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公开(公告)号：US12005078B2
公开(公告)日：2024-06-11
申请号：US15756937
申请日：2016-09-06
IPC分类号： A61K35/17 , A61K31/495 , A61K39/00 , A61K45/06 , A61P35/00 , C07K14/715 , C07K14/725 , C07K16/30 , C12N5/0783 , C12N9/12
CPC分类号： A61K35/17 , A61K31/495 , A61K39/0011 , A61K39/001104 , A61K39/001106 , A61K39/001109 , A61K39/00111 , A61K39/001112 , A61K39/001113 , A61K39/001119 , A61K39/001122 , A61K39/001124 , A61K39/001126 , A61K39/001129 , A61K39/00115 , A61K39/001151 , A61K39/001164 , A61K39/001166 , A61K39/001168 , A61K39/001171 , A61K39/001174 , A61K39/001181 , A61K39/001182 , A61K39/001188 , A61K39/001189 , A61K39/00119 , A61K39/001193 , A61K39/001195 , A61K45/06 , A61P35/00 , C07K14/7051 , C07K14/7155 , C07K16/30 , C12N5/0636 , C12N5/0638 , C12N5/0646 , C12N9/12 , C12Y207/10001 , A61K2039/5156 , A61K2039/5158 , A61K2300/00 , C07K2319/70 , C12N2501/72 , C12N2510/00 , A61K31/495 , A61K2300/00
摘要： The present disclosure provides novel cell compositions engineered to express at least a chimeric antigen receptor and a survival factor. Methods of using such cell compositions are also described.
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公开(公告)号：US20180250337A1
公开(公告)日：2018-09-06
申请号：US15756937
申请日：2016-09-06
IPC分类号： A61K35/17 , A61K31/495 , C12N5/0783 , C12N9/12 , C07K14/715 , C07K16/30
CPC分类号： A61K35/17 , A61K31/495 , A61K39/0011 , A61K39/001104 , A61K39/001171 , A61K45/06 , A61K2039/5156 , A61K2039/5158 , A61K2300/00 , A61P35/00 , C07K14/7051 , C07K14/7155 , C07K16/30 , C07K2319/70 , C12N5/0636 , C12N5/0638 , C12N5/0646 , C12N9/12 , C12N2501/72 , C12N2510/00 , C12Y207/10001
摘要： The present disclosure provides novel cell compositions engineered to express at least a chimeric antigen receptor and a survival factor. Methods of using such cell compositions are also described.
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3.发明公开公开(公告)号：US20240139253A1
公开(公告)日：2024-05-02
申请号：US18129398
申请日：2023-03-31
申请人： Wake Forest University Health Sciences , Emory University , Children's Healthcare of Atlanta, Inc.
发明人： Maria Graca N.D. Almeida-Porada , Christopher D. Porada , Anthony Atala , Christopher B. Doering , H. Trent Spencer
IPC分类号： A61K35/28 , A61K38/37 , C12N5/0775
CPC分类号： A61K35/28 , A61K38/37 , C12N5/0663 , C12N5/0668 , C12N2510/00
摘要： Disclosed herein are method of treating hemophilia A in a subject comprising injecting the subject with mesenchymal stromal/stem cells (MSC) modified to express high levels of Factor VIII protein. The MSC are isolated prenatally, at birth, or after the subject's birth. The modified MSC may also express high levels von Willebrand factor protein.
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公开(公告)号：US11136369B2
公开(公告)日：2021-10-05
申请号：US16400501
申请日：2019-05-01
IPC分类号： C07K14/705 , C07K14/725 , C07K14/46 , A61K35/17 , C12N15/85 , A61K45/06 , A61K38/00 , A61K35/12
摘要： This disclosure relates to recombinant cellular expression of chimeric proteins with peptide sequences derived from lymphocyte receptors and uses for treating cancer. In certain embodiments, the disclosure relates to a recombinant vector comprising a nucleic acid that encodes a chimeric protein with a segment with a targeting moiety based on a variable lymphocyte receptor (VLR) capable of binding a tumor associated antigen and a segment with a T cell signal transduction subunit. In certain embodiments, the recombinant vectors are used in immune based cancer treatments.
