公开(公告)号：US20060009959A1

公开(公告)日：2006-01-12

申请号：US11089588

申请日：2004-07-07

Applicant: Timothy Fischer ,  Rohit Bhatia

Inventor： Timothy Fischer ,  Rohit Bhatia

IPC: G06F17/50

CPC classification number: G06F17/5036 ,  G06F2217/08

Abstract: Systems, methodologies, media, and other embodiments associated with activity factor based design are described. One exemplary system embodiment includes an activity factor logic configured to determine an activity factor for a first node. The activity factor relates an input activity for the first node to an output activity for the first node. The example system may also include a transmission factor logic configured to determine a transmission factor for the first node. The transmission factor describes a degree of causal power switching between the first node and a second node. The example system may also include a downstream power logic operably connected to the activity factor logic or the transmission factor logic. The downstream power logic may be configured to determine a power consumption amount for the second node. The power consumption amount may depend, for example, on the activity factor and the transmission factor.

Abstract translation: 描述了与基于活动因素的设计相关联的系统，方法，介质和其他实施例。 一个示例性系统实施例包括被配置为确定第一节点的活动因子的活动因素逻辑。 活动因素将第一节点的输入活动与第一个节点的输出活动相关联。 示例系统还可以包括被配置为确定第一节点的传输因子的传输因子逻辑。 传输因子描述了第一节点和第二节点之间的因果功率切换程度。 示例系统还可以包括可操作地连接到活动因子逻辑或传输因子逻辑的下游功率逻辑。 下游功率逻辑可以被配置为确定第二节点的功耗量。 功耗量可以取决于例如活动因素和传输因子。

公开(公告)号：US07300748B2

公开(公告)日：2007-11-27

申请号：US11172057

申请日：2005-06-29

Applicant: Timothy Fischer ,  Walter Sherman

Inventor： Timothy Fischer ,  Walter Sherman

IPC: A01N1/00

CPC classification number: G01N1/30 ,  G01N2001/302

Abstract: The invention is directed to a method and composition of matter for enhancing the staining of tissue or features of interest therein by applying an effective amount of a bile salt in combination with a special stain to a tissue suspected of harboring a microorganism or other feature of diagnostic interest. The particular invention herein is directed to detecting H. pylori, the microorganism responsible for gastrointestinal ulcers. The composition of matter is a sensitizer for Alcian Yellow stain.

Abstract translation: 本发明涉及用于通过将有效量的胆汁盐与特殊污渍组合施用于怀疑携带微生物的组织或其它诊断特征的组织或其特征来增强组织或其特征的染色的方法和组合物 利益。 本发明的特定发明涉及检测幽门螺杆菌，其是负责胃肠溃疡的微生物。 物质的组成是Alcian黄色染色剂的敏化剂。

公开(公告)号：US20060286595A1

公开(公告)日：2006-12-21

申请号：US11506012

申请日：2006-08-17

Applicant: Timothy Fischer ,  Douglas Malinowski ,  Adriann Taylor ,  Margaret Parker

Inventor： Timothy Fischer ,  Douglas Malinowski ,  Adriann Taylor ,  Margaret Parker

IPC: C12Q1/70 ,  C12Q1/68

CPC classification number: G01N33/57411 ,  C07K16/3069 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/158 ,  G01N33/6875 ,  G01N2333/025

Abstract: Methods and compositions for identifying high-grade cervical disease in a patient sample are provided. The methods of the invention comprise detecting overexpression of at least one biomarker in a body sample, wherein the biomarker is selectively overexpressed in high-grade cervical disease. In particular claims, the body sample is a cervical smear or monolayer of cervical cells. The biomarkers of the invention include genes and proteins that are involved in cell cycle regulation, signal transduction, and DNA replication and transcription. In particular claims, the biomarker is an S-phase gene. In some aspects of the invention, overexpression of a biomarker of interest is detected at the protein level using biomarker-specific antibodies or at the nucleic acid level using nucleic acid hybridization techniques. Kits for practicing the methods of the invention are further provided.

