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1.发明授权System and method for promoting selective tissue in-growth for an implantable medical device 有权用于促进可植入医疗装置的选择性组织生长的系统和方法公开(公告)号：US06704604B2
公开(公告)日：2004-03-09
申请号：US09827103
申请日：2001-04-05
IPC分类号： A61N105
CPC分类号： A61N1/0563 , A61N2001/0578
摘要： Disclosed is an improved system and method to selectively promote tissue in-growth on, or adjacent to, an implantable medical device. In one embodiment, at least one surface of the housing of a medical device is in contact with a first portion of a porous PTFE having a pore size adapted to prevent substantially all tissue in-growth. This first portion, or layer, of porous PTFE material is further in contact at predetermined locations with an additional porous PTFE layer having a pore size adapted to selectively promote tissue in-growth only at the predetermined locations. Each of the PTFE layers may be formed of porous PTFE tubing or tape. Alternatively, the two layers may comprise a single composite structure that has a more porous material exposed on a first surface, and a less porous, more dense, material on a second surface. Another embodiment of the invention involves forming the layers of PTFE into a removable member that is adjacent to at least one surface of the implantable medical device. The removable member may take the form of a sleeve that surrounds a portion of a the medical device and is adapted to remain in the body during an extraction process. For example, during the removal of a lead, the sleeve remains within the body and is capable of receiving a replacement lead, making it unnecessary to disturb tissue in-growth attached to the sleeve.
摘要翻译： 公开了一种改进的系统和方法，用于选择性地促进在可植入医疗装置上或与植入式医疗装置相邻的组织生长。 在一个实施例中，医疗装置的壳体的至少一个表面与多孔PTFE的第一部分接触，孔的孔径适于防止基本上所有的组织生长。 多孔PTFE材料的该第一部分或多层进一步在预定位置处接触，另外的多孔PTFE层具有适于仅在预定位置选择性地促进组织生长的孔径。 每个PTFE层可以由多孔PTFE管或带形成。 或者，两层可以包括单个复合结构，其具有在第二表面上暴露在第一表面上的多孔材料和较少多孔，更致密的材料。 本发明的另一实施例涉及将PTFE层形成为与可植入医疗装置的至少一个表面相邻的可移除构件。 可移除构件可以采取围绕医疗装置的一部分的套筒的形式，并且适于在提取过程期间保持在身体中。 例如，在去除引线期间，套筒保持在主体内并且能够接收替换引线，使得不必干扰附着到套筒上的组织生长。
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2.发明授权System for promoting selective tissue in-growth for an implantable medical device 失效用于促进植入式医疗装置的选择性组织生长的系统公开(公告)号：US07079902B2
公开(公告)日：2006-07-18
申请号：US10671103
申请日：2003-09-25
IPC分类号： A61N1/05
CPC分类号： A61N1/0563 , A61N2001/0578
摘要： A system including an implantable defibrillation electrode includes a first layer of porous Polytetrafluoroethylene (PTFE) adjacent to at least one surface of the defibrillation electrode, the first layer of porous PTFE having a fibril length adapted to bleed gas away from the at least one surface of the defibrillation electrode, and a second layer of porous PTFE formed over the first layer, the second layer of porous PTFE having a fibril length adapted to prevent substantially all tissue in-growth.
摘要翻译： 包括植入式除颤电极的系统包括与除颤电极的至少一个表面相邻的多孔聚四氟乙烯（PTFE）的第一层，第一层多孔PTFE具有原纤维长度，其适于将气体从至少一个表面 除颤电极和形成在第一层上的第二多孔PTFE层，第二层多孔PTFE具有适于防止基本上所有组织生长的原纤维长度。
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公开(公告)号：US06697676B2
公开(公告)日：2004-02-24
申请号：US09836015
申请日：2001-04-17
IPC分类号： A61N104
CPC分类号： A61N1/056 , A61N2001/0578
摘要： An implantable device including an elastically compressible member coupled to a distal end of a lead and further coupled to at least one electrode. The compressible member is in a contracted state when the electrode is being delivered to an implant site. At the implant site, the compressible member is expanded to urge the electrode into contact with tissue. Compressible member further includes a keyed structure to engage a stiffening member such as a stylet. The stiffening member is used both to deliver the electrode to the implant site, and to rotate the compressible member, if necessary, so that the electrode contacts predetermined body tissue. According to one aspect of the invention, an introducer having an inner lumen with a diameter that is smaller than that of the compressible member may be used to disengage the stiffening member from the compressible member. In one embodiment, compressible member includes a conductor wound to form multiple turns that are aligned during electrode delivery, but which expand into a non-aligned configuration after deployment. In another embodiment, compressible member includes a spring clip that has a compressed profile during delivery, and an expanded profile after deployment.
