公开(公告)号：US10130822B2

公开(公告)日：2018-11-20

申请号：US13009629

申请日：2011-01-19

申请人： Thierry Legay ,  Dominique Decoene

发明人： Thierry Legay ,  Dominique Decoene

IPC分类号： A61N1/39 ,  A61N1/37 ,  A61B5/055

摘要： An implantable cardiac device that detects and protects against strong magnetic fields produced by MRI equipment is disclosed. The device has a magnetic field sensor for detecting the presence of a relatively weak static magnetic field (102, 110, 118, 122) of a level equivalent to that of a permanent magnet in the vicinity of the device. The device is switched from a standard operating mode (100) where the nominal functions of the device are active, to a specific protected MRI mode (114, 116) in the presence of a magnetic static field of a level corresponding to that emitted by MRI equipment. The device further temporarily switches the device from the standard operating mode (100) to an MRI stand-by state (108) when a magnetic field is detected by the magnetic field sensor such that a subsequent detection of a magnetic field switches the device from an MRI stand-by state to the specific protected MRI mode.

公开(公告)号：US06487452B2

公开(公告)日：2002-11-26

申请号：US09816646

申请日：2001-03-23

申请人： Thierry Legay

发明人： Thierry Legay

IPC分类号： A61N137

CPC分类号： G01V3/101

摘要： A circuit for detection of the presence of a permanent magnet in the vicinity of an active implantable medical device, in particular a pacemaker, a defibrillator, a cardioverter and/or a multisite device. This circuit includes a coil (12), able to respond to the presence of the magnet (16) so as to present a decreased value of its inductance, a resonant LC circuit (10) including the aforementioned coil, a generator (18) for pulse excitation of the resonant circuit; a circuit to analyze the pulse response of the resonant circuit, and a discriminating circuit, able to evaluate the value of the coil inductance from the analyzed pulse response and, correlatively, to determine therefrom the presence or the absence of the magnet. The excitation generator is able to deliver to the resonant circuit a burst of N successive pulses, and the analyzing circuit determines N corresponding pulse responses, and the discriminating circuit determines the presence of the magnet if, among N analyzed pulse responses, a number M (M≦N) of them correspond to a decreased value of the inductance of the coil.

摘要翻译： 一种用于检测在有源可植入医疗装置，特别是起搏器，除颤器，心律转复器和/或多位置装置附近的永磁体的存在的电路。 该电路包括能够响应于磁体（16）的存在以便呈现其电感值减小的线圈（12），包括上述线圈的谐振LC电路（10），用于 谐振电路的脉冲激励; 用于分析谐振电路的脉冲响应的电路，以及鉴别电路，其能够根据分析的脉冲响应来评估线圈电感的值，并且相应地确定磁体的存在或不存在。 励磁发生器能够向谐振电路输送N个连续脉冲的突发，并且分析电路确定N个对应的脉冲响应，并且鉴别电路确定磁体的存在，如果在N个分析的脉冲响应中存在M个（ M <= N）对应于线圈的电感值的减小。

公开(公告)号：US06251703B1

公开(公告)日：2001-06-26

申请号：US09459272

申请日：1999-12-13

申请人： Yves Van Campenhout ,  Dominique Gilet ,  Thierry Legay ,  Hubert Bono

发明人： Yves Van Campenhout ,  Dominique Gilet ,  Thierry Legay ,  Hubert Bono

IPC分类号： H01L2144

CPC分类号： H01L23/3107 ,  H01L21/56 ,  H01L24/48 ,  H01L29/0657 ,  H01L2224/451 ,  H01L2224/48091 ,  H01L2224/4824 ,  H01L2224/48465 ,  H01L2924/00014 ,  H01L2924/0102 ,  H01L2924/10158 ,  H01L2924/10253 ,  H01L2924/14 ,  H01L2924/181 ,  H01L2924/00 ,  H01L2224/45099

