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公开(公告)号：US20160152665A1
公开(公告)日：2016-06-02
申请号：US15040228
申请日：2016-02-10
CPC分类号： C07K7/08 , A61K31/7048 , A61K38/00 , A61K38/06 , A61K38/07 , A61K38/08 , A61K38/10 , A61K45/06 , C07K5/081 , C07K5/1013 , C07K5/1016 , C07K5/1019 , C07K7/06 , C12N9/88 , C12Y406/01002 , A61K2300/00
摘要： Described herein are compositions and methods useful to treat cancers. In addition, the present invention provides screening assays, diagnostic assays, methods to prognose, methods to treat, and kits.
摘要翻译： 本文描述的是用于治疗癌症的组合物和方法。 此外，本发明提供筛选测定，诊断测定，预测方法，治疗方法和试剂盒。
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公开(公告)号：US20140057853A1
公开(公告)日：2014-02-27
申请号：US14067084
申请日：2013-10-30
摘要： The present invention provides materials and methods useful to treat various sGCα1-expressing cancers. Materials include peptides which interfere with sGCα1's pro-survival functions, thereby resulting in apoptosis of sGCα1-expressing cells. In addition, the present invention provides screening assays, diagnostic assays, methods to prognose, methods to treat, and kits.
摘要翻译： 本发明提供用于治疗各种sGCalpha1表达癌症的材料和方法。 材料包括干扰sGCalpha1的前存活功能的肽，从而导致sGCalpha1表达细胞的凋亡。 此外，本发明提供筛选测定，诊断测定，预测方法，治疗方法和试剂盒。
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公开(公告)号：US09546196B2
公开(公告)日：2017-01-17
申请号：US15040228
申请日：2016-02-10
IPC分类号： A61K38/04 , C07K7/08 , A61K38/10 , C07K7/06 , C07K5/103 , C07K5/083 , A61K38/08 , A61K38/06 , A61K38/07 , A61K31/7048 , C07K5/11 , C07K5/107 , C12N9/88 , A61K45/06 , A61K38/00
CPC分类号： C07K7/08 , A61K31/7048 , A61K38/00 , A61K38/06 , A61K38/07 , A61K38/08 , A61K38/10 , A61K45/06 , C07K5/081 , C07K5/1013 , C07K5/1016 , C07K5/1019 , C07K7/06 , C12N9/88 , C12Y406/01002 , A61K2300/00
摘要： Described herein are compositions and methods useful to treat cancers. In addition, the present invention provides screening assays, diagnostic assays, methods to prognose, methods to treat, and kits.
摘要翻译： 本文描述的是用于治疗癌症的组合物和方法。 此外，本发明提供筛选测定，诊断测定，预测方法，治疗方法和试剂盒。
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公开(公告)号：US09393254B2
公开(公告)日：2016-07-19
申请号：US14067084
申请日：2013-10-30
摘要： The present invention provides materials and methods useful to treat various sGCα1-expressing cancers. Materials include peptides which interfere with sGCα1's pro-survival functions, thereby resulting in apoptosis of sGCα1-expressing cells. In addition, the present invention provides screening assays, diagnostic assays, methods to prognose, methods to treat, and kits.
摘要翻译： 本发明提供用于治疗各种sGCα1表达癌症的材料和方法。 材料包括干扰sGCα1的前存活功能的肽，从而导致表达sGCα1的细胞凋亡。 此外，本发明提供筛选测定，诊断测定，预测方法，治疗方法和试剂盒。
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公开(公告)号：US09295686B2
公开(公告)日：2016-03-29
申请号：US14067116
申请日：2013-10-30
摘要： The present invention provides materials and methods useful to treat various sGCα1-expressing cancers. Materials include peptides which interfere with sGCα1's pro-survival functions, thereby resulting in apoptosis of sGCα1-expressing cells. In addition, the present invention provides screening assays, diagnostic assays, methods to prognose, methods to treat, and kits.
