公开(公告)号：US06251703B1

公开(公告)日：2001-06-26

申请号：US09459272

申请日：1999-12-13

申请人： Yves Van Campenhout ,  Dominique Gilet ,  Thierry Legay ,  Hubert Bono

发明人： Yves Van Campenhout ,  Dominique Gilet ,  Thierry Legay ,  Hubert Bono

IPC分类号： H01L2144

CPC分类号： H01L23/3107 ,  H01L21/56 ,  H01L24/48 ,  H01L29/0657 ,  H01L2224/451 ,  H01L2224/48091 ,  H01L2224/4824 ,  H01L2224/48465 ,  H01L2924/00014 ,  H01L2924/0102 ,  H01L2924/10158 ,  H01L2924/10253 ,  H01L2924/14 ,  H01L2924/181 ,  H01L2924/00 ,  H01L2224/45099

摘要： A microelectronic coated CMS component, in particular for an active implantable medical device, and its method of manufacture. The process is applied to a wafer from which will be formed, after cutting, a plurality of CMS components of the CSP type, i.e., having appreciably the same dimensions as those of the chip. The process includes (a) obtaining a wafer (10) on which are formed the chips (12), each chip having a contact pad (16) on at least one side of the chip; (b) sealing on this wafer a cap (18) having openings (20) authorizing an access to the subjacent contact pads of the chips; (c) forming in the cap distinct trenches (22) according to the periphery of each chip; (d) establishing in the openings an electrical connection to the contact pads, these connections (26) emerging through the upper face of the cap; (e) flowing a coating resin (34) into the openings and the trenches; (f) polishing and metallizing the cap; and (g) cutting the wafer thus prepared into individual components.

摘要翻译： 微电子涂覆的CMS组分，特别是用于有源可植入医疗装置及其制造方法。 该方法被应用于在切割之后将形成CSP型的多个CMS部件的晶片，即，具有与芯片的尺寸相当的尺寸。 该方法包括（a）获得其上形成有芯片（12）的晶片（10），每个芯片在芯片的至少一侧具有接触焊盘（16）; （b）在该晶片上密封具有开口（20）的盖子（18），该开口（20）授权访问芯片的下面的接触焊盘; （c）根据每个芯片的周边在盖形成不同的沟槽（22）; （d）在开口中建立与接触垫的电连接，通过盖的上表面出现的这些连接（26） （e）使涂覆树脂（34）流入开口和沟槽中; （f）抛光和金属化盖子; 和（g）将如此制备的晶片切割成各个部件。

公开(公告)号：US06898845B2

公开(公告)日：2005-05-31

申请号：US10056843

申请日：2002-01-17

申请人： Yves Van Campenhout ,  Dominique Gilet ,  Thierry Legay

发明人： Yves Van Campenhout ,  Dominique Gilet ,  Thierry Legay

IPC分类号： A61N1/36 ,  A61N1/375 ,  A61N1/39 ,  H01L21/56 ,  H01L23/31 ,  H01L25/065 ,  H05K3/36 ,  H01L23/02

CPC分类号： H01L21/561 ,  A61N1/375 ,  H01L23/3121 ,  H01L24/48 ,  H01L24/49 ,  H01L24/97 ,  H01L25/0652 ,  H01L2224/05554 ,  H01L2224/05599 ,  H01L2224/45099 ,  H01L2224/48091 ,  H01L2224/48227 ,  H01L2224/49175 ,  H01L2224/85399 ,  H01L2224/97 ,  H01L2924/00014 ,  H01L2924/01004 ,  H01L2924/01005 ,  H01L2924/01006 ,  H01L2924/0102 ,  H01L2924/01033 ,  H01L2924/01057 ,  H01L2924/01058 ,  H01L2924/01075 ,  H01L2924/01079 ,  H01L2924/01082 ,  H01L2924/01094 ,  H01L2924/181 ,  H01L2924/3025 ,  Y10T29/49126 ,  Y10T29/49128 ,  Y10T29/4913 ,  Y10T29/49135 ,  Y10T29/49146 ,  H01L2224/85 ,  H01L2224/45015 ,  H01L2924/207 ,  H01L2924/00012

