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    Novel anti-feline albumin antibodies and methods of detecting early renal disease
    1.
    发明申请
    Novel anti-feline albumin antibodies and methods of detecting early renal disease 失效
    新型抗猫白蛋白抗体及早期肾病检测方法

    公开(公告)号：US20060281131A1

    公开(公告)日：2006-12-14

    申请号：US10550563

    申请日：2004-03-25

    申请人： Wayne Jensen ,  Shirley Hunter ,  Karen Sverlow ,  Thomas McDonald ,  Annika Weber ,  Janet Andrews

    发明人： Wayne Jensen ,  Shirley Hunter ,  Karen Sverlow ,  Thomas McDonald ,  Annika Weber ,  Janet Andrews

    IPC分类号： G01N33/53 ,  C12N5/06

    CPC分类号： G01N33/6893 ,  C07K16/18 ,  G01N33/6827 ,  G01N2333/765 ,  G01N2800/347 ,  G01N2800/52

    摘要： The present invention provides isolated monoclonal antibodies that selectively bind albumin from animals. Also provided are methods using such antibodies for the detection of early renal disease in animals. The method includes the steps of (a) obtaining a sample from an animal to be tested; (b) contacting the sample with an antibody having a greater avidity for feline albumin than for other proteins or components in the sample; (c) detecting the complex formed by the antibody and albumin; and (d) determining the amount of albumin in the sample from the amount of antibody-albumin complex detected. An amount of albumin in the range of from 10 μg/ml to about 300 μg/ml indicates the presence of early renal disease.

    摘要翻译： 本发明提供了从动物中选择性结合白蛋白的分离的单克隆抗体。 还提供了使用这种抗体检测动物早期肾脏疾病的方法。 该方法包括以下步骤：（a）从待测动物获得样品; （b）使样品与样品中其它蛋白质或组分具有比猫眼白蛋白更高亲合力的抗体接触; （c）检测由抗体和白蛋白形成的复合物; 和（d）从检测到的抗体 - 白蛋白复合物的量确定样品中白蛋白的量。 10μg/ ml至约300μg/ ml范围内的白蛋白量表明存在早期肾脏疾病。

    Methods of detecting early renal disease in animals
    6.
    发明授权
    Methods of detecting early renal disease in animals 有权
    检测动物早期肾病的方法

    公开(公告)号：US07172873B2

    公开(公告)日：2007-02-06

    申请号：US10112648

    申请日：2002-03-28

    申请人： Thomas McDonald ,  Wayne Arthur Jensen ,  Annika Weber ,  Janet S. Andrews

    发明人： Thomas McDonald ,  Wayne Arthur Jensen ,  Annika Weber ,  Janet S. Andrews

    IPC分类号： G01N33/53

    CPC分类号： G01N33/68 ,  C07K16/18 ,  G01N33/6893 ,  G01N2800/347 ,  Y10S436/808 ,  Y10S436/815

    摘要： The present invention provides a method for the detection of early renal disease in animals. The method includes the steps of (a) obtaining a sample from an animal to be tested and (b) determining the amount of albumin in the sample. An amount of albumin in the range of from 10 μg/ml to about 300 μg/ml indicates the presence of early renal disease. The present invention also provides antibodies to canine, feline and equine albumin which can be used to detect the presence of early renal disease.

    摘要翻译： 本发明提供一种检测动物早期肾病的方法。 该方法包括以下步骤：（a）从待测试的动物获得样品，和（b）测定样品中白蛋白的量。 10μg/ ml至约300μg/ ml范围内的白蛋白量表明存在早期肾脏疾病。 本发明还提供了可用于检测早期肾病的存在的犬，猫和马白蛋白的抗体。

    Mammary-associated serum amuloid a3 promoter sequences and used for same
    7.
    发明申请
    Mammary-associated serum amuloid a3 promoter sequences and used for same 审中-公开
    乳腺相关血清amuloid a3启动子序列并用于相同

    公开(公告)号：US20050107315A1

    公开(公告)日：2005-05-19

    申请号：US10494484

    申请日：2002-11-20

    申请人： Thomas McDonald ,  Marilynn Larson ,  Annika Weber

    发明人： Thomas McDonald ,  Marilynn Larson ,  Annika Weber

    IPC分类号： A61K38/00 ,  C07K14/47 ,  A61K48/00 ,  A61K38/17 ,  C07H21/04 ,  C12N9/64

    CPC分类号： C07K14/4711 ,  A61K38/00

    摘要： Novel colostrum associated mammalian Serum Amyloid A (SAA) promoter sequences are disclosed. These promoters can be used in transgenic protocols for tissue specific expression and expression constructs, vectors and host cells are disclosed. Also the regulatory features of these promoters in colostrum associated SAA productions are exploited to treat disease states associated with or influenced by colostrum associated SAA production.

