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1.发明申请公开(公告)号：US20060212950A1
公开(公告)日：2006-09-21
申请号：US10542592
申请日：2004-01-15
申请人： Thomas Tuschl , Tilmann Achsel , Reinhard Luhrmann , Jutta Meyer
发明人： Thomas Tuschl , Tilmann Achsel , Reinhard Luhrmann , Jutta Meyer
CPC分类号： C12N15/111 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K48/0058 , C12N2310/111 , C12N2310/14 , C12N2310/53 , C12N2330/30
摘要： The invention relates to vectors for the inducible expression of RNA molecules in eukaryotic, particularly mammalian cells and transgenic animals.
摘要翻译： 本发明涉及用于在真核细胞，特别是哺乳动物细胞和转基因动物中可诱导表达RNA分子的载体。
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2.发明授权公开(公告)号：US08198077B2
公开(公告)日：2012-06-12
申请号：US10542592
申请日：2004-01-15
申请人： Thomas Tuschl , Tilmann Achsel , Reinhard Lührmann , Jutta Meyer
发明人： Thomas Tuschl , Tilmann Achsel , Reinhard Lührmann , Jutta Meyer
IPC分类号： C12N15/00
CPC分类号： C12N15/111 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K48/0058 , C12N2310/111 , C12N2310/14 , C12N2310/53 , C12N2330/30
摘要： The invention relates to vectors for the inducible expression of RNA molecules in eukaryotic, particularly mammalian cells and transgenic animals.
摘要翻译： 本发明涉及用于在真核细胞，特别是哺乳动物细胞和转基因动物中可诱导表达RNA分子的载体。
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公开(公告)号：US20120255045A1
公开(公告)日：2012-10-04
申请号：US13438170
申请日：2012-04-03
申请人： Thomas Tuschl , Tilmann Achsel , Reinhard Lührmann , Jutta Meyer
发明人： Thomas Tuschl , Tilmann Achsel , Reinhard Lührmann , Jutta Meyer
IPC分类号： A61K31/7088 , C12N15/85 , A61P37/00 , A61P35/00 , A61P29/00 , A61P31/00 , A01K67/027 , C12Q1/68
CPC分类号： C12N15/111 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K48/0058 , C12N2310/111 , C12N2310/14 , C12N2310/53 , C12N2330/30
摘要： The invention relates to vectors for the inducible expression of RNA molecules in eukaryotic, particularly mam
摘要翻译： 本发明涉及用于在真核生物，特别是母体中可诱导表达RNA分子的载体
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4.发明授权公开(公告)号：US08470797B2
公开(公告)日：2013-06-25
申请号：US13438170
申请日：2012-04-03
申请人： Thomas Tuschl , Tilmann Achsel , Reinhard Luehrmann , Jutta Myer
发明人： Thomas Tuschl , Tilmann Achsel , Reinhard Luehrmann , Jutta Myer
IPC分类号： C12N15/11
CPC分类号： C12N15/111 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K48/0058 , C12N2310/111 , C12N2310/14 , C12N2310/53 , C12N2330/30
摘要： The invention relates to vectors for the inducible expression of RNA molecules in eukaryotic, particularly mammalian cells and transgenic animals.
摘要翻译： 本发明涉及用于在真核细胞，特别是哺乳动物细胞和转基因动物中可诱导表达RNA分子的载体。
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公开(公告)号：US20060166910A1
公开(公告)日：2006-07-27
申请号：US10520470
申请日：2003-07-10
IPC分类号： A61K48/00
CPC分类号： C12N15/113 , A61K47/549 , A61K47/557 , C07K14/4705 , C07K19/00 , C12N15/111 , C12N2310/14 , C12N2310/351 , C12N2310/3513 , C12N2320/30 , C12N2320/51 , C12N2330/30
摘要： The present invention relates to sequence and structural features of single-stranded (ss) RNA molecules required to mediate target-specific nucleic acid modifications by RNA-interference (RNAi), such as target mRNA degradation and/or DNA methylation.
摘要翻译： 本发明涉及通过RNA干扰（RNAi）介导靶特异性核酸修饰所需的单链（ss）RNA分子的序列和结构特征，例如靶mRNA降解和/或DNA甲基化。
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公开(公告)号：US08198428B2
公开(公告)日：2012-06-12
申请号：US12775952
申请日：2010-05-07
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/14 , C12N2310/141 , C12N2310/53 , C12N2330/10 , C12Q1/6876 , C12Q2600/136 , C12Q2600/178
摘要： In Caenorhabditis elegans, lin-4 and let-7 enclode 22- and 21 -nucleotide RNAs, respectively, that function as key regulators of developmental timing. Because the appearance of these short RNAs is regulated during development, they are also referred to as “small temporal RNAs” (stRNAs). We show that many more 21- and 22-nt expressed RNAs, termed microRNAs, (miRNAs), exist in invertebrates and vertebrates, and that some of these novel RNAs, similar to let-7 stRAN, are also highly conserved. This suggests that sequence-specific post-transcriptional regulatory mechanisms mediated by small RNAs are more general than previously appreciated.
