利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

17 条记录 (耗时 0.019 秒)

    Method for Producing Polyether Alcohols
    1.
    发明申请
    Method for Producing Polyether Alcohols 有权
    生产聚醚醇的方法

    公开(公告)号：US20070225394A1

    公开(公告)日：2007-09-27

    申请号：US11570794

    申请日：2005-06-22

    申请人： Thomas Ostrowski ,  Stephan Bauer ,  Achim Loffler ,  Jurgen Winkler

    发明人： Thomas Ostrowski ,  Stephan Bauer ,  Achim Loffler ,  Jurgen Winkler

    IPC分类号： C08G73/10 ,  C08G65/34 ,  C08G85/00

    CPC分类号： C08G65/2663 ,  C08G18/4837 ,  C08G18/4866 ,  C08G2101/0008 ,  C08G2101/0083

    摘要： The invention provides a process for continuously preparing polyether alcohols by adding alkylene oxides to H-functional starter substances using a DMC catalyst, comprising the steps of a) preparing a precursor by continuously metering an H-functional starter substance, an alkylene oxide or a mixture of at least two alkylene oxides and the required amount of DMC catalyst into a continuous reactor, b) continuously withdrawing the precursor from step a) from the reactor, c) continuously metering the product from step a), an alkylene oxide different from that in step a) or a mixture of at least two alkylene oxides different from that in step a) and, if appropriate, the required amount of DMC catalyst into a further continuous reactor.

    摘要翻译： 本发明提供一种通过使用DMC催化剂向环氧化物加成烯键式氧化物连续制备聚醚醇的方法，该方法包括以下步骤：a）通过连续计量H-功能起始物质，烯化氧或混合物来制备前体 的至少两种烯化氧和所需量的DMC催化剂进入连续反应器，b）从反应器中连续地从步骤a）中取出前体，c）连续计量来自步骤a）的产物，不同于 步骤a）或至少两种不同于步骤a）中的环氧烷烃的混合物，如果合适的话，将所需量的DMC催化剂加入另外的连续反应器中。

    Method for the production of low-emission polyurethane soft foams
    2.
    发明申请
    Method for the production of low-emission polyurethane soft foams 审中-公开
    生产低排放聚氨酯软泡沫的方法

    公开(公告)号：US20060167125A1

    公开(公告)日：2006-07-27

    申请号：US10524039

    申请日：2003-07-24

    申请人： Stephan Bauer ,  Raimund Ruppel ,  Eva Baum ,  Jurgen Winkler

    发明人： Stephan Bauer ,  Raimund Ruppel ,  Eva Baum ,  Jurgen Winkler

    IPC分类号： C08G18/00

    CPC分类号： C08G18/4891 ,  C08G18/4866 ,  C08G65/2663 ,  C08G2101/0008 ,  C08G2101/005 ,  C08G2101/0083 ,  C08G2290/00

    摘要： The present invention provides a process for producing low-emission flexible polyurethane foams having a reduced odor and reduced fogging by reacting a) polyisocyanates with b) compounds having at least two hydrogen atoms which are reactive toward isocyanate groups, c) blowing agents wherein polyether alcohols which have been prepared by addition of alkylene oxides onto compounds derived from renewable raw materials using DMC catalysts are used as compounds b) having at least two hydrogen atoms which are reactive toward isocyanate groups.

    摘要翻译： 本发明提供一种生产具有减少的气味和减少雾化的低发射柔性聚氨酯泡沫的方法，其通过使a）多异氰酸酯与b）具有至少两个对异氰酸酯基团反应的氢原子的化合物，c）发泡剂，其中聚醚醇 使用通过使用DMC催化剂将烯化氧加成到可再生原料的化合物上制备的化合物用作具有至少两个对异氰酸酯基团具有反应性的氢原子的化合物b）。

    Method for Producing Polyether Alcohols
    4.
    发明申请
    Method for Producing Polyether Alcohols 审中-公开
    生产聚醚醇的方法

    公开(公告)号：US20090005533A1

    公开(公告)日：2009-01-01

    申请号：US11910936

    申请日：2006-04-05

    申请人： Stefan Dinsch ,  Jurgen Winkler ,  Gerd Hoppner ,  Holger Seifert

    发明人： Stefan Dinsch ,  Jurgen Winkler ,  Gerd Hoppner ,  Holger Seifert

    IPC分类号： C08G65/26

    CPC分类号： C08G18/4883 ,  C08G65/2606 ,  C08G65/2648 ,  C08G65/2651 ,  C08G65/2696

    摘要： The invention relates to a process for preparing polyether alcohols by catalytic addition of alkylene oxides onto a starter substance mixture comprising water-soluble H-functional starter substances which are solid at room temperature, alcohols which are liquid at the reaction temperature and water using alkali metal hydroxides and/or alkaline earth metal hydroxides as catalysts, wherein the amount of water is from 1.0 to 6.0% by weight, based on the weight of the starter substance mixture, and the starter substance mixture comprises no amine constituents.

