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    Catheter devices for myocardial injections or other uses
    3.
    发明授权
    Catheter devices for myocardial injections or other uses 有权
    用于心肌注射或其他用途的导管器械

    公开(公告)号：US08292873B2

    公开(公告)日：2012-10-23

    申请号：US12187439

    申请日：2008-08-07

    申请人： Timothy J. Mickley ,  Erik Sperry ,  Stephanie Webber ,  Chad Harris ,  Samuel J. Epstein ,  Grace Kim

    发明人： Timothy J. Mickley ,  Erik Sperry ,  Stephanie Webber ,  Chad Harris ,  Samuel J. Epstein ,  Grace Kim

    IPC分类号： A61M25/00

    CPC分类号： A61M25/0084 ,  A61B2017/00247 ,  A61B2017/22077 ,  A61B2018/00392

    摘要： A catheter device includes an elongate tubular housing, a cannula, and a flexible proboscis. The cannula defines a cannula lumen which is in fluid communication with a cannula exit port located adjacent the distal end of the elongate housing. The distal tip of the cannula is disposed within the cannula lumen. The cannula defines a proboscis lumen and the cannula has a proboscis exit port in fluid communication with the proboscis lumen. The proboscis exit port is located at the distal tip of the cannula. The flexible proboscis has a distal tip and is disposed within the proboscis lumen.

    摘要翻译： 导管装置包括细长管状外壳，套管和柔性长鼻子。 套管限定套管腔，其与位于细长壳体的远端附近的套管出口相流体连通。 套管的远端设置在套管腔内。 套管限定了长鼻腔，并且套管具有与长鼻腔流体连通的长鼻出口。 长鼻子出口位于套管的远端。 柔性长鼻具有远端尖端并且设置在长鼻腔内。

    Medical device for vessel compatibility during high pressure infusion
    4.
    发明授权
    Medical device for vessel compatibility during high pressure infusion 失效
    用于高压输注期间血管相容性的医疗装置

    公开(公告)号：US07938799B2

    公开(公告)日：2011-05-10

    申请号：US11780885

    申请日：2007-07-20

    申请人： Samuel J. Epstein ,  Toby Freyman ,  Chad G. Harris ,  Timothy J. Mickley

    发明人： Samuel J. Epstein ,  Toby Freyman ,  Chad G. Harris ,  Timothy J. Mickley

    IPC分类号： A61M31/00 ,  A61M37/00

    CPC分类号： A61M29/02 ,  A61B17/12022 ,  A61B17/1204 ,  A61B17/12104 ,  A61B17/12131 ,  A61B17/12172 ,  A61B2017/1205 ,  A61M2025/0024 ,  A61M2025/1052 ,  A61M2025/1081 ,  A61M2025/1095

    摘要： The invention provides devices that can be used to deliver a therapeutic agent to a treatment site within the vessel of a patient at increased pressure, while limiting the contact with and pressure placed on the vessel walls. Devices according to the invention include an expandable structure arranged around and on a tube having a lumen. The expandable structure may include a sealing ring that makes contact with the interior surface of a vessel to prevent or decrease fluid flow during delivery of a therapeutic agent. This allows delivery of a therapeutic agent with decreased risk of injury to the treatment site. The invention also provides for large lumen diameters, preventing shearing stress on therapeutic agents such as cell slurries.

    摘要翻译： 本发明提供了可用于将治疗剂递送到患者血管内的治疗部位的装置，所述治疗部位在增加的压力下同时限制与血管壁上的接触和压力。 根据本发明的装置包括布置在具有内腔的管周围和管上的可扩张结构。 可膨胀结构可包括与血管内表面接触以防止或减少递送治疗剂期间的流体流动的密封环。 这允许递送具有降低治疗部位损伤风险的治疗剂。 本发明还提供大的管腔直径，防止治疗剂如细胞浆液的剪切应力。

    Elongated medical device with functional distal end
    5.
    发明授权
    Elongated medical device with functional distal end 有权
    具有功能性远端的细长的医疗装置

    公开(公告)号：US07544183B2

    公开(公告)日：2009-06-09

    申请号：US11360764

    申请日：2006-02-24

    申请人： Matthew Hawk ,  Scott Larson ,  Timothy J. Mickley ,  Chad Harris

    发明人： Matthew Hawk ,  Scott Larson ,  Timothy J. Mickley ,  Chad Harris

    IPC分类号： A61M5/178

    CPC分类号： A61M25/0069 ,  A61B17/3478 ,  A61B2017/00247 ,  A61B2017/22069 ,  A61B2017/22077 ,  A61B2017/348 ,  A61B2017/3488 ,  A61B2018/00392 ,  A61B2018/00738 ,  A61B2090/036 ,  A61B2218/002 ,  A61M25/10 ,  A61M2025/1093

    摘要： An elongate medical device that may be used for performing medical procedures on a patient is provided. This elongate medical device may include a first member having a distal end, an outer surface, and a first lumen, where the first member may have an elongated configuration such that the length of the first member is at least ten times greater than the width of the first member. The elongate medical device may also have a second member positioned within the first member and a hood stop. The hood stop in this device may be positioned within the first member and may have a distal region and a shoulder region where the shoulder region may be configured to limit the travel of the first member or the second member past the hood stop.

