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公开(公告)号：US07590500B2
公开(公告)日：2009-09-15
申请号：US10587887
申请日：2005-02-28
IPC分类号： G01D18/00
CPC分类号： G01N15/1459 , G01N15/1429 , G01N2015/149
摘要： A flow cytometer capable of using electronics to analyze a large dynamic range while avoiding and/or correcting traditional limitations of acquisition electronics. The invention allows for measuring signal characteristics, which may include but are not limited to linear peak, integral, logarithmic peak, and pulse width. Other system parameters may also be generated by the invention to indicate timing or status information. Accurate and precise measurements may be performed by correcting for input errors if needed, and by transforming the input signal to produce a more easily measured form.
摘要翻译： 流式细胞仪能够使用电子学来分析大的动态范围，同时避免和/或纠正采集电子的传统限制。 本发明允许测量信号特性，其可以包括但不限于线性峰值，积分，对数峰值和脉冲宽度。 本发明也可以产生其他系统参数以指示定时或状态信息。 可以通过根据需要校正输入误差，并且通过变换输入信号以产生更容易测量的形式来执行准确和精确的测量。
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2.发明授权Multi-gain adaptive linear processing and gated digital system for use in flow cytometry 有权多增益自适应线性处理和门控数字系统用于流式细胞术公开(公告)号：US09243995B2
公开(公告)日：2016-01-26
申请号：US13619845
申请日：2012-09-14
申请人： Daniel N. Fox , Thomas L. Thrasher
发明人： Daniel N. Fox , Thomas L. Thrasher
CPC分类号： G01N15/147 , G01N15/1429 , G01N2015/1477 , H04B17/0082 , H04B17/0085
摘要： Disclosed is an electronic processing system for a flow cytometer that uses a processing chip that processes data in a parallel architecture on a sample by sample basis and provides for high throughput of data. In addition, multi-gain linear amplifiers are used which are matched using feedback circuits to provide accurate data and high resolution data having high dynamic range.
摘要翻译： 公开了一种用于流式细胞仪的电子处理系统，其使用处理芯片，其以逐个样本的形式处理并行架构中的数据，并提供高吞吐量的数据。 此外，使用多增益线性放大器，其使用反馈电路匹配以提供具有高动态范围的精确数据和高分辨率数据。
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3.发明申请Multi-gain Adaptive Linear Processing and Gated Digital System for Use in Flow Cytometry 有权用于流式细胞术的多增益自适应线性处理和门控数字系统公开(公告)号：US20130013226A1
公开(公告)日：2013-01-10
申请号：US13619845
申请日：2012-09-14
申请人： Daniel N. Fox , Thomas L. Thrasher
发明人： Daniel N. Fox , Thomas L. Thrasher
CPC分类号： G01N15/147 , G01N15/1429 , G01N2015/1477 , H04B17/0082 , H04B17/0085
摘要： Disclosed is an electronic processing system for a flow cytometer that uses a processing chip that processes data in a parallel architecture on a sample by sample basis and provides for high throughput of data. In addition, multi-gain linear amplifiers are used which are matched using feedback circuits to provide accurate data and high resolution data having high dynamic range.
摘要翻译： 公开了一种用于流式细胞仪的电子处理系统，其使用处理芯片，其以逐个样本的形式处理并行架构中的数据，并提供高吞吐量的数据。 此外，使用多增益线性放大器，其使用反馈电路匹配以提供具有高动态范围的精确数据和高分辨率数据。
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公开(公告)号：US20110303859A1
公开(公告)日：2011-12-15
申请号：US13044685
申请日：2011-03-10
CPC分类号： G01N15/1429 , G01N15/1427 , G01N15/1459 , G01N2015/1438
摘要： A method is provided for generating measurement parameters for a particle sample in a particle analyzer. The method includes, interrogating the particle sample with a triggering interrogator and one or more secondary interrogators respectively positioned along a length of an interrogation area, generating respective pulses based upon the interrogation of a first particle from the particle sample, determining a primary pulse detection window based upon a triggering pulse, determining a search interval to find a secondary pulse based upon factors including the primary pulse detection window and a laser delay, adjusting the search interval for laser delay variation dynamically based on the interrogation of the first particle, identifying the secondary pulse in the adjusted search interval, and processing the secondary pulse to determine a peak value of the secondary pulse. Corresponding apparatus are also provided.