摘要： A method for manufacturing a plurality of hybrid electronic circuits for active implantable medical devices and circuits made by the process. The process includes the following stages: a) preparing a collective plane plate-substrate (10) carrying on a first surface a pattern of contact areas (16) for chips and, on a second surface (the back), a pattern of metallization areas for components, with a repetition of the same patterns for a corresponding plurality of circuits to be made from said substrate; b) gluing on the first surface of the plate of a plurality of chips (12, 14); c) cabling (wiring-bonding) the chips (12, 14) to their corresponding contact areas (16); d) pouring a coating resin over the first surface of the plate to achieve a uniform layer of coating resin (22), e) hardening the resin; f) cutting the plate to form the plurality of individual substrates, with each substrate having on its first surface coated chips, each one of these substrates corresponding to an implantable device individual circuit, and g) mounting SMC components (38, 40, 42) and/or connector elements (44) to the second surface of each individual substrate, so as to complete the electron circuits of the active implantable medical devices.

摘要翻译： 一种用于制造用于有源可植入医疗装置的多个混合电子电路的方法和通过该方法制造的电路。 该方法包括以下阶段：a）制备在第一表面上承载用于切屑的接触区域（16）的图案的集体平面板 - 基板（10），并且在第二表面（背面）上形成金属化区域的图案 对于组件，对于由所述衬底制成的对应的多个电路重复相同的图案; b）胶合在多个芯片（12,14）的板的第一表面上; c）将芯片（12,14）布线（接线）连接到其对应的接触区域（16）; d）将涂层树脂浇注在板的第一表面上，以实现均匀的涂层树脂层（22），e）硬化树脂; f）切割所述板以形成所述多个单独的基板，其中每个基板在其第一表面涂覆有切屑，这些基板中的每一个对应于可植入装置的单独电路，以及g）安装SMC部件（38,40,42） 和/或连接器元件（44）连接到每个单独基板的第二表面，以便完成有源可植入医疗装置的电子电路。

公开(公告)号：US06236111B1

公开(公告)日：2001-05-22

申请号：US09196078

申请日：1998-11-18

申请人： Thierry Legay ,  Dominique Gilet ,  Yves Campenhout

发明人： Thierry Legay ,  Dominique Gilet ,  Yves Campenhout

IPC分类号： H01L2304

CPC分类号： H05K3/3442 ,  H01L23/3107 ,  H01L29/0657 ,  H01L2924/0002 ,  H01L2924/09701 ,  H05K2201/09154 ,  H05K2201/10727 ,  Y02P70/613 ,  H01L2924/00

摘要： A micro-electromechanical component (10) which includes a micro-system in a chip made by deposit, photolithography and micro-manufacturing of successive layers. The micro-system comprises a plurality of contact pads for electrical connection (16). The chip is provided with a localized external coating (20) to allow its transfer onto a substrate (28). This coating has on its surface a plurality of external metallizations (22) connected electrically through the coating material to the underlying contact pads of the chip. The coated component has approximately the same length and width as those of the chip before coating. The coating is formed only in a localized region on a reduced portion of the chip, essentially in the region of the pads and the metallizations, the sensing part of the micro-system not so coated and thus protected from mechanical constraints caused due to the application and hardening of the coating material.

摘要翻译： 一种微电子机械部件（10），其包括通过沉积制造的芯片中的微系统，光刻和连续层的微制造。 微系统包括用于电连接（16）的多个接触垫。 该芯片设置有局部外部涂层（20）以允许其转移到基底（28）上。 该涂层在其表面上具有多个通过涂层材料电连接到芯片的下面接触焊盘的外部金属化层（22）。 涂布的部件具有与涂覆前的芯片大致相同的长度和宽度。 涂层仅形成在芯片的减少部分上的局部区域中，基本上在焊盘和金属化区域中，微系统的感测部分不被涂覆并因此防止由于应用而引起的机械约束 和涂层材料的硬化。

