公开(公告)号：US10130822B2

公开(公告)日：2018-11-20

申请号：US13009629

申请日：2011-01-19

申请人： Thierry Legay ,  Dominique Decoene

发明人： Thierry Legay ,  Dominique Decoene

IPC分类号： A61N1/39 ,  A61N1/37 ,  A61B5/055

摘要： An implantable cardiac device that detects and protects against strong magnetic fields produced by MRI equipment is disclosed. The device has a magnetic field sensor for detecting the presence of a relatively weak static magnetic field (102, 110, 118, 122) of a level equivalent to that of a permanent magnet in the vicinity of the device. The device is switched from a standard operating mode (100) where the nominal functions of the device are active, to a specific protected MRI mode (114, 116) in the presence of a magnetic static field of a level corresponding to that emitted by MRI equipment. The device further temporarily switches the device from the standard operating mode (100) to an MRI stand-by state (108) when a magnetic field is detected by the magnetic field sensor such that a subsequent detection of a magnetic field switches the device from an MRI stand-by state to the specific protected MRI mode.

公开(公告)号：US07440801B2

公开(公告)日：2008-10-21

申请号：US11186623

申请日：2005-07-20

申请人： Thierry Legay ,  Dominique Decoene

发明人： Thierry Legay ,  Dominique Decoene

IPC分类号： A61N1/00

CPC分类号： A61N1/3706 ,  A61N2001/083

摘要： An implantable cardiac pacemaker with automatic control of the connection of a probe and the implantation of the case. The device includes a generator and its energy source. The generator includes: circuits for scanning battery consumption, able to measure current output by the battery and to deliver a measured value of the output current; comparator circuits, able to compare the current value measured with a pre-programmed value of threshold of current. It includes moreover circuits suited to: detect and count the spontaneous depolarizations collected between the aforementioned terminals of the head of connector; to compare the number of depolarizations thus counted with a pre-programmed threshold of counting; and to deliver a signal of suspicion of implantation in the event of crossing of this threshold of counting.

摘要翻译： 可植入心脏起搏器，可自动控制探头的连接和外壳的植入。 该装置包括发电机及其能量源。 发生器包括：用于扫描电池消耗的电路，能够测量电池的电流输出并输出测量的输出电流值; 比较器电路，能够比较当前测量的电流值与电流阈值的预编程值。 它还包括适合于：检测和计数在连接器头部的上述端子之间收集的自发去极化的电路; 将这样计数的去极化数与预编程的计数阈值进行比较; 并且在跨越这个计数阈值的情况下传递怀疑植入的信号。

公开(公告)号：US07203544B2

公开(公告)日：2007-04-10

申请号：US10745472

申请日：2003-12-22

申请人： Thierry Legay ,  Dominique Decoene

发明人： Thierry Legay ,  Dominique Decoene

IPC分类号： A61N1/37

CPC分类号： A61N1/371

摘要： Detection of an evoked post-stimulation potential, in particular atrial potentials, in an active implantable medical device such as a cardiac pacemaker, a defibrillator, a cardioveter, or a multisite device. This device applies a stimulation pulse (40), then shorts-circuit for a discharge period (42, OCD) the output circuit, which includes discharging a connection capacitor, the self-impedance of the probe, and the impedance of the interface heart-electrode. A detection circuit includes an amplifier and a blanking circuit to temporarily uncouple the input terminal from the amplifier. A sequencer control circuit activates during a first time (micro blanking) the blanking circuit throughout the stimulation pulse (40), activates the discharging circuit with a delay after the application of the stimulation pulse, then inhibits the blanking circuit for a listening period (44), defining at least part of this delay, so as to authorize detection by the amplifier, during the listening period, of the evoked post-stimulation potentials, and then activates the blanking circuit a second time (BLANKING) after the listening period throughout the discharge period (42, OCD).