摘要翻译： 提供了一种用于在粒子分析仪中产生粒子样本的测量参数的方法。 该方法包括：用触发询问器和一个或多个二级询问器询问粒子样本，该询问器分别沿着询问区域的长度定位，根据来自粒子样本的第一粒子的询问产生相应的脉冲，确定主脉冲检测窗口 基于触发脉冲，基于包括主脉冲检测窗口和激光延迟的因素来确定搜索间隔以找到辅助脉冲，基于第一颗粒的询问来动态地调整激光延迟变化的搜索间隔，识别次级 脉冲在调整的搜索间隔中，并且处理辅助脉冲以确定次级脉冲的峰值。 还提供了相应的装置。
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5.发明申请MULTI-GAIN ADAPTIVE LINEAR PROCESSING AND GATED DIGITAL SYSTEM FOR USE IN FLOW CYTOMETRY 有权多增益自适应线性处理和流动细胞计数中使用的数字系统公开(公告)号：US20080319680A1
公开(公告)日：2008-12-25
申请号：US12053439
申请日：2008-03-21
申请人： Daniel N. Fox , Thomas L. Thrasher
发明人： Daniel N. Fox , Thomas L. Thrasher
CPC分类号： G01N15/147 , G01N15/1429 , G01N2015/1477 , H04B17/0082 , H04B17/0085
摘要： Disclosed is an electronic processing system for a flow cytometer that uses a processing chip that processes data in a parallel architecture on a sample by sample basis and provides for high throughput of data. In addition, multi-gain linear amplifiers are used which are matched using feedback circuits to provide accurate data and high resolution data having high dynamic range.
摘要翻译： 公开了一种用于流式细胞仪的电子处理系统，其使用处理芯片，其以逐个样本的形式处理并行架构中的数据，并提供高吞吐量的数据。 此外，使用多增益线性放大器，其使用反馈电路匹配以提供具有高动态范围的精确数据和高分辨率数据。
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6.发明申请MULTI-GAIN ADAPTIVE LINEAR PROCESSING AND GATED DIGITAL SYSTEM FOR USE IN FLOW CYTOMETRY 有权多增益自适应线性处理和流动细胞计数中使用的数字系统公开(公告)号：US20110213591A1
公开(公告)日：2011-09-01
申请号：US13082283
申请日：2011-04-07
申请人： Daniel N. FOX , Thomas L. Thrasher
发明人： Daniel N. FOX , Thomas L. Thrasher
IPC分类号： G06F15/00
CPC分类号： G01N15/147 , G01N15/1429 , G01N2015/1477 , H04B17/0082 , H04B17/0085
摘要： Disclosed is an electronic processing system for a flow cytometer that uses a processing chip that processes data in a parallel architecture on a sample by sample basis and provides for high throughput of data. In addition, multi-gain linear amplifiers are used which are matched using feedback circuits to provide accurate data and high resolution data having high dynamic range.
摘要翻译： 公开了一种用于流式细胞仪的电子处理系统，其使用处理芯片，其以逐个样本的形式处理并行架构中的数据，并提供高吞吐量的数据。 此外，使用多增益线性放大器，其使用反馈电路匹配以提供具有高动态范围的精确数据和高分辨率数据。
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公开(公告)号：US08754390B2
公开(公告)日：2014-06-17
申请号：US13044685
申请日：2011-03-10
CPC分类号： G01N15/1429 , G01N15/1427 , G01N15/1459 , G01N2015/1438
摘要： A method is provided for generating measurement parameters for a particle sample in a particle analyzer. The method includes, interrogating the particle sample with a triggering interrogator and one or more secondary interrogators respectively positioned along a length of an interrogation area, generating respective pulses based upon the interrogation of a first particle from the particle sample, determining a primary pulse detection window based upon a triggering pulse, determining a search interval to find a secondary pulse based upon factors including the primary pulse detection window and a laser delay, adjusting the search interval for laser delay variation dynamically based on the interrogation of the first particle, identifying the secondary pulse in the adjusted search interval, and processing the secondary pulse to determine a peak value of the secondary pulse. Corresponding apparatus are also provided.
