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公开(公告)号:US20130259830A1
公开(公告)日:2013-10-03
申请号:US13809548
申请日:2011-06-24
申请人: Timothy Barden , Colleen Hudson , James Jia , Charles Kim , Regina Graul , Ara Mermerian , Joel Moore , Kevin Sprott , Yueh-tyng Chien
发明人: Timothy Barden , Colleen Hudson , James Jia , Charles Kim , Regina Graul , Ara Mermerian , Joel Moore , Kevin Sprott , Yueh-tyng Chien
IPC分类号: C07D209/14 , A61K31/4439 , C07D409/06 , A61K31/405 , A61K45/06 , A61K31/496 , C07D209/30 , C07D471/04 , A61K31/437 , A61K31/5377 , C07D401/06 , C07D491/052
CPC分类号: C07D209/14 , A61K31/404 , A61K31/405 , A61K31/437 , A61K31/4439 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D209/10 , C07D209/30 , C07D401/06 , C07D403/06 , C07D409/06 , C07D471/04 , C07D491/052 , C07D493/04
摘要: Modulators of CRTH2, particularly antagonists of CRTH2, that are useful for treating various disorders, including asthma and respiratory disorders are disclosed. The compounds fall within a genus described by Formula I:
摘要翻译: 公开了可用于治疗各种疾病(包括哮喘和呼吸系统疾病)的CRTH2调节剂,特别是CRTH2拮抗剂。 化合物属于由式I描述的属:
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公开(公告)号:US20110150834A1
公开(公告)日:2011-06-23
申请号:US12969840
申请日:2010-12-16
申请人: Ara MERMERIAN , Bo Peng , Colleen Hudson , Charles Kim , Joel Moore , Jason Rohde , Kevin Sprott , Regina Graul , Takashi Nakai , James Jia , Wilmin Bartolini
发明人: Ara MERMERIAN , Bo Peng , Colleen Hudson , Charles Kim , Joel Moore , Jason Rohde , Kevin Sprott , Regina Graul , Takashi Nakai , James Jia , Wilmin Bartolini
IPC分类号: A61K31/4025 , C07D403/12 , C07D401/04 , A61K31/4439 , C07D413/12 , A61K31/5377 , A61K31/56 , A61K38/21 , A61K31/7028 , A61K31/606 , A61K38/22 , A61P29/00 , A61P11/00 , A61P37/08 , A61P11/06 , A61P19/02 , A61P1/00 , A61P37/06 , A61P3/10 , A61P25/00 , A61P35/02 , A61P1/04 , A61P17/00
CPC分类号: C07D403/12 , C07D207/325 , C07D401/04 , C07D413/14
摘要: Modulators of CRTH2, particularly antagonists of CRTH2, that are useful for treating various disorders, including asthma and respiratory disorders are disclosed. The compounds fall within a genus described by formula I:
摘要翻译: 公开了可用于治疗各种疾病(包括哮喘和呼吸系统疾病)的CRTH2调节剂,特别是CRTH2拮抗剂。 化合物属于式I所述的一类:
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公开(公告)号:US08674115B2
公开(公告)日:2014-03-18
申请号:US12969840
申请日:2010-12-16
申请人: Ara Mermerian , Bo Peng , Colleen Hudson , Charles Kim , Joel Moore , Jason Rohde , Kevin Sprott , Regina Graul , Takashi Nakai , James Jia , Wilmin Bartolini
发明人: Ara Mermerian , Bo Peng , Colleen Hudson , Charles Kim , Joel Moore , Jason Rohde , Kevin Sprott , Regina Graul , Takashi Nakai , James Jia , Wilmin Bartolini
IPC分类号: C07D207/30 , A61K31/40
CPC分类号: C07D403/12 , C07D207/325 , C07D401/04 , C07D413/14
摘要: Modulators of CRTH2, particularly antagonists of CRTH2, that are useful for treating various disorders, including asthma and respiratory disorders are disclosed. The compounds fall within a genus described by formula I:
摘要翻译: 公开了可用于治疗各种疾病(包括哮喘和呼吸系统疾病)的CRTH2调节剂,特别是CRTH2拮抗剂。 化合物属于式I所述的一类:
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公开(公告)号:US20110312945A1
公开(公告)日:2011-12-22
申请号:US13121669
申请日:2009-10-01
申请人: James Jia , Ara Mermerian , Charles Kim , Regina Graul , Joel Moore
发明人: James Jia , Ara Mermerian , Charles Kim , Regina Graul , Joel Moore
IPC分类号: A61K31/55 , C07D209/12 , C07D403/12 , C07D401/12 , C07D413/14 , C07D409/12 , A61K31/5377 , A61K31/403 , A61K31/496 , A61K31/454 , A61P11/06 , A61P29/00 , A61P37/08 , A61P11/00 , A61P11/02 , A61P19/02 , A61P19/08 , A61P17/06 , A61P17/02 , A61P3/10 , A61P1/00 , C07D413/12
CPC分类号: C07D209/10 , C07D403/12