摘要： A microelectronic coated CMS component, in particular for an active implantable medical device, and its method of manufacture. The process is applied to a wafer from which will be formed, after cutting, a plurality of CMS components of the CSP type, i.e., having appreciably the same dimensions as those of the chip. The process includes (a) obtaining a wafer (10) on which are formed the chips (12), each chip having a contact pad (16) on at least one side of the chip; (b) sealing on this wafer a cap (18) having openings (20) authorizing an access to the subjacent contact pads of the chips; (c) forming in the cap distinct trenches (22) according to the periphery of each chip; (d) establishing in the openings an electrical connection to the contact pads, these connections (26) emerging through the upper face of the cap; (e) flowing a coating resin (34) into the openings and the trenches; (f) polishing and metallizing the cap; and (g) cutting the wafer thus prepared into individual components.

摘要翻译： 微电子涂覆的CMS组分，特别是用于有源可植入医疗装置及其制造方法。 该方法被应用于在切割之后将形成CSP型的多个CMS部件的晶片，即，具有与芯片的尺寸相当的尺寸。 该方法包括（a）获得其上形成有芯片（12）的晶片（10），每个芯片在芯片的至少一侧具有接触焊盘（16）; （b）在该晶片上密封具有开口（20）的盖子（18），该开口（20）授权访问芯片的下面的接触焊盘; （c）根据每个芯片的周边在盖形成不同的沟槽（22）; （d）在开口中建立与接触垫的电连接，通过盖的上表面出现的这些连接（26） （e）使涂覆树脂（34）流入开口和沟槽中; （f）抛光和金属化盖子; 和（g）将如此制备的晶片切割成各个部件。

公开(公告)号：US5702424A

公开(公告)日：1997-12-30

申请号：US657802

申请日：1996-05-31

申请人： Thierry Legay ,  Jean-Luc Bonnet ,  Laurence Geroux

发明人： Thierry Legay ,  Jean-Luc Bonnet ,  Laurence Geroux

IPC分类号： A61N1/365 ,  A61N1/39 ,  A61N1/362

CPC分类号： A61N1/365

摘要： An active implantable medical device, notably a cardiac pacemaker or fibrillator, which detects the instantaneous cardiac rhythm, spontaneous or stimulated, of the bearer of the device, and delivers stimulation pulses with a variable escape interval and which increases gradually this escape interval. The gradual increase of the escape interval is obtained by memorizing information corresponding to the evolution of the cardiac rhythm sensed by a conventional detection circuit over a first time period, wherein the escape interval to be adjusted is later in time to the memorized information, notably by determining a variable rate of increase of the escape interval, which variable rate is essentially determined as a function of the memorized information, and/or by operating an integration of the previously detected cardiac rhythm.

摘要翻译： 主动植入式医疗装置，特别是心脏起搏器或纤颤器，其检测装置的承载物的自发或刺激的瞬时心律，并且递送具有可变逸出间隔的刺激脉冲，并逐渐增加该逃逸间隔。 逃避间隔的逐渐增加通过存储与常规检测电路在第一时间段感测到的心律的演变相对应的信息来获得，其中要调整的逃避间隔时间晚于存储的信息，特别是通过 确定逃生间隔的可变增加率，该可变速率基本上被确定为存储信息的函数，和/或通过操作先前检测到的心律的积分。

公开(公告)号：US08554318B2

公开(公告)日：2013-10-08

申请号：US12684798

申请日：2010-01-08

申请人： Thierry Legay

发明人： Thierry Legay

IPC分类号： A61N1/05

CPC分类号： A61N1/3925 ,  A61N1/37 ,  A61N1/3718 ,  G01R33/288

摘要： An active implantable medical device for one of cardiac stimulation, resynchronization, and defibrillation is shown and described. The device includes means for placing an electronic circuit in a safekeeping operating mode in response to detecting a first magnetic field associated with a permanent magnet and detecting a second magnetic field associated with an MRI imager.