公开(公告)号：US20080117226A1

公开(公告)日：2008-05-22

申请号：US12020062

申请日：2008-01-25

Applicant: Christopher Edge ,  Timothy Fischer ,  William Rozzi

Inventor： Christopher Edge ,  Timothy Fischer ,  William Rozzi

IPC: G09G5/02 ,  H04N1/60

CPC classification number: H04N1/407 ,  G09G5/02 ,  H04N1/603 ,  H04N1/6052

Abstract: A method for performing color conversion includes configuring a color transformer to perform black point scaling when converting image data from a source device to a destination device. Another method for performing black point adjustment while performing color management conversions includes determining a device independent black reference vector for a device that corresponds to a predetermined set of device dependent values for that device. Converting the device dependent values to device independent data and adjusting the device independent data based on the device independent black reference vector.

Abstract translation: 执行颜色转换的方法包括：在将图像数据从源设备转换为目的地设备时，配置彩色变换器以执行黑点缩放。 执行颜色管理转换时执行黑点调整的另一种方法包括确定与设备相关的设备相关值的设备对应的设备独立的黑色参考向量。 将设备相关值转换为与设备无关的数据，并根据设备无关的黑色参考向量调整设备独立数据。

公开(公告)号：US20070080974A1

公开(公告)日：2007-04-12

申请号：US11611190

申请日：2006-12-15

Applicant: Christopher Edge ,  Timothy Fischer ,  William Rozzi

Inventor： Christopher Edge ,  Timothy Fischer ,  William Rozzi

IPC: G09G5/02

CPC classification number: H04N1/407 ,  G09G5/02 ,  H04N1/603 ,  H04N1/6052

Abstract: A color mapping method is used in transforming colors between color imaging systems. The method includes using forward transformation profiles that characterize the color imaging systems to generate respective sets of device-independent color values for the color imaging systems. Color conversions are calculated by recursively reducing differences between the respective sets of device-independent color values. Based on these color conversions, a color map is constructed that describes a relationship between the color imaging systems.

Abstract translation: 颜色映射方法用于在彩色成像系统之间转换颜色。 该方法包括使用表征彩色成像系统的正向变换曲线，以生成用于彩色成像系统的各组与设备无关的颜色值。 通过递归减少各组与设备无关的颜色值之间的差异来计算颜色转换。 基于这些颜色转换，构建了描绘彩色成像系统之间的关系的颜色图。

公开(公告)号：US20060078926A1

公开(公告)日：2006-04-13

申请号：US11233243

申请日：2005-09-22

Applicant: Raphael Marcelpoil ,  Clark Merrill Whitehead ,  Timothy Fischer

Inventor： Raphael Marcelpoil ,  Clark Merrill Whitehead ,  Timothy Fischer

IPC: C12Q1/68 ,  G01N33/574 ,  G06F19/00

CPC classification number: C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/158 ,  G01N33/574 ,  G01N33/57415 ,  G06F19/18

Abstract: Methods and computer program products for evaluating and optimizing one or more markers for use in establishing a prognosis for a patient suffering from a disease are provided. More particularly, the methods include steps for systematically evaluating a number of features that may be extracted from an image of a body sample, such as a histological slide, that has been exposed to one or more biomarkers so as to establish a prognostic decision rule based on one or more of the extracted features such that the decision rule yields a prognosis that is optimally predictive of actual patient outcome. Thus, the methods and computer program products provided yield optimally predictive prognoses to assist clinicians in developing strategies for effective patient care management.

