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公开(公告)号：US20220415641A1
公开(公告)日：2022-12-29
申请号：US17355958
申请日：2021-06-23
申请人： THERMO FINNIGAN LLC
摘要： A mass spectrometry method comprises: storing a first packet of ions within an ion storage apparatus; transferring the first ion packet into an electrostatic trap mass analyzer through a set of electrostatic lenses, wherein, during the transfer, either the lenses are operated in a first mode of operation or an injection voltage of a first pre-determined magnitude is applied to an electrode of the mass analyzer; mass analyzing the first ion packet using the mass analyzer; storing a second packet of ions within the ion storage apparatus; transferring the second ion packet into the mass analyzer through the set of lenses, wherein, during the transfer, either the lenses are operated in a second mode of operation or an injection voltage of a second pre-determined magnitude is applied to the electrode of the mass analyzer; and mass analyzing the second packet of ions using the electrostatic trap mass analyzer.
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2.发明申请公开(公告)号：US20190013188A1
公开(公告)日：2019-01-10
申请号：US16028932
申请日：2018-07-06
申请人： Thermo Finnigan LLC
IPC分类号： H01J49/00
摘要： Isobaric mass spectrometry tags (e.g., TMT) are susceptible to ratio compression, which arises from the co-isolation and co-fragmentation of interfering species that also contribute to the final reporter ion ratios. Additional stages of ion activation/transformation (e.g., MSn and PTR) have been shown to decrease ratio compression. Embodiments of the present invention include a mass spectrometry cleavable moiety on the isobaric mass tags. The cleavable moiety allows for a predictable mass loss, and results in an improved tag reporter ion purity.
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3.发明申请公开(公告)号：US20140306107A1
公开(公告)日：2014-10-16
申请号：US14251137
申请日：2014-04-11
申请人： Thermo Finnigan LLC
发明人： Philip M. REMES , Michael W. SENKO
IPC分类号： H01J49/42
CPC分类号： H01J49/4265
摘要： A method for mass analyzing ions comprising a restricted range mass-to-charge (m/z) ratios comprising performing a survey mass analysis using a mass analyzer to measure a flux of ions having m/z ratios within said restricted range and performing a dependent mass analysis of an optimal quantity of ions having m/z ratios within said restricted range, said optimal quantity collected for a time period determined by the measured ion flux, CHARACTERIZED IN THAT: the time period is determined using a corrected ion flux that accounts for one or more of: (a) imperfect restriction of collected ions to the range of m/z ratios, (b) inclusion of ions within the range of m/z ratios that are undetected by the survey mass analysis, (c) different mass analyzers used for the dependent and survey mass analyses, and (d) different ion pathways used during dependent and the survey mass analyses.
摘要翻译： 一种用于质量分析离子的方法，包括受限范围的质量比（m / z）比，包括使用质量分析器进行测量质量分析，以测量在所述限制范围内具有m / z比的离子的通量并执行依赖 质量分析在所述限制范围内具有m / z比的最佳离子量，所述最佳量由所测量的离子通量确定一段时间，其特征在于：使用补偿离子通量 一个或多个：（a）收集的离子对m / z比的范围的不完全限制，（b）在m / z比范围内包含离子，其不被检测质量分析检测到，（c）不同质量 用于依赖和调查质量分析的分析仪，以及（d）在依赖和调查质量分析期间使用的不同离子途径。
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公开(公告)号：US20210384026A1
公开(公告)日：2021-12-09
申请号：US17406710
申请日：2021-08-19
申请人： THERMO FINNIGAN LLC
发明人： Philip M. REMES , Michael W. SENKO
摘要： A space-time buffer includes a plurality of discrete trapping regions and a controller. The plurality of discrete trapping regions is configured to trap ions as individual trapping regions or as combinations of trapping regions. The controller is configured to combine at least a portion of the plurality of trapping regions into a larger trap region; fill the larger trap region with a plurality of ions; split the larger trap region into individual trapping regions each containing a portion of the plurality of ions; and eject ions from the trapping regions.
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公开(公告)号：US20210183639A1
公开(公告)日：2021-06-17
申请号：US16711263
申请日：2019-12-11
申请人： Thermo Finnigan LLC
发明人： Philip M. REMES , Michael W. SENKO
摘要： A space-time buffer includes a plurality of discrete trapping regions and a controller. The plurality of discrete trapping regions is configured to trap ions as individual trapping regions or as combinations of trapping regions. The controller is configured to combine at least a portion of the plurality of trapping regions into a larger trap region; fill the larger trap region with a plurality of ions; split the larger trap region into individual trapping regions each containing a portion of the plurality of ions; and eject ions from the trapping regions.