    摘要翻译： 提供了可用于对患者执行医疗程序的细长医疗装置。 该细长的医疗装置可以包括具有远端，外表面和第一内腔的第一构件，其中第一构件可以具有细长构造，使得第一构件的长度比第一构件的宽度大至少十倍 第一个成员。 细长医疗装置还可以具有定位在第一构件内的第二构件和罩止动件。 该装置中的罩止挡件可以定位在第一构件内并且可以具有远侧区域和肩部区域，其中肩部区域可以被配置为限制第一构件或第二构件经过罩止挡件的移动。

    Tortuous path injection device and method
    6.
    发明授权
    Tortuous path injection device and method 失效

    公开(公告)号：US06595958B1

    公开(公告)日：2003-07-22

    申请号：US09634117

    申请日：2000-08-08

    申请人： Timothy J. Mickley

    发明人： Timothy J. Mickley

    IPC分类号： A61M5178

    CPC分类号： A61M25/0136 ,  A61M25/0041 ,  A61M25/0084 ,  A61M25/0133 ,  A61M25/0662 ,  A61M2025/0089 ,  A61M2025/0681

    摘要： Devices and methods for delivering therapeutic or diagnostic agents to a target tissue of a human body are disclosed. A catheter in accordance with the present invention includes an elongate shaft having a distal end, a proximal end, and a lumen therethrough. The elongate shaft includes a first curved portion proximate the distal end of the elongate shaft. The first curved portion of the elongate shaft defines a first plane. The elongate shaft also includes a second curved portion disposed between the distal end of the elongate shaft and the first curved portion of the elongate shaft. The second curved portion of the elongate shaft defines a second plane. The second plane intersects the first plane at an angle.

    Variable tip catheter
    7.
    发明授权
    Variable tip catheter 失效
    可变尖端导管

    公开(公告)号：US06582400B1

    公开(公告)日：2003-06-24

    申请号：US09695527

    申请日：2000-10-24

    申请人： Matthew Hawk ,  Scott Larson ,  Timothy J. Mickley ,  Chad Harris

    发明人： Matthew Hawk ,  Scott Larson ,  Timothy J. Mickley ,  Chad Harris

    IPC分类号： A61M5178

    CPC分类号： A61M25/0069 ,  A61B17/3478 ,  A61B2017/00247 ,  A61B2017/22069 ,  A61B2017/22077 ,  A61B2017/348 ,  A61B2017/3488 ,  A61B2018/00392 ,  A61B2018/00738 ,  A61B2090/036 ,  A61B2218/002 ,  A61M25/10 ,  A61M2025/1093

    摘要： Therapeutic catheters for increasing myocardial blood perfusion in procedures including percutaneous myocardial revascularization (PMR), which can include tips for cutting into the myocardium to stimulate a healing response and/or for injecting angiogenic substances. PMR catheters can include an outer shaft slidably housing an inner shaft having a distal therapeutic tip. The outer shaft can be slidably disposed in a guide catheter and have an expandable atraumatic distal tip for presenting an enlarged distal profile against the heart chamber wall. The enlarged atraumatic profile can reduce the likelihood of the outer shaft penetrating undesirably into the myocardium. One expandable distal tip expands radially when forced against the endocardium. Another expandable tip expands when unconstrained by the guide catheter. Yet another expandable tip expands when manipulated by an elongate manipulation member.

    摘要翻译： 用于在包括经皮心肌血运重建（PMR）的手术中增加心肌血液灌注的治疗导管，其可以包括切入心肌以刺激愈合反应和/或注射血管生成物质的尖端。 PMR导管可以包括可滑动地容纳具有远侧治疗末端的内轴的外轴。 外轴可以可滑动地设置在引导导管中并且具有可膨胀的无创伤的远侧末端，用于呈现抵靠心室壁的扩大的远端轮廓。 扩大的无创伤轮廓可以减少外轴不期望地进入心肌的可能性。 一个可扩展的远侧末端在被迫靠在心内膜上时径向扩张。 当引导导管不受约束时，另一个可扩展的尖端膨胀。 当由细长的操纵构件操纵时，另一个可膨胀尖端膨胀。

    Deflectable tip guide in guide system
    8.
    发明授权
    Deflectable tip guide in guide system 有权