    摘要翻译： 公开了新型初乳相关哺乳动物血清淀粉样蛋白A（SAA）启动子序列。 这些启动子可以用于组织特异性表达和表达构建体的转基因方案，载体和宿主细胞被公开。 此外，这些启动子在初乳相关SAA生产中的调节特征也被用于治疗与初乳相关的SAA产生相关或受其影响的疾病状态。

    Vehicle with Enhanced Entertainment and Storage Options
    8.
    发明申请
    Vehicle with Enhanced Entertainment and Storage Options 有权

    公开(公告)号：US20220355707A1

    公开(公告)日：2022-11-10

    申请号：US17314207

    申请日：2021-05-07

    申请人： Thomas McDonald

    发明人： Thomas McDonald

    IPC分类号： B60N2/01 ,  B60R7/04 ,  B60R11/02

    摘要： A family sized vehicle or car with enhanced entertainment and storage options is disclosed. The vehicle or car of the present invention offers a family functionality, comfort, and style when traveling, especially when traveling long distances with children. The vehicle or car of the present invention includes three rows of seats, having two seats in each of the first and second rows, and four seats connected and arc-positioned in a rear third row. The novel vehicle of the present invention also includes two hidden compartments for the storage of personal items, a relatively deep trunk storage area for luggage, suicide doors, a moonroof and two nine-inch televisions for entertainment.

    Processor including fallback branch prediction mechanism for far jump and far call instructions
    10.
    发明申请
    Processor including fallback branch prediction mechanism for far jump and far call instructions 有权
    处理器包括远程跳转和远程呼叫指令的后备分支预测机制

    公开(公告)号：US20050210224A1

    公开(公告)日：2005-09-22

    申请号：US10279208

    申请日：2002-10-22

    申请人： Gerard Col ,  Thomas McDonald

    发明人： Gerard Col ,  Thomas McDonald

    IPC分类号： G06F7/38 ,  G06F9/00 ,  G06F9/32 ,  G06F9/38

    CPC分类号： G06F9/3806 ,  G06F9/30054 ,  G06F9/383 ,  G06F9/3842

    摘要： A method and apparatus are provided for processing far jump-call branch instructions within a processor in a manner which reduces the number of stalls of the processor pipeline. The processor includes an apparatus, for providing a fallback far jump-call speculative target address that corresponds to a current far jump-call branch instruction. The microprocessor apparatus includes a far jump-call branch target buffer and a fallback speculative target address generator. The far jump-call branch target buffer stores a plurality of code segment bases and offsets corresponding to a plurality of previously executed far jump-call branch instructions, and determines if a hit for the current far jump-call branch instruction is contained therein. The fallback speculative target address generator is coupled to the far jump-call branch target buffer. In the event of a miss in the far jump-call branch target buffer, the fall back speculative target address generator venerates the fallback far jump-call speculative target address from a current code segment base and a current offset, the current offset corresponding to the current far jump-call branch instruction.

    摘要翻译： 提供了一种方法和装置，用于以减少处理器流水线的停顿次数的方式处理处理器内的远程跳转呼叫分支指令。 处理器包括用于提供对应于当前远程跳转呼叫分支指令的后备远程跳转呼叫推测目标地址的装置。 微处理器装置包括远程跳转呼叫分支目标缓冲器和后备推测目标地址发生器。 远程跳转呼叫分支目标缓冲器存储与多个先前执行的远程跳转分支指令对应的多个代码段基站和偏移量，并且确定是否包含当前远程跳转呼叫分支指令的命中。 回退推测目标地址发生器耦合到远程跳转呼叫分支目标缓冲器。 在远程跳转呼叫分支目标缓冲器中的错过的情况下，倒退的推测目标地址发生器从当前代码段基址和当前偏移量中提取回退远程呼叫推测目标地址，当前偏移对应于 当前远程跳转呼叫分支指令。