摘要翻译： 提供了一种用于在粒子分析仪中产生粒子样本的测量参数的方法。 该方法包括：用触发询问器和一个或多个二级询问器询问粒子样本，该询问器分别沿着询问区域的长度定位，根据来自粒子样本的第一粒子的询问产生相应的脉冲，确定主脉冲检测窗口 基于触发脉冲，基于包括主脉冲检测窗口和激光延迟的因素来确定搜索间隔以找到辅助脉冲，基于第一颗粒的询问来动态地调整激光延迟变化的搜索间隔，识别次级 脉冲在调整的搜索间隔中，并且处理辅助脉冲以确定次级脉冲的峰值。 还提供了相应的装置。
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8.发明授权Multi-gain adaptive linear processing and gated digital system for use in flow cytometry 有权多增益自适应线性处理和门控数字系统用于流式细胞术公开(公告)号：US08290751B2
公开(公告)日：2012-10-16
申请号：US13082283
申请日：2011-04-07
申请人： Daniel N. Fox , Thomas L. Thrasher
发明人： Daniel N. Fox , Thomas L. Thrasher
CPC分类号： G01N15/147 , G01N15/1429 , G01N2015/1477 , H04B17/0082 , H04B17/0085
摘要： Disclosed is an electronic processing system for a flow cytometer that uses a processing chip that processes data in a parallel architecture on a sample by sample basis and provides for high throughput of data. In addition, multi-gain linear amplifiers are used which are matched using feedback circuits to provide accurate data and high resolution data having high dynamic range.
摘要翻译： 公开了一种用于流式细胞仪的电子处理系统，其使用处理芯片，其以逐个样本的形式处理并行架构中的数据，并提供高吞吐量的数据。 此外，使用多增益线性放大器，其使用反馈电路匹配以提供具有高动态范围的精确数据和高分辨率数据。
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9.发明授权Multi-gain adaptive linear processing and gated digital system for use in flow cytometry 有权多增益自适应线性处理和门控数字系统用于流式细胞术公开(公告)号：US07945428B2
公开(公告)日：2011-05-17
申请号：US12053439
申请日：2008-03-21
申请人： Daniel N. Fox , Thomas L. Thrasher
发明人： Daniel N. Fox , Thomas L. Thrasher
CPC分类号： G01N15/147 , G01N15/1429 , G01N2015/1477 , H04B17/0082 , H04B17/0085
摘要： Disclosed is an electronic processing system for a flow cytometer that uses a processing chip that processes data in a parallel architecture on a sample by sample basis and provides for high throughput of data. In addition, multi-gain linear amplifiers are used which are matched using feedback circuits to provide accurate data and high resolution data having high dynamic range.
摘要翻译： 公开了一种用于流式细胞仪的电子处理系统，其使用处理芯片，其以逐个样本的形式处理并行架构中的数据，并提供高吞吐量的数据。 此外，使用多增益线性放大器，其使用反馈电路匹配以提供具有高动态范围的精确数据和高分辨率数据。
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公开(公告)号：US06992670B2
公开(公告)日：2006-01-31
申请号：US10746787
申请日：2003-12-23
CPC分类号： G06T11/203
摘要： In one embodiment, selecting a screen region on a screen of a monitor of a computer graphics display system to activate in rendering a straight line segment. Steps of aligning a rectangular grid to screen region boundaries, wherein the screen includes a screen space divided into at least one screen region, locating a first and second endpoints of the straight line segment on the screen space, defining a rectangular bounding box in the screen space having vertices at the first and second endpoints, identifying each screen region that at least partially overlaps the bounding box, and selecting each identified screen region through which the straight line segment passes to activate for rendering the straight line segment on the screen are disclosed.
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