公开(公告)号：US08871789B2

公开(公告)日：2014-10-28

申请号：US13747406

申请日：2013-01-22

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services

发明人： Thomas Michael Kristie ,  Yu Liang ,  Jodi Vogel ,  David J. Maloney ,  Ganesha Rai Bantukallu ,  Anton Simeonov ,  Ajit Jadhav

IPC分类号： A61K31/47 ,  A61K31/535 ,  A61K31/497 ,  C07D239/42 ,  A61K31/496 ,  A61K31/165 ,  A61K31/7088 ,  A61K31/505 ,  A61K31/44 ,  A61K45/06 ,  C07D215/14 ,  A61K31/198 ,  A61K31/166 ,  A61K31/195 ,  A61K31/135 ,  A61K31/00 ,  A61K31/225 ,  A61K31/551 ,  A61K31/137 ,  A61K31/194 ,  A61K31/506 ,  A61K31/444 ,  C07C233/56 ,  A61K31/5377

CPC分类号： A61K31/551 ,  A61K31/00 ,  A61K31/135 ,  A61K31/137 ,  A61K31/165 ,  A61K31/166 ,  A61K31/194 ,  A61K31/195 ,  A61K31/198 ,  A61K31/225 ,  A61K31/44 ,  A61K31/444 ,  A61K31/47 ,  A61K31/496 ,  A61K31/505 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/7088 ,  A61K45/06 ,  C07C233/56 ,  C07D215/14 ,  A61K2300/00

摘要： Disclosed are compounds and pharmaceutical compositions containing compounds that inhibit JMJD2 proteins, including those of the formula (I): wherein R1, R2, R3, R4, and R5 are as defined herein or pharmaceutically acceptable salts thereof. Also disclosed is a method of preventing or treating a viral infection of a host, comprising administering to the host an effective amount of an inhibitor of the JMJD2 family of histone demethylases, for example, a compound of the formula (I). The viral infection may be a primary infection, reactivation of a virus after latency in a host, or may be in a mammal that has undergone, is undergoing, or will undergo immunosuppressive therapy.

摘要翻译： 公开了含有抑制JMJD2蛋白质的化合物和药物组合物，包括式（I）的化合物：其中R 1，R 2，R 3，R 4和R 5如本文所定义或其药学上可接受的盐。 还公开了一种预防或治疗宿主的病毒感染的方法，包括向宿主施用有效量的组蛋白脱甲基酶JMJD2家族抑制剂，例如式（I）化合物。 病毒感染可能是主要感染，宿主潜伏期后病毒的再活化，或可能在已经经历或将进行免疫抑制治疗的哺乳动物中。

公开(公告)号：US20130123344A1

公开(公告)日：2013-05-16

申请号：US13747406

申请日：2013-01-22

申请人： The United States of America, as Represented by the Secretary, Department of Health and Human Services

发明人： Thomas Michael Kristie ,  Yu Liang ,  Jodi Vogel ,  David J. Maloney ,  Ganesha Rai Bantukallu ,  Anton Simeonov ,  Ajit Jadhav

IPC分类号： A61K31/551 ,  C07D215/14 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/47 ,  A61K31/496

CPC分类号： A61K31/551 ,  A61K31/00 ,  A61K31/135 ,  A61K31/137 ,  A61K31/165 ,  A61K31/166 ,  A61K31/194 ,  A61K31/195 ,  A61K31/198 ,  A61K31/225 ,  A61K31/44 ,  A61K31/444 ,  A61K31/47 ,  A61K31/496 ,  A61K31/505 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/7088 ,  A61K45/06 ,  C07C233/56 ,  C07D215/14 ,  A61K2300/00

摘要： Disclosed are compounds and pharmaceutical compositions containing compounds that inhibit JMJD2 proteins, including those of the formula (I): wherein R1, R2, R3, R4, and R5 are as defined herein or pharmaceutically acceptable salts thereof. Also disclosed is a method of preventing or treating a viral infection of a host, comprising administering to the host an effective amount of an inhibitor of the JMJD2 family of histone demethylases, for example, a compound of the formula (I). The viral infection may be a primary infection, reactivation of a virus after latency in a host, or may be in a mammal that has undergone, is undergoing, or will undergo immunosuppressive therapy.

摘要翻译： 公开了含有抑制JMJD2蛋白质的化合物和药物组合物，包括式（I）的化合物：其中R 1，R 2，R 3，R 4和R 5如本文所定义或其药学上可接受的盐。 还公开了一种预防或治疗宿主的病毒感染的方法，包括向宿主施用有效量的组蛋白脱甲基酶JMJD2家族抑制剂，例如式（I）化合物。 病毒感染可能是主要感染，宿主潜伏期后病毒的再活化，或可能在已经经历或将进行免疫抑制治疗的哺乳动物中。