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    Medical device including unitary, continuous portion of varying durometer
    5.
    发明申请
    Medical device including unitary, continuous portion of varying durometer 有权
    医疗设备包括单位，连续部分变化的硬度

    公开(公告)号：US20060016064A1

    公开(公告)日：2006-01-26

    申请号：US10813415

    申请日：2004-03-30

    申请人： Scott Boatman ,  David Burton ,  Michael Hoffa ,  Thomas Osborne ,  David Drewes ,  David Lessard ,  Maggie Hupcey

    发明人： Scott Boatman ,  David Burton ,  Michael Hoffa ,  Thomas Osborne ,  David Drewes ,  David Lessard ,  Maggie Hupcey

    IPC分类号： B29C47/20 ,  B29C35/08 ,  B21B1/46

    CPC分类号： A61M25/0009 ,  A61L29/06 ,  B29C35/08 ,  B29K2077/00 ,  B29L2031/7542 ,  C08F283/04 ,  C08G69/48 ,  Y10T29/4998 ,  C08L77/00 ,  C08F218/16

    摘要： A medical device (110) including a catheter shaft (111) and a unitarily and continuously formed portion (108) having a varying durometer, and optionally including an expandable balloon (18, 118). One or both of the unitarily and continuously formed portion (108) and the balloon (18, 118) are made from an irradiation cross-linked or cross-linkable mixture of a polyamide elastomer and at least one additional cross-linking reactant. The polyamide elastomer can be a polyester amide, a polyether ester amide or a polyether amide, and is preferably a nylon block copolymer. The aromatic molecule can be 1,3,5 triethyl benzene; 1,2,4 triethyl benzene; and 1,3,5 triisopropyl benzene. The cross-linking reactant can be: (a) a difunctional material, (b) a trifunctional material, (c) a tetrafunctional material, or (d) an aromatic molecule containing at least two ring substituents, each of the ring substituents having labile hydrogens at a benzylic site therein. The cross-linking reactant can also be diallyl phthalate or meta-phenylene dimaleimide.

    摘要翻译： 一种医疗装置（110），包括导管轴（111）和具有变化的硬度的整体连续形成部分（108），并且可选地包括可膨胀气囊（18,118）。 整体和连续形成的部分（108）和球囊（18,118）中的一个或两个由聚酰胺弹性体和至少一种另外的交联反应物的照射交联或可交联混合物制成。 聚酰胺弹性体可以是聚酯酰胺，聚醚酯酰胺或聚醚酰胺，优选为尼龙嵌段共聚物。 芳族分子可以是1,3,5三乙基苯; 1,2,4三乙苯; 和1,3,5三异丙基苯。 交联反应物可以是：（a）双官能材料，（b）三官能材料，（c）四官能材料，或（d）含有至少两个环取代基的芳族分子，每个环取代基具有不稳定性 在其苄基位点处的氢。 交联反应物也可以是邻苯二甲酸二烯丙酯或间亚苯基二马来酰亚胺。

    IMPLANTABLE MEDICAL DEVICE WITH CONSTRAINED EXPANSION
    8.
    发明申请
    IMPLANTABLE MEDICAL DEVICE WITH CONSTRAINED EXPANSION 有权
    具有约束扩张的可植入医疗装置

    公开(公告)号：US20070106372A1

    公开(公告)日：2007-05-10

    申请号：US11539925

    申请日：2006-10-10

    申请人： Thomas Osborne ,  Brian Case ,  Jacob Flagle ,  Andrew Hoffa ,  Michael Garrison

    发明人： Thomas Osborne ,  Brian Case ,  Jacob Flagle ,  Andrew Hoffa ,  Michael Garrison

    IPC分类号： A61F2/06

    CPC分类号： A61F2/2418 ,  A61F2/2475 ,  A61F2220/0008 ,  A61F2220/0016 ,  A61F2220/0075 ,  A61F2230/0026 ,  A61F2230/0095

    摘要： Medical devices for implantation in a body vessel are provided. A medical device according to the invention comprises a support structure and one or more graft members comprising a valve portion and a constraining portion. The support structure has a first, unexpanded configuration and a second, expanded configuration. The constraining portion is adapted to substantially prevent the support structure from achieving the second, expanded configuration. The valve portion is adapted to permit fluid flow through a body vessel in a first direction and substantially prevent fluid flow through the vessel in a second, opposite direction.

    摘要翻译： 提供用于植入体内的医疗装置。 根据本发明的医疗装置包括支撑结构和包括阀部分和约束部分的一个或多个移植部件。 支撑结构具有第一，未膨胀的构造和第二扩展构型。 约束部分适于基本上防止支撑结构实现第二扩张构型。 阀部分适于允许流体沿第一方向流过身体容器，并且基本上防止流体沿第二相反方向流过血管。

    Percutaneously placed prosthesis with thromboresistant valve portion
    9.
    发明申请
    Percutaneously placed prosthesis with thromboresistant valve portion 审中-公开
    经皮放置假体与抗血栓阀部分

    公开(公告)号：US20050182483A1

    公开(公告)日：2005-08-18

    申请号：US11056903

    申请日：2005-02-11

    申请人： Thomas Osborne ,  Brian Case ,  Jacob Flagle ,  Grant Hoffman

    发明人： Thomas Osborne ,  Brian Case ,  Jacob Flagle ,  Grant Hoffman

    IPC分类号： A61F2/06 ,  A61F2/24

    CPC分类号： A61F2/2424 ,  A61F2/2403 ,  A61F2/2418 ,  A61F2/2475 ,  A61F2220/0016 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2230/0054 ,  A61F2230/0078 ,  A61F2230/008

    摘要： A venous valve prosthesis having a substantially non-expandable, valve portion comprising a valve-closing mechanism, such as a pair of opposing leaflets; and an anchoring portion, such as one or more self-expanding frames or stents that are expandable to anchor the prosthesis at the implantation site. In one embodiment, the rigid valve portion includes a deposition of material such as pyrolitic carbon to reduce the thrombogenecity of the blood-contacting surfaces. The anchoring portions preferably include a covering, such as a tubular construct of synthetic or collagen-derived material (such as a bioremodelable ECM material), which attaches about the support structure such that blood flow is directed through the valve mechanism as it transitions from the larger diameter anchoring portion to the intermediate, smaller-diameter portion of the prosthesis. In another embodiment, the valve support housing and valve-closing elements are delivered in a collapsed, folded, and/or dissembled state sized for delivery, then manipulated in situ to the second expanded configured following deployment.

    摘要翻译： 一种静脉瓣膜假体，其具有基本上不可扩张的阀部分，其包括阀关闭机构，例如一对相对的传单; 以及锚固部分，例如一个或多个自扩张框架或支架，其可扩张以在植入部位处锚固假体。 在一个实施例中，刚性瓣膜部分包括诸如热解碳的材料的沉积，以降低血液接触表面的血栓形成。 锚定部分优选地包括覆盖物，例如由合成或胶原衍生的材料（例如生物可重构的ECM材料）组成的管状构件，其附接在支撑结构上，使得当血液流过 较大直径的锚固部分到假体的中间较小直径部分。 在另一个实施例中，阀支撑壳体和阀关闭元件以折叠，折叠和/或拆卸状态被输送，其尺寸适于输送，然后在原位操作到第二扩张配置的后续部署。