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公开(公告)号:US09724435B2
公开(公告)日:2017-08-08
申请号:US14196483
申请日:2014-03-04
发明人: Christopher R. McCurdy , Christophe Mesangeau , Frederick T. Chin , Michelle L. James , Bin Shen , Sanjiv Gambhir , Sandip Biswal , Deepak Behera
IPC分类号: A61K31/428 , C07D209/48 , C07D235/26 , C07D263/58 , C07D277/68 , C07D403/06 , C07D405/04 , C07D413/06 , C07D413/12 , C07D417/06 , C07D491/107 , C07D491/20 , A61K51/04 , C07D265/36 , C07D209/08 , C07D209/10 , C07D277/70 , C07D279/16 , C07D295/13 , C07D277/74
CPC分类号: A61K51/0468 , A61K31/428 , A61K51/0453 , A61K51/0455 , A61K51/0459 , C07D209/08 , C07D209/10 , C07D209/48 , C07D235/26 , C07D263/58 , C07D265/36 , C07D277/68 , C07D277/70 , C07D277/74 , C07D279/16 , C07D295/13 , C07D403/06 , C07D405/04 , C07D413/06 , C07D413/12 , C07D417/06 , C07D491/107 , C07D491/20
摘要: A method for localizing and quantifying S1R role in nociceptive processing; for providing a guide to providing an analgesic therapy; of using an S1R selective ligand as a biomarker for pathphysiological study of memory deficits and cognitive disorders; or of detecting increased S1R density at the site of nerve injury arising from neuropathic pain comprising using as a probe at least one SR1 selective compound or radioligand of the general formula III′, or IV′: