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    Methods of detecting early renal disease in animals
    3.
    发明授权
    Methods of detecting early renal disease in animals 有权
    检测动物早期肾病的方法

    公开(公告)号：US07172873B2

    公开(公告)日：2007-02-06

    申请号：US10112648

    申请日：2002-03-28

    申请人： Thomas McDonald ,  Wayne Arthur Jensen ,  Annika Weber ,  Janet S. Andrews

    发明人： Thomas McDonald ,  Wayne Arthur Jensen ,  Annika Weber ,  Janet S. Andrews

    IPC分类号： G01N33/53

    CPC分类号： G01N33/68 ,  C07K16/18 ,  G01N33/6893 ,  G01N2800/347 ,  Y10S436/808 ,  Y10S436/815

    摘要： The present invention provides a method for the detection of early renal disease in animals. The method includes the steps of (a) obtaining a sample from an animal to be tested and (b) determining the amount of albumin in the sample. An amount of albumin in the range of from 10 μg/ml to about 300 μg/ml indicates the presence of early renal disease. The present invention also provides antibodies to canine, feline and equine albumin which can be used to detect the presence of early renal disease.

    摘要翻译： 本发明提供一种检测动物早期肾病的方法。 该方法包括以下步骤：（a）从待测试的动物获得样品，和（b）测定样品中白蛋白的量。 10μg/ ml至约300μg/ ml范围内的白蛋白量表明存在早期肾脏疾病。 本发明还提供了可用于检测早期肾病的存在的犬，猫和马白蛋白的抗体。

    Mammary-associated serum amuloid a3 promoter sequences and used for same
    4.
    发明申请
    Mammary-associated serum amuloid a3 promoter sequences and used for same 审中-公开
    乳腺相关血清amuloid a3启动子序列并用于相同

    公开(公告)号：US20050107315A1

    公开(公告)日：2005-05-19

    申请号：US10494484

    申请日：2002-11-20

    申请人： Thomas McDonald ,  Marilynn Larson ,  Annika Weber

    发明人： Thomas McDonald ,  Marilynn Larson ,  Annika Weber

    IPC分类号： A61K38/00 ,  C07K14/47 ,  A61K48/00 ,  A61K38/17 ,  C07H21/04 ,  C12N9/64

    CPC分类号： C07K14/4711 ,  A61K38/00

    摘要： Novel colostrum associated mammalian Serum Amyloid A (SAA) promoter sequences are disclosed. These promoters can be used in transgenic protocols for tissue specific expression and expression constructs, vectors and host cells are disclosed. Also the regulatory features of these promoters in colostrum associated SAA productions are exploited to treat disease states associated with or influenced by colostrum associated SAA production.

    摘要翻译： 公开了新型初乳相关哺乳动物血清淀粉样蛋白A（SAA）启动子序列。 这些启动子可以用于组织特异性表达和表达构建体的转基因方案，载体和宿主细胞被公开。 此外，这些启动子在初乳相关SAA生产中的调节特征也被用于治疗与初乳相关的SAA产生相关或受其影响的疾病状态。

    Novel anti-feline albumin antibodies and methods of detecting early renal disease
    6.
    发明申请
    Novel anti-feline albumin antibodies and methods of detecting early renal disease 失效
    新型抗猫白蛋白抗体及早期肾病检测方法

    公开(公告)号：US20060281131A1

    公开(公告)日：2006-12-14

    申请号：US10550563

    申请日：2004-03-25

    申请人： Wayne Jensen ,  Shirley Hunter ,  Karen Sverlow ,  Thomas McDonald ,  Annika Weber ,  Janet Andrews

    发明人： Wayne Jensen ,  Shirley Hunter ,  Karen Sverlow ,  Thomas McDonald ,  Annika Weber ,  Janet Andrews

    IPC分类号： G01N33/53 ,  C12N5/06

    CPC分类号： G01N33/6893 ,  C07K16/18 ,  G01N33/6827 ,  G01N2333/765 ,  G01N2800/347 ,  G01N2800/52

    摘要： The present invention provides isolated monoclonal antibodies that selectively bind albumin from animals. Also provided are methods using such antibodies for the detection of early renal disease in animals. The method includes the steps of (a) obtaining a sample from an animal to be tested; (b) contacting the sample with an antibody having a greater avidity for feline albumin than for other proteins or components in the sample; (c) detecting the complex formed by the antibody and albumin; and (d) determining the amount of albumin in the sample from the amount of antibody-albumin complex detected. An amount of albumin in the range of from 10 μg/ml to about 300 μg/ml indicates the presence of early renal disease.

    摘要翻译： 本发明提供了从动物中选择性结合白蛋白的分离的单克隆抗体。 还提供了使用这种抗体检测动物早期肾脏疾病的方法。 该方法包括以下步骤：（a）从待测动物获得样品; （b）使样品与样品中其它蛋白质或组分具有比猫眼白蛋白更高亲合力的抗体接触; （c）检测由抗体和白蛋白形成的复合物; 和（d）从检测到的抗体 - 白蛋白复合物的量确定样品中白蛋白的量。 10μg/ ml至约300μg/ ml范围内的白蛋白量表明存在早期肾脏疾病。

    Diagnostic assays of secreted biological fluids for detection of infection and inflammatory conditions
    8.
    发明授权
    Diagnostic assays of secreted biological fluids for detection of infection and inflammatory conditions 有权
    用于检测感染和炎症状态的分泌生物液体的诊断测定

    公开(公告)号：US07569338B1

    公开(公告)日：2009-08-04

    申请号：US10069810

    申请日：1999-08-25

    申请人： Thomas L. McDonald ,  Annika Weber

    发明人： Thomas L. McDonald ,  Annika Weber

    IPC分类号： C12Q1/00 ,  G01N33/53

    CPC分类号： C12Q1/6883 ,  C12Q2600/158 ,  G01N33/6893

    摘要： A rapid and convenient method for detecting inflammatory conditions in breast tissue, such as those associated with mastitis, is described. The method comprises measuring the presence and quantity of Serum Amyloid A (SAA) in milk samples obtained from the breast tissue. The amount of SAA present in the milk is positively correlated with the level of inflammation of the breast tissue, and can localize the inflammation to a particular region of the breast organ, such as a specific quadrant of a cow's udder. Test kits and their use in the method are also described.

    摘要翻译： 描述了用于检测乳腺组织中炎症状况的快速方便的方法，例如与乳腺炎相关的那些。 该方法包括测量从乳房组织获得的乳样品中血清淀粉样蛋白A（SAA）的存在和量。 牛奶中存在的SAA的量与乳房组织的炎症水平正相关，并且可以将炎症定位到乳房器官的特定区域，例如牛乳房的特定象限。 还描述了测试试剂盒及其在该方法中的用途。

    Serum amyloid a isoform from colostrum
    10.
    发明授权
    Serum amyloid a isoform from colostrum 失效
    来自初乳的血清淀粉样蛋白a同种型

    公开(公告)号：US06509444B1

    公开(公告)日：2003-01-21

    申请号：US09425679

    申请日：1999-10-22

    申请人： Thomas L. McDonald ,  Annika Weber

    发明人： Thomas L. McDonald ,  Annika Weber

    IPC分类号： C07K1400

    CPC分类号： C07K14/4711 ,  A61K38/00

    摘要： A novel Serum Amyloid A (SAA), isolated and purified from mammalian colostrum, is disclosed. The SAA has been isolated from colostrum of several mammalian species, including horse, cow and sheep. Nucleic acid molecules encoding the colostrum SAA, and antibodies immunologically specific for the colostrum SAA, are also disclosed.

    摘要翻译： 公开了一种从哺乳动物初乳中分离纯化的新型血清淀粉样蛋白A（SAA）。 SAA已经从几种哺乳动物物种的初乳中分离出来，包括马，牛和羊。 还公开了编码初乳SAA的核酸分子和对初乳SAA具有免疫学特异性的抗体。