公开(公告)号：US20110137298A1

公开(公告)日：2011-06-09

申请号：US13019563

申请日：2011-02-02

申请人： Tho Hoang NGUYEN ,  Cary HATA ,  Alan DE LA RAMA ,  Vivian TRAN ,  Peter C. CHEN

发明人： Tho Hoang NGUYEN ,  Cary HATA ,  Alan DE LA RAMA ,  Vivian TRAN ,  Peter C. CHEN

IPC分类号： A61B17/00

CPC分类号： A61B17/2202 ,  A61B5/01 ,  A61B5/0402 ,  A61B5/6852 ,  A61B2017/00243 ,  A61B2017/00247 ,  A61B2017/22021 ,  A61B2017/320084 ,  A61B2018/00392 ,  A61N7/022 ,  A61N2007/003 ,  A61N2007/0078

摘要： An ablation apparatus comprises an ultrasonic transducer which includes a piezoelectric element having a cylindrical shape; a plurality of external electrodes disposed on the outer surface of the piezoelectric element; and at least one internal electrode disposed on the inner surface of the piezoelectric element. The at least one internal electrode provides corresponding internal electrode portions that are disposed opposite the external electrodes with respect to the piezoelectric element, the external electrodes and the at least one internal electrode to be energized to apply an electric field across the piezoelectric element. The ultrasonic ablation zones of the external electrodes are distributed in a staggered configuration so as to span one or more open arc segments around the longitudinal axis, and the ultrasound ablation zones of all external electrodes projected longitudinally onto any lateral plane which is perpendicular to the longitudinal axis span a substantially closed loop around the longitudinal axis.

摘要翻译： 消融装置包括：超声波换能器，其包括具有圆筒形状的压电元件; 设置在所述压电元件的外表面上的多个外部电极; 以及设置在压电元件的内表面上的至少一个内部电极。 所述至少一个内部电极相对于所述压电元件，所述外部电极和所述至少一个内部电极与所述外部电极相对设置相应的内部电极部分，以在所述压电元件上施加电场。 外部电极的超声波消融区域以交错的构型分布，以跨越纵向轴线的一个或多个开放弧段，并且所有外部电极的超声消融区域纵向地突出到垂直于纵向的任何横向平面 轴线围绕纵向轴线跨越基本上闭合的环路。

公开(公告)号：US20100286684A1

公开(公告)日：2010-11-11

申请号：US12436977

申请日：2009-05-07

申请人： Cary HATA ,  Thu Xuan Tran ,  Alan de la Rama ,  Tho Hoang Nguyen ,  Irvin John Narciso ,  Peter C. Chen ,  Hanh Ngoc Do

发明人： Cary HATA ,  Thu Xuan Tran ,  Alan de la Rama ,  Tho Hoang Nguyen ,  Irvin John Narciso ,  Peter C. Chen ,  Hanh Ngoc Do

IPC分类号： A61B18/18 ,  A61B18/14

CPC分类号： A61B18/1492 ,  A61B2017/003 ,  A61B2017/00867 ,  A61B2018/00029 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/00839 ,  A61B2018/1467 ,  A61B2218/002 ,  C08L2201/12

摘要： In one embodiment, an irrigated catheter ablation apparatus comprises an elongated body having a distal end, a proximal end, and at least one fluid lumen extending longitudinally therein; and a plurality of segmented ablation electrodes on a distal portion of the elongated body. The electrodes are spaced from the proximal end and from the distal end of the elongated body by electrically nonconductive segments. The electrodes are spaced from each other longitudinally by electrically nonconductive segments. For each electrode that is longitudinally disposed next to one of the nonconductive segments, an edge is formed between an electrode end of the electrode and a nonconductive segment end of the nonconductive segment. A plurality of elution holes are disposed adjacent to the edges. A plurality of ducts establish fluid communication between the elution holes and the fluid lumen.

