公开(公告)号：US20220098286A1

公开(公告)日：2022-03-31

申请号：US17551066

申请日：2021-12-14

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Servic ,  The Trustees of Columbia University in the City of New York

发明人： Peter Kwong ,  Young Do Kwon ,  Ivelin Georgiev ,  Gilad Ofek ,  Baoshan Zhang ,  Krisha McKee ,  John Mascola ,  Mark Connors ,  Gwo-Yu Chuang ,  Sijy O'Dell ,  Robert Bailer ,  Mark Louder ,  Mangaiarkarasi Asokan ,  Richard Schwartz ,  Jonathan Cooper ,  Kevin Carlton ,  Michael Bender ,  Amarendra Pegu ,  Lawrence Shapiro ,  Tatyana Gindin ,  Lisa Kueltzo

IPC分类号： C07K16/10 ,  A61P31/18

摘要： Neutralizing antibodies that specifically bind to HIV-1 Env and antigen binding fragments of these antibodies are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting HIV-1 using these antibodies are disclosed. In addition, the use of these antibodies, antigen binding fragment, nucleic acids and vectors to prevent and/or treat an HIV-1 infection is disclosed.

公开(公告)号：US20200231658A1

公开(公告)日：2020-07-23

申请号：US16786267

申请日：2020-02-10

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Servic

发明人： Mark Connors ,  Jinghe Huang ,  Byong Ha Kang ,  John Mascola ,  Elise Ishida ,  Tongqing Zhou ,  Peter Kwong ,  Anqi Zheng

IPC分类号： C07K16/10 ,  A61P31/18 ,  C07K16/28 ,  C07K16/46 ,  G01N33/569

摘要： Antibodies and antigen binding fragments that specifically bind to gp120 and neutralize HIV-1 are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting HIV-1 using these antibodies are disclosed. In addition, the use of these antibodies, antigen binding fragment, nucleic acids and vectors to prevent and/or treat an HIV-1 infection is disclosed.

公开(公告)号：US12043660B2

公开(公告)日：2024-07-23

申请号：US17551066

申请日：2021-12-14

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services ,  The Trustees of Columbia University in the City of New York

发明人： Peter Kwong ,  Young Do Kwon ,  Ivelin Georgiev ,  Gilad Ofek ,  Baoshan Zhang ,  Krisha McKee ,  John Mascola ,  Mark Connors ,  Gwo-Yu Chuang ,  Sijy O'Dell ,  Robert Bailer ,  Mark Louder ,  Mangaiarkarasi Asokan ,  Richard Schwartz ,  Jonathan Cooper ,  Kevin Carlton ,  Michael Bender ,  Amarendra Pegu ,  Lawrence Shapiro ,  Tatyana Gindin ,  Lisa Kueltzo

IPC分类号： C07K16/10 ,  A61P31/18

CPC分类号： C07K16/1063 ,  A61P31/18 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/52 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  G01N2333/162

摘要： Neutralizing antibodies that specifically bind to HIV-1 Env and antigen binding fragments of these antibodies are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting HIV-1 using these antibodies are disclosed. In addition, the use of these antibodies, antigen binding fragment, nucleic acids and vectors to prevent and/or treat an HIV-1 infection is disclosed.

公开(公告)号：US20190077849A1

公开(公告)日：2019-03-14

申请号：US15772443

申请日：2016-11-03

申请人： The United States of America,as represented by the Secretary, Department of Health and Human Service ,  The Trustees of Columbia University in the City of New York

发明人： Peter Kwong ,  Young Do Kwon ,  Ivelin Georgiev ,  Gilad Ofek ,  Baoshan Zhang ,  Krisha McKee ,  John Mascola ,  Mark Connors ,  Gwo-Yu Chuang ,  Sijy O'Dell ,  Robert Bailer ,  Mark Louder ,  Mangaiarkarasi Asokan ,  Richard Schwartz ,  Jonathan Cooper ,  Kevin Carlton ,  Michael Bender ,  Amarendra Pegu ,  Lawrence Shapiro ,  Tatyana Gindin ,  Lisa Kueltzo

IPC分类号： C07K16/10 ,  A61P31/18

摘要： Neutralizing antibodies that specifically bind to HIV-1 Env and antigen binding fragments of these antibodies are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting HIV-1 using these antibodies are disclosed. In addition, the use of these antibodies, antigen binding fragment, nucleic acids and vectors to prevent and/or treat an HIV-1 infection is disclosed.

公开(公告)号：US11236152B2

公开(公告)日：2022-02-01

申请号：US15772443

申请日：2016-11-03

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services ,  The Trustees of Columbia University in the City of New York

发明人： Peter Kwong ,  Young Do Kwon ,  Ivelin Georgiev ,  Gilad Ofek ,  Baoshan Zhang ,  Krisha McKee ,  John Mascola ,  Mark Connors ,  Gwo-Yu Chuang ,  Sijy O'Dell ,  Robert Bailer ,  Mark Louder ,  Mangaiarkarasi Asokan ,  Richard Schwartz ,  Jonathan Cooper ,  Kevin Carlton ,  Michael Bender ,  Amarendra Pegu ,  Lawrence Shapiro ,  Tatyana Gindin ,  Lisa Kueltzo

IPC分类号： C07K16/10 ,  A61P31/18

摘要： Neutralizing antibodies that specifically bind to HIV-1 Env and antigen binding fragments of these antibodies are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting HIV-1 using these antibodies are disclosed. In addition, the use of these antibodies, antigen binding fragment, nucleic acids and vectors to prevent and/or treat an HIV-1 infection is disclosed.