-
公开(公告)号:US06858412B2
公开(公告)日:2005-02-22
申请号:US09999362
申请日:2001-10-24
申请人: Thomas D. Willis , Paul Hardenbol , Maneesh Jain , Viktor Stolc , Mostafa Ronaghi , Ronald W. Davis
发明人: Thomas D. Willis , Paul Hardenbol , Maneesh Jain , Viktor Stolc , Mostafa Ronaghi , Ronald W. Davis
IPC分类号: G01N33/53 , C07H21/02 , C07H21/04 , C12N15/09 , C12P19/34 , C12Q1/48 , C12Q1/68 , G01N33/566
CPC分类号: C12Q1/6827 , C12Q1/6858 , C12Q1/686 , C12Q2531/113 , C12Q2525/307 , C12Q2537/143
摘要: The invention is directed to novel methods of multiplexing nucleic acid reactions, including amplification, detection and genotyping. The invention relies on the use of precircle probes that are circularized in the presence of the corresponding target nucleic acids, cleaved, and then amplified.
摘要翻译: 本发明涉及复制核酸反应的新方法,包括扩增,检测和基因分型。 本发明依赖于在相应靶核酸存在下被环化的前循环探针的使用,被切割,然后扩增。
-
公开(公告)号:US20120065091A1
公开(公告)日:2012-03-15
申请号:US13206120
申请日:2011-08-09
申请人: Thomas D. Willis , Paul Hardenbol , Maneesh Jain , Viktor Stolc , Mostafa Ronaghi , Ronald W. Davis
发明人: Thomas D. Willis , Paul Hardenbol , Maneesh Jain , Viktor Stolc , Mostafa Ronaghi , Ronald W. Davis
CPC分类号: C12Q1/6827 , C12Q1/6858 , C12Q1/686 , C12Q2531/113 , C12Q2525/307 , C12Q2537/143
摘要: The invention is directed to novel methods of multiplexing nucleic acid reactions, including amplification, detection and genotyping. The invention relies on the use of precircle probes that are circularized in the presence of the corresponding target nucleic acids, cleaved, and then amplified.
摘要翻译: 本发明涉及复制核酸反应的新方法,包括扩增,检测和基因分型。 本发明依赖于在相应靶核酸存在下被环化的前循环探针的使用,被切割,然后扩增。
-
公开(公告)号:US20100330619A1
公开(公告)日:2010-12-30
申请号:US12709319
申请日:2010-02-19
申请人: Thomas D. Willis , Paul Hardenbol , Maneesh Jain , Viktor Stolc , Mostafa Ronaghi , Ronald W. Davis
发明人: Thomas D. Willis , Paul Hardenbol , Maneesh Jain , Viktor Stolc , Mostafa Ronaghi , Ronald W. Davis
IPC分类号: C12P19/34
CPC分类号: C12Q1/6827 , C12Q1/6858 , C12Q1/686 , C12Q2531/113 , C12Q2525/307 , C12Q2537/143
摘要: The invention is directed to novel methods of multiplexing nucleic acid reactions, including amplification, detection and genotyping. The invention relies on the use of precircle probes that are circularized in the presence of the corresponding target nucleic acids, cleaved, and then amplified.
摘要翻译: 本发明涉及复制核酸反应的新方法,包括扩增,检测和基因分型。 本发明依赖于在相应靶核酸存在下被环化的前循环探针的使用,被切割,然后扩增。
-
公开(公告)号:US07993880B2
公开(公告)日:2011-08-09
申请号:US12709319
申请日:2010-02-19
申请人: Thomas D. Willis , Paul Hardenbol , Maneesh Jain , Viktor Stolc , Mostafa Ronaghi , Ronald W. Davis
发明人: Thomas D. Willis , Paul Hardenbol , Maneesh Jain , Viktor Stolc , Mostafa Ronaghi , Ronald W. Davis
CPC分类号: C12Q1/6827 , C12Q1/6858 , C12Q1/686 , C12Q2531/113 , C12Q2525/307 , C12Q2537/143
摘要: The invention is directed to novel methods of multiplexing nucleic acid reactions, including amplification, detection and genotyping. The invention relies on the use of precircle probes that are circularized in the presence of the corresponding target nucleic acids, cleaved, and then amplified.
摘要翻译: 本发明涉及复制核酸反应的新方法,包括扩增,检测和基因分型。 本发明依赖于在相应靶核酸存在下被环化的前循环探针的使用,被切割,然后扩增。
-
公开(公告)号:US07700323B2
公开(公告)日:2010-04-20
申请号:US10826633
申请日:2004-04-15
申请人: Thomas D Willis , Paul Hardenbol , Maneesh Jain , Viktor Stolc , Mostafa Ronaghi , Ronald W Davis
发明人: Thomas D Willis , Paul Hardenbol , Maneesh Jain , Viktor Stolc , Mostafa Ronaghi , Ronald W Davis
CPC分类号: C12Q1/6827 , C12Q1/6858 , C12Q1/686 , C12Q2531/113 , C12Q2525/307 , C12Q2537/143
摘要: The invention is directed to novel methods of multiplexing nucleic acid reactions, including amplification, detection and genotyping. The invention relies on the use of precircle probes that are circularized in the presence of the corresponding target nucleic acids, cleaved, and then amplified.
