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1.发明授权System for promoting selective tissue in-growth for an implantable medical device 失效用于促进植入式医疗装置的选择性组织生长的系统公开(公告)号：US07079902B2
公开(公告)日：2006-07-18
申请号：US10671103
申请日：2003-09-25
IPC分类号： A61N1/05
CPC分类号： A61N1/0563 , A61N2001/0578
摘要： A system including an implantable defibrillation electrode includes a first layer of porous Polytetrafluoroethylene (PTFE) adjacent to at least one surface of the defibrillation electrode, the first layer of porous PTFE having a fibril length adapted to bleed gas away from the at least one surface of the defibrillation electrode, and a second layer of porous PTFE formed over the first layer, the second layer of porous PTFE having a fibril length adapted to prevent substantially all tissue in-growth.
摘要翻译： 包括植入式除颤电极的系统包括与除颤电极的至少一个表面相邻的多孔聚四氟乙烯（PTFE）的第一层，第一层多孔PTFE具有原纤维长度，其适于将气体从至少一个表面 除颤电极和形成在第一层上的第二多孔PTFE层，第二层多孔PTFE具有适于防止基本上所有组织生长的原纤维长度。
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2.发明授权System and method for promoting selective tissue in-growth for an implantable medical device 有权用于促进可植入医疗装置的选择性组织生长的系统和方法公开(公告)号：US06704604B2
公开(公告)日：2004-03-09
申请号：US09827103
申请日：2001-04-05
IPC分类号： A61N105
CPC分类号： A61N1/0563 , A61N2001/0578
摘要： Disclosed is an improved system and method to selectively promote tissue in-growth on, or adjacent to, an implantable medical device. In one embodiment, at least one surface of the housing of a medical device is in contact with a first portion of a porous PTFE having a pore size adapted to prevent substantially all tissue in-growth. This first portion, or layer, of porous PTFE material is further in contact at predetermined locations with an additional porous PTFE layer having a pore size adapted to selectively promote tissue in-growth only at the predetermined locations. Each of the PTFE layers may be formed of porous PTFE tubing or tape. Alternatively, the two layers may comprise a single composite structure that has a more porous material exposed on a first surface, and a less porous, more dense, material on a second surface. Another embodiment of the invention involves forming the layers of PTFE into a removable member that is adjacent to at least one surface of the implantable medical device. The removable member may take the form of a sleeve that surrounds a portion of a the medical device and is adapted to remain in the body during an extraction process. For example, during the removal of a lead, the sleeve remains within the body and is capable of receiving a replacement lead, making it unnecessary to disturb tissue in-growth attached to the sleeve.
摘要翻译： 公开了一种改进的系统和方法，用于选择性地促进在可植入医疗装置上或与植入式医疗装置相邻的组织生长。 在一个实施例中，医疗装置的壳体的至少一个表面与多孔PTFE的第一部分接触，孔的孔径适于防止基本上所有的组织生长。 多孔PTFE材料的该第一部分或多层进一步在预定位置处接触，另外的多孔PTFE层具有适于仅在预定位置选择性地促进组织生长的孔径。 每个PTFE层可以由多孔PTFE管或带形成。 或者，两层可以包括单个复合结构，其具有在第二表面上暴露在第一表面上的多孔材料和较少多孔，更致密的材料。 本发明的另一实施例涉及将PTFE层形成为与可植入医疗装置的至少一个表面相邻的可移除构件。 可移除构件可以采取围绕医疗装置的一部分的套筒的形式，并且适于在提取过程期间保持在身体中。 例如，在去除引线期间，套筒保持在主体内并且能够接收替换引线，使得不必干扰附着到套筒上的组织生长。
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公开(公告)号：US08271100B2
公开(公告)日：2012-09-18
申请号：US12726875
申请日：2010-03-18
CPC分类号： A61N1/04 , A61N1/025 , A61N1/056 , H01R4/70 , H01R2201/12 , Y10S439/909
摘要： A medical electrical lead includes a lead body, an inner assembly extending throught the lead body, an outer insulative layer covering the inner assembly, and an electrode mounted outside the exterior surface of the outer insulative layer. The inner assembly includes an elongate inner structure forming a lumen, an elongate conductor extending along an outer surface of the inner structure, and a conductive fitting coupled to the elongate conductor.