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5.发明申请公开(公告)号：US20190256574A1
公开(公告)日：2019-08-22
申请号：US16400501
申请日：2019-05-01
IPC分类号： C07K14/705 , C07K14/725 , C07K14/46 , A61K45/06 , A61K35/17 , C12N15/85
摘要： This disclosure relates to recombinant cellular expression of chimeric proteins with peptide sequences derived from lymphocyte receptors and uses for treating cancer. In certain embodiments, the disclosure relates to a recombinant vector comprising a nucleic acid that encodes a chimeric protein with a segment with a targeting moiety based on a variable lymphocyte receptor (VLR) capable of binding a tumor associated antigen and a segment with a T cell signal transduction subunit. In certain embodiments, the recombinant vectors are used in immune based cancer treatments.
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公开(公告)号：US20210128751A1
公开(公告)日：2021-05-06
申请号：US17143019
申请日：2021-01-06
IPC分类号： A61K48/00 , A61P7/02 , C07K14/755 , C12N7/00 , C12N9/64 , C12N15/85 , C12N15/861 , C12N15/867 , C12N15/864
摘要： Disclosed herein are recombinant viral vectors comprising a liver specific promotor in operable combination with a heterologous nucleic acid sequence encoding a protein, such as a clotting factor. Methods of treating a subject with a clotting disorder, such as hemophilia A or hemophilia B, are also provided.
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公开(公告)号：US10323077B2
公开(公告)日：2019-06-18
申请号：US15117811
申请日：2015-02-09
IPC分类号： C07K14/705 , A61K39/00 , C07K14/725 , C07K14/46 , A61K35/17 , A61K45/06 , C12N15/85 , A61K38/00 , A61K35/12
摘要： This disclosure relates to recombinant cellular expression of chimeric proteins with peptide sequences derived from lymphocyte receptors and uses for treating cancer. In certain embodiments, the disclosure relates to a recombinant vector comprising a nucleic acid that encodes a chimeric protein with a segment with a targeting moiety based on a variable lymphocyte receptor (VLR) capable of binding a tumor associated antigen and a segment with a T cell signal transduction subunit. In certain embodiments, the recombinant vectors are used in immune based cancer treatments.
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公开(公告)号：US20180344877A1
公开(公告)日：2018-12-06
申请号：US16058808
申请日：2018-08-08
IPC分类号： A61K48/00 , C07K14/755 , C12N7/00 , C12N15/85
CPC分类号： A61K48/0058 , A61K38/00 , C07K14/755 , C12N7/00 , C12N9/644 , C12N15/85 , C12N2750/14132 , C12N2750/14143 , C12N2830/008 , C12Y304/21022
摘要： Disclosed herein are recombinant viral vectors comprising a liver specific promotor in operable combination with a heterologous nucleic acid sequence encoding a protein, such as a clotting factor. Methods of treating a subject with a clotting disorder, such as hemophilia A or hemophilia B, are also provided.
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公开(公告)号：US10058624B2
公开(公告)日：2018-08-28
申请号：US15128912
申请日：2016-04-15
IPC分类号： C07K14/745 , C07K14/755 , C12N15/85 , A61K48/00 , C12N7/00 , A61K38/00
CPC分类号： A61K48/0058 , A61K38/00 , C07K14/755 , C12N7/00 , C12N9/644 , C12N15/85 , C12N2750/14132 , C12N2750/14143 , C12N2830/008 , C12Y304/21022
摘要： Disclosed herein are recombinant viral vectors comprising a liver specific promotor in operable combination with a heterologous nucleic acid sequence encoding a protein, such as a clotting factor. Methods of treating a subject with a clotting disorder, such as hemophilia A or hemophilia B, are also provided.
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公开(公告)号：US20240066067A1
公开(公告)日：2024-02-29
申请号：US18129399
申请日：2023-03-31
申请人： Wake Forest University Health Sciences , Emory University , Children's Healthcare of Atlanta, Inc.
发明人： Maria Graca N.D. Almeida-Porada , Christopher D. Porada , Anthony Atala , Christopher B. Doering , H. Trent Spencer
IPC分类号： A61K35/28 , C07K14/755 , C12N5/0775
CPC分类号： A61K35/28 , C07K14/755 , C12N5/0668
摘要： Disclosed herein are method of treating hemophilia A in a subject comprising injecting the subject with mesenchymal stromal/stem cells (MSC) modified to express high levels of Factor VIII protein. The MSC are injected into the subject prenatally. The modified MSC may also express high levels von Willebrand factor protein.
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