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12 条记录 (耗时 0.027 秒)

    Soft type binding for distributed systems
    1.
    发明授权
    Soft type binding for distributed systems 有权
    分布式系统的软类型绑定

    公开(公告)号：US09124648B2

    公开(公告)日：2015-09-01

    申请号：US12404385

    申请日：2009-03-16

    申请人： Pablo Castro ,  Andrew Conrad ,  Michael Flasko ,  Pratik Patel ,  Mark Ashton

    发明人： Pablo Castro ,  Andrew Conrad ,  Michael Flasko ,  Pratik Patel ,  Mark Ashton

    IPC分类号： G06F15/16 ,  G06F3/00 ,  H04L29/08

    CPC分类号： H04L67/2823 ,  H04L67/02 ,  H04L67/2876

    摘要： Data communications are enabled to be performed between first and second computer systems without having to match data types at the first and second computer systems. A first data type is associated with a request for a resource. The request for the resource is transmitted from a first agent at the first computer system to a second agent at the second computer system. The resource is instantiated at the second computer system according to a second data type that is different from the first data type. The resource is received by the first agent from the second agent. The received resource is materialized into an instance of the first data type using the first agent.

    摘要翻译： 能够在第一和第二计算机系统之间执行数据通信，而不必在第一和第二计算机系统处匹配数据类型。 第一种数据类型与资源请求相关联。 资源的请求从第一计算机系统的第一代理发送到第二计算机系统处的第二代理。 该资源根据与第一数据类型不同的第二数据类型在第二计算机系统中实例化。 该资源由第二代理程序接收第一代理程序。 接收的资源使用第一代理实现为第一数据类型的实例。

    Compounds Having Crth2 Antagonist Activity
    2.
    发明申请
    Compounds Having Crth2 Antagonist Activity 审中-公开

    公开(公告)号：US20070232681A1

    公开(公告)日：2007-10-04

    申请号：US10573670

    申请日：2004-10-13

    申请人： David Middlemiss ,  Mark Ashton ,  Edward Boyd ,  Frederick Brookfield ,  Richard Armer ,  Eric Pettipher

    发明人： David Middlemiss ,  Mark Ashton ,  Edward Boyd ,  Frederick Brookfield ,  Richard Armer ,  Eric Pettipher

    IPC分类号： A61K31/40 ,  A61K31/405 ,  C07D209/04 ,  C07D209/34

    CPC分类号： C04B35/632 ,  C07D209/30 ,  C07D401/12 ,  C07D403/12 ,  C07D417/12

    摘要： Compounds of general formula (I): wherein R1, R2, R3 and R4 are independently hydrogen, halo, C1-C6 alkyl, —O(C1-C6 alkyl), —CON(R9)2, —SOR9, —SO2R9, —SO2N(R9)2, —N(R9)2, —NR9COR9, —CO2R9, —COR9, —SR9, —OH, —NO2 or —CN; each R9 is independently hydrogen or C1-C6 alkyl; R5 and R6 are each independently hydrogen, or C1-C6 alkyl or together with the carbon atom to which they are attached form a C3-C7 cycloalkyl group; R7 is hydrogen or C1-C6 alkyl n is 1 or 2; X is a bond or, when n is 2, X may also be a NR9 group; wherein R9 is as defined above; when X is a bond R8 is C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, biphenyl or a 9-14 membered bicyclic or tricyclic heteroaryl group; when X is a NR9 group R8 may additionally be phenyl, naphthyl or a 5-7 membered heteroaromatic ring; and the R8 group is optionally substituted with one or more substituents selected from halo, C1-C6 alkyl, —O(C1-C6)alkyl, aryl, —O-aryl, heteroaryl, —O-heteroaryl, —CON(R9)2, —SOR9, —SO2R9, SO2N(9)2, —N(9)2, —NR9COR9, —CO2R9, —COR9, —SR9, —OH, —NO2 or —CN; wherein R9 is as defined above; and their pharmaceutically acceptable salts, hydrates, solvates, complexes and prodrugs are useful in the treatment of allergic diseases such as asthma, allergic rhinitis and atopic dermatitis.

    MACROPHYTE-BASED BIOPLASTIC
    5.
    发明申请
    MACROPHYTE-BASED BIOPLASTIC 有权
    基于大理石的生物塑料

    公开(公告)号：US20130220173A1

    公开(公告)日：2013-08-29

    申请号：US13594680

    申请日：2012-08-24

    申请人： Suraj Sharma ,  Ryan W. Hunt ,  Mark Ashton Zeller

    发明人： Suraj Sharma ,  Ryan W. Hunt ,  Mark Ashton Zeller

    IPC分类号： C08L1/00 ,  C08L1/12 ,  C08L1/10 ,  C08L89/00

    CPC分类号： C08L1/00 ,  C08L1/10 ,  C08L1/12 ,  C08L89/00 ,  C08L97/02 ,  C08L101/16 ,  C08L2666/26 ,  C08L101/00

    摘要： A bioplastic composition may contain certain biodegradable and renewable components. In some examples, the bioplastic composition includes at least one kind of aquatic macrophyte biomass, which may contain a native composition of protein and carbohydrates, in a blend with one or more types of biodegradable or durable thermoplastic polymers. The aquatic macrophyte composition may provide a balance of both polymeric and reinforcing properties to the blended bioplastic not typically exhibited by terrestrial feedstock such as soy meal or corn starch. Such a bioplastic composition may be formed into molded articles using extrusion, injection molding, compression molding, or the like.

