572 , A61K2039/892
摘要： Provided herein is an immunogenic composition comprising a synthetic consensus antigen to Follicle Stimulating Hormone Receptor (FSHR) protein which is abundant in many ovarian cancer sub-types. Also disclosed herein is a method of treating a tumor associated pathology in a subject in need thereof, by administering the immunogenic composition to the subject.
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公开(公告)号：US11865166B2
公开(公告)日：2024-01-09
申请号：US16328404
申请日：2017-08-29
申请人： The Trustees of the University of Pennsylvania , Inovio Pharmaceuticals, Inc. , THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY
CPC分类号： A61K39/001102 , A61K38/1796 , A61K39/0011 , A61P35/00 , C07K14/723 , A61K2039/5256 , A61K2039/53 , A61K2039/572 , A61K2039/892
摘要： Provided herein is an immunogenic composition comprising a synthetic consensus antigen to Follicle Stimulating Hormone Receptor (FSHR) protein which is abundant in many ovarian cancer sub-types. Also disclosed herein is a method of treating a tumor associated pathology in a subject in need thereof, by administering the immunogenic composition to the subject.
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4.发明申请公开(公告)号：US20190290751A1
公开(公告)日：2019-09-26
申请号：US16465691
申请日：2017-12-01
发明人： David Weiner , Ami Patel , Sarah Elliott
IPC分类号： A61K39/12 , A61P31/14 , A61P37/04 , C07K14/005
摘要： Nucleic acid molecules and compositions comprising one or more nucleic acid sequences that encode a consensus Marburgvirus filovirus glycoprotein immunogens. Immunomodulatory methods and methods of inducing an immune response against Marburgvirus are disclosed. Method of preventing infection by Marburgvirus and methods of treating individuals infected with Marburgvirus are disclosed. Consensus Marburgvirus filovirus glycoprotein immunogens are disclosed.
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5.发明公开公开(公告)号：US20240131154A1
公开(公告)日：2024-04-25
申请号：US18477785
申请日：2023-09-28
申请人： The Trustees of the University of Pennsylvania , Inovio Pharmaceuticals, Inc. , The Wistar Institute of Anatomy and Biology
发明人： David Weiner , Karuppiah Muthumani , Jian Yan
CPC分类号： A61K39/42 , A61K39/12 , A61P31/14 , C07K14/18 , C07K16/10 , C07K16/1081 , A61K2039/53
摘要： Disclosed herein is a composition comprising a recombinant nucleic acid sequence that encodes an antibody to a Zika viral antigen, and functional fragments thereof. The invention also relates to a composition comprising the combination of a first composition that elicits an immune response in a mammal against zika virus and a second composition comprising a recombinant nucleic acid sequence encoding an antibody, a fragment thereof, a variant thereof, or a combination thereof. In some instances, the nucleic acid molecule comprises a nucleotide sequence encoding an anti-ZIKV-Envelope (anti-ZIKV E) Protein antibody.
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公开(公告)号：US20230115179A1
公开(公告)日：2023-04-13
申请号：US18045575
申请日：2022-10-11
申请人： The Trustees of the University of Pennsylvania , THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY , INOVIO PHARMACEUTICALS, INC.
发明人： David Weiner , Jian Yan
摘要： Disclosed herein are compositions comprising optimized consensus TERT antigens and methods for treating cancer and in particular immunogenic compositions that treat and provide protection against tumor.
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公开(公告)号：US11596678B2
公开(公告)日：2023-03-07
申请号：US16465691
申请日：2017-12-01
发明人： David Weiner , Ami Patel , Sarah Elliott
摘要： Nucleic acid molecules and compositions comprising one or more nucleic acid sequences that encode a consensus Marburgvirus filovirus glycoprotein immunogens. Immunomodulatory methods and methods of inducing an immune response against Marburgvirus are disclosed. Method of preventing infection by Marburgvirus and methods of treating individuals infected with Marburgvirus are disclosed. Consensus Marburgvirus filovirus glycoprotein immunogens are disclosed.
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8.发明公开公开(公告)号：US20240226291A9
公开(公告)日：2024-07-11
申请号：US18477785
申请日：2023-09-29
申请人： The Trustees of the University of Pennsylvania , Inovio Pharmaceuticals, Inc. , The Wistar Institute of Anatomy and Biology
发明人： David Weiner , Karuppiah Muthumani , Jian Yan
CPC分类号： A61K39/42 , A61K39/12 , A61P31/14 , C07K14/18 , C07K16/10 , C07K16/1081 , A61K2039/53
摘要： Disclosed herein is a composition comprising a recombinant nucleic acid sequence that encodes an antibody to a Zika viral antigen, and functional fragments thereof. The invention also relates to a composition comprising the combination of a first composition that elicits an immune response in a mammal against zika virus and a second composition comprising a recombinant nucleic acid sequence encoding an antibody, a fragment thereof, a variant thereof, or a combination thereof. In some instances, the nucleic acid molecule comprises a nucleotide sequence encoding an anti-ZIKV-Envelope (anti-ZIKV E) Protein antibody.
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9.发明公开公开(公告)号：US20230293664A1
公开(公告)日：2023-09-21
申请号：US18179668
申请日：2023-03-07
发明人： David Weiner , Ami Patel , Sarah Elliott
IPC分类号： A61K39/12 , A61P37/04 , A61P31/14 , C07K14/005
CPC分类号： A61K39/12 , A61P31/14 , A61P37/04 , C07K14/005 , A61K2039/53
摘要： Nucleic acid molecules and compositions comprising one or more nucleic acid sequences that encode a consensus Marburgvirus filovirus glycoprotein immunogens. Immunomodulatory methods and methods of inducing an immune response against Marburgvirus are disclosed. Method of preventing infection by Marburgvirus and methods of treating individuals infected with Marburgvirus are disclosed. Consensus Marburgvirus filovirus glycoprotein immunogens are disclosed.
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10.发明申请公开(公告)号：US20190307870A1
公开(公告)日：2019-10-10
申请号：US16302718
申请日：2017-05-19
申请人： Ahmed S.I. Aly , The Trustees of the University of Pennsylvania , Inovio Pharmaceuticals, Inc. , THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY
IPC分类号： A61K39/015 , A61P33/06 , C07K14/445
摘要： Provided herein are sequences of Plasmodium spp. liver stage exported proteins as well as expression constructs expressing the sequences. Also provided herein are methods for generating an immune response against malaria using the expression constructs provided herein.
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