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公开(公告)号：US09248107B2
公开(公告)日：2016-02-02
申请号：US13355158
申请日：2012-01-20
IPC分类号： A61K47/18 , A61P31/12 , A61K39/12 , A61K47/42 , A61K39/00 , A61P37/04 , A61K31/13 , A01N1/02 , A61K47/02 , A61K9/00 , A61K47/26
CPC分类号： A61K47/186 , A01N1/021 , A61K9/0019 , A61K31/13 , A61K39/12 , A61K47/02 , A61K47/18 , A61K47/183 , A61K47/26 , A61K2039/5252 , C12N2770/24134 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/395 , Y02A50/465
摘要： Disclosed herein is a formulation capable of enhancing thermostability and shelf-life of a biological product, the formulation comprising: a tertiary amine N-oxide or a derivative thereof represented by the formulae: wherein R1, R2, and R3 may be identical or different and each is a straight or branched lower alkyl group having from 1 to 4 carbon atoms; an inorganic salt; glutamic acid or a salt thereof; a polyol; a physiologically acceptable buffer, and a pharmaceutically acceptable carrier. The tertiary amine N-oxide may be trimethylamine-N-oxide, (CH3)3NO. The formulation is useful for vaccine stabilization.
摘要翻译： 本文公开了能够增强生物产品的热稳定性和保质期的制剂，该制剂包含：由下式表示的叔胺N-氧化物或其衍生物：其中R1，R2和R3可以相同或不同， 各自为具有1至4个碳原子的直链或支链低级烷基; 无机盐; 谷氨酸或其盐; 多元醇 生理上可接受的缓冲剂和药学上可接受的载体。 叔胺N-氧化物可以是三甲胺-N-氧化物，（CH 3）3 NO。 该制剂可用于疫苗稳定化。
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公开(公告)号：US20120201849A1
公开(公告)日：2012-08-09
申请号：US13355158
申请日：2012-01-20
CPC分类号： A61K47/186 , A01N1/021 , A61K9/0019 , A61K31/13 , A61K39/12 , A61K47/02 , A61K47/18 , A61K47/183 , A61K47/26 , A61K2039/5252 , C12N2770/24134 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/395 , Y02A50/465
摘要： Disclosed herein is a formulation capable of enhancing thermostability and shelf-life of a biological product, the formulation comprising: a tertiary amine N-oxide or a derivative thereof represented by the formulae: wherein R1, R2, and R3 may be identical or different and each is a straight or branched lower alkyl group having from 1 to 4 carbon atoms; an inorganic salt; glutamic acid or a salt thereof; a polyol; a physiologically acceptable buffer, and a pharmaceutically acceptable carrier. The tertiary amine N-oxide may be trimethylamine-N-oxide, (CH3)3NO. The formulation is useful for vaccine stabilisation.
摘要翻译： 本文公开了能够增强生物产品的热稳定性和保质期的制剂，该制剂包含：由下式表示的叔胺N-氧化物或其衍生物：其中R1，R2和R3可以相同或不同， 各自为具有1至4个碳原子的直链或支链低级烷基; 无机盐; 谷氨酸或其盐; 多元醇 生理上可接受的缓冲剂和药学上可接受的载体。 叔胺N-氧化物可以是三甲胺-N-氧化物，（CH 3）3 NO。 该制剂对于疫苗稳定是有用的。
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公开(公告)号：US5837240A
公开(公告)日：1998-11-17
申请号：US920095
申请日：1997-08-26
申请人： Cynthia K. Lee , Thomas P. Monath , Samuel K. Ackerman , William D. Thomas , Gopalan Soman , Harold Kleanthous , Richard A. Weltzin , Jacques Pappo , Thomas Ermak , Farshad Guirakhoo , Hitesh Bhagat , Ilene Sussman
发明人： Cynthia K. Lee , Thomas P. Monath , Samuel K. Ackerman , William D. Thomas , Gopalan Soman , Harold Kleanthous , Richard A. Weltzin , Jacques Pappo , Thomas Ermak , Farshad Guirakhoo , Hitesh Bhagat , Ilene Sussman
IPC分类号： A61K38/46 , A61K39/02 , A61K39/106
CPC分类号： A61K39/105 , Y10S514/925 , Y10S514/926 , Y10S514/927
摘要： Methods and compositions are provided for prophylactic and antibacterial therapy for Helicobacter, particularly for Helicobacter pylori, infection of humans. The immunogenic composition of the invention is composed of a plurality of multimeric complexes, each complex being composed of recombinant, enzymatically inactive Helicobacter pylori urease. Each multimeric complex is composed of six Urease A subunits and six Urease B subunits. Alternatively, the composition is composed of a mixture of multimeric complexes, wherein each multimeric complex in the mixture is composed of six Urease A subunits and six Urease B subunits or four Urease A subunits and four Urease B subunits.
