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102 条记录 (耗时 0.047 秒)

    SYSTEM AND METHOD FOR HOME ENERGY MONITOR AND CONTROL
    2.
    发明申请
    SYSTEM AND METHOD FOR HOME ENERGY MONITOR AND CONTROL 有权
    家庭能源监测与控制系统与方法

    公开(公告)号：US20120316808A1

    公开(公告)日：2012-12-13

    申请号：US13557144

    申请日：2012-07-24

    申请人： SETH FRADER-THOMPSON ,  Stephan von Muehlen ,  Thomas Kennedy

    发明人： SETH FRADER-THOMPSON ,  Stephan von Muehlen ,  Thomas Kennedy

    IPC分类号： G01R21/00 ,  G06F19/00

    CPC分类号： G01R21/00 ,  G01D4/002 ,  G01R21/133 ,  H02J3/008 ,  Y02B70/3208 ,  Y02B70/343 ,  Y02B90/241 ,  Y02B90/245 ,  Y04S20/32 ,  Y04S20/34 ,  Y04S20/40 ,  Y04S20/46 ,  Y04S50/10

    摘要： The invention generally concerns systems and methods for monitoring and controlling the power consumption of a power-consuming device. The system and method may connect to a power source and a power-consuming device, connecting the power-consuming device to the power source. The power usage of the power-consuming device may then be measured and monitored. This monitoring data may then be stored and optionally sent to a controlling device on a data network. The location of the power-consuming device may also be determined, recorded, and sent to a controlling device. The system may also control the power usage of the power-consuming device. In some cases, a remote server may connect multiple energy monitoring systems in order to gain additional efficiencies and foster a community-based social network.

    摘要翻译： 本发明一般涉及用于监视和控制功耗设备的功耗的系统和方法。 该系统和方法可以连接到电源和功耗设备，将功耗设备连接到电源。 然后可以测量和监测耗电装置的功率使用。 然后可以将该监视数据存储并且可选地发送到数据网络上的控制设备。 功耗设备的位置也可以被确定，记录并发送到控制设备。 该系统还可以控制功耗设备的功率使用。 在某些情况下，远程服务器可以连接多个能量监控系统，以获得更多的效率，并促进基于社区的社交网络。

    Golf Ball with Deep Depressions
    7.
    发明申请
    Golf Ball with Deep Depressions 有权
    高尔夫球与深度压抑

    公开(公告)号：US20060223654A1

    公开(公告)日：2006-10-05

    申请号：US11426521

    申请日：2006-06-26

    申请人： Thomas Kennedy ,  Viktor Keller ,  David Melanson ,  Michael Tzivanis

    发明人： Thomas Kennedy ,  Viktor Keller ,  David Melanson ,  Michael Tzivanis

    IPC分类号： A63B37/04

    CPC分类号： A63B37/0004 ,  A63B37/0006 ,  A63B37/0013 ,  A63B37/0015 ,  A63B37/0019 ,  A63B37/002 ,  A63B37/0027 ,  A63B37/0075 ,  A63B37/0076 ,  A63B37/0095 ,  A63B37/0096 ,  A63B45/00 ,  B29C33/123 ,  B29C39/10 ,  B29C45/02 ,  B29C45/14065 ,  B29C67/246 ,  B29L2031/54 ,  B29L2031/545

    摘要： A golf ball comprising a core and a cover layer, wherein the cover layer provides one or more deep depressions that extend through the cover layer to and/or into a layer or component underneath is disclosed. The cover may be a single layer or it may include multiple layers. If the cover is a multi-layer cover, the deep depressions extend to or into at least the first inner cover layer, and may extend to and/or into two or more inner cover layers. If the cover is a single layer, the deep depressions extend to and/or into the core. The cover layer(s) may be formed from any material suitable for use as a cover, including, but not limited to, ionomers, non-ionomers and blends of ionomers and non-ionomers. The deep depressions may be spherical or non-spherical, and the portion of the deep depression that extends to or into the next inner layer may be the same or different shape as the outer portion of the deep depression.