    摘要翻译： 本发明涉及通过将环氧烷催化加成到起始物质混合物上制备聚醚醇的方法，该起始物质混合物包括在室温下为固体的水溶性H官能起始物质，在反应温度下为液体的醇和使用碱金属的水 氢氧化物和/或碱土金属氢氧化物作为催化剂，其中水的量为起始物质混合物重量的1.0至6.0重量％，起始物质混合物不包含胺组分。

    Inhibitors of TGF-R signaling for treatment of CNS disorders
    6.
    发明授权
    Inhibitors of TGF-R signaling for treatment of CNS disorders 有权
    抑制TGF-R信号传导治疗CNS疾病

    公开(公告)号：US08283334B2

    公开(公告)日：2012-10-09

    申请号：US13028035

    申请日：2011-02-15

    申请人： Ulrich Bogdahn ,  Ludwig Aigner ,  Frank-Peter Wachs ,  Beate Winner ,  Jurgen Winkler

    发明人： Ulrich Bogdahn ,  Ludwig Aigner ,  Frank-Peter Wachs ,  Beate Winner ,  Jurgen Winkler

    IPC分类号： A61K31/70 ,  C07H21/02 ,  C07H21/04

    CPC分类号： C12N15/1138 ,  A61K38/00 ,  C07K14/71 ,  C12N2310/11

    摘要： The present invention relates to the use of oligonucleotides for the preparation of a pharmaceutical composition for the prevention or treatment of a disease, wherein neurogenesis and/or neuroregeneration has a beneficial effect, in particular a disease like Morbus Alzheimer, Morbus Parkinson, Lewy Body Dementia, Amyotrophic Lateral Sclerosis, Spinocerebellar Atrophies, Creutzfeldt Jakob Disease, Frontemporal Dementia, Morbus Pick, AIDS Dementia Complex, Vascular Dementia, Progressive Supranuclear Palsy, Corticobasal Degeneration, Multisystem-Atrophy, Hallervorden Spatz Disease, Huntington's disease, Stroke, Traumatic Brain and spinal cord Injury, Retinitis Pigmentosa, Macular Degeneration, Glaucoma, Cochlea Degeneration, Depression, Schizophrenia, Multiple Sclerosis, and developmental neurodegeneration.

    摘要翻译： 本发明涉及寡核苷酸用于制备用于预防或治疗疾病的药物组合物的用途，其中神经发生和/或神经再生具有有益效果，特别是诸如Morbus阿尔茨海默氏症，Morbus帕金森氏病，路易体痴呆症 ，肌萎缩性侧索硬化症，脊髓小脑萎缩症，Creutzfeldt雅各布病，前痴呆症，Morbus拣选，艾滋病痴呆复合物，血管性痴呆，进行性核核麻痹，皮质基底变性，多系统萎缩，霍氏阴道病，亨廷顿病，中风，创伤性脑和脊髓 损伤，色素性视网膜炎，黄斑变性，青光眼，耳蜗变性，抑郁，精神分裂症，多发性硬化和发育性神经变性。

    Method for producing polyether alcohols
    7.
    发明申请
    Method for producing polyether alcohols 审中-公开
    聚醚醇的制造方法

    公开(公告)号：US20050177005A1

    公开(公告)日：2005-08-11

    申请号：US10515350

    申请日：2003-06-06

    申请人： Raimund Ruppel ,  Eva Baum ,  Jurgen Winkler ,  Edward Bohres

    发明人： Raimund Ruppel ,  Eva Baum ,  Jurgen Winkler ,  Edward Bohres

    IPC分类号： C08G65/26 ,  C07C41/03

    CPC分类号： C08G65/2663 ,  C08G65/2648 ,  C08G65/2696

    摘要： The invention relates to a method for producing polyether alcohols, comprising the following steps: a) reacting a low-molecular alcohol with alkylene oxide in the presence of a basic catalyst in order to form an alkylene oxide addition product having a molecular weight ranging from 200 to 900 g/mol; b) separating the basic catalyst from the product obtained in step a), and; c) reacting the product obtained in step b) with another alkylene oxide in order to produce the desired final product while using at least one DMC catalyst. The inventive method is characterized in that sodium hydroxide is used as the basic catalyst in step a).