摘要翻译： 显示和描述了用于心脏刺激，再同步和除颤中的一种的主动植入式医疗装置。 该装置包括用于响应于检测到与永磁体相关联的第一磁场并检测与MRI成像器相关联的第二磁场而将电子电路放置在保管操作模式中的装置。

公开(公告)号：US07440801B2

公开(公告)日：2008-10-21

申请号：US11186623

申请日：2005-07-20

申请人： Thierry Legay ,  Dominique Decoene

发明人： Thierry Legay ,  Dominique Decoene

IPC分类号： A61N1/00

CPC分类号： A61N1/3706 ,  A61N2001/083

摘要： An implantable cardiac pacemaker with automatic control of the connection of a probe and the implantation of the case. The device includes a generator and its energy source. The generator includes: circuits for scanning battery consumption, able to measure current output by the battery and to deliver a measured value of the output current; comparator circuits, able to compare the current value measured with a pre-programmed value of threshold of current. It includes moreover circuits suited to: detect and count the spontaneous depolarizations collected between the aforementioned terminals of the head of connector; to compare the number of depolarizations thus counted with a pre-programmed threshold of counting; and to deliver a signal of suspicion of implantation in the event of crossing of this threshold of counting.

摘要翻译： 可植入心脏起搏器，可自动控制探头的连接和外壳的植入。 该装置包括发电机及其能量源。 发生器包括：用于扫描电池消耗的电路，能够测量电池的电流输出并输出测量的输出电流值; 比较器电路，能够比较当前测量的电流值与电流阈值的预编程值。 它还包括适合于：检测和计数在连接器头部的上述端子之间收集的自发去极化的电路; 将这样计数的去极化数与预编程的计数阈值进行比较; 并且在跨越这个计数阈值的情况下传递怀疑植入的信号。

公开(公告)号：US07203544B2

公开(公告)日：2007-04-10

申请号：US10745472

申请日：2003-12-22

申请人： Thierry Legay ,  Dominique Decoene

发明人： Thierry Legay ,  Dominique Decoene

IPC分类号： A61N1/37

CPC分类号： A61N1/371

摘要： Detection of an evoked post-stimulation potential, in particular atrial potentials, in an active implantable medical device such as a cardiac pacemaker, a defibrillator, a cardioveter, or a multisite device. This device applies a stimulation pulse (40), then shorts-circuit for a discharge period (42, OCD) the output circuit, which includes discharging a connection capacitor, the self-impedance of the probe, and the impedance of the interface heart-electrode. A detection circuit includes an amplifier and a blanking circuit to temporarily uncouple the input terminal from the amplifier. A sequencer control circuit activates during a first time (micro blanking) the blanking circuit throughout the stimulation pulse (40), activates the discharging circuit with a delay after the application of the stimulation pulse, then inhibits the blanking circuit for a listening period (44), defining at least part of this delay, so as to authorize detection by the amplifier, during the listening period, of the evoked post-stimulation potentials, and then activates the blanking circuit a second time (BLANKING) after the listening period throughout the discharge period (42, OCD).

摘要翻译： 检测在诸如心脏起搏器，除颤器，心脏病或多位置装置的有源可植入医疗装置中的诱发后刺激电位，特别是心房电位。 该装置施加刺激脉冲（40），然后对输出电路进行短路放电周期（42，OCD），其包括放电连接电容器，探针的自身阻抗以及接口心脏的阻抗， 电极。 检测电路包括放大器和消隐电路，以暂时将放大器与输入端分离。 定序器控制电路在整个刺激脉冲（40）中的第一次（消隐）消隐电路期间激活，在施加刺激脉冲之后延迟地激活放电电路，然后在收听期间禁止消隐电路（44 ），定义该延迟的至少一部分，以便授权在听觉期间放大器在诱发后刺激电位之后的检测，然后在整个听觉周期之后再次激活消隐电路（BLANKING） 放电期（42，OCD）。

