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公开(公告)号：US20220098286A1
公开(公告)日：2022-03-31
申请号：US17551066
申请日：2021-12-14
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Servic , The Trustees of Columbia University in the City of New York
发明人： Peter Kwong , Young Do Kwon , Ivelin Georgiev , Gilad Ofek , Baoshan Zhang , Krisha McKee , John Mascola , Mark Connors , Gwo-Yu Chuang , Sijy O'Dell , Robert Bailer , Mark Louder , Mangaiarkarasi Asokan , Richard Schwartz , Jonathan Cooper , Kevin Carlton , Michael Bender , Amarendra Pegu , Lawrence Shapiro , Tatyana Gindin , Lisa Kueltzo
摘要： Neutralizing antibodies that specifically bind to HIV-1 Env and antigen binding fragments of these antibodies are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting HIV-1 using these antibodies are disclosed. In addition, the use of these antibodies, antigen binding fragment, nucleic acids and vectors to prevent and/or treat an HIV-1 infection is disclosed.
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公开(公告)号：US20240024458A1
公开(公告)日：2024-01-25
申请号：US18462340
申请日：2023-09-06
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Servic , Institute For Research in Biomedicine
发明人： Peter Kwong , Michael Gordon Joyce , Baoshan Zhang , Yongping Yang , Peter Collins , Ursula Buchholz , Davide Corti , Antonio Lanzavecchia , Guillaume Stewart-Jones
IPC分类号： A61K39/155 , A61K39/39 , C07K14/005 , A61K48/00 , C07K14/135
CPC分类号： A61K39/155 , A61K39/39 , C07K14/005 , A61K48/00 , C07K14/135 , C07K2319/73 , C12N2760/18322 , C12N2760/18334 , C07K2319/70 , C12N2760/18522 , C12N2760/18534
摘要： Metapneumovirus (MPV) F proteins stabilized in a prefusion conformation, nucleic acid molecules and vectors encoding these proteins, and methods of their use and production are disclosed. In several embodiments, the MPV F proteins and/or nucleic acid molecules can be used to generate an immune response to MPV in a subject. In additional embodiments, the therapeutically effective amount of the MPV F ectodomain trimers and/or nucleic acid molecules can be administered to a subject in a method of treating or preventing MPV infection.
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公开(公告)号：US20230227512A1
公开(公告)日：2023-07-20
申请号：US17937719
申请日：2022-10-03
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Servic
发明人： Peter Kwong , Marie Pancera , Tongqing Zhou , Ivelin Georgiev , Michael Gordon Joyce , Priyamvada Acharya , Jason Gorman , Yongping Yang , Guillaume Stewart-Jones , Rita Chen , Gwo-Yu Chuang , John Mascola , Baoshan Zhang , Cheng Cheng , Mallika Sastry , Aliaksandr Druz
IPC分类号： C07K14/435 , A61K39/12 , C07K14/005 , A61K39/21 , C07K16/10 , G01N33/569
CPC分类号： C07K14/435 , A61K39/12 , C07K14/005 , A61K39/21 , C07K16/1063 , G01N33/56988 , C12N2740/16122 , C12N2740/16134 , A61K2039/55555
摘要： HIV-1 Env ectodomain trimers stabilized in a prefusion mature closed conformation and methods of their use and production are disclosed. In several embodiments, the HIV-1 Env ectodomain trimers and/or nucleic acid molecules can be used to generate an immune response to HIV-1 in a subject. In additional embodiments, the therapeutically effective amount of the HIV-1 Env ectodomain trimers can be administered to a subject in a method of treating or preventing HIV-1 infection.
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公开(公告)号：US20220064222A1
公开(公告)日：2022-03-03
申请号：US17524380
申请日：2021-11-11
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Servic
发明人： Peter Kwong , Barney Graham , John Mascola , Li Ou , Aliaksandr Druz , Man Chen , Wing-Pui Kong , Ivelin Stefanov Georgiev , Emily Rundlet , Michael Gordon Joyce , Yaroslav Tsybovsky , Paul Thomas , Marie Pancera , Mallika Sastry , Cinque Soto , Joseph Van Galen , Guillaume Stewart-Jones , Yongping Yang , Baoshan Zhang , Ulrich Baxa
IPC分类号： C07K14/005 , A61K39/12 , A61P37/04 , A61P31/14
摘要： Embodiments of a recombinant Respiratory Syncytial Virus (RSV) F ectodomain trimer stabilized in a prefusion conformation are provided. Also disclosed are nucleic acids encoding the RSV F ectodomain trimer and methods of producing the RSV F ectodomain trimer. Methods for inducing an immune response in a subject are also disclosed. In some embodiments, the method can be a method for treating or preventing a RSV infection in a subject by administering a therapeutically effective amount of the recombinant RSV F ectodomain trimer to the subject.
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公开(公告)号：US20210353740A1
公开(公告)日：2021-11-18
申请号：US17277694
申请日：2019-09-23
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Servic
发明人： Peter Kwong , Li Ou , John Mascola , Baoshan Zhang , Kai Xu , Wing-Pui Kong , Yaroslav Tsybovsky , Cara W. Chao , Jeffrey Boyington , Yiran Wang
摘要： Embodiments of immunogenic conjugates including the HIV-1 Env fusion peptide and methods of their use and production are disclosed. In several embodiments, the immunogenic conjugates can be used to generate an immune response to HIV-1 Env in a subject, for example, to treat or prevent an HIV-1 infection in the subject.