摘要翻译： 在一个实施例中，灌溉导管消融装置包括细长体，其具有远端，近端和在其中纵向延伸的至少一个流体腔; 以及在所述细长体的远侧部分上的多个分段的消融电极。 电极通过非导电段与细长主体的近端和远端隔开。 电极通过非导电段纵向间隔开。 对于纵向设置在非导电段之一处的每个电极，在电极的电极端和非导电段的非导电段端之间形成边缘。 多个洗脱孔与边缘相邻设置。 多个管道在洗脱孔和流体腔之间建立流体连通。

公开(公告)号：US20110118726A1

公开(公告)日：2011-05-19

申请号：US12945982

申请日：2010-11-15

申请人： Alan DE LA RAMA ,  Cary HATA

发明人： Alan DE LA RAMA ,  Cary HATA

IPC分类号： A61B18/14 ,  A61B18/18

CPC分类号： A61B18/1492 ,  A61B2017/00867 ,  A61B2018/00011 ,  A61B2018/0016 ,  A61B2018/00214 ,  A61B2018/00267 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/00654 ,  A61B2018/00797 ,  A61B2018/124 ,  A61B2018/1467 ,  A61B2018/1475 ,  A61B2018/1497 ,  A61B2218/002 ,  C08L2201/12

摘要： An ablation catheter comprises a catheter body extending longitudinally between a proximal end and a distal end along a longitudinal axis; and an ablation element assembly comprising ablation elements connected to the catheter body, each ablation element to be energized to produce an ablation zone. The ablation elements are distributed in a staggered configuration such that the ablation zones of the ablation elements span one or more open arc segments around the longitudinal axis, but the ablation zones of all ablation elements projected longitudinally onto any lateral plane which is perpendicular to the longitudinal axis span a substantially closed loop around the longitudinal axis. Since the ablation zones do not form a closed loop, the risk of renal artery/vein stenosis is reduced or eliminated. Since the ablation zones of all ablation elements projected longitudinally onto any lateral plane span a substantially closed loop, substantially complete renal denervation is achieved.

摘要翻译： 消融导管包括沿纵向轴线在近端和远端之间纵向延伸的导管主体; 以及消融元件组件，其包括连接到导管主体的消融元件，每个消融元件被激励以产生消融区域。 消融元件以交错构型分布，使得消融元件的消融区域围绕纵向轴线跨越一个或多个开放弧形段，但是所有消融元件的消融区域纵向投影到垂直于纵向的任何侧向平面 轴线围绕纵向轴线跨越基本上闭合的环路。 由于消融区不形成闭环，所以肾动脉/静脉狭窄的风险降低或消除。 由于所有消融元件的消融区域纵向投影到任何横向平面上跨过基本闭合的环路，所以实现了基本上完全的肾去神经支配。

公开(公告)号：US20110313417A1

公开(公告)日：2011-12-22

申请号：US13159446

申请日：2011-06-14

申请人： Alan De La Rama ,  Cary HATA

发明人： Alan De La Rama ,  Cary HATA

IPC分类号： A61B18/14

CPC分类号： A61M25/0052 ,  A61B18/1492 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/00821 ,  A61B2018/00869 ,  A61B2018/00875 ,  A61B2018/1407

摘要： A catheter apparatus comprises an elongated catheter body having a distal end, a proximal end, and at least one fluid lumen extending longitudinally therein; and a plurality of flexible electrode segments on a distal portion of the catheter body adjacent the distal end, each pair of neighboring flexible electrode segments being spaced from each other longitudinally by a corresponding electrically nonconductive segment. Each flexible electrode segment comprises a sidewall provided with one or more elongated stiffness reductions extending through the sidewall, the one or more elongated stiffness reductions providing flexibility in the sidewall for bending movement relative to a longitudinal axis of the catheter body. The electrically nonconductive segment is substantially smaller in length than each of the corresponding pair of neighboring flexible electrode segments.