Abstract translation: 提供了用于评估和优化用于确定患有疾病的患者的预后的一种或多种标记物的方法和计算机程序产品。 更具体地，所述方法包括用于系统地评估可以从已经暴露于一个或多个生物标志物的身体样品（例如组织学载玻片）的图像中提取的许多特征的步骤，以便建立基于预后决定规则 在一个或多个提取的特征上，使得决策规则产生最佳预测实际患者结果的预后。 因此，提供的方法和计算机程序产品产生了最佳预测预测，以帮助临床医生制定有效的患者护理管理策略。

公开(公告)号：US20050076257A1

公开(公告)日：2005-04-07

申请号：US10679725

申请日：2003-10-06

Applicant: Timothy Fischer ,  Samuel Naffziger

Inventor： Timothy Fischer ,  Samuel Naffziger

IPC: G06F1/12 ,  G06F1/32 ,  G06F1/26

CPC classification number: G06F1/3203 ,  G06F1/12 ,  G06F1/324 ,  G06F1/3287 ,  Y02D10/126 ,  Y02D10/171

Abstract: One embodiment of the invention comprises, in each clock zone of a central processing unit, at least one sensor that generates a power signal indicative of a power supply voltage within the clock zone, a clock generator for providing a variable frequency clock to the clock zone, and a controller for controlling an operating frequency of the clock generator in response to the power signal and in response to frequency adjustment communications from other clock zones.

Abstract translation: 本发明的一个实施例在中央处理单元的每个时钟区域中包括至少一个传感器，其生成指示时钟区域内的电源电压的功率信号，用于向时钟区域提供可变频率时钟的时钟发生器 以及控制器，用于响应于功率信号和响应于来自其它时钟频带的频率调整通信来控制时钟发生器的工作频率。

公开(公告)号：US20050038979A1

公开(公告)日：2005-02-17

申请号：US10945710

申请日：2004-09-21

Applicant: Timothy Fischer ,  Daniel Leibholz ,  James Farrell

Inventor： Timothy Fischer ,  Daniel Leibholz ,  James Farrell

IPC: G06F7/48 ,  G06F7/50 ,  G06F7/52 ,  G06F7/535 ,  G06F9/38 ,  G06F9/30

CPC classification number: G06F7/535 ,  G06F7/4824 ,  G06F7/508 ,  G06F9/3802 ,  G06F9/3814 ,  G06F9/3838 ,  G06F9/384 ,  G06F2207/5352

Abstract: In a pipelined computer architecture in which instructions may be removed from the instruction queue out of sequence, instruction queue status at a cycle K is determined by adding together the number of invalid instructions or free rows in the queue during cycle K-2, the number of instructions issued for cycle K-1 and the number of instructions speculatively issued in cycle K-1 that have produced a cache hit, and subtracting from the sum the number of instructions enqueued for cycle K-1. The result indicates the number of invalid instructions in the queue cycle K. The number of invalid entries instructions, the number of issued instructions, and the number of enqueued instructions are preferably represented as flat vectors, so that adding is performed by shifting in one direction, while subtracting is performed by shifting in the opposite direction. The result is compared with either the number of instructions to be enqueued in the present cycle, which number is encoded, or with a predetermined value. A stall signal is generated if the indicative value is less than the encoded number or the predetermined value.

Abstract translation: 在可以从指令队列中排除指令的流水线计算机体系结构中，循环K处的指令队列状态通过在循环K-2期间将队列中的无效指令或空闲行的数量相加在一起而确定， 针对循环K-1发出的指令和在循环K-1中推测发出的产生高速缓存命中的指令的数量，并从总和中减去循环K-1排队的指令数。 结果表示队列周期K中的无效指令的数量。无效条目指令的数量，发出的指令的数量和入队指令的数量优选地被表示为平坦向量，使得通过在一个方向上移位来执行加法 ，而通过在相反方向上移动来执行减法。 将结果与在本周期中排队的指令的数量，编号的数量或预定值进行比较。 如果指示值小于编码数或预定值，则产生失速信号。