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公开(公告)号：US20240101609A1
公开(公告)日：2024-03-28
申请号：US18537448
申请日：2023-12-12
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Servic , Institute for Research in Biomedicine
发明人： Baoshan Zhang , Guillaume Stewart-Jones , Tongqing Zhou , John Mascola , Kai Xu , Yongping Yang , Paul Thomas , Gwo-Yu Chuang , Li Ou , Peter Kwong , Yaroslav Tsybovsky , Wing-Pui Kong , Aliaksandr Druz , Davide Corti , Antonio Lanzavecchia
IPC分类号： C07K14/005 , A61K39/155 , A61P31/14 , C12N7/00
CPC分类号： C07K14/005 , A61K39/155 , A61P31/14 , C12N7/00 , C07K2319/50 , C12N2760/18634 , C12N2760/18734
摘要： Embodiments of a recombinant human Parainfluenza Virus (hPIV) F ectodomain trimer stabilized in a prefusion conformation are provided. Also disclosed are nucleic acids encoding the hPIV F ectodomain trimer and methods of producing the hPIV F ectodomain trimer. Methods for inducing an immune response in a subject are also disclosed. In some embodiments, the method can be a method for treating or inhibiting a hPIV infection in a subject by administering a effective amount of the recombinant hPIV F ectodomain trimer to the subject.
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公开(公告)号：US20210198324A1
公开(公告)日：2021-07-01
申请号：US17202231
申请日：2021-03-15
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Servic
发明人： Peter Kwong , Ivelin Georgiev , Michael Gordon Joyce , Masaru Kanekiyo , Aliaksandr Druz , Ulrich Baxa , Joseph Van Galen , Cheng Cheng , John Mascola , Yaroslav Tsybovsky , Yongping Yang , Barney Graham , Syed Mohammad Moin , Jeffrey Boyington
IPC分类号： C07K14/11 , A61K39/21 , C07K14/08 , C07K14/16 , C07K14/165 , C07K14/435 , C12N7/00
摘要： Disclosed are recombinant insect ferritin nanoparticles that can be used to display two different trimeric antigens at an equal ratio. Also disclosed are nucleic acids encoding the recombinant insect ferritin nanoparticles and methods of producing the recombinant insect ferritin nanoparticles. Methods for eliciting an immune response in a subject are also provided.
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公开(公告)号：US20200009243A1
公开(公告)日：2020-01-09
申请号：US16578748
申请日：2019-09-23
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Servic , Institute for Research in Biomedicine
发明人： Peter Kwong , Michael Gordon Joyce , Baoshan Zhang , Yongping Yang , Peter Collins , Ursula Buchholz , Davide Corti , Antonio Lanzavecchia , Guillaume Stewart-Jones
IPC分类号： A61K39/155 , A61K39/39 , A61K48/00 , C07K14/005 , C07K14/135
摘要： Metapneumovirus (MPV) F proteins stabilized in a prefusion conformation, nucleic acid molecules and vectors encoding these proteins, and methods of their use and production are disclosed. In several embodiments, the MPV F proteins and/or nucleic acid molecules can be used to generate an immune response to MPV in a subject. In additional embodiments, the therapeutically effective amount of the MPV F ectodomain trimers and/or nucleic acid molecules can be administered to a subject in a method of treating or preventing MPV infection.
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9.发明公开公开(公告)号：US20240309053A1
公开(公告)日：2024-09-19
申请号：US18665309
申请日：2024-05-15
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Servic
发明人： Peter Collins , Bo Liang , Shirin Munir , Anne Schaap Nutt , Ursula Buchholz , Natalie Mackow , Peter Kwong , Barney Graham , Jason McLellan
IPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/155 , A61P31/14
CPC分类号： C07K14/005 , A61K39/12 , A61K39/155 , A61P31/14 , A61K2039/5254 , A61K2039/5256 , A61K2039/575 , A61K2039/70 , C07K2319/03 , C07K2319/033 , C12N2760/00022 , C12N2760/18534 , C12N2760/18571 , C12N2760/18622 , C12N2760/18634 , C12N2760/18641 , C12N2760/18643 , C12N2760/18671 , C12N2760/18722 , C12N2760/18734 , C12N2760/18741 , C12N2760/18743 , C12N2760/18771
摘要： Recombinant paramyxoviruses including a viral genome encoding a heterologous gene are provided. In several embodiments, the recombinant paramyxovirus is a recombinant parainfluenza virus, such as a recombinant PIV3 including a viral genome encoding a heterologous respiratory syncytial virus F ectodomain linked to the transmembrane domain and the cytoplasmic tail of the F protein from the PIV3. Nucleic acid molecules including the genome of a recombinant paramyxoviruses are also provided. The recombinant viruses may advantageously be used in vaccine formulations, such as for vaccines against parainfluenza virus and respiratory syncytial virus.
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公开(公告)号：US20200231658A1
公开(公告)日：2020-07-23
申请号：US16786267
申请日：2020-02-10
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Servic
发明人： Mark Connors , Jinghe Huang , Byong Ha Kang , John Mascola , Elise Ishida , Tongqing Zhou , Peter Kwong , Anqi Zheng
IPC分类号： C07K16/10 , A61P31/18 , C07K16/28 , C07K16/46 , G01N33/569
摘要： Antibodies and antigen binding fragments that specifically bind to gp120 and neutralize HIV-1 are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting HIV-1 using these antibodies are disclosed. In addition, the use of these antibodies, antigen binding fragment, nucleic acids and vectors to prevent and/or treat an HIV-1 infection is disclosed.
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