摘要翻译： 检测在诸如心脏起搏器，除颤器，心脏病或多位置装置的有源可植入医疗装置中的诱发后刺激电位，特别是心房电位。 该装置施加刺激脉冲（40），然后对输出电路进行短路放电周期（42，OCD），其包括放电连接电容器，探针的自身阻抗以及接口心脏的阻抗， 电极。 检测电路包括放大器和消隐电路，以暂时将放大器与输入端分离。 定序器控制电路在整个刺激脉冲（40）中的第一次（消隐）消隐电路期间激活，在施加刺激脉冲之后延迟地激活放电电路，然后在收听期间禁止消隐电路（44 ），定义该延迟的至少一部分，以便授权在听觉期间放大器在诱发后刺激电位之后的检测，然后在整个听觉周期之后再次激活消隐电路（BLANKING） 放电期（42，OCD）。

公开(公告)号：US20110178562A1

公开(公告)日：2011-07-21

申请号：US13009629

申请日：2011-01-19

申请人： Thierry Legay ,  Dominique Decoene

发明人： Thierry Legay ,  Dominique Decoene

IPC分类号： A61N1/39 ,  A61N1/362

CPC分类号： A61N1/3925 ,  A61B5/055 ,  A61N1/3718

摘要： An implantable cardiac device that detects and protects against strong magnetic fields produced by MRI equipment is disclosed. The device has a magnetic field sensor for detecting the presence of a relatively weak static magnetic field (102, 110, 118, 122) of a level equivalent to that of a permanent magnet in the vicinity of the device. The device is switched from a standard operating mode (100) where the nominal functions of the device are active, to a specific protected MRI mode (114, 116) in the presence of a magnetic static field of a level corresponding to that emitted by MRI equipment. The device further temporarily switches the device from the standard operating mode (100) to an MRI stand-by state (108) when a magnetic field is detected by the magnetic field sensor such that a subsequent detection of a magnetic field switches the device from an MRI stand-by state to the specific protected MRI mode.

摘要翻译： 公开了一种用于检测和保护由MRI设备产生的强磁场的可植入心脏装置。 该装置具有磁场传感器，用于检测存在与设备附近的永久磁铁相当程度的相对较弱的静态磁场（102,110,118,122）。 在存在与MRI发射的电平相对应的磁场的磁场的情况下，该设备从设备的标称功能的活动的标准操作模式（100）切换到特定的受保护的MRI模式（114,116） 设备。 当由磁场传感器检测到磁场时，该装置进一步临时将装置从标准操作模式（100）切换到MRI待机状态（108），使得随后的磁场检测将该装置从 MRI待机状态到具体的保护MRI模式。

公开(公告)号：US20060052833A1

公开(公告)日：2006-03-09

申请号：US11186623

申请日：2005-07-20

申请人： Thierry Legay ,  Dominique Decoene

发明人： Thierry Legay ,  Dominique Decoene

IPC分类号： A61N1/37

CPC分类号： A61N1/3706 ,  A61N2001/083

摘要： An implantable cardiac pacemaker with automatic control of the connection of a probe and the implantation of the case. The device includes a generator and its energy source. The generator includes: circuits for scanning battery consumption, able to measure current output by the battery and to deliver a measured value of the output current; comparator circuits, able to compare the current value measured with a pre-programmed value of threshold of current. It includes moreover circuits suited to: detect and count the spontaneous depolarizations collected between the aforementioned terminals of the head of connector; to compare the number of depolarizations thus counted with a pre-programmed threshold of counting; and to deliver a signal of suspicion of implantation in the event of crossing of this threshold of counting.

摘要翻译： 可植入心脏起搏器，可自动控制探头的连接和外壳的植入。 该装置包括发电机及其能量源。 发生器包括：用于扫描电池消耗的电路，能够测量电池的电流输出并输出测量的输出电流值; 比较器电路，能够比较当前测量的电流值与电流阈值的预编程值。 它还包括适合于：检测和计数在连接器头部的上述端子之间收集的自发去极化的电路; 将这样计数的去极化数与预编程的计数阈值进行比较; 并且在跨越这个计数阈值的情况下传递怀疑植入的信号。

公开(公告)号：US06487452B2

公开(公告)日：2002-11-26

申请号：US09816646

申请日：2001-03-23

申请人： Thierry Legay

发明人： Thierry Legay

IPC分类号： A61N137

CPC分类号： G01V3/101

摘要： A circuit for detection of the presence of a permanent magnet in the vicinity of an active implantable medical device, in particular a pacemaker, a defibrillator, a cardioverter and/or a multisite device. This circuit includes a coil (12), able to respond to the presence of the magnet (16) so as to present a decreased value of its inductance, a resonant LC circuit (10) including the aforementioned coil, a generator (18) for pulse excitation of the resonant circuit; a circuit to analyze the pulse response of the resonant circuit, and a discriminating circuit, able to evaluate the value of the coil inductance from the analyzed pulse response and, correlatively, to determine therefrom the presence or the absence of the magnet. The excitation generator is able to deliver to the resonant circuit a burst of N successive pulses, and the analyzing circuit determines N corresponding pulse responses, and the discriminating circuit determines the presence of the magnet if, among N analyzed pulse responses, a number M (M≦N) of them correspond to a decreased value of the inductance of the coil.

