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公开(公告)号：US20130164315A1
公开(公告)日：2013-06-27
申请号：US13336648
申请日：2011-12-23
IPC分类号： A61K39/12 , C40B30/06 , C07K7/06 , A61P31/12 , C07K14/11 , A61K39/145 , A61P31/16 , C12Q1/02 , C07K7/08
CPC分类号： G01N33/505 , A61K39/12 , A61K39/145 , C07K14/005 , C12N2760/16122 , C12N2760/16134
摘要： The present invention provides a screening method for identifying a peptide capable of inducing a T cell response comprising: a) contacting a peptide having a level of identity with a sequence of a protein of a virus, with a test sample comprising T cells obtained from blood from a subject who is currently or has been recently infected with the virus, b) quantifying the response of the T cells to the peptide, c) comparing the T cells' response in b) to a response of a control sample comprising T cells obtained from blood from a subject who is not currently infected nor been recently infected with the virus, when contacted with the peptide, wherein a greater response to the peptide in b) than in c) is indicative of a peptide capable of inducing a T cell response.
摘要翻译： 本发明提供了一种用于鉴定能够诱导T细胞应答的肽的筛选方法，包括：a）将与病毒蛋白质序列具有一致性的肽与包含从血液获得的T细胞的测试样品 来自目前或已经最近感染病毒的受试者，b）量化T细胞对肽的反应，c）比较b）中T细胞的反应与包含获得的T细胞的对照样品的应答 来自未被感染的受试者的血液或最近感染了病毒，当与肽接触时，其中b）中对肽的更大反应比c）指示能够诱导T细胞应答的肽 。
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公开(公告)号：US4417384A
公开(公告)日：1983-11-29
申请号：US298419
申请日：1981-09-01
申请人： Thomas Wilkinson
发明人： Thomas Wilkinson
CPC分类号： B23Q16/001 , B23Q35/02 , Y10T29/49888 , Y10T29/49963
摘要： An elongate member capable of forming a part of a support structure for a coordinate machine tool comprises a first relatively rigid elongate part 11 for supporting the weight of a movable load, a second relatively resilient elongate part 12 for locating the movable load on the elongate member, and a plurality of spaced dowels 13 engaging said first and second parts 11, 12 for locating said second part 12 at a predetermined position spaced from the first part 11. The first part 11 is provided with counterbores each of which accommodate a shoulder on each dowel which shoulder accurately locates and spaces the second part 12 relative to the first part 11.
摘要翻译： 能够形成用于坐标机床的支撑结构的一部分的细长构件包括用于支撑可移动载荷的第一相对刚性的细长部分11，用于将可移动载荷定位在细长构件上的第二相对弹性的细长部分12 以及与所述第一和第二部分11,12接合的多个间隔开的销钉13，用于将所述第二部件12定位在与第一部分11间隔开的预定位置处。第一部分11设置有每个在每个部分上容纳肩部的沉孔 肩部准确地定位并且相对于第一部分11使第二部分12空间。
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公开(公告)号：US20100282883A1
公开(公告)日：2010-11-11
申请号：US12681168
申请日：2008-01-29
申请人： Graham Dixon , Thomas Wilkinson
发明人： Graham Dixon , Thomas Wilkinson
CPC分类号： B02C15/12 , B02C15/02 , B02C15/08 , B02C2015/126
摘要： A multi-sectional roller mill comprises at least two mill sections (2, 2′) each including a plurality of 'rollers (20, 20′), wherein each mill section includes a-drive shaft (16, 16′) and male and female parts of a coupling element (15) attached to respective ends of said drive shaft for rotation therewith, and wherein the said coupling element provides for rotation between said male and female parts of drive shafts of adjacent mill sections.
摘要翻译： 多级辊磨机包括至少两个每个包括多个辊（20,20'）的轧机部分（2,2'），其中每个轧机部分包括驱动轴（16,16'）和公制和 耦合元件（15）的阴部分附接到所述驱动轴的相应端部以与其一起旋转，并且其中所述联接元件提供在相邻轧机部分的驱动轴的所述阳部件和阴部件之间的旋转。
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公开(公告)号：US20080001317A1
公开(公告)日：2008-01-03
申请号：US11427089
申请日：2006-06-28
申请人： Jason Tokarski , Kevin P. McCabe , Vincent H. Barre , Changhong Yin , Thomas Wilkinson , Robert J. Watterson , Jeffery S. Longo
发明人： Jason Tokarski , Kevin P. McCabe , Vincent H. Barre , Changhong Yin , Thomas Wilkinson , Robert J. Watterson , Jeffery S. Longo
CPC分类号： B29D11/00125 , B29C33/3842 , B29C33/40 , B29C33/52 , B29C45/1642 , B29L2011/0041
摘要： The present invention includes methods and appartus for forming a biomedical device, such as an ophthalmic lens, wherein the biomedical device is formed with a mold part which is water soluble.
摘要翻译： 本发明包括用于形成诸如眼科镜片的生物医学装置的方法和装置，其中生物医学装置形成有水溶性的模具部件。
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公开(公告)号：US08360351B2
公开(公告)日：2013-01-29
申请号：US12681168
申请日：2008-01-29
申请人： Graham Dixon , Thomas Wilkinson
发明人： Graham Dixon , Thomas Wilkinson
IPC分类号： B02C4/42
CPC分类号： B02C15/12 , B02C15/02 , B02C15/08 , B02C2015/126
摘要： A multi-sectional roller mill comprises at least two mill sections (2, 2′) each including a plurality of ‘rollers (20, 20′), wherein each mill section includes a-drive shaft (16, 16′) and male and female parts of a coupling element (15) attached to respective ends of said drive shaft for rotation therewith, and wherein the said coupling element provides for rotation between said male and female parts of drive shafts of adjacent mill sections.
摘要翻译： 多级辊磨机包括至少两个分别包括多个辊子（20,20'）的轧机部分（2,2'），其中每个轧机部分包括一个驱动轴（16,16'），并且公和母 附接到所述驱动轴的相应端部以与其一起旋转的联接元件（15）的部分，并且其中所述联接元件提供在相邻轧机部分的驱动轴的所述阳部件和阴部件之间的旋转。
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公开(公告)号：US20100233665A1
公开(公告)日：2010-09-16
申请号：US12477156
申请日：2009-06-03
申请人： Thomas Wilkinson
发明人： Thomas Wilkinson
IPC分类号： G09B19/00
CPC分类号： G09B19/0015
摘要： A dance training aid ‘Daryll-eyes’, for general use is disclosed to be fabricated such that it rests on the head of the user. The frame is supported by the nose and ears. The device blocks the vision of the wearer in the downward direction.
摘要翻译： 公开了一种用于一般用途的舞蹈训练辅助器“Daryll-eyes”，以使其搁置在使用者的头上。 框架由鼻子和耳朵支撑。 该装置沿着向下的方向阻挡佩戴者的视觉。
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