公开(公告)号：US07142924B2

公开(公告)日：2006-11-28

申请号：US10846803

申请日：2004-05-14

申请人： Thierry Legay ,  Karim Amara

发明人： Thierry Legay ,  Karim Amara

IPC分类号： A61N1/00

CPC分类号： G06F11/1008 ,  G06F19/00 ,  G16H10/60 ,  G16H40/63

摘要： An active medical device equipped with a memory for the storage of medical data such as Holter data and instructions for controlling a microprocessor. This device comprises a micro-processor operating (14) on N bits, and a memory organized in words of 2N bits, with a first sector (22) storing a control software for the microprocessor, and a second sector (24) storing of the elementary medical data of N bits. Each word of the first sector includes N bits of operating code and n bits of error detection and correction code, with 1≦n≦N. An interfacing circuit (18) allows, according to commands delivered by the microprocessor, to read in parallel N+n bits of a word from the first sector, or to read or to write N bits of low weight of a word of the second sector, or to read or write N bits of high weight of a word of the second sector.

摘要翻译： 配备有用于存储诸如Holter数据的医疗数据的存储器和用于控制微处理器的指令的主动医疗设备。 该装置包括对N比特操作（14）的微处理器和以2N比特的单词组织的存储器，其中存储用于微处理器的控制软件的第一扇区（22）和存储微处理器的第二扇区（24） N位的基本医学数据。 第一扇区的每个字包括N位操作码和n位错误检测和校正码，其中1 <= n <= N。 接口电路（18）根据微处理器传递的命令，允许从第一扇区并行地读出一个字的N + n个比特，或者读取或写入第二个扇区的一个单词的低权重的N比特 ，或者读取或写入第二扇区的单词的高权重的N位。

公开(公告)号：US06898845B2

公开(公告)日：2005-05-31

申请号：US10056843

申请日：2002-01-17

申请人： Yves Van Campenhout ,  Dominique Gilet ,  Thierry Legay

发明人： Yves Van Campenhout ,  Dominique Gilet ,  Thierry Legay

IPC分类号： A61N1/36 ,  A61N1/375 ,  A61N1/39 ,  H01L21/56 ,  H01L23/31 ,  H01L25/065 ,  H05K3/36 ,  H01L23/02

CPC分类号： H01L21/561 ,  A61N1/375 ,  H01L23/3121 ,  H01L24/48 ,  H01L24/49 ,  H01L24/97 ,  H01L25/0652 ,  H01L2224/05554 ,  H01L2224/05599 ,  H01L2224/45099 ,  H01L2224/48091 ,  H01L2224/48227 ,  H01L2224/49175 ,  H01L2224/85399 ,  H01L2224/97 ,  H01L2924/00014 ,  H01L2924/01004 ,  H01L2924/01005 ,  H01L2924/01006 ,  H01L2924/0102 ,  H01L2924/01033 ,  H01L2924/01057 ,  H01L2924/01058 ,  H01L2924/01075 ,  H01L2924/01079 ,  H01L2924/01082 ,  H01L2924/01094 ,  H01L2924/181 ,  H01L2924/3025 ,  Y10T29/49126 ,  Y10T29/49128 ,  Y10T29/4913 ,  Y10T29/49135 ,  Y10T29/49146 ,  H01L2224/85 ,  H01L2224/45015 ,  H01L2924/207 ,  H01L2924/00012