摘要: Modulators of CRTH2, particularly antagonists of CRTH2, that are useful for treating various disorders, including asthma and respiratory disorders are disclosed. The compounds fall within a genus described by formula I
摘要翻译: 公开了可用于治疗各种疾病(包括哮喘和呼吸系统疾病)的CRTH2调节剂,特别是CRTH2拮抗剂。 化合物属于式I所述的一类
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公开(公告)号:US20130216552A1
公开(公告)日:2013-08-22
申请号:US13809553
申请日:2011-06-24
申请人: Takashi Nakai , James Jia , Jason Rohde , Regina Graul , Ara Mermerian
发明人: Takashi Nakai , James Jia , Jason Rohde , Regina Graul , Ara Mermerian
IPC分类号: A61K31/407 , A61K45/06 , A61K31/429 , A61K31/5377 , C07D495/04 , C07D513/04
CPC分类号: A61K31/407 , A61K31/429 , A61K31/5377 , A61K45/06 , C07D495/04 , C07D513/04
摘要: Modulators of CRTH2, particularly antagonists of CRTH2, that are useful for treating various disorders, including asthma and respiratory disorders are disclosed herein. The compounds are described by structural Formula I:
摘要翻译: CRTH2的调节剂,特别是CRTH2拮抗剂,可用于治疗各种疾病,包括哮喘和呼吸系统疾病。 化合物由结构式I描述:
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公开(公告)号:US20110312938A1
公开(公告)日:2011-12-22
申请号:US13001809
申请日:2009-06-30
申请人: Regina Graul , John Jeffrey Talley , Ara Mermerian
发明人: Regina Graul , John Jeffrey Talley , Ara Mermerian
IPC分类号: A61K31/554 , A61K31/437 , A61K31/5415 , A61K31/5513 , A61P25/24 , A61K31/519 , A61P25/00 , A61P25/18 , A61P25/28 , C07D471/04 , A61K31/496
CPC分类号: C07D471/04 , A61K31/407 , A61K45/06
摘要: Disclosed are compounds and pharmaceutically acceptable salts of Formula (I) wherein R1, R2, R3, and RN are as defined herein. Compounds of Formula (I) are useful in the prevention and/or treatment of neurological and psychiatric disorder, or the like. Also disclosed are pharmaceutical compositions comprising compounds of the disclosure and methods of treating the aforementioned conditions using such compounds.
摘要翻译: 公开了式(I)的化合物和药学上可接受的盐,其中R 1,R 2,R 3和RN如本文所定义。 式(I)的化合物可用于预防和/或治疗神经和精神疾病等。 还公开了包含本公开的化合物和使用这些化合物治疗上述病症的方法的药物组合物。
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公开(公告)号:US20140187795A1
公开(公告)日:2014-07-03
申请号:US13992099
申请日:2011-06-17
申请人: James Jia , Regina Graul , Wayne C Schairer , Vishnu Karnati , Ray Forslund
发明人: James Jia , Regina Graul , Wayne C Schairer , Vishnu Karnati , Ray Forslund
IPC分类号: C07D207/34 , C07D207/48
CPC分类号: C07D207/34 , C07D207/48
摘要: The present invention relates to processes and intermediates for the preparation of compounds useful as CRTH2 antagonists. Compounds prepared by the processes of the invention are of Formula (AI), (All) and Compound (I).
摘要翻译: 本发明涉及制备可用作CRTH2拮抗剂的化合物的方法和中间体。 通过本发明方法制备的化合物具有式(AI),(全部)和化合物(I)。
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公开(公告)号:US20120149743A9
公开(公告)日:2012-06-14
申请号:US12995967
申请日:2009-06-02
申请人: Regina Graul
发明人: Regina Graul
IPC分类号: A61K31/407 , A61P25/00 , A61P25/18 , A61P25/24 , C07D517/04 , A61P25/28
CPC分类号: C07D517/04
摘要: Derivatives of selenophene and selenazole heterocycles are disclosed. The compounds are useful as inhibitors of D-amino acid oxidase (DAO) and in the treatment of neurodegenerative and psychiatric diseases and disorders.
摘要翻译: 公开了硒吩和硒唑杂环的衍生物。 该化合物可用作D-氨基酸氧化酶(DAO)的抑制剂和治疗神经变性和精神疾病和病症。
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公开(公告)号:US20110275683A1
公开(公告)日:2011-11-10
申请号:US12995967
申请日:2009-06-02
申请人: Regina Graul
发明人: Regina Graul
IPC分类号: A61K31/407 , A61P25/00 , A61P25/18 , A61P25/24 , C07D517/04 , A61P25/28
CPC分类号: C07D517/04
摘要: Derivatives of selenophene and selenazole heterocycles are disclosed. The compounds are useful as inhibitors of D-amino acid oxidase (DAO) and in the treatment of neurodegenerative and psychiatric diseases and disorders.
摘要翻译: 公开了硒吩和硒唑杂环的衍生物。 该化合物可用作D-氨基酸氧化酶(DAO)的抑制剂和治疗神经变性和精神疾病和病症。
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