摘要翻译： 一种用于检测在有源可植入医疗装置，特别是起搏器，除颤器，心律转复器和/或多位置装置附近的永磁体的存在的电路。 该电路包括能够响应于磁体（16）的存在以便呈现其电感值减小的线圈（12），包括上述线圈的谐振LC电路（10），用于 谐振电路的脉冲激励; 用于分析谐振电路的脉冲响应的电路，以及鉴别电路，其能够根据分析的脉冲响应来评估线圈电感的值，并且相应地确定磁体的存在或不存在。 励磁发生器能够向谐振电路输送N个连续脉冲的突发，并且分析电路确定N个对应的脉冲响应，并且鉴别电路确定磁体的存在，如果在N个分析的脉冲响应中存在M个（ M <= N）对应于线圈的电感值的减小。

公开(公告)号：US06251703B1

公开(公告)日：2001-06-26

申请号：US09459272

申请日：1999-12-13

申请人： Yves Van Campenhout ,  Dominique Gilet ,  Thierry Legay ,  Hubert Bono

发明人： Yves Van Campenhout ,  Dominique Gilet ,  Thierry Legay ,  Hubert Bono

IPC分类号： H01L2144

CPC分类号： H01L23/3107 ,  H01L21/56 ,  H01L24/48 ,  H01L29/0657 ,  H01L2224/451 ,  H01L2224/48091 ,  H01L2224/4824 ,  H01L2224/48465 ,  H01L2924/00014 ,  H01L2924/0102 ,  H01L2924/10158 ,  H01L2924/10253 ,  H01L2924/14 ,  H01L2924/181 ,  H01L2924/00 ,  H01L2224/45099

摘要： A microelectronic coated CMS component, in particular for an active implantable medical device, and its method of manufacture. The process is applied to a wafer from which will be formed, after cutting, a plurality of CMS components of the CSP type, i.e., having appreciably the same dimensions as those of the chip. The process includes (a) obtaining a wafer (10) on which are formed the chips (12), each chip having a contact pad (16) on at least one side of the chip; (b) sealing on this wafer a cap (18) having openings (20) authorizing an access to the subjacent contact pads of the chips; (c) forming in the cap distinct trenches (22) according to the periphery of each chip; (d) establishing in the openings an electrical connection to the contact pads, these connections (26) emerging through the upper face of the cap; (e) flowing a coating resin (34) into the openings and the trenches; (f) polishing and metallizing the cap; and (g) cutting the wafer thus prepared into individual components.

摘要翻译： 微电子涂覆的CMS组分，特别是用于有源可植入医疗装置及其制造方法。 该方法被应用于在切割之后将形成CSP型的多个CMS部件的晶片，即，具有与芯片的尺寸相当的尺寸。 该方法包括（a）获得其上形成有芯片（12）的晶片（10），每个芯片在芯片的至少一侧具有接触焊盘（16）; （b）在该晶片上密封具有开口（20）的盖子（18），该开口（20）授权访问芯片的下面的接触焊盘; （c）根据每个芯片的周边在盖形成不同的沟槽（22）; （d）在开口中建立与接触垫的电连接，通过盖的上表面出现的这些连接（26） （e）使涂覆树脂（34）流入开口和沟槽中; （f）抛光和金属化盖子; 和（g）将如此制备的晶片切割成各个部件。

公开(公告)号：US5702424A

公开(公告)日：1997-12-30

申请号：US657802

申请日：1996-05-31

申请人： Thierry Legay ,  Jean-Luc Bonnet ,  Laurence Geroux

发明人： Thierry Legay ,  Jean-Luc Bonnet ,  Laurence Geroux

IPC分类号： A61N1/365 ,  A61N1/39 ,  A61N1/362

CPC分类号： A61N1/365

摘要： An active implantable medical device, notably a cardiac pacemaker or fibrillator, which detects the instantaneous cardiac rhythm, spontaneous or stimulated, of the bearer of the device, and delivers stimulation pulses with a variable escape interval and which increases gradually this escape interval. The gradual increase of the escape interval is obtained by memorizing information corresponding to the evolution of the cardiac rhythm sensed by a conventional detection circuit over a first time period, wherein the escape interval to be adjusted is later in time to the memorized information, notably by determining a variable rate of increase of the escape interval, which variable rate is essentially determined as a function of the memorized information, and/or by operating an integration of the previously detected cardiac rhythm.