公开(公告)号：US10130822B2

公开(公告)日：2018-11-20

申请号：US13009629

申请日：2011-01-19

申请人： Thierry Legay ,  Dominique Decoene

发明人： Thierry Legay ,  Dominique Decoene

IPC分类号： A61N1/39 ,  A61N1/37 ,  A61B5/055

摘要： An implantable cardiac device that detects and protects against strong magnetic fields produced by MRI equipment is disclosed. The device has a magnetic field sensor for detecting the presence of a relatively weak static magnetic field (102, 110, 118, 122) of a level equivalent to that of a permanent magnet in the vicinity of the device. The device is switched from a standard operating mode (100) where the nominal functions of the device are active, to a specific protected MRI mode (114, 116) in the presence of a magnetic static field of a level corresponding to that emitted by MRI equipment. The device further temporarily switches the device from the standard operating mode (100) to an MRI stand-by state (108) when a magnetic field is detected by the magnetic field sensor such that a subsequent detection of a magnetic field switches the device from an MRI stand-by state to the specific protected MRI mode.

公开(公告)号：US06487452B2

公开(公告)日：2002-11-26

申请号：US09816646

申请日：2001-03-23

申请人： Thierry Legay

发明人： Thierry Legay

IPC分类号： A61N137

CPC分类号： G01V3/101

摘要： A circuit for detection of the presence of a permanent magnet in the vicinity of an active implantable medical device, in particular a pacemaker, a defibrillator, a cardioverter and/or a multisite device. This circuit includes a coil (12), able to respond to the presence of the magnet (16) so as to present a decreased value of its inductance, a resonant LC circuit (10) including the aforementioned coil, a generator (18) for pulse excitation of the resonant circuit; a circuit to analyze the pulse response of the resonant circuit, and a discriminating circuit, able to evaluate the value of the coil inductance from the analyzed pulse response and, correlatively, to determine therefrom the presence or the absence of the magnet. The excitation generator is able to deliver to the resonant circuit a burst of N successive pulses, and the analyzing circuit determines N corresponding pulse responses, and the discriminating circuit determines the presence of the magnet if, among N analyzed pulse responses, a number M (M≦N) of them correspond to a decreased value of the inductance of the coil.

摘要翻译： 一种用于检测在有源可植入医疗装置，特别是起搏器，除颤器，心律转复器和/或多位置装置附近的永磁体的存在的电路。 该电路包括能够响应于磁体（16）的存在以便呈现其电感值减小的线圈（12），包括上述线圈的谐振LC电路（10），用于 谐振电路的脉冲激励; 用于分析谐振电路的脉冲响应的电路，以及鉴别电路，其能够根据分析的脉冲响应来评估线圈电感的值，并且相应地确定磁体的存在或不存在。 励磁发生器能够向谐振电路输送N个连续脉冲的突发，并且分析电路确定N个对应的脉冲响应，并且鉴别电路确定磁体的存在，如果在N个分析的脉冲响应中存在M个（ M <= N）对应于线圈的电感值的减小。

公开(公告)号：US5702424A

公开(公告)日：1997-12-30

申请号：US657802

申请日：1996-05-31

申请人： Thierry Legay ,  Jean-Luc Bonnet ,  Laurence Geroux

发明人： Thierry Legay ,  Jean-Luc Bonnet ,  Laurence Geroux

IPC分类号： A61N1/365 ,  A61N1/39 ,  A61N1/362

CPC分类号： A61N1/365

摘要： An active implantable medical device, notably a cardiac pacemaker or fibrillator, which detects the instantaneous cardiac rhythm, spontaneous or stimulated, of the bearer of the device, and delivers stimulation pulses with a variable escape interval and which increases gradually this escape interval. The gradual increase of the escape interval is obtained by memorizing information corresponding to the evolution of the cardiac rhythm sensed by a conventional detection circuit over a first time period, wherein the escape interval to be adjusted is later in time to the memorized information, notably by determining a variable rate of increase of the escape interval, which variable rate is essentially determined as a function of the memorized information, and/or by operating an integration of the previously detected cardiac rhythm.

