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公开(公告)号：US20130243855A1
公开(公告)日：2013-09-19
申请号：US13694290
申请日：2012-11-14
申请人： Jorge Oyhenart , Xavier Gallet , Gilles Borrelly , Thierry Guyon , Manuel Vega , Lila Drittanti
发明人： Jorge Oyhenart , Xavier Gallet , Gilles Borrelly , Thierry Guyon , Manuel Vega , Lila Drittanti
IPC分类号： C12N9/64
CPC分类号： C12N9/644 , C12Y304/21022
摘要： Provided are modified factor IX (FIX) polypeptides and methods of generating modified FIX polypeptides. Also provided are pharmaceutical compositions, including compositions formulation for oral administration, that contain the modified FIX polypeptides, and methods of treatment using modified FIX polypeptides.
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2.发明授权公开(公告)号：US08383388B2
公开(公告)日：2013-02-26
申请号：US11818985
申请日：2007-06-15
申请人： Jorge Oyhenart , Xavier Gallet , Gilles Borrelly , Thierry Guyon , Manuel Vega , Lila Drittanti
发明人： Jorge Oyhenart , Xavier Gallet , Gilles Borrelly , Thierry Guyon , Manuel Vega , Lila Drittanti
CPC分类号： C12N9/644 , C12Y304/21022
摘要： Provided are modified factor IX (FIX) polypeptides and methods of generating modified FIX polypeptides. Also provided are pharmaceutical compositions, including compositions formulation for oral administration, that contain the modified FIX polypeptides, and methods of treatment using modified FIX polypeptides.
摘要翻译： 提供了修饰因子IX（FIX）多肽和产生修饰的FIX多肽的方法。 还提供了药物组合物，包括用于口服给药的组合物制剂，其含有修饰的FIX多肽，以及使用修饰的FIX多肽的治疗方法。
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3.发明申请MODIFIED ERYTHROPOIETIN (EPO) POLYPEPTIDES THAT EXHIBIT INCREASED PROTEASE RESISTANCE AND PHARMACEUTICAL COMPOSITIONS THEREOF 审中-公开改良的抗坏血酸蛋白酶（EPO）多肽，其具有增加的抗蛋白酶和药物组合物公开(公告)号：US20120264686A9
公开(公告)日：2012-10-18
申请号：US12736959
申请日：2009-05-29
申请人： Thierry Guyon , Gilles Borrelly , Xavier Gallet , Lila Drittanti , Manuel Vega
发明人： Thierry Guyon , Gilles Borrelly , Xavier Gallet , Lila Drittanti , Manuel Vega
IPC分类号： A61K38/18 , C12N15/12 , C12N15/63 , A61P7/06 , C12N1/19 , C12N5/10 , C12N1/13 , C07K14/505 , C12N1/21
CPC分类号： C07K14/505 , A61K38/00
摘要： Modified erythropoietin (EPO) polypeptides and other modified therapeutic polypeptides are provided. The EPO polypeptides and other therapeutic polypeptides are modified to exhibit physical properties and activities that differ from the unmodified EPO polypeptides and other unmodified therapeutic polypeptides, respectively. Nucleic acid molecules encoding these polypeptides also are provided. Also provided are methods of treatment and diagnosis using the polypeptides.