    公开(公告)号：US06530914B1

    公开(公告)日：2003-03-11

    申请号：US09695525

    申请日：2000-10-24

    申请人： Timothy J. Mickley

    发明人： Timothy J. Mickley

    IPC分类号： A61M2501

    CPC分类号： A61M25/0147 ,  A61M25/0662 ,  A61M2025/0063 ,  A61M2025/0161

    摘要： Guide catheters which can be used in percutaneous myocardial revascularization (PMR) to deliver therapeutic catheters to difficult to reach heart chamber wall regions. Some guide catheters include distal regions which can be bent under control from the proximal region of the catheter. One steerable guide catheter has a flexible distal region, a more proximal, less flexible intermediate region, a first lumen for receiving a therapeutic catheter, and an elongate manipulation member slidably disposed in a second, blind lumen. The elongate manipulation member can be secured off-center near the distal end of the flexible distal region. The distal region can be bent by retracting the manipulation member and straightened by pushing the manipulation member. Controllably bendable guide catheters according to the present invention can be nested inside other, similar guide catheters. The invention also includes means for resisting free rotation of guide catheters relative to other adjacent catheters or tubes.

    Medical device with drug delivery member
    9.
    发明授权
    Medical device with drug delivery member 失效
    医疗器械配药

    公开(公告)号：US08740844B2

    公开(公告)日：2014-06-03

    申请号：US10645653

    申请日：2003-08-20

    申请人： Toby Freyman ,  Timothy J. Mickley ,  Maria J. Palasis ,  Wendy Naimark

    发明人： Toby Freyman ,  Timothy J. Mickley ,  Maria J. Palasis ,  Wendy Naimark

    IPC分类号： A61M31/00 ,  A61M29/02

    CPC分类号： A61M29/02 ,  A61M25/1029 ,  A61M2025/0057 ,  A61M2025/105

    摘要： The present invention generally relates to a medical device for delivering a therapeutic agent to an internal portion of a patient's body. The medical device includes a shaft and a self-expanding delivery member in operative communication with the shaft. The delivery member is shaped from a porous material that is capable of releasing a therapeutic agent to an internal portion of a patient's body. The medical device further includes a therapeutic agent delivery lumen in fluid communication with the delivery member to fluidly connect the delivery member with a therapeutic agent source. A retention member may also be provided to selectively collapse the delivery member.

    摘要翻译： 本发明一般涉及用于将治疗剂递送到患者身体的内部的医疗装置。 该医疗装置包括轴和与该轴可操作地连通的自扩张输送构件。 递送构件由能够将治疗剂释放到患者身体的内部的多孔材料成形。 医疗装置还包括与递送构件流体连通以将递送构件与治疗剂源流体连接的治疗剂递送腔。 还可以设置保持构件以选择性地折叠输送构件。

    Precision pen height control for micro-scale direct writing technology
    10.
    发明授权
    Precision pen height control for micro-scale direct writing technology 有权
    精密笔高度控制微尺度直写技术

    公开(公告)号：US08430059B2

    公开(公告)日：2013-04-30

    申请号：US12137235

    申请日：2008-06-11

    申请人： Timothy J. Mickley ,  Frank Genovese ,  James Feng ,  Leonard B. Richardson

    发明人： Timothy J. Mickley ,  Frank Genovese ,  James Feng ,  Leonard B. Richardson

    IPC分类号： B05C11/00 ,  G01D15/16

    CPC分类号： G05B19/25 ,  G05B2219/37131 ,  G05B2219/45238 ,  H05K3/1241 ,  H05K2203/0126 ,  H05K2203/163

    摘要： An apparatus for precision pen height control which includes a dispensing member, a fluid dispensing system, a vertical position sensing system, and a vertical position controller. The fluid dispensing system is in fluid communication with an opening in the dispensing member via a tubular member. A vertical position sensing system, which includes a diffraction grating and a sensor, is engaged to the tubular member. The sensor is positioned adjacent the diffraction grating. The diffraction grating is engaged to a vertical support, which is engaged to the tubular member. The sensor produces a vertical position signal based upon the position of the vertical support. The vertical position controller is engaged to the vertical position sensing system, and receives a control signal generated from the vertical position signal. The vertical position controller produces and applies vertical forces to the vertical support in response to the control signal.

    摘要翻译： 一种用于精密笔高度控制的装置，包括分配构件，流体分配系统，垂直位置感测系统和垂直位置控制器。 流体分配系统经由管状构件与分配构件中的开口流体连通。 包括衍射光栅和传感器的垂直位置传感系统与管状部件接合。 传感器位于衍射光栅附近。 衍射光栅接合到垂直支撑件，该支撑件与管状构件接合。 传感器基于垂直支撑件的位置产生垂直位置信号。 垂直位置控制器接合到垂直位置感测系统，并且接收从垂直位置信号产生的控制信号。 垂直位置控制器响应于控制信号产生并向垂直支撑件施加垂直力。