摘要翻译： 提供了用于幽门螺杆菌的预防和抗菌治疗的方法和组合物，特别是用于幽门螺杆菌，人的感染。 本发明的免疫原性组合物由多个多聚体复合物组成，每个复合物由重组的酶促活化的幽门螺旋杆菌脲酶组成。 每个多聚体复合物由六个脲酶A亚基和六个脲酶B亚基组成。 或者，组合物由多聚体复合物的混合物组成，其中混合物中的每个多聚复合物由六个脲酶A亚基和六个脲酶B亚基或四个脲酶A亚基和四个脲酶B亚基组成。
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4.发明授权公开(公告)号：US06585975B1
公开(公告)日：2003-07-01
申请号：US09431705
申请日：1999-11-01
申请人： Harold Kleanthous , Patricia Londono-Arcila , Donna Freeman , Cynthia K. Lee , Thomas P. Monath
发明人： Harold Kleanthous , Patricia Londono-Arcila , Donna Freeman , Cynthia K. Lee , Thomas P. Monath
IPC分类号： A61K3902
CPC分类号： A61K39/105 , A61K2039/523 , A61K2039/541 , C12N15/74 , Y02A50/484
摘要： The invention provides a method of immunization against Helicobacter, involving mucosal administration of an attenuated Salmonella vector including a nucleic acid molecule encoding a Helicobacter antigen, and parenteral administration of a soluble Helicobacter antigen, co-administered with a suitable parenteral adjuvant. Also provided by the invention are attenuated Salmonella vectors for use in this method.
摘要翻译： 本发明提供了针对幽门螺杆菌免疫的方法，涉及粘膜施用减毒沙门氏菌载体，包括编码幽门螺杆菌抗原的核酸分子，以及肠胃外施用可溶性幽门螺杆菌抗原，与合适的肠胃外辅助剂共同施用。 本发明还提供了用于该方法的减毒沙门氏菌载体。
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5.发明授权公开(公告)号：US08741312B2
公开(公告)日：2014-06-03
申请号：US13012917
申请日：2011-01-25
CPC分类号： A61K39/12 , A61K2039/5252 , A61K2039/55505 , A61K2039/55566 , C12N7/00 , C12N2770/24121 , C12N2770/24134 , Y02A50/388
摘要： The invention provides a an inactive, non-replicating vaccine comprising whole virion, chemically inactivated Yellow Fever virus which is inactivated using a method that ensures preservation of critical, neutralizing epitopes. The Yellow Fever virus has been adapted to propagate in cells to higher yields than the unadapted virus. The invention also provides methods for preventing Yellow Fever viral infection.
摘要翻译： 本发明提供了一种非活性的非复制疫苗，其包含完整的病毒体，化学灭活的黄热病病毒，其使用确保保存关键的中和表位的方法灭活。 黄热病病毒已经适应于在细胞中传播比未适应病毒更高的产量。 本发明还提供了防止黄热病毒感染的方法。
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