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    Percutaneously placed prosthesis with thromboresistant valve portion
    1.
    发明申请
    Percutaneously placed prosthesis with thromboresistant valve portion 审中-公开
    经皮放置假体与抗血栓阀部分

    公开(公告)号：US20050182483A1

    公开(公告)日：2005-08-18

    申请号：US11056903

    申请日：2005-02-11

    申请人： Thomas Osborne ,  Brian Case ,  Jacob Flagle ,  Grant Hoffman

    发明人： Thomas Osborne ,  Brian Case ,  Jacob Flagle ,  Grant Hoffman

    IPC分类号： A61F2/06 ,  A61F2/24

    CPC分类号： A61F2/2424 ,  A61F2/2403 ,  A61F2/2418 ,  A61F2/2475 ,  A61F2220/0016 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2230/0054 ,  A61F2230/0078 ,  A61F2230/008

    摘要： A venous valve prosthesis having a substantially non-expandable, valve portion comprising a valve-closing mechanism, such as a pair of opposing leaflets; and an anchoring portion, such as one or more self-expanding frames or stents that are expandable to anchor the prosthesis at the implantation site. In one embodiment, the rigid valve portion includes a deposition of material such as pyrolitic carbon to reduce the thrombogenecity of the blood-contacting surfaces. The anchoring portions preferably include a covering, such as a tubular construct of synthetic or collagen-derived material (such as a bioremodelable ECM material), which attaches about the support structure such that blood flow is directed through the valve mechanism as it transitions from the larger diameter anchoring portion to the intermediate, smaller-diameter portion of the prosthesis. In another embodiment, the valve support housing and valve-closing elements are delivered in a collapsed, folded, and/or dissembled state sized for delivery, then manipulated in situ to the second expanded configured following deployment.

    摘要翻译： 一种静脉瓣膜假体，其具有基本上不可扩张的阀部分，其包括阀关闭机构，例如一对相对的传单; 以及锚固部分，例如一个或多个自扩张框架或支架，其可扩张以在植入部位处锚固假体。 在一个实施例中，刚性瓣膜部分包括诸如热解碳的材料的沉积，以降低血液接触表面的血栓形成。 锚定部分优选地包括覆盖物，例如由合成或胶原衍生的材料（例如生物可重构的ECM材料）组成的管状构件，其附接在支撑结构上，使得当血液流过 较大直径的锚固部分到假体的中间较小直径部分。 在另一个实施例中，阀支撑壳体和阀关闭元件以折叠，折叠和/或拆卸状态被输送，其尺寸适于输送，然后在原位操作到第二扩张配置的后续部署。

    IMPLANTABLE MEDICAL DEVICE WITH CONSTRAINED EXPANSION
    3.
    发明申请
    IMPLANTABLE MEDICAL DEVICE WITH CONSTRAINED EXPANSION 有权
    具有约束扩张的可植入医疗装置

    公开(公告)号：US20070106372A1

    公开(公告)日：2007-05-10

    申请号：US11539925

    申请日：2006-10-10

    申请人： Thomas Osborne ,  Brian Case ,  Jacob Flagle ,  Andrew Hoffa ,  Michael Garrison

    发明人： Thomas Osborne ,  Brian Case ,  Jacob Flagle ,  Andrew Hoffa ,  Michael Garrison

    IPC分类号： A61F2/06

    CPC分类号： A61F2/2418 ,  A61F2/2475 ,  A61F2220/0008 ,  A61F2220/0016 ,  A61F2220/0075 ,  A61F2230/0026 ,  A61F2230/0095

    摘要： Medical devices for implantation in a body vessel are provided. A medical device according to the invention comprises a support structure and one or more graft members comprising a valve portion and a constraining portion. The support structure has a first, unexpanded configuration and a second, expanded configuration. The constraining portion is adapted to substantially prevent the support structure from achieving the second, expanded configuration. The valve portion is adapted to permit fluid flow through a body vessel in a first direction and substantially prevent fluid flow through the vessel in a second, opposite direction.

