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1.发明申请Metabolically engineered bacterial strains having enhanced 2-keto-D-gluconate accumulation 审中-公开具有增强的2-酮-D-葡萄糖酸盐积累的代谢改造的细菌菌株公开(公告)号：US20070184540A1
公开(公告)日：2007-08-09
申请号：US11731923
申请日：2007-04-02
申请人： Timothy Dodge , M. Rashid , Fernando Valle
发明人： Timothy Dodge , M. Rashid , Fernando Valle
CPC分类号： C12P7/60 , C12N9/0006 , C12P19/02
摘要： The present invention relates to a method of altering bacterial host cells to accumulate 2-keto-D-gluconic acid (2-KDG) by inactivating an endogenous membrane bound 2-keto-D-gluconate dehydrogenase (2-KDGDH), which prior to inactivation catalyzed the conversion of 2-KDG to 2,5-diketogluconate (2,5-DKG).
摘要翻译： 本发明涉及通过灭活内源性膜结合的2-酮-D-葡萄糖酸脱氢酶（2-KDGDH）来改变细菌宿主细胞以积累2-酮-D-葡萄糖酸（2-KDG）的方法，其在 失活催化了2-KDG转化为2,5-二酮葡萄糖酸盐（2,5-DKG）。
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2.发明申请Metabolically engineered bacterial strains having non-functional endogenous gluconate transporters 失效具有非功能性内源葡萄糖酸盐转运蛋白的代谢改造的细菌菌株公开(公告)号：US20050112734A1
公开(公告)日：2005-05-26
申请号：US10842929
申请日：2004-05-10
申请人： Timothy Dodge , Manoj Kumar , M. Rashid , Fernando Valle
发明人： Timothy Dodge , Manoj Kumar , M. Rashid , Fernando Valle
摘要： The present invention relates to engineering metabolic pathways in bacterial host cells which results in enhanced carbon flow for the production of ascorbic acid (ASA) intermediates. In particular, the invention relates to increasing the production of ASA intermediates in bacterial cells by enhancing the availability of gluconate resulting from the inactivation of endogenous gluconate transporter genes.
摘要翻译： 本发明涉及在细菌宿主细胞中工程代谢途径，其导致用于生产抗坏血酸（ASA）中间体的增强的碳流。 特别地，本发明涉及通过增加由内源性葡萄糖酸转运蛋白基因失活产生的葡萄糖酸盐的可利用性来增加细菌细胞中ASA中间体的产生。
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3.发明申请Metabolically engineered bacterial strains having enhanced 2-keto-D-gluconate accumulation 审中-公开具有增强的2-酮-D-葡萄糖酸盐积累的代谢改造的细菌菌株公开(公告)号：US20050106693A1
公开(公告)日：2005-05-19
申请号：US10899602
申请日：2004-07-27
申请人： Timothy Dodge , M. Rashid , Fernando Valle
发明人： Timothy Dodge , M. Rashid , Fernando Valle
CPC分类号： C12P7/60 , C12N9/0006 , C12P19/02
摘要： The present invention relates to a method of altering bacterial host cells to accumulate 2-keto-D-gluconic acid (2-KDG) by inactivating an endogenous membrane bound 2-keto-D-gluconate dehydrogenase (2-KDGDH), which prior to inactivation catalyzed the conversion of 2-KDG to 2,5-diketogluconate (2,5-DKG).
摘要翻译： 本发明涉及通过灭活内源性膜结合的2-酮-D-葡萄糖酸脱氢酶（2-KDGDH）来改变细菌宿主细胞以积累2-酮-D-葡萄糖酸（2-KDG）的方法，其在 失活催化了2-KDG转化为2,5-二酮葡萄糖酸盐（2,5-DKG）。
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公开(公告)号：US20050080248A1
公开(公告)日：2005-04-14
申请号：US10899557
申请日：2004-07-27
申请人： Robert Caldwell , M. Rashid , Fernando Valle
发明人： Robert Caldwell , M. Rashid , Fernando Valle
摘要： The present invention concerns multimeric oxidoreductase complexes which function in the enzymatic conversion of a carbon substrate, said complexes having a dehydrogenase subunit and a cytochrome C subunit. The invention further relates to polynucleotides coding for the multimeric complexes and methods of use thereof.
摘要翻译： 本发明涉及在碳底物的酶促转化中起作用的多聚体氧化还原酶复合物，所述复合物具有脱氢酶亚基和细胞色素C亚基。 本发明还涉及编码多聚体复合物的多核苷酸及其使用方法。
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