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公开(公告)号：US5869448A
公开(公告)日：1999-02-09
申请号：US519109
申请日：1995-08-25
IPC分类号： A61K38/00 , C07K5/083 , C07K5/103 , C07K5/117 , C07K5/12 , C07K14/78 , A61K38/08 , A61K38/12 , C07K7/00 , C07K7/56
CPC分类号： C07K5/1024 , C07K14/78 , C07K5/0808 , C07K5/1013 , C07K5/126 , A61K38/00 , Y10S930/26 , Y10S930/27
摘要： The present invention contemplates a cyclic peptide that inhibits the binding between the VLA-4 receptor expressed on inflammatory leukocytes and the fibronectin CS-1 peptide expressed on endothelial cells that are involved in immunoinflammatory disease states. Pharmaceutical compositions containing a contemplated cyclic peptide and processes for treating immunoinflammatory conditions using a binding-inhibitory cyclic peptide are also disclosed.
摘要翻译： 本发明考虑了抑制在炎性白细胞上表达的VLA-4受体与参与免疫炎性疾病状态的内皮细胞上表达的纤连蛋白CS-1肽之间的结合的环肽。 还公开了含有预期的环肽的药物组合物和使用结合抑制性环肽治疗免疫炎性病症的方法。
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公开(公告)号：US5811391A
公开(公告)日：1998-09-22
申请号：US483077
申请日：1995-06-07
IPC分类号： A61K38/00 , C07K5/083 , C07K5/103 , C07K5/117 , C07K5/12 , C07K14/78 , A61K38/12 , C07K7/06 , C07K7/08
CPC分类号： C07K5/1024 , C07K14/78 , C07K5/0808 , C07K5/1013 , C07K5/126 , A61K38/00 , Y10S930/26 , Y10S930/27
摘要： The present invention contemplates a cyclic peptide that inhibits the binding between the VLA-4 receptor expressed on inflammatory leukocytes and the fibronectin CS-1 peptide expressed on endothelial cells that are involved in immunoinflammatory disease states. Pharmaceutical compositions containing a contemplated cyclic peptide and processes for treating immunoinflammatory conditions using a binding-inhibitory cyclic peptide are also disclosed.
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公开(公告)号：US5821231A
公开(公告)日：1998-10-13
申请号：US461056
申请日：1995-06-05
IPC分类号： A61K38/00 , A61K38/06 , A61K38/07 , A61K38/08 , A61P11/00 , A61P17/00 , A61P25/00 , A61P29/00 , C07K5/02 , C07K5/06 , C07K5/072 , C07K5/08 , C07K5/083 , C07K5/087 , C07K5/09 , C07K5/093 , C07K5/097 , C07K5/10 , C07K5/103 , C07K5/107 , C07K5/11 , C07K7/06 , C07K14/78 , A61K38/05 , C07K5/04
CPC分类号： C07K7/06 , C07K14/78 , C07K5/0205 , C07K5/0207 , C07K5/021 , C07K5/06034 , C07K5/06113 , C07K5/0804 , C07K5/0808 , C07K5/081 , C07K5/0812 , C07K5/0815 , C07K5/0819 , C07K5/0821 , C07K5/1005 , C07K5/1008 , C07K5/101 , C07K5/1013 , C07K5/1016 , C07K5/1019 , A61K38/00
摘要： The present invention contemplates a compound defined by the following formula: ##STR1## that inhibits the binding between the VLA-4 and the fibronectin CS-1 compound. Pharmaceutical compositions containing a contemplated compound and methods for treating immunoinflammatory conditions using the compound are also disclosed.