摘要翻译： 主动植入式医疗装置，特别是心脏起搏器或纤颤器，其检测装置的承载物的自发或刺激的瞬时心律，并且递送具有可变逸出间隔的刺激脉冲，并逐渐增加该逃逸间隔。 逃避间隔的逐渐增加通过存储与常规检测电路在第一时间段感测到的心律的演变相对应的信息来获得，其中要调整的逃避间隔时间晚于存储的信息，特别是通过 确定逃生间隔的可变增加率，该可变速率基本上被确定为存储信息的函数，和/或通过操作先前检测到的心律的积分。

公开(公告)号：US08583255B2

公开(公告)日：2013-11-12

申请号：US12643846

申请日：2009-12-21

申请人： Thierry Legay

发明人： Thierry Legay

IPC分类号： A61N1/00

CPC分类号： A61N1/3962 ,  A61N1/086 ,  A61N1/37 ,  A61N1/3718 ,  A61N1/3931

摘要： A generator for an implantable cardiac prosthesis, having a safekeeping mode of operation during an exposure to a magnetic field. The generator is connected to a lead including a first conductor (18) connected to a distal electrode (14), and a second conductor (20) connected to a proximal electrode (16). The generator to which the lead is connected includes a switch that temporarily switches to the potential of the metal housing of the generator (i.e., the ground potential) a first terminal connection (26) coupled to the external conductor (20) of the lead, and connects to the electronic circuit of detection/stimulation a second terminal connection (24) coupled to the internal conductor (18) of the lead. The first conductor temporarily acts as a shield for the second conductor for the duration of an MRI examination ensuring protection against the deleterious effects of exposure of the lead to the magnetic field generated by the MRI apparatus, notably heating of the electrodes due to induced currents in the conductors.

摘要翻译： 一种用于植入式心脏假体的发生器，其在暴露于磁场期间具有操作保管模式。 发生器连接到包括连接到远端电极（14）的第一导体（18）的引线和连接到近端电极（16）的第二导体（20）。 引线所连接的发生器包括临时切换到发生器的金属外壳（即，接地电位）的电位的开关，耦合到引线的外部导体（20）的第一端子连接（26） 并且连接到检测/刺激电子电路，耦合到引线的内部导体（18）的第二端子连接（24）。 在MRI检查期间，第一导体临时充当第二导体的屏蔽，确保防止引线暴露于MRI装置产生的磁场的有害影响，特别是由于感应电流引起的电极的加热 导体。

公开(公告)号：US06907290B2

公开(公告)日：2005-06-14

申请号：US10033692

申请日：2001-12-21

申请人： Thierry Legay

发明人： Thierry Legay

IPC分类号： A61N1/08 ,  A61N1/37 ,  G01R27/02

CPC分类号： A61N1/3706 ,  A61N2001/083 ,  G01R27/02

摘要： A process for the measurement of the complex impedance of a lead for an active implantable medical device, in particular a pacemaker, defibrillator and or cardiovertor. This process includes the steps of producing a stimulation pulse by the discharge on the lead (10) of a tank-capacitor (22) of the device (20), charged beforehand to a given voltage level; measuring the voltage variation (V(t)) at the terminals of the tank-capacitor during the discharge; and determining the lead impedance (Zs) from the voltage thus measured. The measurement stage includes sampling at least three successive values of the voltage at the terminals of the tank capacitor, and the determining stage includes the separate determination of the resistive (Rs) and/or capacitive (CH) components of the complex impedance of the lead from the aforesaid at least three sampled values of voltage thus obtained.

