公开(公告)号：US20060255289A1

公开(公告)日：2006-11-16

申请号：US11129647

申请日：2005-05-13

申请人： Thomas Cygan ,  Vincent Tsang ,  Raymond Burke ,  Richard Gill ,  Roy Martin ,  Timothy Hutchins

发明人： Thomas Cygan ,  Vincent Tsang ,  Raymond Burke ,  Richard Gill ,  Roy Martin ,  Timothy Hutchins

IPC分类号： G21K5/10

CPC分类号： H01J49/0495

摘要： In various aspects, the present teaching provide systems for providing sample ions, methods for providing sample ions, and sample support handling mechanisms. The sample support handling mechanisms of the present teachings comprising a sample support transfer mechanism portion and a sample support changing mechanism portion, where the sample support changing mechanism portion is disposed in a vacuum lock chamber. In various embodiments, the sample support handling mechanism facilitates providing consistent positioning of a sample support for subsequent ion generation by MALDI.

摘要翻译： 在各个方面，本教导提供用于提供样品离子的系统，用于提供样品离子的方法和样品支持处理机构。 本发明的样品支持处理机构包括样品支承转移机构部分和样品支撑体改变机构部分，其中样品支撑体改变机构部分设置在真空锁定室中。 在各种实施方案中，样品支持处理机制有助于提供样品载体的一致的定位，以便随后通过MALDI产生离子。

公开(公告)号：US07405396B2

公开(公告)日：2008-07-29

申请号：US11129647

申请日：2005-05-13

申请人： Thomas R. Cygan ,  Vincent Tsang ,  Raymond P. Burke ,  Richard Gill ,  Roy E. Martin ,  Timothy E. Hutchins

发明人： Thomas R. Cygan ,  Vincent Tsang ,  Raymond P. Burke ,  Richard Gill ,  Roy E. Martin ,  Timothy E. Hutchins

IPC分类号： H01J49/04

CPC分类号： H01J49/0495

摘要： In various aspects, the present teaching provide systems for providing sample ions, methods for providing sample ions, and sample support handling mechanisms. The sample support handling mechanisms of the present teachings comprising a sample support transfer mechanism portion and a sample support changing mechanism portion, where the sample support changing mechanism portion is disposed in a vacuum lock chamber. In various embodiments, the sample support handling mechanism facilitates providing consistent positioning of a sample support for subsequent ion generation by MALDI.

摘要翻译： 在各个方面，本教导提供用于提供样品离子的系统，用于提供样品离子的方法和样品支持处理机构。 本发明的样品支持处理机构包括样品支承转移机构部分和样品支撑体改变机构部分，其中样品支撑体改变机构部分设置在真空锁定室中。 在各种实施方案中，样品支持处理机制有助于提供样品载体的一致的定位，以便随后通过MALDI产生离子。

公开(公告)号：US20060289063A1

公开(公告)日：2006-12-28

申请号：US11165370

申请日：2005-06-24

申请人： Richard Gill

发明人： Richard Gill

IPC分类号： F17D1/00

CPC分类号： F16L37/62 ,  F16L37/002 ,  F16L55/18 ,  F16L2101/30 ,  Y10T137/598 ,  Y10T137/6109

摘要： A self-extracting service module for piping infrastructures comprises a platform on which is mounted equipment for controlling and or monitoring the flow of liquid or gaseous media throughout the piping infrastructures. A first remote-controllable pipe coupling system is interconnected with the equipment inlet and a second pipe coupling system is interconnected to the equipment outlet. The pipe coupling systems are remotely manipulable for engaging and disengaging the equipment with piping infrastructure inlets and outlets. The platform is attached to actuators positioned near each corner of the platform. The service module is extracted from the piping infrastructure by first isolating the equipment from the flow of liquid media after which, the pipe coupling systems are remotely disengaged from the piping infrastructure inlet and outlet. The actuators are then operated to move the platform from within the piping infrastructure to a position where service work is easily performed on the equipment.