摘要翻译： 提供了修饰的促红细胞生成素（EPO）多肽和其他修饰的治疗多肽。 EPO多肽和其他治疗性多肽被修饰以显示分别与未修饰的EPO多肽和其他未修饰的治疗性多肽不同的物理性质和活性。 还提供了编码这些多肽的核酸分子。 还提供了使用多肽的治疗和诊断的方法。
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4.发明授权公开(公告)号：US08252743B2
公开(公告)日：2012-08-28
申请号：US11998387
申请日：2007-11-28
申请人： Thierry Guyon , Gilles Borrelly , Xavier Gallet , Lila Drittanti , Manuel Vega
发明人： Thierry Guyon , Gilles Borrelly , Xavier Gallet , Lila Drittanti , Manuel Vega
IPC分类号： A61K38/18 , C07K14/505
CPC分类号： C07K14/505 , A61K31/555 , A61K33/26 , A61K38/00 , A61K38/193 , A61K45/06 , Y02A50/473 , A61K2300/00
摘要： Modified erythropoietin (EPO) polypeptides and other modified therapeutic polypeptides are provided. The EPO polypeptides and other therapeutic polypeptides are modified to exhibit physical properties and activities that differ from the unmodified EPO polypeptides and other unmodified therapeutic polypeptides, respectively. Nucleic acid molecules encoding these polypeptides also are provided. Also provided are methods of treatment and diagnosis using the polypeptides.
摘要翻译： 提供了修饰的促红细胞生成素（EPO）多肽和其他修饰的治疗多肽。 EPO多肽和其他治疗性多肽被修饰以显示分别与未修饰的EPO多肽和其他未修饰的治疗性多肽不同的物理性质和活性。 还提供了编码这些多肽的核酸分子。 还提供了使用多肽的治疗和诊断的方法。
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5.发明申请公开(公告)号：US20120094906A1
公开(公告)日：2012-04-19
申请号：US12736959
申请日：2009-05-29
申请人： Thierry Guyon , Gilles Borrelly , Xavier Gallet , Lila Drittanti , Manuel Vega
发明人： Thierry Guyon , Gilles Borrelly , Xavier Gallet , Lila Drittanti , Manuel Vega
IPC分类号： A61K38/18 , C12N15/12 , C12N15/63 , A61P7/06 , C12N1/19 , C12N5/10 , C12N1/13 , C07K14/505 , C12N1/21
CPC分类号： C07K14/505 , A61K38/00
摘要： Modified erythropoietin (EPO) polypeptides and other modified therapeutic polypeptides are provided. The EPO polypeptides and other therapeutic polypeptides are modified to exhibit physical properties and activities that differ from the unmodified EPO polypeptides and other unmodified therapeutic polypeptides, respectively. Nucleic acid molecules encoding these polypeptides also are provided. Also provided are methods of treatment and diagnosis using the polypeptides.
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公开(公告)号：US20090238789A1
公开(公告)日：2009-09-24
申请号：US11998387
申请日：2007-11-28
申请人： Thierry Guyon , Gilles Borrelly , Xavier Gallet , Lila Drittanti , Manuel Vega
发明人： Thierry Guyon , Gilles Borrelly , Xavier Gallet , Lila Drittanti , Manuel Vega
IPC分类号： A61K38/20 , A61K38/18 , A61K38/21 , A61K38/22 , C07K14/575 , C12N15/18 , C12N15/85 , C12N5/10 , C12P21/02 , C12N1/21 , C12N15/74
CPC分类号： C07K14/505 , A61K31/555 , A61K33/26 , A61K38/00 , A61K38/193 , A61K45/06 , Y02A50/473 , A61K2300/00
摘要： Modified erythropoietin (EPO) polypeptides and other modified therapeutic polypeptides are provided. The EPO polypeptides and other therapeutic polypeptides are modified to exhibit physical properties and activities that differ from the unmodified EPO polypeptides and other unmodified therapeutic polypeptides, respectively. Nucleic acid molecules encoding these polypeptides also are provided. Also provided are methods of treatment and diagnosis using the polypeptides.
