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1.发明授权System for promoting selective tissue in-growth for an implantable medical device 失效用于促进植入式医疗装置的选择性组织生长的系统公开(公告)号：US07079902B2
公开(公告)日：2006-07-18
申请号：US10671103
申请日：2003-09-25
IPC分类号： A61N1/05
CPC分类号： A61N1/0563 , A61N2001/0578
摘要： A system including an implantable defibrillation electrode includes a first layer of porous Polytetrafluoroethylene (PTFE) adjacent to at least one surface of the defibrillation electrode, the first layer of porous PTFE having a fibril length adapted to bleed gas away from the at least one surface of the defibrillation electrode, and a second layer of porous PTFE formed over the first layer, the second layer of porous PTFE having a fibril length adapted to prevent substantially all tissue in-growth.
摘要翻译： 包括植入式除颤电极的系统包括与除颤电极的至少一个表面相邻的多孔聚四氟乙烯（PTFE）的第一层，第一层多孔PTFE具有原纤维长度，其适于将气体从至少一个表面 除颤电极和形成在第一层上的第二多孔PTFE层，第二层多孔PTFE具有适于防止基本上所有组织生长的原纤维长度。
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2.发明授权System and method for promoting selective tissue in-growth for an implantable medical device 有权用于促进可植入医疗装置的选择性组织生长的系统和方法公开(公告)号：US06704604B2
公开(公告)日：2004-03-09
申请号：US09827103
申请日：2001-04-05
IPC分类号： A61N105
CPC分类号： A61N1/0563 , A61N2001/0578
摘要： Disclosed is an improved system and method to selectively promote tissue in-growth on, or adjacent to, an implantable medical device. In one embodiment, at least one surface of the housing of a medical device is in contact with a first portion of a porous PTFE having a pore size adapted to prevent substantially all tissue in-growth. This first portion, or layer, of porous PTFE material is further in contact at predetermined locations with an additional porous PTFE layer having a pore size adapted to selectively promote tissue in-growth only at the predetermined locations. Each of the PTFE layers may be formed of porous PTFE tubing or tape. Alternatively, the two layers may comprise a single composite structure that has a more porous material exposed on a first surface, and a less porous, more dense, material on a second surface. Another embodiment of the invention involves forming the layers of PTFE into a removable member that is adjacent to at least one surface of the implantable medical device. The removable member may take the form of a sleeve that surrounds a portion of a the medical device and is adapted to remain in the body during an extraction process. For example, during the removal of a lead, the sleeve remains within the body and is capable of receiving a replacement lead, making it unnecessary to disturb tissue in-growth attached to the sleeve.
摘要翻译： 公开了一种改进的系统和方法，用于选择性地促进在可植入医疗装置上或与植入式医疗装置相邻的组织生长。 在一个实施例中，医疗装置的壳体的至少一个表面与多孔PTFE的第一部分接触，孔的孔径适于防止基本上所有的组织生长。 多孔PTFE材料的该第一部分或多层进一步在预定位置处接触，另外的多孔PTFE层具有适于仅在预定位置选择性地促进组织生长的孔径。 每个PTFE层可以由多孔PTFE管或带形成。 或者，两层可以包括单个复合结构，其具有在第二表面上暴露在第一表面上的多孔材料和较少多孔，更致密的材料。 本发明的另一实施例涉及将PTFE层形成为与可植入医疗装置的至少一个表面相邻的可移除构件。 可移除构件可以采取围绕医疗装置的一部分的套筒的形式，并且适于在提取过程期间保持在身体中。 例如，在去除引线期间，套筒保持在主体内并且能够接收替换引线，使得不必干扰附着到套筒上的组织生长。
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公开(公告)号：US06697676B2
公开(公告)日：2004-02-24
申请号：US09836015
申请日：2001-04-17
IPC分类号： A61N104
CPC分类号： A61N1/056 , A61N2001/0578
摘要： An implantable device including an elastically compressible member coupled to a distal end of a lead and further coupled to at least one electrode. The compressible member is in a contracted state when the electrode is being delivered to an implant site. At the implant site, the compressible member is expanded to urge the electrode into contact with tissue. Compressible member further includes a keyed structure to engage a stiffening member such as a stylet. The stiffening member is used both to deliver the electrode to the implant site, and to rotate the compressible member, if necessary, so that the electrode contacts predetermined body tissue. According to one aspect of the invention, an introducer having an inner lumen with a diameter that is smaller than that of the compressible member may be used to disengage the stiffening member from the compressible member. In one embodiment, compressible member includes a conductor wound to form multiple turns that are aligned during electrode delivery, but which expand into a non-aligned configuration after deployment. In another embodiment, compressible member includes a spring clip that has a compressed profile during delivery, and an expanded profile after deployment.
