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公开(公告)号:US06432645B1
公开(公告)日:2002-08-13
申请号:US09510257
申请日:2000-02-22
申请人: Timothy J. Jegla , Alan Wickenden , Yi Liu
发明人: Timothy J. Jegla , Alan Wickenden , Yi Liu
IPC分类号: C12Q168
CPC分类号: C07K14/705
摘要: The invention provides isolated nucleic acid and amino acid sequences of BK beta 2, BK beta 3, and BK beta 4, antibodies to the BK beta subunits, methods of detecting the BK beta subunits, methods of screening for modulators of Slo potassium channels comprising BK beta subunits, and kits for screening for activators and inhibitors of the Slo family potassium channels comprising BK beta subunits.
摘要翻译: 本发明提供了BKβ2,BKβ3和BKβ4的分离的核酸和氨基酸序列,BKβ亚基的抗体,检测BKβ亚基的方法,筛选包含BK的Slo钾通道调节剂的方法 β亚基和用于筛选包含BKβ亚基的Slo家族钾通道的激活剂和抑制剂的试剂盒。
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公开(公告)号:US06413741B1
公开(公告)日:2002-07-02
申请号:US09343494
申请日:1999-06-30
申请人: Timothy J. Jegla , Alan Wickenden
发明人: Timothy J. Jegla , Alan Wickenden
IPC分类号: C12N1512
CPC分类号: G01N33/6872 , C07H21/04 , C07K14/705 , G01N2333/70571
摘要: The invention provides isolated nucleic acid and amino acid sequences of hElk, antibodies to hElk, methods of detecting hElk, methods of screening for voltage-gated potassium channel activators and inhibitors using biologically active hElk, and kits for screening for activators and inhibitors of voltage-gated potassium channels comprising hElk.
摘要翻译: 本发明提供hElk的分离的核酸和氨基酸序列,hElk的抗体,检测hElk的方法,筛选电压门控的钾通道激活剂的方法和使用生物活性的hElk的抑制剂,以及用于筛选激活剂和电压 - 门控钾通道包括hElk。
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公开(公告)号:US07355009B2
公开(公告)日:2008-04-08
申请号:US10966297
申请日:2004-10-15
申请人: Timothy J. Jegla , Alan Wickenden
发明人: Timothy J. Jegla , Alan Wickenden
IPC分类号: C07K16/28
CPC分类号: G01N33/6872 , C07H21/04 , C07K14/705 , G01N2333/70571
摘要: The invention provides isolated nucleic acid and amino acid sequences of hElk, antibodies to hElk, methods of detecting hElk, methods of screening for voltage-gated potassium channel activators and inhibitors using biologically active hElk, and kits for screening for activators and inhibitors of voltage-gated potassium channels comprising hElk.
摘要翻译: 本发明提供hElk的分离的核酸和氨基酸序列,hElk的抗体,检测hElk的方法,筛选电压门控的钾通道激活剂的方法和使用生物活性的hElk的抑制剂,以及用于筛选激活剂和电压 - 门控钾通道包括hElk。
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公开(公告)号:US06833440B2
公开(公告)日:2004-12-21
申请号:US10160224
申请日:2002-05-28
申请人: Timothy J. Jegla , Alan Wickenden
发明人: Timothy J. Jegla , Alan Wickenden
IPC分类号: C07K1400
CPC分类号: G01N33/6872 , C07H21/04 , C07K14/705 , G01N2333/70571
摘要: The invention provides isolated nucleic acid and amino acid sequences of hElk, antibodies to hElk, methods of detecting hElk, methods of screening for voltage-gated potassium channel activators and inhibitors using biologically active hElk, and kits for screening for activators and inhibitors of voltage-gated potassium channels comprising hElk.