    摘要翻译： 提供用于植入体内的医疗装置。 根据本发明的医疗装置包括支撑结构和包括阀部分和约束部分的一个或多个移植部件。 支撑结构具有第一，未膨胀的构造和第二扩展构型。 约束部分适于基本上防止支撑结构实现第二扩张构型。 阀部分适于允许流体沿第一方向流过身体容器，并且基本上防止流体沿第二相反方向流过血管。

    Delivery system and devices for the rapid insertion of self-expanding devices
    5.
    发明申请
    Delivery system and devices for the rapid insertion of self-expanding devices 审中-公开
    交付系统和设备，用于快速插入自扩张设备

    公开(公告)号：US20060259118A1

    公开(公告)日：2006-11-16

    申请号：US11408121

    申请日：2006-04-20

    申请人： Dharmendra Pal ,  Charles Agnew ,  Jacob Flagle ,  David Lentz ,  Jeffry Melsheimer ,  Thomas Osborne ,  Fred Parker

    发明人： Dharmendra Pal ,  Charles Agnew ,  Jacob Flagle ,  David Lentz ,  Jeffry Melsheimer ,  Thomas Osborne ,  Fred Parker

    IPC分类号： A61F2/06

    CPC分类号： A61M25/0662 ,  A61F2/95 ,  A61F2002/9517 ,  A61M25/0045 ,  A61M25/005 ,  A61M25/0053

    摘要： Delivery systems for self-expanding devices are provided having a system proximal portion with a handle, an elongate middle section delivery device with an outer sheath and inner compression member, and a system distal portion including an outer guide channel member with first and second end portions defining a guide channel that slidably receives an inner guide channel member having a guide channel, the guide channels being substantially aligned. A mounting region for self-expanding devices is disposed radially between the inner and outer guide channel members. The outer guide channel member has a stepped profile from a first outer diameter to a second smaller outer diameter located near a transition region having a breech position opening for passage of a wire guide, catheter, or other medical instrument. The outer member is axially slideable relative to the inner member to deploy a self-expanding device. Methods of using and manufacturing are also provided.

    摘要翻译： 提供了一种用于自扩张装置的输送系统，其具有带手柄的系统近端部分，具有外护套和内部压缩构件的细长中间部分输送装置，以及包括具有第一和第二端部的外部引导通道构件的系统远端部分 限定了可滑动地容纳具有引导通道的内部引导通道构件的引导通道，所述引导通道基本对齐。 用于自膨胀装置的安装区域径向地设置在内引导通道构件和外引导通道构件之间。 外引导通道构件具有从第一外径到第二较小外径的阶梯轮廓，位于具有用于导线器，导管或其它医疗器械通过的后膛位置开口的过渡区域附近。 外部构件相对于内部构件可轴向滑动以展开自扩张装置。 还提供了使用和制造方法。

    Guidewire with flexible tip
    6.
    发明申请
    Guidewire with flexible tip 审中-公开
    导丝带柔性尖端

    公开(公告)号：US20050131316A1

    公开(公告)日：2005-06-16

    申请号：US10736047

    申请日：2003-12-15

    申请人： Jacob Flagle ,  Thomas Osborne

    发明人： Jacob Flagle ,  Thomas Osborne

    IPC分类号： A61B5/00 ,  A61M25/00 ,  A61M25/01 ,  A61M25/09

    CPC分类号： A61M25/09 ,  A61M2025/0081 ,  A61M2025/09166 ,  A61M2025/09175

    摘要： A guidewire with a flexible tip is provided. The flexible tip comprises a portion of a coating that axially extends beyond a distal end of an elongate member of the guidewire. The length of the flexible tip can be defined in relation to a diameter of the elongate member of the guidewire. Also, the length of the flexible tip can be defined in relation to a length of a distal tip portion of the elongate member of the guidewire. The flexible tip may include agents that facilitate visualization, such as an opacifying agent in the coating and/or a radiopaque marker disposed in the flexible tip.

    摘要翻译： 提供了具有柔性尖端的导丝。 柔性尖端包括轴向延伸超过导丝的细长构件的远端的涂层的一部分。 柔性尖端的长度可以相对于导丝的细长构件的直径来限定。 此外，柔性末端的长度可以相对于导丝的细长构件的远侧末端部分的长度来限定。 柔性末端可以包括促进可视化的试剂，例如涂层中的遮光剂和/或设置在柔性末端中的不透射线的标记。