    摘要翻译： 一种包括芯和覆盖层的高尔夫球，其中所述覆盖层提供了一个或多个延伸穿过所述覆盖层和/或进入下面的层或组件的深凹陷。 盖可以是单层，也可以包括多层。 如果盖是多层盖，则深凹陷至少延伸到第一内覆盖层或至少第一内覆盖层，并且可以延伸到和/或进入两个或更多个内覆盖层。 如果盖是单层，则深凹陷延伸到和/或进入芯。 覆盖层可以由适合用作覆盖物的任何材料形成，包括但不限于离聚物，非离聚物和离聚物和非离聚物的共混物。 深凹陷可以是球形或非球形，并且延伸到下一内层的深凹陷部分可以与深凹陷的外部部分相同或不同的形状。

    REGULATION OF NAD(P)H OXIDASE GROWTH AND TRANSCRIPTION IN MELANOMA CELLS
    10.
    发明申请
    REGULATION OF NAD(P)H OXIDASE GROWTH AND TRANSCRIPTION IN MELANOMA CELLS 失效
    调节NAD（P）H氧化酶生长和转录在MELANOMA细胞

    公开(公告)号：US20050215624A1

    公开(公告)日：2005-09-29

    申请号：US10493936

    申请日：2002-12-19

    申请人： Thomas Kennedy

    发明人： Thomas Kennedy

    IPC分类号： A61K31/12 ,  A61K31/122 ,  A61K31/35 ,  A61K31/366 ,  A61K31/37

    CPC分类号： A61K31/122 ,  A61K31/12 ,  A61K31/35 ,  A61K31/366 ,  A61K31/37 ,  A61K2300/00

    摘要： Malignant melanoma cells spontaneously generate reactive oxygen species (ROS) that promote constitutive activation of the transcription factor nuclear factor-kB (NF-kB). Although antioxidants and inhibitors of NAD(P)H oxidases significantly reduce constitutive NF-kB activation and suppress cell proliferation, the nature of the enzyme responsible for ROS production in melanoma cells has not been determined. To address this issue, we now have characterized the source of ROS production in melanoma cells. ROS are generated by isolated, cytosol-free melanoma plasma membranes, with inhibition by NAD(P)H oxidase inhibitors. The p22phox, gp91phox and p67phox components of the human phagocyte NAD(P)H oxidase, and the 91phox homolog NOX4 were demonstrated in melanomas by RT-PCR and sequencing, and protein product for both p22phox and gp91phox were detected in cell membranes by immunoassay. Normal human epidermal melanocytes expressed only p22phox and NOX4. Melanoma proliferation was reduced by NAD(P)H oxidase inhibitors and by transfection of antisense but not sense oligonucleotides for p22phox and NOX4. Also, the flavoprotein inhibitor diphenylene iodonium inhibited constitutive DNA binding of nuclear protein to the NF-kB and cyclic-AMP response element consensus oligonucleotides, without affecting DNA binding activity to AP-1 or OCT-1.

    摘要翻译： 恶性黑素瘤细胞自发产生促进转录因子核因子-κB（NF-kB）组成型激活的活性氧（ROS）。 尽管NAD（P）H氧化酶的抗氧化剂和抑制剂显着降低组成型NF-kB活化并抑制细胞增殖，但是还未确定负责黑素瘤细胞中ROS产生的酶的性质。 为了解决这个问题，我们现在已经描述了黑素瘤细胞中ROS产生的来源。 ROS由孤立的无细胞溶质黑素瘤细胞膜产生，具有NAD（P）H氧化酶抑制剂的抑制作用。 人吞噬细胞NAD（P）H氧化酶的p22phos，gp91 phox和p67Phox组分， / SUP>同源物NOX4通过RT-PCR和测序证实在黑素瘤中，并且通过免疫测定在细胞膜中检测到p22 phox和gp91 phox的蛋白质产物。 正常人类表皮黑素细胞仅表达p22Phox和NOX4。 通过NAD（P）H氧化酶抑制剂和通过转染p22Phox和NOX4的反义但不正义寡核苷酸来减少黑素瘤增殖。 此外，黄素蛋白抑制剂二亚苯基碘鎓抑制核蛋白的组成型DNA结合NF-kB和环AMP应答元件共有寡核苷酸，而不影响与AP-1或OCT-1的DNA结合活性。