摘要翻译： 用于管道基础设施的自解压服务模块包括其上安装有用于控制和/或监控整个管道基础设施中的液体或气体介质的流动的设备的平台。 第一个远程可控管道联接系统与设备入口互连，第二个管道联接系统与设备出口互连。 管道联接系统可远程操作，用于使设备与管道基础设施入口和出口接合和分离。 该平台连接到位于平台每个角落附近的致动器。 通过首先将设备与液体介质的流动隔离，从而从管道基础设施中提取维修模块，然后将管道联接系统从管道基础结构入口和出口远程脱开。 然后操作致动器以将平台从管道基础设施内移动到容易在设备上进行维修工作的位置。

公开(公告)号：US20060289064A1

公开(公告)日：2006-12-28

申请号：US11391392

申请日：2006-03-29

申请人： Richard Gill

发明人： Richard Gill

IPC分类号： F16K43/00

CPC分类号： F16L55/18 ,  F16L37/002 ,  F16L37/62 ,  F16L2101/30 ,  Y10T137/598 ,  Y10T137/6109

摘要： A self-extracting service module for piping infrastructures comprises a platform on which is mounted equipment for controlling and or monitoring the flow of liquid or gaseous media throughout the piping infrastructures. A first remote-controllable pipe coupling system is interconnected with the equipment inlet and a second pipe coupling system is interconnected to the equipment outlet. The platform is attached to actuators positioned near each corner of the platform. The actuators cooperate with at least one pressure-driven device. The service module is extracted from the piping infrastructure by isolating the equipment from the flow of liquid media after which, the pipe coupling systems are remotely disengaged from the piping infrastructure inlet and outlet. The actuators are operated to move the platform from within the piping infrastructure to a position where service work is easily performed on the equipment without the attendant hazards and constrictions associated with confined spaces.

摘要翻译： 用于管道基础设施的自解压服务模块包括其上安装有用于控制和/或监控整个管道基础设施中的液体或气体介质的流动的设备的平台。 第一个远程可控管道联接系统与设备入口互连，第二个管道联接系统与设备出口互连。 该平台连接到位于平台每个角落附近的致动器。 致动器与至少一个压力驱动装置配合。 通过将设备与液体介质的流动隔离，管道连接系统远离管道基础结构入口和出口，从管道基础设施中提取服务模块。 执行器被操作以将平台从管道基础设施中移动到在设备上容易进行维修工作的位置，而不伴随与密闭空间相关的危险和收缩。

公开(公告)号：US20060211120A1

公开(公告)日：2006-09-21

申请号：US10530959

申请日：2003-10-24

申请人： Richard Gill ,  J Philips

发明人： Richard Gill ,  J Philips

IPC分类号： G01N37/00

CPC分类号： G01N33/143 ,  G01N21/78 ,  G01N21/82 ,  G01N33/14 ,  Y10T436/10 ,  Y10T436/13

摘要： A method is provided for detecting a tracer in a preparation by precipitating a coloring agent from a sample of the preparation, especially where the coloring agent otherwise interferes with detection of the tracer. A sample of the preparation may be contacted with an effective amount of a precipitating agent to precipitate the coloring agent in the sample, yielding a sample supernatant having a reduced concentration of coloring agent compared to the preparation. Detection of the tracer in the supernatant may produce a result which may be evaluated to assist in quality validation in a process of manufacturing the preparation or authenticating the preparation.

摘要翻译： 提供了一种用于通过从制剂样品中沉淀着色剂来检测制剂中的示踪剂的方法，特别是在着色剂干扰示踪剂检测的情况下。 可将制剂样品与有效量的沉淀剂接触以沉淀样品中的着色剂，产生与制剂相比具有降低的着色剂浓度的样品上清液。 检测上清液中的示踪剂可以产生可以在制备制剂或鉴定制剂的过程中进行评估以协助质量验证的结果。