摘要:
Non-aggregating resorbable calcium phosphosilicate nanoparticles (CPNPs) are bioconjugated to targeting molecules that are specific for particular cells. The CPNPs are stable particles at normal physiological pH. Chemotherapy and imaging agents may be integrally formed with the CPNPs so that they are compartmentalized within the CPNPs. In this manner, the agents are protected from interaction with the environment at normal physiological pH. However, once the CPNPs have been taken up, at intracellular pH, the CPNPs dissolve releasing the agent. Thus, chemotherapeutic or imaging agents are delivered to specific cells and permit the treatment and/or imaging of those cells. Use of the bioconjugated CPNPs both limits the amount of systemic exposure to the agent and delivers a higher concentration of the agent to the cell. The methods and principals of bioconjugating CPNPs are taught by examples of bioconjugation of targeting molecules for breast cancer, pancreatic cancer, and leukemia.
摘要:
Non-aggregating resorbable calcium phosphosilicate nanoparticles (CPNPs) are bioconjugated to targeting molecules that are specific for particular cells. The CPNPs are stable particles at normal physiological pH. Chemotherapy and imaging agents may be integrally formed with the CPNPs so that they are compartmentalized within the CPNPs. In this manner, the agents are protected from interaction with the environment at normal physiological pH. However, once the CPNPs have been taken up, at intracellular pH, the CPNPs dissolve releasing the agent. Thus, chemotherapeutic or imaging agents are delivered to specific cells and permit the treatment and/or imaging of those cells. Use of the bioconjugated CPNPs both limits the amount of systemic exposure to the agent and delivers a higher concentration of the agent to the cell. The methods and principals of bioconjugating CPNPs are taught by examples of bioconjugation of targeting molecules for breast cancer, pancreatic cancer, and leukemia.
摘要:
A refrigerated display case with an improved air flow control system located in the lower portion thereof along with an improved means for controlling spillages and other contaminants which commonly fall downwardly into the tank or lower area thereof. The spillage controls including a waste control outlet along with an inclined coil cover and fan housing as well as a deck plate extending thereover. The deck plate also defining the plenum chamber within which the inclined fan housing and inclined coil and coil cover are located. A front bracket is included which allows attachment of a return grill thereto along with a support shelf for holding the refrigeration line means away from the waste receiving outlet.
摘要:
An improved design for a refrigerated display case which significantly enhances airflow characteristics by including a gradual radius within the transition sections in areas where the refrigerated airflow path must change directions to greatly facilitate smooth flow of refrigerated air therethrough. Also disclosed is an improved construction for providing insulation for a refrigerated display case including an inner and outer panel spaced apart to define an insulation holding chamber therebetween and including thermal breakers at the ends thereof for maintaining the panels in spaced relation to each other and for closing off the end section thereof to retain insulation therein. The inner insulation panel defines the outer boundary of the airflow path. Also an improved design for a shelf support standard is positioned within the insulated housing to provide structural strength to the display case apparatus and to support shelving thereon and also to include a case liner secured thereto for defining the inner boundary of the improved airflow path. Thermally non-conductive bolt assemblies are included to attach the insulated foam assemblies to shelf support standards. The design further includes a novel castor configuration to facilitate relocation of the refrigerated display case.
摘要:
An improved lighting apparatus is disclosed for illuminating the interior of a refrigerated display case which uses in combination a unique configuration of a main lighting unit behind the cornice as well as an illumination device under the front edge of each shelf wherein each shelf includes a lightrace extending longitudinally adjacent the front edge thereof for retaining the power supply wires therein and wherein the electrical power is supplied to the lighting means through a one-piece end plug electrical coupling designed to seal the end of the lightrace while simultaneously providing electrical connection to a mounting fixture for a fluorescent lamp. The mounting fixture preferably includes a means for mounting of the lamp therein as well as a coupling adapted to engage the electrical coupling of the one-piece end plug electrical coupling in the end of the lightrace for facilitating powering of the shelf illumination lights. The present design includes a novel ballast retaining chamber behind the cornice as well as several specially designed reflector members to facilitate downward illumination from the main lighting within the upper portion of the housing to fully capture and efficiently direct the lumen output of the fluorescent lamps.