专利检索 ap:("The United States of America, as represented by the Secretary, Department of Health AND Human Servic" OR "The Trustees of Columbia University in the City of New York") AND inv:"Young Do Kwon" 第 1 页

1.

发明申请
NEUTRALIZING ANTIBODIES TO HIV-1 GP41 AND THEIR USE 有权

公开(公告)号：US20220098286A1

公开(公告)日：2022-03-31

申请号：US17551066

申请日：2021-12-14

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Servic , The Trustees of Columbia University in the City of New York

发明人： Peter Kwong , Young Do Kwon , Ivelin Georgiev , Gilad Ofek , Baoshan Zhang , Krisha McKee , John Mascola , Mark Connors , Gwo-Yu Chuang , Sijy O'Dell , Robert Bailer , Mark Louder , Mangaiarkarasi Asokan , Richard Schwartz , Jonathan Cooper , Kevin Carlton , Michael Bender , Amarendra Pegu , Lawrence Shapiro , Tatyana Gindin , Lisa Kueltzo

IPC分类号： C07K16/10 , A61P31/18

摘要： Neutralizing antibodies that specifically bind to HIV-1 Env and antigen binding fragments of these antibodies are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting HIV-1 using these antibodies are disclosed. In addition, the use of these antibodies, antigen binding fragment, nucleic acids and vectors to prevent and/or treat an HIV-1 infection is disclosed.

2.

发明申请
SUBSTITUTED PHENYLPYRROLECARBOXAMIDES WITH THERAPEUTIC ACTIVITY IN HIV 有权

公开(公告)号：US20210340126A1

公开(公告)日：2021-11-04

申请号：US17366920

申请日：2021-07-02

申请人： New York Blood Center, Inc. , The United States of America, As Represented By The Secretary, Department of Health and Human Servic

发明人： Asim Kumar Debnath , Francesca Curreli , Peter D. Kwong , Young Do Kwon

IPC分类号： C07D403/12 , A61P31/18 , C07D207/34 , C07D241/04 , C07D401/14 , C07D405/14 , C07D413/12 , C07D417/12 , C07D417/14

摘要： Substituted phenylpyrrolecarboxamide compounds such as those represented by Formula A can be used in the treatment of HIV infection and related conditions.

3.

发明申请
NEUTRALIZING ANTIBODIES TO HIV-1 ENV AND THEIR USE 有权

公开(公告)号：US20210079070A1

公开(公告)日：2021-03-18

申请号：US16971826

申请日：2019-02-21

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Servic

发明人： Paolo Lusso , Qingbo Liu , Peter Kwong , John Mascola , Young Do Kwon

IPC分类号： C07K16/10 , G01N33/569 , A61P31/18

摘要： Antibodies and antigen binding fragments that specifically bind to HIV-1 Env and neutralize HIV-1 are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting HIV-1 using these antibodies are disclosed. In addition, the use of these antibodies, antigen binding fragment, nucleic acids and vectors to prevent and/or treat an HIV-1 infection is disclosed.

4.

发明授权
10E8 neutralizing antibody variants that bind to the MPER region of HIV-1 GP41 and their use 有权

公开(公告)号：US12043660B2

公开(公告)日：2024-07-23

申请号：US17551066

申请日：2021-12-14

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services , The Trustees of Columbia University in the City of New York

发明人： Peter Kwong , Young Do Kwon , Ivelin Georgiev , Gilad Ofek , Baoshan Zhang , Krisha McKee , John Mascola , Mark Connors , Gwo-Yu Chuang , Sijy O'Dell , Robert Bailer , Mark Louder , Mangaiarkarasi Asokan , Richard Schwartz , Jonathan Cooper , Kevin Carlton , Michael Bender , Amarendra Pegu , Lawrence Shapiro , Tatyana Gindin , Lisa Kueltzo

IPC分类号： C07K16/10 , A61P31/18

CPC分类号： C07K16/1063 , A61P31/18 , C07K2317/21 , C07K2317/31 , C07K2317/33 , C07K2317/52 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , C07K2317/94 , G01N2333/162

摘要： Neutralizing antibodies that specifically bind to HIV-1 Env and antigen binding fragments of these antibodies are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting HIV-1 using these antibodies are disclosed. In addition, the use of these antibodies, antigen binding fragment, nucleic acids and vectors to prevent and/or treat an HIV-1 infection is disclosed.