摘要翻译： 本发明提供用于治疗各种sGCα1表达癌症的材料和方法。 材料包括干扰sGCα1的前存活功能的肽，从而导致表达sGCα1的细胞凋亡。 此外，本发明提供筛选测定，诊断测定，预测方法，治疗方法和试剂盒。
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公开(公告)号：US20170114097A1
公开(公告)日：2017-04-27
申请号：US15374640
申请日：2016-12-09
IPC分类号： C07K7/08 , A61K45/06 , A61K31/7048 , A61K38/10
CPC分类号： C07K7/08 , A61K31/7048 , A61K38/00 , A61K38/06 , A61K38/07 , A61K38/08 , A61K38/10 , A61K45/06 , C07K5/081 , C07K5/1013 , C07K5/1016 , C07K5/1019 , C07K7/06 , C12N9/88 , C12Y406/01002 , A61K2300/00
摘要： Described herein are compositions and methods useful to treat cancers. In addition, the present invention provides screening assays, diagnostic assays, methods to prognose, methods to treat, and kits.
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公开(公告)号：US09301991B2
公开(公告)日：2016-04-05
申请号：US14069790
申请日：2013-11-01
IPC分类号： A61K38/04 , A61K38/10 , C07K7/06 , C07K7/08 , C07K5/103 , C07K5/083 , A61K38/08 , A61K38/06 , A61K38/07 , A61K31/7048 , C07K5/11 , C07K5/107 , C12N9/88 , A61K38/00
CPC分类号： C07K7/08 , A61K31/7048 , A61K38/00 , A61K38/06 , A61K38/07 , A61K38/08 , A61K38/10 , A61K45/06 , C07K5/081 , C07K5/1013 , C07K5/1016 , C07K5/1019 , C07K7/06 , C12N9/88 , C12Y406/01002 , A61K2300/00
摘要： The present invention provides materials and methods useful to treat various sGCα1-expressing cancers. Materials include peptides which interfere with sGCα1's pro-survival functions, thereby resulting in apoptosis of sGCα1-expressing cells. In addition, the present invention provides screening assays, diagnostic assays, methods to prognose, methods to treat, and kits.
摘要翻译： 本发明提供用于治疗各种sGCα1表达癌症的材料和方法。 材料包括干扰sGCα1的前存活功能的肽，从而导致表达sGCα1的细胞凋亡。 此外，本发明提供筛选测定，诊断测定，预测方法，治疗方法和试剂盒。
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8.发明申请sGCalpha1 Inhibiting Compositions, and Methods of Treatment of Cancers Therewith 有权sGCalpha1抑制组合物及其治疗方法公开(公告)号：US20140088023A1
公开(公告)日：2014-03-27
申请号：US14069790
申请日：2013-11-01
IPC分类号： A61K38/10 , C07K7/08 , C07K5/103 , A61K31/7048 , A61K38/08 , A61K38/06 , A61K38/07 , C07K7/06 , C07K5/083
CPC分类号： C07K7/08 , A61K31/7048 , A61K38/00 , A61K38/06 , A61K38/07 , A61K38/08 , A61K38/10 , A61K45/06 , C07K5/081 , C07K5/1013 , C07K5/1016 , C07K5/1019 , C07K7/06 , C12N9/88 , C12Y406/01002 , A61K2300/00
摘要： The present invention provides materials and methods useful to treat various sGCα1-expressing cancers. Materials include peptides which interfere with sGCα1's pro-survival functions, thereby resulting in apoptosis of sGCα1-expressing cells. In addition, the present invention provides screening assays, diagnostic assays, methods to prognose, methods to treat, and kits.
摘要翻译： 本发明提供用于治疗各种sGCα1表达癌症的材料和方法。 材料包括干扰sGCα1的前存活功能的肽，从而导致表达sGCα1的细胞凋亡。 此外，本发明提供筛选测定，诊断测定，预测方法，治疗方法和试剂盒。
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公开(公告)号：US20140057852A1
公开(公告)日：2014-02-27
申请号：US14067116
申请日：2013-10-30
IPC分类号： A61K38/10 , A61K31/7048 , A61K38/08 , C07K7/08 , C07K7/06
摘要： The present invention provides materials and methods useful to treat various sGCα1-expressing cancers. Materials include peptides which interfere with sGCα1's pro-survival functions, thereby resulting in apoptosis of sGCα1-expressing cells. In addition, the present invention provides screening assays, diagnostic assays, methods to prognose, methods to treat, and kits.
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