摘要翻译： 在秀丽隐杆线虫中，lin-4和let-7分别包含22和21个核苷酸RNA，其作为发育时间的关键调节剂。 因为这些短RNA的出现在发育过程中被调节，所以它们也被称为“小时间RNA”（stRNA）。 我们显示，更多的21和22-nt表达的RNA，称为microRNA（miRNA），存在于无脊椎动物和脊椎动物中，并且与let-7 stRAN相似的这些新型RNA中的一些也是高度保守的。 这表明由小RNA介导的序列特异性转录后调控机制比以前赞赏更为普遍。
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公开(公告)号：US20100093837A1
公开(公告)日：2010-04-15
申请号：US12550602
申请日：2009-08-31
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/14 , C12N2310/141 , C12N2310/53 , C12N2330/10 , C12Q1/6876 , C12Q2600/136 , C12Q2600/178
摘要： In Caenorhabditis elegans, lin-4 and let-7 enclode 22- and 21-nucleotide RNAs, respectively, that function as key regulators of developmental timing. Because the appearance of these short RNAs is regulated during development, they are also referred to as “small temporal RNAs” (stRNAs). We show that many more 21- and 22-nt expressed RNAs, termed microRNAs, (miRNAs), exist in invertebrates and vertebrates, and that some of these novel RNAs, similar to let-7 stRAN, are also highly conserved. This suggests that sequence-specific post-transcriptional regulatory mechanisms mediated by small RNAs are more general than previously appreciated.
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公开(公告)号：US07838662B2
公开(公告)日：2010-11-23
申请号：US12550596
申请日：2009-08-31
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/14 , C12N2310/141 , C12N2310/53 , C12N2330/10 , C12Q1/6876 , C12Q2600/136 , C12Q2600/178
摘要： In Caenorhabditis elegans, lin-4 and let-7 enclode 22- and 21-nucleotide RNAs, respectively, that function as key regulators of developmental timing. Because the appearance of these short RNAs is regulated during development, they are also referred to as “small temporal RNAs” (stRNAs). We show that many more 21- and 22-nt expressed RNAs, termed microRNAs, (miRNAs), exist in invertebrates and vertebrates, and that some of these novel RNAs, similar to let-7 stRAN, are also highly conserved. This suggests that sequence-specific post-transcriptional regulatory mechanisms mediated by small RNAs are more general than previously appreciated.
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公开(公告)号：US07723510B1
公开(公告)日：2010-05-25
申请号：US11747409
申请日：2007-05-11
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/14 , C12N2310/141 , C12N2310/53 , C12N2330/10 , C12Q1/6876 , C12Q2600/136 , C12Q2600/178
摘要： In Caenorhabditis elegans, lin-4 and let-7 enclode 22- and 21-nucleotide RNAs, respectively, that function as key regulators of developmental timing. Because the appearance of these short RNAs is regulated during development, they are also referred to as “small temporal RNAs” (stRNAs). We show that many more 21- and 22-nt expressed RNAs, termed microRNAs, (miRNAs), exist in invertebrates and vertebrates, and that some of these novel RNAs, similar to let-7 stRAN, are also highly conserved. This suggests that sequence-specific post-transcriptional regulatory mechanisms mediated by small RNAs are more general than previously appreciated.
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公开(公告)号：US20100087512A1
公开(公告)日：2010-04-08
申请号：US12550579
申请日：2009-08-31
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/14 , C12N2310/141 , C12N2310/53 , C12N2330/10 , C12Q1/6876 , C12Q2600/136 , C12Q2600/178
摘要： In Caenorhabditis elegans, lin-4 and let-7 enclode 22- and 21-nucleotide RNAs, respectively, that function as key regulators of developmental timing. Because the appearance of these short RNAs is regulated during development, they are also referred to as “small temporal RNAs” (stRNAs). We show that many more 21- and 22-nt expressed RNAs, termed microRNAs, (miRNAs), exist in invertebrates and vertebrates, and that some of these novel RNAs, similar to let-7 stRAN, are also highly conserved. This suggests that sequence-specific post-transcriptional regulatory mechanisms mediated by small RNAs are more general than previously appreciated.
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