摘要翻译： 一种可植入装置，其包括耦合到引线的远端并进一步耦合到至少一个电极的弹性可压缩构件。 当电极被输送到植入部位时，可压缩构件处于收缩状态。 在植入位置，可压缩构件被膨胀以促使电极与组织接触。 可压缩构件还包括用于接合诸如探针之类的加强构件的键合结构。 加强构件用于将电极输送到植入位置，并且如果需要，可旋转可压缩构件，使得电极接触预定的身体组织。 根据本发明的一个方面，可以使用具有直径小于可压缩构件直径的内腔的导引器来使加强构件从可压缩构件脱离。 在一个实施例中，可压缩构件包括缠绕以形成多个匝的导体，其在电极传递期间对准，但在展开之后扩展成不对准构造。 在另一个实施例中，可压缩构件包括弹簧夹，其在输送期间具有压缩轮廓，并且在展开之后具有扩展轮廓。
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4.发明授权公开(公告)号：US06901289B2
公开(公告)日：2005-05-31
申请号：US10034905
申请日：2001-12-28
申请人： Roger Dahl , Thomas M. Soukup , Joe Perttu , Arnold Thornton , Elisabeth L. Belden , John L. Sommer
发明人： Roger Dahl , Thomas M. Soukup , Joe Perttu , Arnold Thornton , Elisabeth L. Belden , John L. Sommer
CPC分类号： A61N1/056 , A61N2001/0585
摘要： A medical electrical lead is disclosed that is adapted for placement in the coronary sinus, or a branch vein thereof. The lead includes a first and second pace/sense electrode. A selection mechanism is provided to select either the first or the second electrode for use as a cathode, with the other electrode being selected as the anode. According to another aspect of the invention, a high-voltage coil electrode may be provided between the first and second electrodes. The coil electrode may be electrically coupled to the anode to increase the shadow area of the coil electrode.
摘要翻译： 公开了适于放置在冠状窦或其分支静脉中的医用电线。 引线包括第一和第二步进/感测电极。 提供选择机构来选择用作阴极的第一或第二电极，另一个电极被选择为阳极。 根据本发明的另一方面，可以在第一和第二电极之间设置高压线圈电极。 线圈电极可以电耦合到阳极以增加线圈电极的阴影面积。
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公开(公告)号：US5609622A
公开(公告)日：1997-03-11
申请号：US571580
申请日：1995-12-12
IPC分类号： A61N1/05
CPC分类号： A61N1/056 , A61N1/0565
摘要： An implantable electrode in the form a helically wound conductor having an electrically conductive polymeric layer coaxially surrounding and contacting the helically wound conductor, wherein the electrically conductive polymeric layer is electrically conductive in a dry state prior to implantation. Preferably, the electrode has two conductive portions, the additional second conductive portion being preferably located at the distal tip. The implantable electrode preferably incorporates an insulating portion wherein an additional length of the helically wound conductor is continuous with the remaining length of helically wound conductor coaxially covered by the electrically conductive polymeric layer. The insulating portion has a coaxial covering of impermeable polymeric electrically insulating material which is preferably silicone tubing. More preferably the coaxial covering of impermeably polymeric electrically insulating material has an additional exterior coaxial covering of porous PTFE for improved biocompatibility and flexibility. The porous PTFE is preferably porous expanded PTFE having a fibril length of less than 10 microns in order to substantially preclude tissue ingrowth and tissue attachment. The electrically conductive polymeric layer of the electrode is preferably made of porous expanded PTFE containing an electrically conductive filler, the porous expanded PTFE again having a fibril length of less than 10 microns.