摘要： A method for manufacturing a plurality of hybrid electronic circuits for active implantable medical devices and circuits made by the process. The process includes the following stages: a) preparing a collective plane plate-substrate (10) carrying on a first surface a pattern of contact areas (16) for chips and, on a second surface (the back), a pattern of metallization areas for components, with a repetition of the same patterns for a corresponding plurality of circuits to be made from said substrate; b) gluing on the first surface of the plate of a plurality of chips (12, 14); c) cabling (wiring-bonding) the chips (12, 14) to their corresponding contact areas (16); d) pouring a coating resin over the first surface of the plate to achieve a uniform layer of coating resin (22), e) hardening the resin; f) cutting the plate to form the plurality of individual substrates, with each substrate having on its first surface coated chips, each one of these substrates corresponding to an implantable device individual circuit, and g) mounting SMC components (38, 40, 42) and/or connector elements (44) to the second surface of each individual substrate, so as to complete the electron circuits of the active implantable medical devices.

摘要翻译： 一种用于制造用于有源可植入医疗装置的多个混合电子电路的方法和通过该方法制造的电路。 该方法包括以下阶段：a）制备在第一表面上承载用于切屑的接触区域（16）的图案的集体平面板 - 基板（10），并且在第二表面（背面）上形成金属化区域的图案 对于组件，对于由所述衬底制成的对应的多个电路重复相同的图案; b）胶合在多个芯片（12,14）的板的第一表面上; c）将芯片（12,14）布线（接线）连接到其对应的接触区域（16）; d）将涂层树脂浇注在板的第一表面上，以实现均匀的涂层树脂层（22），e）硬化树脂; f）切割所述板以形成所述多个单独的基板，其中每个基板在其第一表面涂覆有切屑，这些基板中的每一个对应于可植入装置的单独电路，以及g）安装SMC部件（38,40,42） 和/或连接器元件（44）连接到每个单独基板的第二表面，以便完成有源可植入医疗装置的电子电路。

公开(公告)号：US06253106B1

公开(公告)日：2001-06-26

申请号：US09218678

申请日：1998-12-22

申请人： Thierry Legay ,  Anne Bouhour ,  Alain Ripart

发明人： Thierry Legay ,  Anne Bouhour ,  Alain Ripart

IPC分类号： A61N1362

CPC分类号： A61N1/3918 ,  A61N1/3627 ,  A61N1/368

摘要： An active implantable medical device, especially a cardiac pacemaker, defibrillator and/or cardiovertor, of the configurable multisite type. In this multisite device, electrodes are placed in at least three distinct myocardial sites for stimulation (12, 14, 20, 22), of which at least one is a site for ventricular stimulation/detection (14, 22), these electrodes being connected to independent outputs (DA, DV, Da1, Dv2) of the multisite device in a manner as to allow the application of stimulation pulses produced by a plurality of distinct stimulation stages (24, 26, 28, 30). The number of stimulation output stages is at most equal to the number of stimulation sites. The device also includes switches (SA, SV, S1, S2) to connect selectively and according to one of various possible stimulation configurations, the stimulation stages, or selected ones of the stimulation stages, to the various sites of stimulation, or to selected ones of the stimulation sites. The switches can be controlled to modify the stimulation configuration as between the various possibilities in a manner as to research (to identify) the one considered as optimal among the possible variations, which can then be selected.

摘要翻译： 可配置的多站点类型的主动植入式医疗装置，特别是心脏起搏器，除颤器和/或心律转换器。 在该多位置装置中，将电极放置在至少三个不同的心肌部位用于刺激（12,14,20,22），其中至少一个是用于心室刺激/检测的部位（14,22），这些电极被连接 以允许施加由多个不同刺激阶段（24,26,28,30）产生的刺激脉冲的方式到所述多站点设备的独立输出（DA，DV，Da1，Dv2）。 刺激输出阶段的数量最多等于刺激部位的数量。 该设备还包括根据各种可能的刺激配置，刺激阶段或刺激阶段中选定的刺激阶段之一到各种刺激位置之一或选择的那些开关（SA，SV，S1，S2） 的刺激部位。 可以控制开关以以各种可能性之间的刺激配置来修改，以便研究（识别）被认为是可能的变化中的最佳的那些，然后可以被选择。