摘要翻译： 医用电线包括引线体，延伸穿过引线体的内部组件，覆盖内部组件的外部绝缘层和安装在外部绝缘层的外表面外部的电极。 内部组件包括形成内腔的细长内部结构，沿着内部结构的外表面延伸的细长导体，以及耦合到细长导体的导电配件。
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公开(公告)号：US20090254162A1
公开(公告)日：2009-10-08
申请号：US12324018
申请日：2008-11-26
申请人： Thomas Quinci , John Squeri , Gregory A. Boser
发明人： Thomas Quinci , John Squeri , Gregory A. Boser
IPC分类号： A61N1/04
CPC分类号： A61N1/05 , A61N1/056 , H01R4/70 , H01R2201/12
摘要： A method for making an elongate medical device includes coupling a conductive fitting to an elongate conductor and providing an opening through an insulative layer in proximity to the fitting in order to expose the fitting.
摘要翻译： 用于制造细长医疗装置的方法包括将导电配件联接到细长导体并且提供穿过靠近配件的绝缘层的开口，以暴露配件。
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公开(公告)号：US20090082655A1
公开(公告)日：2009-03-26
申请号：US12234466
申请日：2008-09-19
CPC分类号： A61N1/056 , A61N1/05 , H01B7/0823 , Y10T29/49194
摘要： A conductor assembly for a medical electrical lead includes a web and plurality of conductors. The web includes a plurality of longitudinally extending elements, or sidewalls, each of which define a longitudinally extending lumen, and a plurality of longitudinally extending connectors, each of which join a pair of adjacent sidewalls. Each of the plurality of conductors extends within a corresponding lumen, and each may include an insulative jacket. If each conductor includes an insulative jacket, the jacket is preferably formed from one or more of the following materials: PEEK, PVDF and polysulfone. One or more of the connectors of the web may be flexible to allow for a connected separation, or a gap between adjacent sidewalls; and one or more of these connectors may further include a discrete wall section adapted to facilitate widening of the corresponding gap. Preferably the conductor assembly is coiled for incorporation into the lead.
摘要翻译： 用于医疗电线的导体组件包括腹板和多个导体。 腹板包括多个纵向延伸的元件或侧壁，每个侧壁限定纵向延伸的内腔，以及多个纵向延伸的连接器，每个连接件连接一对相邻的侧壁。 多个导体中的每一个在相应的内腔内延伸，并且每个可以包括绝缘护套。 如果每个导体包括绝缘护套，则护套优选由以下一种或多种材料形成：PEEK，PVDF和聚砜。 纤维网的一个或多个连接器可以是柔性的，以允许连接的间隔或相邻侧壁之间的间隙; 并且这些连接器中的一个或多个可以进一步包括适于促进相应间隙加宽的离散壁部分。 优选地，导体组件被卷绕以结合到引线中。
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公开(公告)号：US20110301680A1
公开(公告)日：2011-12-08
申请号：US13209265
申请日：2011-08-12
IPC分类号： A61N1/05
CPC分类号： A61N1/05 , A61N1/0563 , Y10T29/49123 , Y10T29/49204
摘要： A medical device lead is presented. The lead includes one or more jacketed conductive elements. The jacket comprises one or more covers. A first cover of polyether ketone (PEEK) is in direct contact with the at least one conductive element. At least one conductive element and a PEEK cover are coiled. The coiled conductive element can substantially retain its original coiled shape.
摘要翻译： 提供医疗器械引线。 引线包括一个或多个夹套导电元件。 夹克包括一个或多个盖。 聚醚酮（PEEK）的第一盖与至少一个导电元件直接接触。 至少一个导电元件和PEEK盖盘绕。 盘绕的导电元件可以基本上保持其原始的盘绕形状。
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公开(公告)号：US20110282420A1
公开(公告)日：2011-11-17
申请号：US12781181
申请日：2010-05-17
CPC分类号： A61N1/05 , A61N1/056 , H01R4/184 , H01R2201/12 , Y10T29/49174
摘要： An inner surface of a coupling component sidewall forms first and second portions of a cavity of the coupling component. A conductive coupling between an electrode and a conductor of a medical electrical lead may be formed by inserting a segment of the conductor into the first portion of the cavity, crimping the sidewall of the coupling component around the inserted segment, inserting a segment of the electrode into the second portion of the cavity, and welding an edge of the sidewall to the inserted electrode segment. The edge of the sidewall may define a slot, extending between first and second portions of the cavity, or a hole extending through the sidewall. The electrode may be part of an electrode assembly, mounted around an inner insulation layer of the lead, and the conductor may be part of a conductor assembly extending between inner and outer insulation layers of the lead.