摘要翻译： 主动植入式医疗装置，特别是心脏起搏器或纤颤器，其检测装置的承载物的自发或刺激的瞬时心律，并且递送具有可变逸出间隔的刺激脉冲，并逐渐增加该逃逸间隔。 逃避间隔的逐渐增加通过存储与常规检测电路在第一时间段感测到的心律的演变相对应的信息来获得，其中要调整的逃避间隔时间晚于存储的信息，特别是通过 确定逃生间隔的可变增加率，该可变速率基本上被确定为存储信息的函数，和/或通过操作先前检测到的心律的积分。

公开(公告)号：US08583255B2

公开(公告)日：2013-11-12

申请号：US12643846

申请日：2009-12-21

申请人： Thierry Legay

发明人： Thierry Legay

IPC分类号： A61N1/00

CPC分类号： A61N1/3962 ,  A61N1/086 ,  A61N1/37 ,  A61N1/3718 ,  A61N1/3931

摘要： A generator for an implantable cardiac prosthesis, having a safekeeping mode of operation during an exposure to a magnetic field. The generator is connected to a lead including a first conductor (18) connected to a distal electrode (14), and a second conductor (20) connected to a proximal electrode (16). The generator to which the lead is connected includes a switch that temporarily switches to the potential of the metal housing of the generator (i.e., the ground potential) a first terminal connection (26) coupled to the external conductor (20) of the lead, and connects to the electronic circuit of detection/stimulation a second terminal connection (24) coupled to the internal conductor (18) of the lead. The first conductor temporarily acts as a shield for the second conductor for the duration of an MRI examination ensuring protection against the deleterious effects of exposure of the lead to the magnetic field generated by the MRI apparatus, notably heating of the electrodes due to induced currents in the conductors.

摘要翻译： 一种用于植入式心脏假体的发生器，其在暴露于磁场期间具有操作保管模式。 发生器连接到包括连接到远端电极（14）的第一导体（18）的引线和连接到近端电极（16）的第二导体（20）。 引线所连接的发生器包括临时切换到发生器的金属外壳（即，接地电位）的电位的开关，耦合到引线的外部导体（20）的第一端子连接（26） 并且连接到检测/刺激电子电路，耦合到引线的内部导体（18）的第二端子连接（24）。 在MRI检查期间，第一导体临时充当第二导体的屏蔽，确保防止引线暴露于MRI装置产生的磁场的有害影响，特别是由于感应电流引起的电极的加热 导体。

公开(公告)号：US06907290B2

公开(公告)日：2005-06-14

申请号：US10033692

申请日：2001-12-21

申请人： Thierry Legay

发明人： Thierry Legay

IPC分类号： A61N1/08 ,  A61N1/37 ,  G01R27/02

CPC分类号： A61N1/3706 ,  A61N2001/083 ,  G01R27/02

摘要： A process for the measurement of the complex impedance of a lead for an active implantable medical device, in particular a pacemaker, defibrillator and or cardiovertor. This process includes the steps of producing a stimulation pulse by the discharge on the lead (10) of a tank-capacitor (22) of the device (20), charged beforehand to a given voltage level; measuring the voltage variation (V(t)) at the terminals of the tank-capacitor during the discharge; and determining the lead impedance (Zs) from the voltage thus measured. The measurement stage includes sampling at least three successive values of the voltage at the terminals of the tank capacitor, and the determining stage includes the separate determination of the resistive (Rs) and/or capacitive (CH) components of the complex impedance of the lead from the aforesaid at least three sampled values of voltage thus obtained.

摘要翻译： 用于测量有源可植入医疗装置的引线的复阻抗的方法，特别是起搏器，除颤器和/或心律转换器。 该过程包括以下步骤：通过预先充电至给定电压电平的装置（20）的电容器（22）的引线（10）上的放电产生刺激脉冲; 测量放电期间电容器端子处的电压变化（V（t））; 以及根据如此测量的电压确定引线阻抗（Zs）。 测量级包括对储能电容器端子处的至少三个连续的电压进行取样，并且确定级包括单独确定引线的复阻抗的电阻（Rs）和/或电容（CH）分量 从上述至少三个采样的电压值得到。