公开(公告)号：US11574704B2

公开(公告)日：2023-02-07

申请号：US16746347

申请日：2020-01-17

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services ,  British Columbia Cancer Agency Branch ,  Arizona Board of Regents on Behalf of the University of Arizona ,  Universitat de Barcelona ,  Hospital Clinic de Barcelona ,  The Cleveland Clinic Foundation ,  Board of Regents of the University of Nebraska ,  Oregon Health & Science University ,  Julius-Maximilians—University of Würzburg ,  Oslo University Hospital HF

发明人： Louis M. Staudt ,  George W. Wright ,  David William Scott ,  Joseph M. Connors ,  Randy D. Gascoyne ,  Lisa Rimsza ,  Elias Campo Guerri ,  Raymond Tubbs ,  Timothy C. Greiner ,  James Robert Cook ,  Kai Fu ,  Paul Michael Williams ,  Chih-Jian Lih ,  Elaine S. Jaffe ,  Rita M. Braziel ,  Andreas Rosenwald ,  Erlend B. Smeland ,  Wing C. Chan ,  German Ott ,  Jan Delabie ,  Dennis Weisenburger

IPC分类号： G01N33/48 ,  G16B25/10 ,  G16B25/00 ,  G16B5/00 ,  C12Q1/6886

摘要： The invention is directed to methods for selecting a treatment option for an activated B cell-like diffuse large B cell lymphoma (ABC DLBCL) subject, a germinal center B cell-like diffuse large B cell lymphoma (GCB DLBCL) subject, a primary mediastinal B cell lymphoma (PMBL) subject, a Burkitt lymphoma (BL) subject, or a mantle cell lymphoma (MCL) subject by analyzing digital gene expression data obtained from the subject, e.g., from a biopsy sample.

公开(公告)号：US10607717B2

公开(公告)日：2020-03-31

申请号：US15035101

申请日：2014-11-05

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services ,  British Columbia Cancer Agency Branch ,  Arizona Board of Regents on Behalf of the University of Arizona ,  Universitat de Barcelona ,  Hospital Clinic de Barcelona ,  The Cleveland Clinic Foundation ,  The Board of Regents of the University of Nebraska ,  Oregon Health and Science University ,  Julius-Maximilians-University of Würzburg ,  Oslo University Hospital HF

发明人： Louis M. Staudt ,  George W. Wright ,  David William Scott ,  Joseph M. Connors ,  Randy D. Gascoyne ,  Lisa Rimsza ,  Elias Campo Guerri ,  Raymond Tubbs ,  Timothy C. Greiner ,  James Robert Cook ,  Kai Fu ,  Paul Michael Williams ,  Chih-Jian Lih ,  Elaine S. Jaffe ,  Rita M. Braziel ,  Andreas Rosenwald ,  Erlend B. Smeland ,  Wing C. Chan ,  German Ott ,  Jan Delabie ,  Dennis Weisenburger

IPC分类号： G01N33/48 ,  G16B25/00 ,  G16B5/00 ,  C12Q1/6886

摘要： The invention is directed to methods for selecting a treatment option for an activated B cell-like diffuse large B cell lymphoma (ABC DLBCL) subject, a germinal center B cell-like diffuse large B cell lymphoma (GCB DLBCL) subject, a primary mediastinal B cell lymphoma (PMBL) subject, a Burkitt lymphoma (BL) subject, or a mantle cell lymphoma (MCL) subject by analyzing digital gene expression data obtained from the subject, e.g., from a biopsy sample.

公开(公告)号：US09970059B2

公开(公告)日：2018-05-15

申请号：US14540302

申请日：2014-11-13

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services ,  Arizona Board of Regents on behalf of the University of Arizona ,  Queen Mary University of London ,  Board of Regents of the University of Nebraska ,  Oslo University Hospital HF ,  Oregon Health & Science University ,  University of Rochester ,  Hospital Clinic de Barcelona ,  Universitat De Barcelona ,  British Columbia Cancer Agency Branch ,  Julius-Maximilians-University of Wuerzburg

发明人： Lisa Rimsza ,  Andrew T. Lister ,  Wing C. Chan ,  Dennis Weisenburger ,  Jan Delabie ,  Erlend B. Smeland ,  Harald Holte ,  Stein Kvaloy ,  Rita M. Braziel ,  Richard I. Fisher ,  Pedro Jares ,  Armando Lopez-Guillermo ,  Elias Campo Guerri ,  Elaine S. Jaffe ,  Georg Lenz ,  Wyndham H. Wilson ,  George Wright ,  Sandeep S. Dave ,  Louis M. Staudt ,  Randy D. Gascoyne ,  Joseph M. Connors ,  Hans-Konrad Muller-Hermelink ,  Andreas Rosenwald ,  German Ott

IPC分类号： C12Q1/68 ,  G01N33/574

CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/112 ,  G01N33/57407 ,  G01N2800/52 ,  G01N2800/56

摘要： The invention provides methods and materials related to a gene expression-based survival predictor for DLBCL patients.

公开(公告)号：US20160283653A1

公开(公告)日：2016-09-29

申请号：US15035101

申请日：2014-11-05

申请人： THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DE PARTMENT OF HEALTH AND HUMAN SER ,  BRITISH COLUMBIA CANCER AGENCY BRANCH ,  ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNINVERSITY OF ARIZONA ,  UNIVERSITAT DE BARCELONA ,  HOSPITAL CLINIC DE BARCELONA ,  CLEVELAND CLINIC ,  BORD OF REGENTS ON THE UNIVERSITY OF NEBRASKA ,  OREGON HEALTH & SCIENCE UNIVERSITY ,  JULIUS-MAXIMILIANS-UNIVERSITY OF WUERZBURG ,  OSLO UNIVERSITY HOSPITAL HF

发明人： Louis M. Staudt ,  George W. Wright ,  David William Scott ,  Joseph M. Connors ,  Randy D. Gascoyne ,  Lisa Rimsza ,  Elias Campo Guerri ,  Raymond Tubbs (Deceased) ,  Timothy C. Greiner ,  James Robert Cook ,  Kai Fu ,  Paul Michael Williams ,  Chih-Jian Lih ,  Elaine S. Jaffe ,  Rita M. Braziel ,  Andreas Rosenwald ,  Erlend B. Smeland ,  Wing C. Chan ,  German Ott ,  Jan Delabie ,  Dennis Weisenburger

IPC分类号： G06F19/20 ,  G06F19/12 ,  C12Q1/68

CPC分类号： G16B25/00 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/158 ,  C12Q2600/166 ,  G16B5/00

摘要： The invention is directed to methods for selecting a treatment option for an activated B cell-like diffuse large B cell lymphoma (ABC DLBCL) subject, a germinal center B cell-like diffuse large B cell lymphoma (GCB DLBCL) subject, a primary mediastinal B cell lymphoma (PMBL) subject, a Burkitt lymphoma (BL) subject, or a mantle cell lymphoma (MCL) subject by analyzing digital gene expression data obtained from the subject, e.g., from a biopsy sample.

摘要翻译： 本发明涉及用于选择活化的B细胞样弥漫性大B细胞淋巴瘤（ABC DLBCL）受试者，生发中心B细胞样扩散性大B细胞淋巴瘤（GCB DLBCL）受试者，原发性纵隔 B细胞淋巴瘤（PMBL）受试者，伯基特淋巴瘤（BL）受试者或套细胞淋巴瘤（MCL）受试者，通过分析从受试者获得的数字基因表达数据，例如来自活检样本。