摘要翻译： 一种可植入装置，其包括耦合到引线的远端并进一步耦合到至少一个电极的弹性可压缩构件。 当电极被输送到植入部位时，可压缩构件处于收缩状态。 在植入位置，可压缩构件被膨胀以促使电极与组织接触。 可压缩构件还包括用于接合诸如探针之类的加强构件的键合结构。 加强构件用于将电极输送到植入位置，并且如果需要，可旋转可压缩构件，使得电极接触预定的身体组织。 根据本发明的一个方面，可以使用具有直径小于可压缩构件直径的内腔的导引器来使加强构件从可压缩构件脱离。 在一个实施例中，可压缩构件包括缠绕以形成多个匝的导体，其在电极传递期间对准，但在展开之后扩展成不对准构造。 在另一个实施例中，可压缩构件包括弹簧夹，其在输送期间具有压缩轮廓，并且在展开之后具有扩展轮廓。
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公开(公告)号：US06934589B2
公开(公告)日：2005-08-23
申请号：US09827108
申请日：2001-04-05
CPC分类号： A61N1/056 , A61N2001/0578 , A61N2001/0585
摘要： An improved system and method for deploying medical electrical leads is disclosed. The system includes a guiding device such as a guidewire used to navigate the vascular system of a body. The guiding device includes a fixation member that can be deployed to maintain the guiding device at a desired location within the vascular system. The fixation member may be an inflatable device such as a balloon, or alternatively, may be an expandable device constructed of flexible fibers that has both an expanded and a contracted state. The system may further include a coupling member located adjacent to the guiding device. The coupling member may be a rail extending distally from a proximal end of the guiding device to a point proximal the fixation member. In an alternative embodiment of the invention, the coupling member is a channel included in the body of the guiding device adapted to slidably engage an electrode assembly. The coupling member is adapted to allow the electrode assembly to be slid to the distal end of the coupling member and deployed at a predetermined implant site. In one embodiment of the invention, the coupling member is movable with respect to the guiding device. This allows the coupling member to be re-positioned to multiple implant sites to deploy more than one electrode while the fixation mechanism remains stationary within a patient's vascular system. According to yet another aspect of the invention, the guiding device includes a lumen to delivery fluoro visible medium.
摘要翻译： 公开了用于部署医疗电引线的改进的系统和方法。 该系统包括诸如用于导航身体的血管系统的导丝的引导装置。 引导装置包括可以部署以将引导装置保持在血管系统内的期望位置的固定构件。 固定构件可以是诸如气囊的可充气装置，或者可替代地，可以是由具有膨胀和收缩状态的柔性纤维构成的可扩张装置。 该系统还可以包括邻近引导装置定位的联接构件。 联接构件可以是从引导装置的近端向靠近固定构件的点向远侧延伸的轨道。 在本发明的替代实施例中，联接构件是包括在引导装置的主体中的通道，其适于可滑动地接合电极组件。 联接构件适于允许电极组件滑动到联接构件的远端并且在预定的植入位置展开。 在本发明的一个实施例中，联接构件可相对于引导装置移动。 这允许将联接构件重新定位到多个植入位置以展开多于一个电极，同时固定机构在患者的血管系统内保持静止。 根据本发明的另一方面，引导装置包括用于输送氟可见介质的内腔。
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公开(公告)号：US09513443B2
公开(公告)日：2016-12-06
申请号：US14331200
申请日：2014-07-14
申请人： John Lawrence Erb , Stephen Sundquist , James Edward Shapland , Robert Glenmore Walsh , Jin Shimada
发明人： John Lawrence Erb , Stephen Sundquist , James Edward Shapland , Robert Glenmore Walsh , Jin Shimada
CPC分类号： G02B6/3817 , A61N1/05 , G02B6/4416
摘要： A small diameter, shielded, fine wire glass fiber conductor which is capable of transmitting optical and electrical signals in environments with electromagnetic interference or radio frequency interferences. The conductor includes a fiber core, a first insulation layer, a conductive layer, a second insulation layer, a shielding layer, and an outer coating. Applications include use in aerospace, automotive, and other vehicles as well as potential use in electrostimulation devices, such as pacemaker leads, vascular guidewires and other medical applications.
摘要翻译： 一种小直径，屏蔽，细线玻璃光纤导体，能够在具有电磁干扰或射频干扰的环境中传输光信号和电信号。 导体包括纤维芯，第一绝缘层，导电层，第二绝缘层，屏蔽层和外涂层。 应用包括在航空航天，汽车和其他车辆中的应用，以及潜在的电刺激装置，如起搏器引线，血管导丝线和其他医疗应用。
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公开(公告)号：US20140318825A1
公开(公告)日：2014-10-30
申请号：US14331200
申请日：2014-07-14
申请人： John Lawrence Erb , Stephen Sundquist , James Edward Shapland , Robert Glenmore Walsh , Jin Shimada
发明人： John Lawrence Erb , Stephen Sundquist , James Edward Shapland , Robert Glenmore Walsh , Jin Shimada
CPC分类号： G02B6/3817 , A61N1/05 , G02B6/4416
摘要： A small diameter, shielded, fine wire glass fiber conductor which is capable of transmitting optical and electrical signals in environments with electromagnetic interference or radio frequency interferences. The conductor includes a fiber core, a first insulation layer, a conductive layer, a second insulation layer, a shielding layer, and an outer coating. Applications include use in aerospace, automotive, and other vehicles as well as potential use in electrostimulation devices, such as pacemaker leads, vascular guidewires and other medical applications.
摘要翻译： 一种小直径，屏蔽，细线玻璃光纤导体，能够在具有电磁干扰或射频干扰的环境中传输光信号和电信号。 导体包括纤维芯，第一绝缘层，导电层，第二绝缘层，屏蔽层和外涂层。 应用包括在航空航天，汽车和其他车辆中的应用，以及潜在的电刺激装置，如起搏器引线，血管导丝线和其他医疗应用。
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