摘要翻译: 本发明涉及多重核酸反应的新方法,包括扩增,检测和基因分型。 本发明依赖于在相应靶核酸存在下被环化的前循环探针的使用,被切割,然后扩增。
-
公开(公告)号:US08383348B2
公开(公告)日:2013-02-26
申请号:US13206120
申请日:2011-08-09
申请人: Thomas D. Willis , Paul Hardenbol , Maneesh Jain , Viktor Stolc , Mostafa Ronaghi , Ronald W. Davis
发明人: Thomas D. Willis , Paul Hardenbol , Maneesh Jain , Viktor Stolc , Mostafa Ronaghi , Ronald W. Davis
CPC分类号: C12Q1/6827 , C12Q1/6858 , C12Q1/686 , C12Q2531/113 , C12Q2525/307 , C12Q2537/143
摘要: The invention is directed to novel methods of multiplexing nucleic acid reactions, including amplification, detection and genotyping. The invention relies on the use of precircle probes that are circularized in the presence of the corresponding target nucleic acids, cleaved, and then amplified.
摘要翻译: 本发明涉及复制核酸反应的新方法,包括扩增,检测和基因分型。 本发明依赖于在相应靶核酸存在下被环化的前循环探针的使用,被切割,然后扩增。
-
公开(公告)号:US20070264642A1
公开(公告)日:2007-11-15
申请号:US11480270
申请日:2006-06-30
申请人: Thomas Willis , Paul Hardenbol , Maneesh Jain , Viktor Stolc , Mostafa Ronaghi , Ronald Davis
发明人: Thomas Willis , Paul Hardenbol , Maneesh Jain , Viktor Stolc , Mostafa Ronaghi , Ronald Davis
IPC分类号: C12Q1/68
CPC分类号: C12Q1/6827 , C12Q1/6858 , C12Q1/686 , C12Q2531/113 , C12Q2525/307 , C12Q2537/143
摘要: The invention is directed to novel methods of multiplexing nucleic acid reactions, including amplification, detection and genotyping. The invention relies on the use of precircle probes that are circularized in the presence of the corresponding target nucleic acids, cleaved, and then amplified.
摘要翻译: 本发明涉及多重核酸反应的新方法,包括扩增,检测和基因分型。 本发明依赖于在相应靶核酸存在下被环化的前循环探针的使用,被切割,然后扩增。
-
公开(公告)号:US20060252060A1
公开(公告)日:2006-11-09
申请号:US11335174
申请日:2006-01-19
申请人: Thomas Willis , Paul Hardenbol , Maneesh Jain , Viktor Stolc , Mostafa Ronaghi , Ronald Davis
发明人: Thomas Willis , Paul Hardenbol , Maneesh Jain , Viktor Stolc , Mostafa Ronaghi , Ronald Davis
CPC分类号: C12Q1/6827 , C12Q1/6858 , C12Q1/686 , C12Q2531/113 , C12Q2525/307 , C12Q2537/143
摘要: The invention is directed to novel methods of multiplexing nucleic acid reactions, including amplification, detection and genotyping. The invention relies on the use of precircle probes that are circularized in the presence of the corresponding target nucleic acids, cleaved, and then amplified.
摘要翻译: 本发明涉及复制核酸反应的新方法,包括扩增,检测和基因分型。 本发明依赖于在相应靶核酸存在下被环化的前循环探针的使用,被切割,然后扩增。
-
公开(公告)号:US20070178479A1
公开(公告)日:2007-08-02
申请号:US11335196
申请日:2006-01-19
申请人: Thomas Willis , Paul Hardenbol , Maneesh Jain , Viktor Stolc , Mostafa Ronaghi , Ronald Davis
发明人: Thomas Willis , Paul Hardenbol , Maneesh Jain , Viktor Stolc , Mostafa Ronaghi , Ronald Davis
CPC分类号: C12Q1/6827 , C12Q1/6858 , C12Q1/686 , C12Q2531/113 , C12Q2525/307 , C12Q2537/143
摘要: The invention is directed to novel methods of multiplexing nucleic acid reactions, including amplification, detection and genotyping. The invention relies on the use of precircle probes that are circularized in the presence of the corresponding target nucleic acids, cleaved, and then amplified.
-
公开(公告)号:US20060275789A1
公开(公告)日:2006-12-07
申请号:US11335175
申请日:2006-01-19
申请人: Thomas Willis , Paul Hardenbol , Maneesh Jain , Viktor Stolc , Mostafa Ronaghi , Ronald Davis
发明人: Thomas Willis , Paul Hardenbol , Maneesh Jain , Viktor Stolc , Mostafa Ronaghi , Ronald Davis
IPC分类号: C12Q1/68
CPC分类号: C12Q1/6827 , C12Q1/6858 , C12Q1/686 , C12Q2531/113 , C12Q2525/307 , C12Q2537/143
摘要: The invention is directed to novel methods of multiplexing nucleic acid reactions, including amplification, detection and genotyping. The invention relies on the use of precircle probes that are circularized in the presence of the corresponding target nucleic acids, cleaved, and then amplified.
-
-
-
-
-
-
-
-
-