摘要翻译: 本发明提供hElk的分离的核酸和氨基酸序列,hElk的抗体,检测hElk的方法,筛选电压门控的钾通道激活剂的方法和使用生物活性的hElk的抑制剂,以及用于筛选激活剂和电压 - 门控钾通道包括hElk。
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公开(公告)号:US06994968B1
公开(公告)日:2006-02-07
申请号:US09914053
申请日:2000-02-22
申请人: Timothy James Jegla , Alan Wickenden , Yi Liu
发明人: Timothy James Jegla , Alan Wickenden , Yi Liu
CPC分类号: C07K14/705
摘要: The invention provides isolated nucleic acid and amino sequences of BK beta 2, BK beta 3, and BK beta 4, antibodies to the BK beta subunits, methods of detecting the BK beta subunits, methods of screening for modulators of Slo family potassium channels comprising BK beta subunits.
摘要翻译: 本发明提供了BKβ2,BKβ3和BKβ4的分离的核酸和氨基序列,BKβ亚基的抗体,检测BKβ亚基的方法,筛选包含BK的Slo家族钾通道调节剂的方法 β亚基。
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公开(公告)号:US20060004187A1
公开(公告)日:2006-01-05
申请号:US11219359
申请日:2005-09-02
申请人: Timothy Jegla , Alan Wickenden , Yi Liu
发明人: Timothy Jegla , Alan Wickenden , Yi Liu
IPC分类号: C07K14/705 , C12Q1/68 , C07H21/04
CPC分类号: C07K14/705
摘要: The invention provides isolated nucleic acid and amino acid sequences of BK beta 2, BK beta 3, and BK beta 4, antibodies to the BK beta subunits, methods of detecting the BK beta subunits, methods of screening for modulators of Slo potassium channels comprising BK beta subunits, and kits for screening for activators and inhibitors of the Slo family potassium channels comprising BK beta subunits.
摘要翻译: 本发明提供了BKβ2,BKβ3和BKβ4的分离的核酸和氨基酸序列,BKβ亚基的抗体,检测BKβ亚基的方法,筛选包含BK的Slo钾通道调节剂的方法 β亚基和用于筛选包含BKβ亚基的Slo家族钾通道的激活剂和抑制剂的试剂盒。
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公开(公告)号:US07351553B2
公开(公告)日:2008-04-01
申请号:US11219359
申请日:2005-09-02
申请人: Timothy James Jegla , Alan Wickenden , Yi Liu
发明人: Timothy James Jegla , Alan Wickenden , Yi Liu
IPC分类号: C12P21/06
CPC分类号: C07K14/705
摘要: The invention provides isolated nucleic acid and amino acid sequences of BK beta 2, BK beta 3, and BK beta 4, antibodies to the BK beta subunits, methods of detecting the BK beta subunits, methods of screening for modulators of Slo potassium channels comprising BK beta subunits, and kits for screening for activators and inhibitors of the Slo family potassium channels comprising BK beta subunits.
摘要翻译: 本发明提供了BKβ2,BKβ3和BKβ4的分离的核酸和氨基酸序列,BKβ亚基的抗体,检测BKβ亚基的方法,筛选包含BK的Slo钾通道调节剂的方法 β亚基和用于筛选包含BKβ亚基的Slo家族钾通道的激活剂和抑制剂的试剂盒。
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公开(公告)号:US20050227250A1
公开(公告)日:2005-10-13
申请号:US10966297
申请日:2004-10-15
申请人: Timothy Jegla , Alan Wickenden
发明人: Timothy Jegla , Alan Wickenden
CPC分类号: G01N33/6872 , C07H21/04 , C07K14/705 , G01N2333/70571
摘要: The invention provides isolated nucleic acid and amino acid sequences of hElk, antibodies to hElk, methods of detecting hElk, methods of screening for voltage-gated potassium channel activators and inhibitors using biologically active hElk, and kits for screening for activators and inhibitors of voltage-gated potassium channels comprising hElk.
摘要翻译: 本发明提供hElk的分离的核酸和氨基酸序列,hElk的抗体,检测hElk的方法,筛选电压门控的钾通道激活剂的方法和使用生物活性的hElk的抑制剂,以及用于筛选激活剂和电压 - 门控钾通道包括hElk。
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