专利检索 ap:("The United States of America, as represented by the Secretary of Agriculture" OR "CODAGENIX INC.") AND inv:"Teresa B. De Los Santos" 第 1 页

1.

发明授权
Live attenuated strains of foot and mouth disease modified by deoptimization and uses thereof 有权

公开(公告)号：US11793870B2

公开(公告)日：2023-10-24

申请号：US17330545

申请日：2021-05-26

申请人： The United States of America, as represented by the Secretary of Agriculture , CODAGENIX INC.

发明人： Teresa B. De Los Santos , Aida E. Rieder , Fayna C. Diaz-San Segundo , Anna Kloc , John R. Coleman , Steffen Mueller , Gisselle N. Medina

IPC分类号： A61K39/135 , C12N7/00 , A61K39/00

CPC分类号： A61K39/135 , C12N7/00 , A61K2039/5254 , A61K2039/552 , C12N2770/32121 , C12N2770/32134

摘要： The present disclosure describes deoptimized foot and mouth viruses and their use for prophylactic and therapeutic treatment of mammalian subjects. The recombinant viruses provided herein include alterations in several genomic regions as well as Differentiating Infected from Vaccinated Animals (DIVA) markers.

2.

发明授权
Genetically engineered foot and mouth disease virus and related proteins, polynucleotides, compositions, methods and systems 有权

公开(公告)号：US11813320B2

公开(公告)日：2023-11-14

申请号：US17176989

申请日：2021-02-16

申请人： LAWRENCE LIVERMORE NATIONAL SECURITY, LLC , THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF AGRICULTURE , THE UNIVERSITY OF CONNECTICUT

发明人： Aida E. Rieder , Teresa B. De Los Santos , Luis L. Rodriguez , Devendra Rai , Fayna C. Diaz-San Segundo , Paul D. Hoeprich

IPC分类号： A61K39/135 , C12N7/00 , G01N33/53 , C12Q1/70 , A61K39/12 , A61P31/14 , A61K39/00

CPC分类号： A61K39/135 , A61K39/12 , A61P31/14 , C12N7/00 , C12Q1/70 , G01N33/53 , A61K2039/5254 , A61K2039/55555 , A61K2039/55566 , A61K2039/55572 , C12N2770/32122 , C12N2770/32134 , C12N2770/32141 , C12N2770/32162

摘要： Genetically engineered Foot and Mouth Disease Virus (FMDV) and related engineered proteins and polynucleotides, nanolipoprotein particles, compositions, methods and systems are described. The genetically engineered FMDV is modified by the strategic insertion of a protein tag into select regions of the FMDV genome which encode viral proteins that are exposed on the surface of the FMDV viral capsid. The inserted protein tag is displayed as a decoration or attachment on the viral capsid surface.

3.

发明授权
Genetically engineered Foot and Mouth Disease Virus and related proteins, polynucleotides, compositions, methods and systems 有权

公开(公告)号：US10953085B2

公开(公告)日：2021-03-23

申请号：US15590918

申请日：2017-05-09

申请人： LAWRENCE LIVERMORE NATIONAL SECURITY, LLC , THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF AGRICULTURE

发明人： Aida E. Rieder , Teresa B. De Los Santos , Luis L. Rodriguez , Devendra Rai , Fayna C. Diaz-San Segundo , Paul D. Hoeprich

IPC分类号： A61K39/135 , C12N7/00 , G01N33/53 , C12Q1/70 , A61K39/12 , A61P31/14 , A61K39/00

摘要： Genetically engineered Foot and Mouth Disease Virus (FMDV) and related engineered proteins and polynucleotides, nanolipoprotein particles, compositions, methods and systems are described. The genetically engineered FMDV is modified by the strategic insertion of a protein tag into select regions of the FMDV genome which encode viral proteins that are exposed on the surface of the FMDV viral capsid. The inserted protein tag is displayed as a decoration or attachment on the viral capsid surface.