公开(公告)号：US20230227512A1

公开(公告)日：2023-07-20

申请号：US17937719

申请日：2022-10-03

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Servic

发明人： Peter Kwong ,  Marie Pancera ,  Tongqing Zhou ,  Ivelin Georgiev ,  Michael Gordon Joyce ,  Priyamvada Acharya ,  Jason Gorman ,  Yongping Yang ,  Guillaume Stewart-Jones ,  Rita Chen ,  Gwo-Yu Chuang ,  John Mascola ,  Baoshan Zhang ,  Cheng Cheng ,  Mallika Sastry ,  Aliaksandr Druz

IPC分类号： C07K14/435 ,  A61K39/12 ,  C07K14/005 ,  A61K39/21 ,  C07K16/10 ,  G01N33/569

CPC分类号： C07K14/435 ,  A61K39/12 ,  C07K14/005 ,  A61K39/21 ,  C07K16/1063 ,  G01N33/56988 ,  C12N2740/16122 ,  C12N2740/16134 ,  A61K2039/55555

摘要： HIV-1 Env ectodomain trimers stabilized in a prefusion mature closed conformation and methods of their use and production are disclosed. In several embodiments, the HIV-1 Env ectodomain trimers and/or nucleic acid molecules can be used to generate an immune response to HIV-1 in a subject. In additional embodiments, the therapeutically effective amount of the HIV-1 Env ectodomain trimers can be administered to a subject in a method of treating or preventing HIV-1 infection.

公开(公告)号：US20220064222A1

公开(公告)日：2022-03-03

申请号：US17524380

申请日：2021-11-11

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Servic

发明人： Peter Kwong ,  Barney Graham ,  John Mascola ,  Li Ou ,  Aliaksandr Druz ,  Man Chen ,  Wing-Pui Kong ,  Ivelin Stefanov Georgiev ,  Emily Rundlet ,  Michael Gordon Joyce ,  Yaroslav Tsybovsky ,  Paul Thomas ,  Marie Pancera ,  Mallika Sastry ,  Cinque Soto ,  Joseph Van Galen ,  Guillaume Stewart-Jones ,  Yongping Yang ,  Baoshan Zhang ,  Ulrich Baxa

IPC分类号： C07K14/005 ,  A61K39/12 ,  A61P37/04 ,  A61P31/14

摘要： Embodiments of a recombinant Respiratory Syncytial Virus (RSV) F ectodomain trimer stabilized in a prefusion conformation are provided. Also disclosed are nucleic acids encoding the RSV F ectodomain trimer and methods of producing the RSV F ectodomain trimer. Methods for inducing an immune response in a subject are also disclosed. In some embodiments, the method can be a method for treating or preventing a RSV infection in a subject by administering a therapeutically effective amount of the recombinant RSV F ectodomain trimer to the subject.

公开(公告)号：US20210353740A1

公开(公告)日：2021-11-18

申请号：US17277694

申请日：2019-09-23

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Servic

发明人： Peter Kwong ,  Li Ou ,  John Mascola ,  Baoshan Zhang ,  Kai Xu ,  Wing-Pui Kong ,  Yaroslav Tsybovsky ,  Cara W. Chao ,  Jeffrey Boyington ,  Yiran Wang

IPC分类号： A61K39/21 ,  A61K47/69 ,  A61K47/64 ,  A61K9/16 ,  A61P31/18

摘要： Embodiments of immunogenic conjugates including the HIV-1 Env fusion peptide and methods of their use and production are disclosed. In several embodiments, the immunogenic conjugates can be used to generate an immune response to HIV-1 Env in a subject, for example, to treat or prevent an HIV-1 infection in the subject.

公开(公告)号：US20210299242A1

公开(公告)日：2021-09-30

申请号：US17261828

申请日：2019-08-05

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Servic ,  Trustees of Dartmouth College

发明人： Barney Graham ,  Rebecca Loomis ,  Guillaume Stewart-Jones ,  John Mascola ,  Jason McLellan

IPC分类号： A61K39/155 ,  C07K14/005 ,  A61P31/14

摘要： Embodiments of immunogens comprising a recombinant Nipah virus (NiV) F ectodomain trimer stabilized in a prefusion conformation are provided. Also provided are embodiments of immunogens comprising chimeric proteins comprising the recombinant NiV F ectodomain trimer and one or more G ectodomains, a multimer of NiV G ectodomains, and protein nanoparticles comprising the recombinant NiV F ectodomain trimer or an NiV G ectodomain. Also disclosed are nucleic acids encoding the immunogens and methods of their production. Methods for inducing an immune response in a subject by administering a disclosed immunogen to the subject are also provided. In some embodiments, the immune response treats or inhibits NiV infection in a subject.