    摘要翻译： 本发明涉及一种生产聚醚醇的方法，包括以下步骤：a）在碱性催化剂存在下使低分子量醇与环氧烷反应，以形成分子量为200的环氧烷加成产物 至900g / mol; b）将碱性催化剂与步骤a）中得到的产物分离， c）使步骤b）中获得的产物与另一种环氧烷反应，以便在使用至少一种DMC催化剂时产生所需的最终产物。 本发明的方法的特征在于，在步骤a）中使用氢氧化钠作为碱性催化剂。

    Process for preparing TPU molding compositions
    8.
    发明授权
    Process for preparing TPU molding compositions 失效
    制备TPU模塑组合物的方法

    公开(公告)号：US5981655A

    公开(公告)日：1999-11-09

    申请号：US006064

    申请日：1998-01-12

    申请人： Herbert Heidingsfeld ,  Willi Meister ,  Bernhard Schulte ,  Wolfgang Brauer ,  Friedemann Muller ,  Hans-Georg Hoppe ,  Hans-Georg Wussow ,  Jurgen Winkler

    发明人： Herbert Heidingsfeld ,  Willi Meister ,  Bernhard Schulte ,  Wolfgang Brauer ,  Friedemann Muller ,  Hans-Georg Hoppe ,  Hans-Georg Wussow ,  Jurgen Winkler

    IPC分类号： C08L55/02 ,  C08G18/00 ,  C08G18/08 ,  C08G18/65 ,  C08L55/00 ,  C08L75/00 ,  C08L75/04 ,  C08L101/00

    CPC分类号： C08L75/04 ,  C08G18/0895

    摘要： A process for the continuous production of a thermoplastic molding composition containing a mixture of a TPU and a thermoplastic (co)polymer is disclosed. The process comprises(i) introducing into an extruder via a first feed point component I) with at least 3% by weight, with respect to component I), of at least one member selected from the group consisting of components A), B) and C), and(ii) metering in the balance of said A), B) and C) into said extruder via one or more subsequent feed points,(iii) extruding components I) and II) under conditions sufficient to cause A), B) and C) reaction to form TPU, and(iv) upon the completion of said reaction, removing the resulting mixture of TPU and (co)polymer from the extruder,wherein component I) comprises 1 to 60% by weight, with respect to the total mixture, of a thermoplastic (co)polymer, and wherein component II) comprises 99 to 40% by weight, with respect to the total mixture, of the polyurethane-forming components including A) an organic diisocyanate, B) a linear polyol having terminal hydroxyl groups and a number average molecular weight of 500 to 5000, and C) a chain extender having a molecular weight of 60 to 500, and wherein the molar ratio of NCO groups in A) to the groups which react with NCO in B) and C) is in the range of 0.9 to 1.2.

    摘要翻译： 公开了一种用于连续生产含有TPU和热塑性（共）聚合物的混合物的热塑性模塑组合物的方法。 该方法包括（i）通过第一进料点组分I）向至少一种选自组分A），B）中的至少一种成分引入至少3重量％的挤出机，相对于组分I） 和（ii）在所述A），B）和C）的余量中通过一个或多个后续进料点将所述A），B）和C）的余量计量加入到所述挤出机中，（iii）在足以导致A）和 ，B）和C）反应形成TPU，和（iv）在完成所述反应后，从挤出机中除去所得TPU和（共）聚合物的混合物，其中组分I）包含1至60重量％ 相对于总混合物，热塑性（共）聚合物，并且其中组分II）包含相对于总混合物的99至40重量％的形成聚氨酯的组分，包括A）有机二异氰酸酯，B） 具有末端羟基，数均分子量为500〜5000的直链状多元醇，C）扩链剂 分子量为60至500，并且其中A）中的NCO基团与在B）和C）中与NCO反应的基团的摩尔比在0.9至1.2的范围内。