摘要翻译： 提供了修饰的促红细胞生成素（EPO）多肽和其他修饰的治疗多肽。 EPO多肽和其他治疗性多肽被修饰以显示分别与未修饰的EPO多肽和其他未修饰的治疗性多肽不同的物理性质和活性。 还提供了编码这些多肽的核酸分子。 还提供了使用多肽的治疗和诊断的方法。
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7.发明申请公开(公告)号：US20080102115A1
公开(公告)日：2008-05-01
申请号：US11818985
申请日：2007-06-15
申请人： Jorge Oyhenart , Xavier Gallet , Gilles Borrelly , Thierry Guyon , Manuel Vega , Lila Drittanti
发明人： Jorge Oyhenart , Xavier Gallet , Gilles Borrelly , Thierry Guyon , Manuel Vega , Lila Drittanti
IPC分类号： A61K38/48 , A01K67/00 , A61K9/28 , A61K9/52 , C07K14/00 , C12N15/00 , C12N5/06 , C40B40/08 , C40B40/10 , C12P21/04 , C12N15/11 , C12N1/20 , A61P7/02 , A61K9/48 , A61K31/70
CPC分类号： C12N9/644 , C12Y304/21022
摘要： Provided are modified factor IX (FIX) polypeptides and methods of generating modified FIX polypeptides. Also provided are pharmaceutical compositions, including compositions formulation for oral administration, that contain the modified FIX polypeptides, and methods of treatment using modified FIX polypeptides.
摘要翻译： 提供了修饰因子IX（FIX）多肽和产生修饰的FIX多肽的方法。 还提供了药物组合物，包括用于口服给药的组合物制剂，其含有修饰的FIX多肽，以及使用修饰的FIX多肽的治疗方法。
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公开(公告)号：US20110130331A1
公开(公告)日：2011-06-02
申请号：US12931218
申请日：2011-01-25
申请人： Thierry Guyon , Gilles Borrelly , Lila Drittanti , Manuel Vega
发明人： Thierry Guyon , Gilles Borrelly , Lila Drittanti , Manuel Vega
IPC分类号： A61K38/27 , C07K14/61 , A61P31/18 , A61P1/16 , A61P13/12 , A61P3/04 , A61P19/10 , A61P15/16 , A61P25/00 , A61P21/00
摘要： Provided are modified growth hormone polypeptides, nucleic acid molecules encoding modified growth hormone polypeptides and methods of generating modified growth hormone polypeptides. Also provided are methods of treatment using modified growth hormone polypeptides.
摘要翻译： 提供了修饰的生长激素多肽，编码修饰的生长激素多肽的核酸分子和产生修饰的生长激素多肽的方法。 还提供了使用修饰的生长激素多肽的治疗方法。
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9.发明授权Modified growth hormones that exhibit increased protease resistance and pharmaceutical compositions thereof 有权表现出增加的蛋白酶抗性的改良生长激素及其药物组合物公开(公告)号：US08222209B2
公开(公告)日：2012-07-17
申请号：US12931218
申请日：2011-01-25
申请人： Thierry Guyon , Gilles Borrelly , Lila Drittanti , Manuel Vega
发明人： Thierry Guyon , Gilles Borrelly , Lila Drittanti , Manuel Vega
摘要： Provided are modified growth hormone polypeptides, nucleic acid molecules encoding modified growth hormone polypeptides and methods of generating modified growth hormone polypeptides. Also provided are methods of treatment using modified growth hormone polypeptides.
摘要翻译： 提供了修饰的生长激素多肽，编码修饰的生长激素多肽的核酸分子和产生修饰的生长激素多肽的方法。 还提供了使用修饰的生长激素多肽的治疗方法。
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公开(公告)号：US20060247170A1
公开(公告)日：2006-11-02
申请号：US11476173
申请日：2006-06-26
申请人： Thierry Guyon , Gilles Borrelly , Lila Drittanti , Manuel Vega
发明人： Thierry Guyon , Gilles Borrelly , Lila Drittanti , Manuel Vega
摘要： Provided are modified growth hormone polypeptides, nucleic acid molecules encoding modified growth hormone polypeptides and methods of generating modified growth hormone polypeptides. Also provided are methods of treatment using modified growth hormone polypeptides.
摘要翻译： 提供了修饰的生长激素多肽，编码修饰的生长激素多肽的核酸分子和产生修饰的生长激素多肽的方法。 还提供了使用修饰的生长激素多肽的治疗方法。
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