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公开(公告)号：US20210164990A1
公开(公告)日：2021-06-03
申请号：US17151492
申请日：2021-01-18
申请人： Thermo Finnigan LLC
发明人： Michael W. SENKO
摘要： A method includes applying distinct isobaric tags to each of a plurality of samples; combining the samples; performing a separation of species within the combined samples; isolating and fragmenting labeled parent ions within a m/z range to produce a plurality of reporter ions, each reporter ion corresponding to one of the isobaric tags; determining intensities of the plurality of reporter ions and ions representative of a parent species at a plurality of points along a peak; and fitting the intensity of the ions representative of a parent species and the plurality of reporter ions at the plurality of points to obtain a relative abundance of the parent species in each of the plurality of samples.
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公开(公告)号：US20180061625A1
公开(公告)日：2018-03-01
申请号：US15252025
申请日：2016-08-30
申请人： Thermo Finnigan LLC
CPC分类号： H01J49/4245 , H01J49/0031 , H01J49/426 , H01J49/4275
摘要： A method of operating an electrostatic trapping mass analyzer, comprising: introducing a sample of ions into a trapping region of the mass analyzer, wherein a trapping field within the trapping region is such that the ions exhibit radial motion with respect to a central longitudinal axis of the trapping region while undergoing harmonic motion in a dimension defined by the central longitudinal axis, the frequency of harmonic motion of a particular ion being a function of its mass-to-charge ratio; superimposing a modulation field onto the trapping field within the trapping region, the modulation field acting to either increase or reduce the harmonic motion energies of the ions by an amount varying according to the frequency of harmonic motion; and acquiring a mass spectrum of the ions in the trapping region by measuring a signal representative of an image current induced by the harmonic motion of the ions.
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公开(公告)号：US20220414613A1
公开(公告)日：2022-12-29
申请号：US17778805
申请日：2020-11-24
申请人： Thermo Finnigan LLC
发明人： Helene L. CARDASIS , Ping F. YIP , Jacob R. SCHWARTZ , Stephen GNANASAMY , Adam F. Kimball , Michael W. SENKO , Vladimir ZABROUSKOV
摘要： A system comprises: (1) a central location comprising: (a) computer storage media having one or more databases thereon; and (b) one or more computers configured to communicate with the computer storage media: and (2) a plurality of sites, each site comprising: (a) an analytical apparatus; and (b) a site computer system comprising program instructions operable to generate a collection of apparatus signatures, each apparatus signature comprising a collection of data relating to the operation of the analytical apparatus at a time when said signature is generated, wherein the one or more computers at the central location are configured to store each collection of signatures in the one or more databases. In embodiments, each site computer system stores the plurality of apparatus signatures generated at the respective site and transmits the stored apparatus signatures to the one or more computers at the central location.
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公开(公告)号：US20220336198A1
公开(公告)日：2022-10-20
申请号：US17810305
申请日：2022-06-30
申请人： Thermo Finnigan LLC
发明人： Michael W. SENKO , Philip M. REMES
IPC分类号： H01J49/00 , G01N27/622 , H01J49/42
摘要： A method of operating a mass spectrometer that allows for high-speed operation is disclosed. The method consists in separating the various steps needed to produce a mass spectrum into three or more conceptual stages in a pipeline, such that the instrument is performing steps to process more than two precursor-ion species simultaneously. In general, the number of stages in the pipeline should at least one more and, preferably, at least two more than the number of buffering storage devices in the instrument. The presently-taught methods and apparatus allow for nearly 100% duty cycle of ion accumulation for precursors of interest.
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公开(公告)号：US20190187150A1
公开(公告)日：2019-06-20
申请号：US15844233
申请日：2017-12-15
申请人： Thermo Finnigan LLC
发明人： Michael W. SENKO
CPC分类号： G01N33/6848 , G01N30/72 , G01N2560/00 , H01J49/0036 , H01J49/04
摘要： A method includes applying distinct isobaric tags to each of a plurality of samples; combining the samples; performing a separation of species within the combined samples; isolating and fragmenting labeled parent ions within a m/z range to produce a plurality of reporter ions, each reporter ion corresponding to one of the isobaric tags; determining intensities of the plurality of reporter ions and ions representative of a parent species at a plurality of points along a peak; and fitting the intensity of the ions representative of a parent species and the plurality of reporter ions at the plurality of points to obtain a relative abundance of the parent species in each of the plurality of samples.
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