公开(公告)号：US20070212721A1

公开(公告)日：2007-09-13

申请号：US11699229

申请日：2007-01-29

Applicant: Timothy Fischer ,  Douglas Malinowski ,  Qin He ,  Clark Whitehead ,  Robert Cheek

Inventor： Timothy Fischer ,  Douglas Malinowski ,  Qin He ,  Clark Whitehead ,  Robert Cheek

IPC: C12Q1/68 ,  G01N33/574 ,  G06F19/00

CPC classification number: G01N33/57449

Abstract: Screening methods for identifying patients with an increased likelihood of having ovarian cancer are provided. The screening methods involve the detection of expression of a plurality of biomarkers in a body sample, wherein overexpression of the biomarkers is indicative of an increased likelihood of having ovarian cancer. The screening methods may further comprise a two-step analysis. Biomarkers of interest include genes and proteins that are, for example, involved in defects in DNA replication/cell cycle control, cell growth and proliferation, escape from apoptosis, angiogenesis or lymphogenesis, or the mechanisms of cancer cell motility and invasion. In some aspects of the invention, expression of a biomarker is detected at the protein level using a biomarker-specific antibody or at the nucleic acid level using nucleic acid hybridization techniques. Methods for detecting ovarian cancer in patients are further disclosed herein. Kits for practicing the methods of the invention are further provided.

Abstract translation: 提供了鉴定患卵巢癌可能性增加的筛查方法。 筛选方法涉及检测体内样品中多种生物标志物的表达，其中生物标志物的过表达表明卵巢癌的可能性增加。 筛选方法还可以包括两步分析。 感兴趣的生物标志物包括例如参与DNA复制/细胞周期控制，细胞生长和增殖，逃避凋亡，血管生成或淋巴发生的缺陷或癌细胞运动和侵袭的机制的基因和蛋白质。 在本发明的一些方面，使用生物标志物特异性抗体或在核酸水平使用核酸杂交技术在蛋白质水平上检测生物标志物的表达。 本文进一步公开了患者卵巢癌检测方法。 还提供了用于实施本发明的方法的试剂盒。

公开(公告)号：US20070117167A1

公开(公告)日：2007-05-24

申请号：US11643277

申请日：2006-12-21

Applicant: Douglas Malinowski ,  Timothy Fischer ,  Adriann Taylor

Inventor： Douglas Malinowski ,  Timothy Fischer ,  Adriann Taylor

IPC: G01N33/574 ,  C12N5/06 ,  C07K16/30

CPC classification number: G01N33/57411 ,  C07K14/4738 ,  C07K16/3069 ,  C07K2317/34

Abstract: Compositions and methods for diagnosing high-grade cervical disease in a patient sample are provided. The compositions include novel monoclonal antibodies, and variants and fragments thereof, that specifically bind to MCM2. Monoclonal antibodies having the binding characteristics of an MCM2 antibody of the invention are further provided. Hybridoma cell lines that produce an MCM2 monoclonal antibody of the invention are also disclosed herein. The compositions find use in practicing methods for diagnosing high-grade cervical disease comprising detecting overexpression of MCM2 in a cervical sample from a patient. Kits for practicing the methods of the invention are further provided. Polypeptides comprising the amino acid sequence for an MCM2 epitope and methods of using these polypeptides in the production of antibodies are also encompassed by the present invention.

Abstract translation: 提供用于诊断患者样本中高级宫颈疾病的组成和方法。 组合物包括特异性结合MCM2的新单克隆抗体及其变体和片段。 还提供具有本发明的MCM2抗体的结合特征的单克隆抗体。 产生本发明的MCM2单克隆抗体的杂交瘤细胞系也在本文中公开。 该组合物用于诊断高级宫颈疾病的实践方法，包括检测来自患者的子宫颈样品中MCM2的过表达。 还提供了用于实施本发明的方法的试剂盒。 包含MCM2表位的氨基酸序列的多肽和在产生抗体中使用这些多肽的方法也包括在本发明中。