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1.发明授权Compounds and methods for suppressing an immune response to sulfomethoxozale containing substances 失效用于抑制含有磺胺甲氧基的物质的免疫应答的化合物和方法
公开(公告)号：US5599912A
公开(公告)日：1997-02-04
申请号：US118819
申请日：1993-09-10
IPC分类号： A61K31/715 , A61K31/765 , A61K31/785 , A61K38/04 , A61K38/16 , A61K47/48 , C07K14/00 , C07K16/44 , C08B37/16 , A61K39/395 , C07H1/00 , C13K5/00 , C13K7/00
CPC分类号： B82Y5/00 , A61K31/715 , A61K31/765 , A61K31/785 , A61K38/04 , A61K38/16 , A61K47/48169 , A61K47/48969 , C07K14/001 , C07K16/44 , C08B37/0012
摘要： The present invention provides methods of detecting and suppressing an undesired immune response, and agents suitable for use therein. More specifically, the present invention, provides agents and methods for their use, directed at detecting and suppressing an undesired immune response to compositions containing sulfamethoxazole.
摘要翻译： 本发明提供了检测和抑制不期望的免疫应答的方法以及适用于其中的药剂。 更具体地，本发明提供了用于检测和抑制对含有磺胺甲恶唑的组合物的不期望的免疫应答的用途及其用途的方法。
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公开(公告)号：US06685917B2
公开(公告)日：2004-02-03
申请号：US09993383
申请日：2001-11-21
IPC分类号： A61K31195
CPC分类号： A61K31/195 , A61K9/0014 , A61K9/006 , A61K9/06 , A61K31/198 , A61K47/10 , A61K47/34
摘要： This present invention provides a therapeutic composition for use in the treatment of mucositis and a method for using such a therapeutic composition. The therapeutic composition includes a pharmaceutical substance effective for treating mucositis formulated with a biocompatible polymer, such as a biocompatible reverse-thermal gelation polymer.
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3.发明申请COMPOSITIONS AND METHODS FOR ELICITING AN IMMUNE RESPONSE TO ESCAPE MUTANTS OF TARGETED THERAPIES 审中-公开针对特定治疗方法免疫应答的组合物和方法公开(公告)号：US20100034840A1
公开(公告)日：2010-02-11
申请号：US12067802
申请日：2006-07-10
CPC分类号： C12N15/81 , A61K31/506 , A61K39/0011 , A61K39/02 , A61K39/12 , A61K39/21 , A61K39/29 , A61K39/292 , A61K2039/5154 , A61K2039/523 , C12N2730/10111 , C12N2730/10134 , C12N2740/16211 , C12N2740/16234 , C12N2770/24211 , C12N2770/24234
摘要： Provided herein are cells, vectors and viruses in association with a mutant polypeptide that has emerged in response to a therapeutic or prophylactic agent; compositions comprising such cells, vectors and viruses and methods for their use in eliciting an immune response to the mutant polypeptide. In some examples, the immune response is a cellular immune response.
摘要翻译： 本文提供的是与响应于治疗或预防剂而出现的突变多肽相关联的细胞，载体和病毒; 包含这种细胞，载体和病毒的组合物及其用于引发对突变多肽的免疫应答的方法。 在一些实例中，免疫应答是细胞免疫应答。
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4.发明授权Compositions and methods for targeted ablation of mutational escape of targeted therapies for cancer 失效用于靶向治疗癌症突变逃逸的靶向消融的组合物和方法公开(公告)号：US08501167B2
公开(公告)日：2013-08-06
申请号：US12531876
申请日：2008-01-17
IPC分类号： A61K39/00 , A61K31/131 , A61K31/136 , A61K31/166 , A61K31/167
CPC分类号： C12N15/85 , A01K2267/0331 , A61K2039/523
摘要： Provided herein are compositions and methods for targeted ablation of mutational escape in the face of cancer therapeutic agents. Compositions comprising the yeast-based vehicles are used in combination with other cancer therapeutic agents.
摘要翻译： 本文提供了面对癌症治疗剂的靶向消融突变逃逸的组合物和方法。 包含基于酵母的载体的组合物与其它癌症治疗剂组合使用。
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5.发明授权Delivery vehicle composition and methods for delivering antigens and other drugs 有权递送载体组合物和递送抗原和其他药物的方法公开(公告)号：US07767197B2
公开(公告)日：2010-08-03
申请号：US09888235
申请日：2001-06-22
IPC分类号： A61A31/745 , A61A31/00
CPC分类号： A61K39/04 , A61K9/0043 , A61K9/0078 , A61K31/721 , A61K31/722 , A61K31/74 , A61K2039/55561
摘要： The present invention provides an immunogen composition and methods for using the same for the development of immunity, and particularly at mucosal sites in a mammal, thereby providing immunity at the site of entry for many major pathogenic organisms and also systemic immunity. The immunogen composition includes an antigen, a biocompatible polymer, and a liquid vehicle, with the biocompatible polymer and liquid vehicle being present in such proportions and interacting in such a way that the immunogen composition exhibits reverse-thermal viscosity behaviour. A delivery vehicle composition including a drug other than an antigen is also provided. Methods are provided for delivering the compositions of the invention to a host.
摘要翻译： 本发明提供免疫原组合物及其用于发展免疫力的方法，特别是在哺乳动物的粘膜部位，从而在许多主要致病生物体的进入部位提供免疫以及全身免疫。 免疫原组合物包括抗原，生物相容性聚合物和液体媒介物，其中生物相容性聚合物和液体媒介物以这样的比例存在并且以使得免疫原组合物显示出反向热粘性行为的方式相互作用。 还提供了包含除抗原以外的药物的递送载体组合物。 提供了将本发明的组合物递送到宿主的方法。
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6.发明申请COMPOSITIONS AND METHODS FOR TARGETED ABLATION OF MUTATIONAL ESCAPE OF TARGETED THERAPIES FOR CANCER 失效用于癌症的针对性治疗的临时护理的组合物和方法公开(公告)号：US20100111912A1
公开(公告)日：2010-05-06
申请号：US12531876
申请日：2008-01-17
CPC分类号： C12N15/85 , A01K2267/0331 , A61K2039/523
摘要： Provided herein are compositions and methods for targeted ablation of mutational escape in the face of cancer therapeutic agents. Compositions comprising the yeast-based vehicles are used in combination with other cancer therapeutic agents.
摘要翻译： 本文提供了面对癌症治疗剂的靶向消融突变逃逸的组合物和方法。 包含基于酵母的载体的组合物与其它癌症治疗剂组合使用。
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