公开(公告)号：US20240101609A1

公开(公告)日：2024-03-28

申请号：US18537448

申请日：2023-12-12

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Servic ,  Institute for Research in Biomedicine

发明人： Baoshan Zhang ,  Guillaume Stewart-Jones ,  Tongqing Zhou ,  John Mascola ,  Kai Xu ,  Yongping Yang ,  Paul Thomas ,  Gwo-Yu Chuang ,  Li Ou ,  Peter Kwong ,  Yaroslav Tsybovsky ,  Wing-Pui Kong ,  Aliaksandr Druz ,  Davide Corti ,  Antonio Lanzavecchia

IPC分类号： C07K14/005 ,  A61K39/155 ,  A61P31/14 ,  C12N7/00

CPC分类号： C07K14/005 ,  A61K39/155 ,  A61P31/14 ,  C12N7/00 ,  C07K2319/50 ,  C12N2760/18634 ,  C12N2760/18734

摘要： Embodiments of a recombinant human Parainfluenza Virus (hPIV) F ectodomain trimer stabilized in a prefusion conformation are provided. Also disclosed are nucleic acids encoding the hPIV F ectodomain trimer and methods of producing the hPIV F ectodomain trimer. Methods for inducing an immune response in a subject are also disclosed. In some embodiments, the method can be a method for treating or inhibiting a hPIV infection in a subject by administering a effective amount of the recombinant hPIV F ectodomain trimer to the subject.

公开(公告)号：US20210198324A1

公开(公告)日：2021-07-01

申请号：US17202231

申请日：2021-03-15

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Servic

发明人： Peter Kwong ,  Ivelin Georgiev ,  Michael Gordon Joyce ,  Masaru Kanekiyo ,  Aliaksandr Druz ,  Ulrich Baxa ,  Joseph Van Galen ,  Cheng Cheng ,  John Mascola ,  Yaroslav Tsybovsky ,  Yongping Yang ,  Barney Graham ,  Syed Mohammad Moin ,  Jeffrey Boyington

IPC分类号： C07K14/11 ,  A61K39/21 ,  C07K14/08 ,  C07K14/16 ,  C07K14/165 ,  C07K14/435 ,  C12N7/00

摘要： Disclosed are recombinant insect ferritin nanoparticles that can be used to display two different trimeric antigens at an equal ratio. Also disclosed are nucleic acids encoding the recombinant insect ferritin nanoparticles and methods of producing the recombinant insect ferritin nanoparticles. Methods for eliciting an immune response in a subject are also provided.

公开(公告)号：US20200231658A1

公开(公告)日：2020-07-23

申请号：US16786267

申请日：2020-02-10

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Servic

发明人： Mark Connors ,  Jinghe Huang ,  Byong Ha Kang ,  John Mascola ,  Elise Ishida ,  Tongqing Zhou ,  Peter Kwong ,  Anqi Zheng

IPC分类号： C07K16/10 ,  A61P31/18 ,  C07K16/28 ,  C07K16/46 ,  G01N33/569

摘要： Antibodies and antigen binding fragments that specifically bind to gp120 and neutralize HIV-1 are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting HIV-1 using these antibodies are disclosed. In addition, the use of these antibodies, antigen binding fragment, nucleic acids and vectors to prevent and/or treat an HIV-1 infection is disclosed.

公开(公告)号：US20200230229A1

公开(公告)日：2020-07-23

申请号：US16338964

申请日：2017-10-03

申请人： THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVIC

发明人： Peter Kwong ,  Rui Kong ,  Tongqing Zhou ,  John Mascola ,  Kai Xu ,  Michael Gordon Joyce ,  Cheng Cheng ,  Gwo-Yu Chuang ,  Kevin Liu ,  Baoshan Zhang ,  Li Ou ,  Wing-Pui Kong ,  Yongping Yang

IPC分类号： A61K39/21 ,  C12N7/00 ,  A61K47/64 ,  A61P31/18 ,  C07K14/005

摘要： Embodiments of immunogens based on the HIV-1 Env fusion peptide and methods of their use and production are disclosed. Nucleic acid molecules encoding the immunogens are also provided. In several embodiments, the immunogens can be used to generate an immune response to HIV-1 Env in a subject, for example, to treat or prevent an HIV-1 infection in the subject.

公开(公告)号：US20220098286A1

公开(公告)日：2022-03-31

申请号：US17551066

申请日：2021-12-14

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Servic ,  The Trustees of Columbia University in the City of New York

发明人： Peter Kwong ,  Young Do Kwon ,  Ivelin Georgiev ,  Gilad Ofek ,  Baoshan Zhang ,  Krisha McKee ,  John Mascola ,  Mark Connors ,  Gwo-Yu Chuang ,  Sijy O'Dell ,  Robert Bailer ,  Mark Louder ,  Mangaiarkarasi Asokan ,  Richard Schwartz ,  Jonathan Cooper ,  Kevin Carlton ,  Michael Bender ,  Amarendra Pegu ,  Lawrence Shapiro ,  Tatyana Gindin ,  Lisa Kueltzo

IPC分类号： C07K16/10 ,  A61P31/18

摘要： Neutralizing antibodies that specifically bind to HIV-1 Env and antigen binding fragments of these antibodies are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting HIV-1 using these antibodies are disclosed. In addition, the use of these antibodies, antigen binding fragment, nucleic acids and vectors to prevent and/or treat an HIV-1 infection is disclosed.

公开(公告)号：US20210079070A1

公开(公告)日：2021-03-18

申请号：US16971826

申请日：2019-02-21

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Servic

发明人： Paolo Lusso ,  Qingbo Liu ,  Peter Kwong ,  John Mascola ,  Young Do Kwon

IPC分类号： C07K16/10 ,  G01N33/569 ,  A61P31/18

摘要： Antibodies and antigen binding fragments that specifically bind to HIV-1 Env and neutralize HIV-1 are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting HIV-1 using these antibodies are disclosed. In addition, the use of these antibodies, antigen binding fragment, nucleic acids and vectors to prevent and/or treat an HIV-1 infection is disclosed.