摘要翻译： 耦合部件侧壁的内表面形成耦合部件的空腔的第一和第二部分。 医疗电引线的电极和导体之间的导电耦合可以通过将导体的一部分插入空腔的第一部分中，将耦合部件的侧壁压在插入的部分周围，插入电极的一部分 进入空腔的第二部分，并且将侧壁的边缘焊接到插入的电极段。 侧壁的边缘可以限定在空腔的第一和第二部分之间延伸的狭槽或延伸穿过侧壁的孔。 电极可以是围绕引线的内绝缘层安装的电极组件的一部分，并且导体可以是在引线的内绝缘层和外绝缘层之间延伸的导体组件的一部分。
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公开(公告)号：US20090076578A1
公开(公告)日：2009-03-19
申请号：US12211070
申请日：2008-09-15
IPC分类号： A61N1/05
CPC分类号： A61N1/05 , A61N1/0563 , Y10T29/49123 , Y10T29/49204
摘要： A medical device lead is presented. The lead includes one or more jacketed conductive elements. The jacket comprises one or more covers. A first cover of polytetrafluoroethylene (PTFE) is in direct contact with the at least one conductive element. At least one conductive element and a PTFE cover are coiled. The coiled conductive element can substantially retain its original coiled shape.
摘要翻译： 提供医疗器械引线。 引线包括一个或多个夹套导电元件。 夹克包括一个或多个盖。 聚四氟乙烯（PTFE）的第一盖与至少一个导电元件直接接触。 至少一个导电元件和PTFE盖板被卷绕。 盘绕的导电元件可以基本上保持其原始的盘绕形状。
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公开(公告)号：US5837006A
公开(公告)日：1998-11-17
申请号：US711747
申请日：1996-09-10
IPC分类号： A61N1/05
CPC分类号： A61N1/0573
摘要： In an endocardial, active fixation, screw-in lead of the type having a fixation helix adapted to be rotated in a first, advancement direction out of an electrode head chamber and into cardiac tissue by rotation of a lead connector end and attached lead conductor with respect to an insulating sheath in the first direction and retracted into the chamber by rotation of the lead connector in the opposite, retraction direction, a retraction stop mechanism for preventing over rotation of the helix in the retraction direction. The rotational motion of the lead conductor is transmitted to the helix by a connecting assembly and is translated into axial advancement and retraction of the helix by a guide cooperating with the helix turns. A retraction stop mechanism stops rotation of the helix in the retraction direction upon full retraction of the helix into the chamber and allows rotation of helix in the advancement direction. The retraction stop mechanism includes a fixed stop formed of a plurality of fixed cam and axial stop surfaces surrounding a proximal end bore of the chamber through which the lead conductor passes and a movable stop formed in the connecting mechanism of a like plurality of rotatable cam and axial stop surfaces aligned to face the fixed cam and axial stop surfaces adapted to engage in a locked relation of the stop surfaces upon full retraction of the fixation device into the chamber.
摘要翻译： 在心内膜，主动固定中，具有固定螺旋的类型的螺钉引导件，其适于通过引导连接器端部和连接的引线导体的旋转而沿第一前进方向从电极头腔室旋转并进入心脏组织， 相对于第一方向上的绝缘护套并且通过引导连接器沿相反的缩回方向的旋转而缩回到腔室中，用于防止螺旋线沿收回方向过度旋转的缩回停止机构。 引线导体的旋转运动通过连接组件传递到螺旋线，并且通过与螺旋线圈配合的导向器被转换为螺旋线的轴向前进和缩回。 缩回停止机构在将螺旋完全缩回到室中后能够阻止螺旋在回缩方向的旋转，并允许螺旋在推进方向上旋转。 缩回停止机构包括由多个固定凸轮和围绕引线导体穿过的室的近端孔的轴向止动表面形成的固定止动件，以及形成在类似多个可旋转凸轮的连接机构中的可移动止动件， 轴向止动表面，其对准固定凸轮和轴向止动表面，适于在固定装置完全缩回到腔室中时与止动表面接合。
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公开(公告)号：US09402989B2
公开(公告)日：2016-08-02
申请号：US12211070
申请日：2008-09-15
IPC分类号： A61N1/05
CPC分类号： A61N1/05 , A61N1/0563 , Y10T29/49123 , Y10T29/49204
摘要： A medical device lead. The lead includes one or more jacketed conductive elements. The jacket comprises one or more covers. A first cover of polytetrafluoroethylene (PTFE) is in direct contact with the at least one conductive element. The at least one conductive element and the PTFE cover are coiled. The coiled conductive element can substantially retain its original coiled shape.
摘要翻译： 医疗器械铅。 引线包括一个或多个夹套导电元件。 夹克包括一个或多个盖。 聚四氟乙烯（PTFE）的第一盖与至少一个导电元件直接接触。 至少一个导电元件和PTFE盖被卷绕。 盘绕的导电元件可以基本上保持其原始的盘绕形状。
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