公开(公告)号：US20130195819A1

公开(公告)日：2013-08-01

申请号：US13851473

申请日：2013-03-27

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services

发明人： Qiong J. Wang ,  Kenichi Hanada ,  James C. Yang

IPC分类号： C07K14/705 ,  G01N33/68 ,  A61K35/14 ,  C12Q1/68

CPC分类号： C07K14/70503 ,  A61K35/17 ,  A61K38/00 ,  C07K14/7051 ,  C12Q1/6886 ,  G01N33/6893

摘要： The invention provides an isolated or purified T cell receptor (TCR) having antigenic specificity for a cancer antigen, e.g., a renal cell carcinoma antigen, wherein the TCR recognizes the cancer antigen in a major histocompatibility complex (MHC)-independent manner. Also provided are related polypeptides, proteins, nucleic acids, recombinant expression vectors, isolated host cells, populations of cells, antibodies, or antigen binding portions thereof, and pharmaceutical compositions. The invention further provides a method of detecting the presence of cancer in a host and a method of treating or preventing cancer in a host using the inventive TCRs or related materials.

摘要翻译： 本发明提供了对癌症抗原（例如肾细胞癌抗原）具有抗原特异性的分离或纯化的T细胞受体（TCR），其中TCR以主要组织相容性复合体（MHC）为依赖性识别癌抗原。 还提供了相关多肽，蛋白质，核酸，重组表达载体，分离的宿主细胞，细胞群，抗体或其抗原结合部分，以及药物组合物。 本发明还提供了检测宿主中癌症存在的方法以及使用本发明的TCR或相关材料治疗或预防宿主中的癌症的方法。

公开(公告)号：US20210115108A1

公开(公告)日：2021-04-22

申请号：US17051860

申请日：2019-05-01

申请人： The United States of America,as represented by the Secretary,Department of Health and Human Services

发明人： Kenichi Hanada ,  Chihao Zhao ,  Anna Pasetto ,  James C. Yang

IPC分类号： C07K14/725 ,  G01N33/574 ,  A61K35/17

摘要： Disclosed is an isolated or purified T cell receptor (TCR), wherein the TCR has antigenic specificity for a mutated EGFR amino acid sequence with a E746-A750 deletion. Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions are also provided. Also disclosed are methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal.

公开(公告)号：US20220389093A1

公开(公告)日：2022-12-08

申请号：US17817599

申请日：2022-08-04

申请人： The United States of America,as represented by the Secretary,Department of Health and Human Services

发明人： Kenichi Hanada ,  Qiong J. Wang ,  James C. Yang ,  Zhiya Yu

IPC分类号： C07K16/26 ,  C07K14/725 ,  A61P35/04 ,  A61P35/00

摘要： Disclosed is a synthetic T cell receptor (TCR) having antigenic specificity for an HLA-A2-restricted epitope of thyroglobulin (TG), TG470-478. Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, and populations of cells are also provided. Antibodies, or an antigen binding portion thereof, and pharmaceutical compositions relating to the TCRs of the invention are also provided. Also disclosed are methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal.

公开(公告)号：US10450372B2

公开(公告)日：2019-10-22

申请号：US15524869

申请日：2015-11-12

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services

发明人： Kenichi Hanada ,  Qiong J. Wang ,  James C. Yang ,  Zhiya Yu

IPC分类号： C07K16/26 ,  C07K14/725 ,  A61P35/04 ,  A61P35/00 ,  A61K38/00

摘要： Disclosed is a synthetic T cell receptor (TCR) having antigenic specificity for an HLA-A2-restricted epitope of thyroglobulin (TG), TG470-478. Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, and populations of cells are also provided. Antibodies, or an antigen binding portion thereof, and pharmaceutical compositions relating to the TCRs of the disclosure are also provided. Also disclosed are methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal.

公开(公告)号：US11440956B2

公开(公告)日：2022-09-13

申请号：US16586310

申请日：2019-09-27

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services

发明人： Kenichi Hanada ,  Qiong J. Wang ,  James C. Yang ,  Zhiya Yu

IPC分类号： C07K16/26 ,  C07K14/725 ,  A61P35/04 ,  A61P35/00 ,  A61K38/00

摘要： Disclosed is a synthetic T cell receptor (TCR) having antigenic specificity for an HLA-A2-restricted epitope of thyroglobulin (TG), TG470-478. Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, and populations of cells are also provided. Antibodies, or an antigen binding portion thereof, and pharmaceutical compositions relating to the TCRs of the invention are also provided. Also disclosed are methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal.

公开(公告)号：US09567387B2

公开(公告)日：2017-02-14

申请号：US13851473

申请日：2013-03-27

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services

发明人： Qiong J. Wang ,  Kenichi Hanada ,  James C. Yang

IPC分类号： G01N33/49 ,  C07K14/705 ,  C07K14/725 ,  A61K35/17 ,  C12Q1/68 ,  G01N33/68 ,  A61K38/00

CPC分类号： C07K14/70503 ,  A61K35/17 ,  A61K38/00 ,  C07K14/7051 ,  C12Q1/6886 ,  G01N33/6893

摘要： The invention provides an isolated or purified T cell receptor (TCR) having antigenic specificity for a cancer antigen, e.g., a renal cell carcinoma antigen, wherein the TCR recognizes the cancer antigen in a major histocompatibility complex (MHC)-independent manner. Also provided are related polypeptides, proteins, nucleic acids, recombinant expression vectors, isolated host cells, populations of cells, antibodies, or antigen binding portions thereof, and pharmaceutical compositions. The invention further provides a method of detecting the presence of cancer in a host and a method of treating or preventing cancer in a host using the inventive TCRs or related materials.

摘要翻译： 本发明提供了对癌症抗原（例如肾细胞癌抗原）具有抗原特异性的分离或纯化的T细胞受体（TCR），其中TCR以主要组织相容性复合体（MHC）为依赖性识别癌抗原。 还提供了相关多肽，蛋白质，核酸，重组表达载体，分离的宿主细胞，细胞群，抗体或其抗原结合部分，以及药物组合物。 本发明还提供了检测宿主中癌症存在的方法以及使用本发明的TCR或相关材料治疗或预防宿主中的癌症的方法。