公开(公告)号：US5869448A

公开(公告)日：1999-02-09

申请号：US519109

申请日：1995-08-25

申请人： Thomas S. Arrhenius ,  Anna Tempczyk ,  Mariano J. Elices ,  Zhong-Li Zheng

发明人： Thomas S. Arrhenius ,  Anna Tempczyk ,  Mariano J. Elices ,  Zhong-Li Zheng

IPC分类号： A61K38/00 ,  C07K5/083 ,  C07K5/103 ,  C07K5/117 ,  C07K5/12 ,  C07K14/78 ,  A61K38/08 ,  A61K38/12 ,  C07K7/00 ,  C07K7/56

CPC分类号： C07K5/1024 ,  C07K14/78 ,  C07K5/0808 ,  C07K5/1013 ,  C07K5/126 ,  A61K38/00 ,  Y10S930/26 ,  Y10S930/27

摘要： The present invention contemplates a cyclic peptide that inhibits the binding between the VLA-4 receptor expressed on inflammatory leukocytes and the fibronectin CS-1 peptide expressed on endothelial cells that are involved in immunoinflammatory disease states. Pharmaceutical compositions containing a contemplated cyclic peptide and processes for treating immunoinflammatory conditions using a binding-inhibitory cyclic peptide are also disclosed.

摘要翻译： 本发明考虑了抑制在炎性白细胞上表达的VLA-4受体与参与免疫炎性疾病状态的内皮细胞上表达的纤连蛋白CS-1肽之间的结合的环肽。 还公开了含有预期的环肽的药物组合物和使用结合抑制性环肽治疗免疫炎性病症的方法。

公开(公告)号：US5811391A

公开(公告)日：1998-09-22

申请号：US483077

申请日：1995-06-07

申请人： Thomas S. Arrhenius ,  Mariano J. Elices ,  Anna Tempczyk ,  Zhong-Li Zheng

发明人： Thomas S. Arrhenius ,  Mariano J. Elices ,  Anna Tempczyk ,  Zhong-Li Zheng

IPC分类号： A61K38/00 ,  C07K5/083 ,  C07K5/103 ,  C07K5/117 ,  C07K5/12 ,  C07K14/78 ,  A61K38/12 ,  C07K7/06 ,  C07K7/08

CPC分类号： C07K5/1024 ,  C07K14/78 ,  C07K5/0808 ,  C07K5/1013 ,  C07K5/126 ,  A61K38/00 ,  Y10S930/26 ,  Y10S930/27

摘要： The present invention contemplates a cyclic peptide that inhibits the binding between the VLA-4 receptor expressed on inflammatory leukocytes and the fibronectin CS-1 peptide expressed on endothelial cells that are involved in immunoinflammatory disease states. Pharmaceutical compositions containing a contemplated cyclic peptide and processes for treating immunoinflammatory conditions using a binding-inhibitory cyclic peptide are also disclosed.