摘要翻译： 形成螺旋缠绕导体的可植入电极，其具有同轴地围绕并接触螺旋缠绕导体的导电聚合物层，其中导电聚合物层在植入之前处于干燥状态下导电。 优选地，电极具有两个导电部分，附加的第二导电部分优选位于远端。 可植入电极优选地包括绝缘部分，其中螺旋缠绕的导体的额外长度与由导电聚合物层同轴地覆盖的螺旋缠绕导体的剩余长度连续。 绝缘部分具有不可渗透的聚合物电绝缘材料的同轴覆盖物，其优选为硅胶管。 更优选地，不透水聚合物电绝缘材料的同轴覆盖物具有用于改善生物相容性和柔韧性的多孔PTFE的另外的外部同轴覆盖。 多孔PTFE优选是原纤维长度小于10微米的多孔膨体PTFE，以便基本上排除组织向内生长和组织附着。 电极的导电聚合物层优选由含有导电填料的多孔膨体PTFE制成，多孔膨体PTFE再次具有小于10微米的原纤维长度。
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公开(公告)号：US5330700A
公开(公告)日：1994-07-19
申请号：US761576
申请日：1991-09-18
CPC分类号： A61N1/0565 , Y10T428/12021 , Y10T428/12042
摘要： A porous electrode for pacemakers is comprised of a plurality of platinum globules sintered together to form a porous mass of semi-hemispherical shape at the end of a platinum electrode stem. The globules, which are themselves made by sintering together spherically-shaped particles of approximately one micron diameter, provide the globules with an irregular outer surface of high total surface area. The globules have diameters within a critical range of 40-200 microns. The large total surface area of the globules improves the sensing function of an electrode configuration of given size and surface area, while the globule diameters of 40-200 microns have been found to beneficially accommodate tissue ingrowth within the electrode. In a preferred method of making the electrode, the platinum globules, which are formed by sintering together platinum particles of much smaller size, are mixed with organic solvent and organic binder to form a paste. After application of the paste to the base of an electrode stem and pressing of the paste using a mold so as to form the paste into the desired semi-hemispherical shape, the electrode is heated to evaporate the organic solvent, and the electrode is then placed in a sintering furnace to sinter together the platinum globules and form the completed electrode.
摘要翻译： 用于起搏器的多孔电极由多个铂球组成，其在铂电极杆的末端烧结在一起以形成半球形的多孔质量块。 本身通过将大约一微米直径的球形颗粒烧结在一起的小球为球提供了具有高总表面积的不规则外表面。 小球具有在40-200微米的临界范围内的直径。 球的大的总表面积改善了给定尺寸和表面积的电极构型的感测功能，而发现40-200微米的球直径有利地适应电极内的组织向内生长。 在制造电极的优选方法中，将通过将较小尺寸的铂颗粒烧结在一起形成的铂球与有机溶剂和有机粘合剂混合以形成糊料。 在将糊剂施加到电极杆的基部并使用模具压制糊料以形成所需的半球形状的糊料之后，加热电极以蒸发有机溶剂，然后将电极放置 在烧结炉中烧结铂球并形成完成的电极。
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公开(公告)号：US5020545A
公开(公告)日：1991-06-04
申请号：US468527
申请日：1990-01-23
申请人： Thomas M. Soukup
发明人： Thomas M. Soukup
IPC分类号： A61N1/05
CPC分类号： A61N1/0573
摘要： A cardiac lead assembly for use with a heart pacemaker. The assembly has an inner electrode with a corkscrew tip, and an electrode housing which can be comprised of a second electrode. A conductor is connected to the inner electrode for supplying electricity thereto and is comprised of a tubular coil. The inner electrode can be manually moved longitudinally relative to the electrode housing by a stylet. The inner electrode and the housing cooperate to prevent axial rotation of the inner electrode at a first longitudinal position, but allow rotation at a second longitudinal position. The first conductor coil can be suitably twisted such that upon movement of the inner electrode to the second position the coil can automatically axially rotate the inner electrode to screw the corkscrew tip into a patient's heart.
摘要翻译： 心脏引导组件，用于心脏起搏器。 该组件具有带螺塞头的内部电极和可由第二电极组成的电极壳体。 导线与内电极相连，用于供电，并由管状线圈构成。 内部电极可以通过探针通过手动方式相对于电极壳体移动。 内部电极和壳体协作以防止内部电极在第一纵向位置处的轴向旋转，但允许在第二纵向位置处的旋转。 第一导体线圈可以适当地扭曲，使得当内部电极移动到第二位置时，线圈可以自动轴向旋转内部电极以将开塞杆尖端旋入病人的心脏。
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公开(公告)号：US5466252A
公开(公告)日：1995-11-14
申请号：US955611
申请日：1992-10-02
CPC分类号： A61N1/05
摘要： An implantable lead for use with cardiac pacemakers, defibrillators and other long term implantable electrical devices intended for sensing or tissue stimulation, having a helically wound conductor with a surrounding tubular insulating layer of elastomeric material such as silicone or polyurethane and an additional coaxial tubular exterior biocompatible layer of porous PTFE having a microstructure of nodes interconnected by fibrils. The exterior tubular layer of porous PTFE may be fitted coaxially over the elastomeric tubular layer whereby the porous PTFE tubular layer is in longitudinal compression and the fibrils within the microstructure have a bent and wavy appearance. Any portion of the length of the porous PTFE tubing in longitudinal compression allows that portion of the length of the lead wire to be extensible to a controlled extent limited by the straightening of the bent fibrils within the porous PTFE microstructure.