    摘要翻译： 生物塑料组合物可以含有某些可生物降解和可再生的组分。 在一些实例中，生物塑料组合物包括至少一种水生植物生物质，其可以含有蛋白质和碳水化合物的天然组合物，其与一种或多种类型的可生物降解或耐久的热塑性聚合物的共混物。 水生植物组合物可以提供与通常由陆生原料如大豆粉或玉米淀粉显示的共混生物塑料的聚合物和增强性质的平衡。 这样的生物塑料组合物可以使用挤出，注射成型，压缩成型等形成成型制品。

    SOFT TYPE BINDING FOR DISTRIBUTED SYSTEMS
    8.
    发明申请
    SOFT TYPE BINDING FOR DISTRIBUTED SYSTEMS 有权
    用于分布式系统的软式绑定

    公开(公告)号：US20100146036A1

    公开(公告)日：2010-06-10

    申请号：US12404385

    申请日：2009-03-16

    申请人： Pablo Castro ,  Andrew Conrad ,  Michael Flasko ,  Pratik Patel ,  Mark Ashton

    发明人： Pablo Castro ,  Andrew Conrad ,  Michael Flasko ,  Pratik Patel ,  Mark Ashton

    IPC分类号： G06F15/16

    CPC分类号： H04L67/2823 ,  H04L67/02 ,  H04L67/2876

    摘要： Data communications are enabled to be performed between first and second computer systems without having to match data types at the first and second computer systems. A first data type is associated with a request for a resource. The request for the resource is transmitted from a first agent at the first computer system to a second agent at the second computer system. The resource is instantiated at the second computer system according to a second data type that is different from the first data type. The resource is received by the first agent from the second agent. The received resource is materialized into an instance of the first data type using the first agent.

    摘要翻译： 能够在第一和第二计算机系统之间执行数据通信，而不必在第一和第二计算机系统处匹配数据类型。 第一种数据类型与资源请求相关联。 资源的请求从第一计算机系统的第一代理发送到第二计算机系统处的第二代理。 该资源根据与第一数据类型不同的第二数据类型在第二计算机系统中实例化。 该资源由第二代理程序接收第一代理程序。 接收的资源使用第一代理实现为第一数据类型的实例。

    Glyoxalase inhibitors
    9.
    发明申请
    Glyoxalase inhibitors 审中-公开
    乙二醛酶抑制剂

    公开(公告)号：US20070015799A1

    公开(公告)日：2007-01-18

    申请号：US10556901

    申请日：2004-05-14

    申请人： Mark Ashton ,  Alan Davidson ,  Russell Thomas ,  Mark Whittaker

    发明人： Mark Ashton ,  Alan Davidson ,  Russell Thomas ,  Mark Whittaker

    IPC分类号： A61K31/4436 ,  A61K31/44 ,  A61K31/381

    CPC分类号： C07D405/04 ,  A61K31/10 ,  A61K31/381 ,  A61K31/44 ,  A61K31/4436 ,  C07C323/62 ,  C07D213/85 ,  C07D217/26 ,  C07D409/04 ,  C07D409/14

    摘要： This invention relates to compounds of formula (I) which are glyoxalase I inhibitors, pharmaceutical salts or compositions comprising such compounds, and the use of such compositions and compounds to treat various conditions alleviated by the inhibition of glyoxalase 1. Wherein X is N or CH. R2 is H, CF3; or optionally substituted C5-6 aryl, C3-7 cycloalkyl, C5-7 heterocyclyl. R3 is H; or optionally substituted C5-6 aryl, C3-7 cycloalkyl, C5-7 heterocyclyl. Alternatively R2 and R3 together form an optionally substituted C3-4alkylene group wherein L3 and L4 are single bonds thus forming a C5-6 ring fused with the aromatic ring to which L3 and L4 are attached. L3 and L4 are independently selected from a single bond, optionally substituted C1-4 alkylene, -L9YN(OH)C(═O)L10- and -L9C(═O)N(OH)YL10-, wherein L9 and L10 are independently selected from optionally substituted C1-4 alkylene, C5-6 arylene, C1-4 alkylene-C5-6arylene and a single bond, wherein Y is NH or a single bond.

    摘要翻译： 本发明涉及作为乙二醛酶I抑制剂的式（I）化合物，包含这些化合物的药物盐或组合物，以及这些组合物和化合物用于治疗通过抑制乙二醛酶1减轻的各种病症的用途。其中X是N或CH 。 R 2是H，CF 3 N; 或任选取代的C 5-6芳基，C 3-7环烷基，C 5-7杂环基。 R 3是H; 或任选取代的C 5-6芳基，C 3-7环烷基，C 5-7杂环基。 或者R 2和R 3一起形成任选取代的C 3-4亚烷基，其中L 3和L 3 因此形成与L 3和L 4的芳环稠合的C 5〜6环， SUP>连接。 L 3和L 4独立地选自单键，任选取代的C 1-4亚烷基，-L 9， SUP-YN（OH）C（-O）L 10 - 和-L 9 C（ - ）N（OH）Y L 10 - ，其中L 9和L 10独立地选自任选取代的C 1-4 - 亚烷基，C 5-6 - 亚芳基，C 1-4亚烷基-C 5-6亚芳基和单键，其中Y是NH或单键。