摘要翻译： 本发明涉及由下式限定的化合物：抑制VLA-4与纤连蛋白CS-1化合物之间结合的“IMAGE”。 还公开了含有预期化合物的药物组合物和使用该化合物治疗免疫炎性病症的方法。
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公开(公告)号：US5936065A
公开(公告)日：1999-08-10
申请号：US462424
申请日：1995-06-05
IPC分类号： A61K38/00 , A61K38/06 , A61K38/07 , A61K38/08 , A61P11/00 , A61P17/00 , A61P25/00 , A61P29/00 , C07K5/02 , C07K5/06 , C07K5/072 , C07K5/08 , C07K5/083 , C07K5/087 , C07K5/09 , C07K5/093 , C07K5/097 , C07K5/10 , C07K5/103 , C07K5/107 , C07K5/11 , C07K7/06 , C07K14/78
CPC分类号： C07K7/06 , C07K14/78 , C07K5/0205 , C07K5/0207 , C07K5/021 , C07K5/06034 , C07K5/06113 , C07K5/0804 , C07K5/0808 , C07K5/081 , C07K5/0812 , C07K5/0815 , C07K5/0819 , C07K5/0821 , C07K5/1005 , C07K5/1008 , C07K5/101 , C07K5/1013 , C07K5/1016 , C07K5/1019 , A61K38/00
摘要： The present invention contemplates a compound defined by the following formula: ##STR1## that inhibits the binding between the VLA-4 and the fibronectin CS-1 compound. Pharmaceutical compositions containing a contemplated compound and methods for treating immunoinflammatory conditions using the compound are also disclosed.
摘要翻译： 本发明考虑由下式限定的化合物：其抑制VLA-4与纤连蛋白CS-1化合物之间的结合。 还公开了含有预期化合物的药物组合物和使用该化合物治疗免疫炎性病症的方法。
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公开(公告)号：US5770573A
公开(公告)日：1998-06-23
申请号：US462219
申请日：1995-06-05
IPC分类号： A61K38/00 , A61K38/06 , A61K38/07 , A61K38/08 , A61P11/00 , A61P17/00 , A61P25/00 , A61P29/00 , C07K5/02 , C07K5/06 , C07K5/072 , C07K5/08 , C07K5/083 , C07K5/087 , C07K5/09 , C07K5/093 , C07K5/097 , C07K5/10 , C07K5/103 , C07K5/107 , C07K5/11 , C07K7/06 , C07K14/78 , A61K38/05 , C07K5/04
CPC分类号： C07K7/06 , C07K14/78 , C07K5/0205 , C07K5/0207 , C07K5/021 , C07K5/06034 , C07K5/06113 , C07K5/0804 , C07K5/0808 , C07K5/081 , C07K5/0812 , C07K5/0815 , C07K5/0819 , C07K5/0821 , C07K5/1005 , C07K5/1008 , C07K5/101 , C07K5/1013 , C07K5/1016 , C07K5/1019 , A61K38/00
摘要： The present invention contemplates a compound defined by the following formula: ##STR1## that inhibits the binding between the VLA-4 and the fibronectin CS-1 compound. Pharmaceutical compositions containing a contemplated compound and methods for treating immunoinflammatory conditions using the compound are also disclosed.
摘要翻译： 本发明涉及由下式限定的化合物：抑制VLA-4与纤连蛋白CS-1化合物之间结合的“IMAGE”。 还公开了含有预期化合物的药物组合物和使用该化合物治疗免疫炎性病症的方法。
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公开(公告)号：US6117840A
公开(公告)日：2000-09-12
申请号：US837154
申请日：1997-04-14
IPC分类号： A61K38/00 , A61K38/06 , A61K38/07 , A61K38/08 , A61P11/00 , A61P17/00 , A61P25/00 , A61P29/00 , C07K5/02 , C07K5/06 , C07K5/072 , C07K5/08 , C07K5/083 , C07K5/087 , C07K5/09 , C07K5/093 , C07K5/097 , C07K5/10 , C07K5/103 , C07K5/107 , C07K5/11 , C07K7/06 , C07K14/78 , A61K38/05
CPC分类号： C07K7/06 , C07K14/78 , C07K5/0205 , C07K5/0207 , C07K5/021 , C07K5/06034 , C07K5/06113 , C07K5/0804 , C07K5/0808 , C07K5/081 , C07K5/0812 , C07K5/0815 , C07K5/0819 , C07K5/0821 , C07K5/1005 , C07K5/1008 , C07K5/101 , C07K5/1013 , C07K5/1016 , C07K5/1019 , A61K38/00
摘要： The present invention contemplates a peptide that inhibits the binding between the VLA-4 receptor expressed on inflammatory leukocytes and the fibronectin CS-1 peptide expressed on endothelial cells that are involved in immunoinflammatory disease states. Pharmaceutical compositions containing a contemplated peptide and processes for treating immunoinflammatory conditions using a binding-inhibitory peptide are also disclosed.