摘要翻译： 用于心脏起搏器，除颤器和用于感测或组织刺激的其它长期可植入电气装置的可植入导线，具有螺旋缠绕的导体，其具有诸如硅树脂或聚氨酯的弹性体材料的周围管状绝缘层，以及另外的同轴管状外部生物相容性 具有通过原纤维互连的节点的微结构的多孔PTFE层。 多孔PTFE的外部管状层可以同轴地装配在弹性体管层上，由此多孔PTFE管状层处于纵向压缩状态，并且微结构体内的原纤维具有弯曲和波浪形的外观。 多孔PTFE管的纵向压缩长度的任何部分允许引线长度的那部分可延伸到受多孔PTFE微结构内弯曲原纤维矫正所限制的受限程度。
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公开(公告)号：US5097843A
公开(公告)日：1992-03-24
申请号：US507698
申请日：1990-04-10
IPC分类号： A61N1/05
CPC分类号： A61N1/0565 , Y10T428/12021 , Y10T428/12042
摘要： A porous electrode for pacemakers is comprised of a plurality of platinum globules sintered together to form a porous mass of semi-hemispherical shape at the end of a platinum electrode stem. The globules, which are themselves made by sintering together spherically-shaped particles of approximately one micron diameter, provide the globules with an irregular outer surface of high total surface area. The globules have diameters within a critical range of 40-200 microns. The large total surface area of the globules improves the sensing function of an electrode configuration of given size and surface area, while the globule diameters of 40-200 microns have been found to beneficially accommodate tissue ingrowth within the electrode. In a preferred method of making the electrode, the platinum globules, which are formed by sintering together platinum particles of much smaller size, are mixed with organic solvent and organic binder to form a paste. After application of the paste to the base of an electrode stem and pressing of the paste using a mold so as to form the paste into the desired semi-hemispherical shape, the electrode is heated to evaporate the organic solvent, and the electrode is then placed in a sintering furnace to sinter together the platinum globules and form the completed electrode.
摘要翻译： 用于起搏器的多孔电极由多个铂球组成，其在铂电极杆的末端烧结在一起以形成半球形的多孔质量块。 本身通过将大约一微米直径的球形颗粒烧结在一起的小球为球提供了具有高总表面积的不规则外表面。 小球具有在40-200微米的临界范围内的直径。 球的大的总表面积改善了给定尺寸和表面积的电极构型的感测功能，而发现40-200微米的球直径有利地适应电极内的组织向内生长。 在制造电极的优选方法中，将通过将较小尺寸的铂颗粒烧结在一起形成的铂球与有机溶剂和有机粘合剂混合以形成糊料。 在将糊剂施加到电极杆的基部并使用模具压制糊料以形成所需的半球形状的糊料之后，加热电极以蒸发有机溶剂，然后将电极放置 在烧结炉中烧结铂球并形成完成的电极。
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公开(公告)号：US07892186B2
公开(公告)日：2011-02-22
申请号：US11298548
申请日：2005-12-09
CPC分类号： A61M25/0136 , A61B2017/00469 , A61B2017/2919
摘要： The invention includes an assembly having a handle for articulating an articulator in an ergonomically improved manner. The handle can be adapted to articulate a distal portion of the articulator when squeezed. The handle can have at least one accessible attachment mechanism useful for reattachably attaching the articulator and the handle during a medical procedure. The invention also includes methods of making and using such a handle.
摘要翻译： 本发明包括具有用于以人体工程学改进的方式铰接咬合器的手柄的组件。 手柄可以适于在挤压时将咬合器的远端部分铰接。 手柄可以具有至少一个可接近的附接机构，用于在医疗过程期间可重新附接关节器和手柄。 本发明还包括制造和使用这种手柄的方法。
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