摘要翻译： 导管装置包括细长的导管主体，其具有远端，近端和至少一个在其中纵向延伸的流体腔; 以及多个柔性电极段，其在导管本体的远端附近的远侧部分上，每对相邻的柔性电极段通过相应的非导电段彼此间隔开。 每个柔性电极段包括设置有延伸穿过侧壁的一个或多个细长刚度降低的侧壁，所述一个或多个细长刚度减小件在侧壁中提供相对于导管主体的纵向轴线的弯曲运动的柔性。 电非导电段的长度比相应的一对相邻柔性电极段的长度短得多。

公开(公告)号：US20120290053A1

公开(公告)日：2012-11-15

申请号：US13105391

申请日：2011-05-11

申请人： Yongxing ZHANG ,  Cary HATA

发明人： Yongxing ZHANG ,  Cary HATA

IPC分类号： A61N1/05

CPC分类号： A61N1/36117 ,  A61N1/0558 ,  A61N1/3684

摘要： A lead for nerve modulation comprises an elongated body which includes a proximal end, a distal portion having a distal end, and an intermediate portion disposed between the proximal end and the distal portion. The distal portion includes a distal portion anchoring mechanism to anchor the distal portion to a first biological cavity of a patient. The intermediate portion includes an intermediate portion anchoring mechanism to anchor the intermediate portion to a second biological cavity of the patient. The intermediate portion anchoring mechanism is larger in lateral dimension than and is spaced from the distal portion anchoring mechanism. The distal portion and/or the intermediate portion includes a plurality of modulation electrodes. The distal portion anchoring mechanism and/or the intermediate portion anchoring mechanism is configured to position the modulation electrodes to contact tissue of the patient at multiple locations.

摘要翻译： 用于神经调节的引线包括细长体，其包括近端，具有远端的远端部分和设置在近端和远端部分之间的中间部分。 远端部分包括远侧部分锚固机构，用于将远侧部分锚定到患者的第一生物腔。 中间部分包括中间部分锚固机构，以将中间部分锚定到患者的第二生物腔。 中间部分锚固机构的横向尺寸大于和远离部分锚固机构的间隔。 远端部分和/或中间部分包括多个调制电极。 远侧部分锚固机构和/或中间部分锚定机构构造成定位调节电极以在多个位置接触患者的组织。

公开(公告)号：US20120290024A1

公开(公告)日：2012-11-15

申请号：US13105419

申请日：2011-05-11

申请人： Yongxing ZHANG ,  Cary HATA

发明人： Yongxing ZHANG ,  Cary HATA

IPC分类号： A61N1/365 ,  A61N1/36

CPC分类号： A61N1/36139 ,  A61N1/36057 ,  A61N1/36117 ,  A61N1/3627 ,  A61N1/36564

摘要： A transvenous renal nerve modulation system comprises: a blood pressure monitoring device to be implanted in a patient to monitor the patient's blood pressure; one or more transvenous renal nerve modulation leads to be implanted in one or more renal blood vessels of the patient; a pulse generator coupled to the transvenous renal nerve modulation leads to deliver electrical pulses to the one or more transvenous renal nerve modulation leads for modulating renal nerves of the patient; and a control unit coupled to the blood pressure monitoring device and the pulse generator to control delivery of the electrical pulses by the pulse generator based on the patient's blood pressure from the blood pressure monitoring device. The pulse generator delivers high frequency pulses of greater than about 10 Hz to the transvenous renal nerve modulation leads if the patient's blood pressure is greater than a high blood pressure threshold.

摘要翻译： 经静脉肾神经调节系统包括：植入患者体内以监测患者血压的血压监测装置; 一个或多个经静脉肾神经调节导致植入患者的一个或多个肾血管中; 耦合到经静脉肾神经调节的脉冲发生器导致将电脉冲传递到一个或多个经静脉肾神经调节引线，用于调节患者的肾神经; 以及控制单元，其耦合到所述血压监测装置和所述脉冲发生器，以基于来自所述血压监测装置的患者的血压来控制所述脉冲发生器的电脉冲的输送。 如果患者的血压高于高血压阈值，则脉冲发生器将高于约10Hz的高频脉冲传送给经静脉肾神经调制线。