5.

发明申请
NEUTRALIZING ANTIBODIES TO HIV-1 GP41 AND THEIR USE 审中-公开

公开(公告)号：US20190077849A1

公开(公告)日：2019-03-14

申请号：US15772443

申请日：2016-11-03

申请人： The United States of America,as represented by the Secretary, Department of Health and Human Service , The Trustees of Columbia University in the City of New York

发明人： Peter Kwong , Young Do Kwon , Ivelin Georgiev , Gilad Ofek , Baoshan Zhang , Krisha McKee , John Mascola , Mark Connors , Gwo-Yu Chuang , Sijy O'Dell , Robert Bailer , Mark Louder , Mangaiarkarasi Asokan , Richard Schwartz , Jonathan Cooper , Kevin Carlton , Michael Bender , Amarendra Pegu , Lawrence Shapiro , Tatyana Gindin , Lisa Kueltzo

IPC分类号： C07K16/10 , A61P31/18

摘要： Neutralizing antibodies that specifically bind to HIV-1 Env and antigen binding fragments of these antibodies are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting HIV-1 using these antibodies are disclosed. In addition, the use of these antibodies, antigen binding fragment, nucleic acids and vectors to prevent and/or treat an HIV-1 infection is disclosed.

6.

发明申请
CD4-MIMETIC INHIBITORS OF HIV-1 ENTRY AND METHODS OF USE THEREOF 有权
标题翻译： HIV-1入侵的CD4-物质抑制剂及其使用方法

公开(公告)号：US20140350113A1

公开(公告)日：2014-11-27

申请号：US14365389

申请日：2012-12-14

申请人： Dana-Farber Cancer Institute, Inc. , The Trustees of the University of Pennsylvania , United States of Americas as Represented By The Secretary, Department of Health and Human Services , Bryn Mawr College , The Johns Hopkins University , The Trustees of Columbia University in the City of New York

发明人： Joseph Sodroski , Judith M. LaLonde , Amos B. Smith, III , Peter D. Kwong , Young Do Kwon , David M. Jones , Alexander W. Sun , Joel R. Courter , Takahiro Soeta , Toyoharu Kobayashi , Amy M. Princiotto , Xueling Wu , John R. Mascola , Ame Schon , Emesto Freire , Navid Madani , Matthew Le-Khac , Wayne A. Hendrickson

IPC分类号： C07C279/16 , C07C237/06

CPC分类号： C07C279/16 , A61K31/167 , A61K31/185 , C07C233/56 , C07C237/06 , C07C237/22 , C07C279/12 , C07C2601/14 , C07C2602/08 , C07D207/335 , C07D207/34 , C07D209/88 , C07D209/94 , C07D233/88 , C07D235/02 , C07D235/06 , C07D271/07 , C07D307/52

摘要： Described herein are small-molecule mimics of CD4, which both enter the Phe43 cavity and target Asp368 of gp120, the HIV-1 envelope protein. Also described herein are methods of using these compounds to inhibit the transmission or progression of HIV infection. These compounds exhibit antiviral potency greater than that of a known antiviral, NBD-556, with 100% breadth against clade B and C viruses. Importantly, the compounds do not activate HIV infection of CD4-negative, CCR5-positive cells, in contrast to NBD-556.

摘要翻译： 本文描述的是CD4的小分子模拟物，其都进入Phe43腔，并且gp120的靶标Asp368（HIV-1包膜蛋白）。本文还描述了使用这些化合物抑制HIV感染的传播或进展的方法。这些化合物显示出比已知的抗病毒剂NBD-556的抗病毒效力更大，对于进化枝B和C病毒具有100％的广度。重要的是，与NBD-556相比，化合物不能激活CD4阴性CCR5阳性细胞的HIV感染。