摘要翻译： 本发明考虑了抑制炎性白细胞上表达的VLA-4受体与参与免疫炎性疾病状态的内皮细胞上表达的纤连蛋白CS-1肽之间的结合的肽。 还公开了含有预期肽的药物组合物和使用结合抑制肽治疗免疫炎性病症的方法。
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公开(公告)号：US6103870A
公开(公告)日：2000-08-15
申请号：US923026
申请日：1997-09-03
IPC分类号： A61K38/00 , C07K5/02 , C07K5/06 , C07K5/072 , C07K5/083 , C07K5/087 , C07K5/09 , C07K5/093 , C07K5/097 , C07K5/103 , C07K5/107 , C07K5/11 , C07K7/06 , C07K14/78 , A61K38/06
CPC分类号： C07K7/06 , C07K14/78 , C07K5/0205 , C07K5/0207 , C07K5/021 , C07K5/06034 , C07K5/06113 , C07K5/0804 , C07K5/0808 , C07K5/081 , C07K5/0812 , C07K5/0815 , C07K5/0819 , C07K5/0821 , C07K5/1005 , C07K5/1008 , C07K5/101 , C07K5/1013 , C07K5/1016 , C07K5/1019 , A61K38/00
摘要： The present invention contemplates a peptide that inhibits the binding between the VLA-4 receptor expressed on inflammatory leukocytes and the fibronectin CS-1 peptide expressed on endothelial cells that are involved in immunoinflammatory disease states. Pharmaceutical compositions containing a contemplated peptide and processes for treating immunoinflammatory conditions using a binding-inhibitory peptide are also disclosed.
摘要翻译： 本发明考虑了抑制炎性白细胞上表达的VLA-4受体与参与免疫炎性疾病状态的内皮细胞上表达的纤连蛋白CS-1肽之间的结合的肽。 还公开了含有预期肽的药物组合物和使用结合抑制肽治疗免疫炎性病症的方法。
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公开(公告)号：US5688913A
公开(公告)日：1997-11-18
申请号：US435286
申请日：1995-05-05
IPC分类号： A61K38/00 , C07K5/02 , C07K5/06 , C07K5/072 , C07K5/083 , C07K5/087 , C07K5/09 , C07K5/093 , C07K5/097 , C07K5/103 , C07K5/107 , C07K5/11 , C07K7/06 , C07K14/78 , A61K38/07
CPC分类号： C07K7/06 , C07K14/78 , C07K5/0205 , C07K5/0207 , C07K5/021 , C07K5/06034 , C07K5/06113 , C07K5/0804 , C07K5/0808 , C07K5/081 , C07K5/0812 , C07K5/0815 , C07K5/0819 , C07K5/0821 , C07K5/1005 , C07K5/1008 , C07K5/101 , C07K5/1013 , C07K5/1016 , C07K5/1019 , A61K38/00
摘要： The present invention contemplates a peptide that inhibits the binding between the VLA-4 receptor expressed on inflammatory leukocytes and the fibronectin CS-1 peptide expressed on endothelial cells that are involved in immunoinflammatory disease states. Pharmaceutical compositions containing a contemplated peptide and processes for treating immunoinflammatory conditions using a binding-inhibitory peptide are also disclosed.
摘要翻译： 本发明考虑了抑制炎性白细胞上表达的VLA-4受体与参与免疫炎性疾病状态的内皮细胞上表达的纤连蛋白CS-1肽之间的结合的肽。 还公开了含有预期肽的药物组合物和使用结合抑制肽治疗免疫炎性病症的方法。
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