摘要翻译： 用于测量有源可植入医疗装置的引线的复阻抗的方法，特别是起搏器，除颤器和/或心律转换器。 该过程包括以下步骤：通过预先充电至给定电压电平的装置（20）的电容器（22）的引线（10）上的放电产生刺激脉冲; 测量放电期间电容器端子处的电压变化（V（t））; 以及根据如此测量的电压确定引线阻抗（Zs）。 测量级包括对储能电容器端子处的至少三个连续的电压进行取样，并且确定级包括单独确定引线的复阻抗的电阻（Rs）和/或电容（CH）分量 从上述至少三个采样的电压值得到。

公开(公告)号：US06337996B1

公开(公告)日：2002-01-08

申请号：US09326207

申请日：1999-06-04

申请人： Thierry Legay ,  Jean-Luc Bonnet ,  Anne Bouhour

发明人： Thierry Legay ,  Jean-Luc Bonnet ,  Anne Bouhour

IPC分类号： A61N1362

CPC分类号： A61N1/3622 ,  A61N1/3962

摘要： An active implantable medical device with a sophisticated management of the refractory periods. Such devices typically include a detection circuit and a stimulation circuit and a circuit which applies a refractory period to the detection circuit, including an absolute refractory period (ARP), which can be fixed or pre-programmed, and a relative refractory period (RRP), which is variable. The relative refractory period includes a succession of elementary periods (X) of a fixed or programmable duration, which elementary period is further subdivided into sub-periods (Y) such that an elementary period X is retriggered or restarted at the end of a sub-period Y if a residual potential of a level higher than a given threshold is detected at output of the detection circuit during that sub-period. In the absence of a detected residual potential being detected during the successive sub-periods comprising the elementary period, then the refractory period ends.

摘要翻译： 具有复杂管理不良期的主动植入式医疗器械。 这种装置通常包括检测电路和刺激电路以及对检测电路施加不应期的电路，包括可以固定或预编程的绝对不应期（ARP）和相对不应期（RRP） ，这是可变的。 相对不应期包括固定或可编程持续时间的一系列基本周期（X），该基本周期进一步细分为子周期（Y），使得基本周期X在子周期X的末尾重新触发或重新启动， 如果在该子周期期间在检测电路的输出处检测到高于给定阈值的电平的剩余电位的周期Y。 在包含基本期间的连续子期间检测不到检测到的残留电位的情况下，不良期结束。

公开(公告)号：US06230058B1

公开(公告)日：2001-05-08

申请号：US09425032

申请日：1999-10-19

申请人： Thierry Legay

发明人： Thierry Legay

IPC分类号： A61N108

CPC分类号： G06F11/183 ,  G06F19/00 ,  G16H40/40 ,  G16H40/63 ,  Y02A90/26

摘要： An active medical device including protected registers for containing digital adjustment parameter values used for the functioning of functional modules of the device. This device includes at least one module (12) for achieving a predetermined device function, this module including a circuit specific for performing the function and which has an adjustable parameter value in the form of a digital word of N bits. Each such module includes a plurality of volatile storage registers having N bits storing the aforementioned digital words, and circuits for comparing (32, 36), the respective contents of the registers and producing an anomaly signal (IT1, IT2 . . . ITi . . . ITk) in the event of a discordance between the contents of the plurality of registers for a given module. The anomaly signal may be an interrupt signal applied to a microcontroller (10). The module also includes a majority circuit (30) receiving at its input the contents of the registers and delivering at its output to the specific circuit (24) the resulting value as the adjustment parameter value to be used in performing the function. It also is contemplated to restore the contents of corrupted registers in the event of a discordance detected by the comparison.

摘要翻译： 一种有源医疗设备，包括受保护的寄存器，用于包含用于设备功能模块功能的数字调整参数值。 该设备包括用于实现预定的设备功能的至少一个模块（12），该模块包括专用于执行功能的电路，并具有N位数字字形式的可调参数值。 每个这样的模块包括多个具有存储上述数字字的N位的易失性存储寄存器，以及用于比较（32,36）寄存器的各个内容并产生异常信号的电路（IT1，IT2 ... ITI。 如果给定模块的多个寄存器的内容不一致，则ITk）。 异常信号可以是施加到微控制器（10）的中断信号。 模块还包括多数电路（30），在其输入端接收寄存器的内容，并在其输出端向特定电路（24）输出所得到的值作为用于执行功能的调整参数值。 也可以考虑在比较检测到不一致的情况下恢复损坏的寄存器的内容。