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1.发明申请PRESSURE-ASSISTED MOLECULAR RECOVERY (PAMR) OF BIOMOLECULES, PRESSURE-ASSISTED ANTIGEN RETRIEVAL (PAAR), AND PRESSURE-ASSISTED TISSUE HISTOLOGY (PATH) 有权生物分子的压力辅助分子恢复（PAMR），压力辅助抗体检索（PAAR）和压力协助组织学（PATH）公开(公告)号：US20100136613A1
公开(公告)日：2010-06-03
申请号：US12630746
申请日：2009-12-03
IPC分类号： G01N1/28
CPC分类号： A01N1/0231 , G01N1/30
摘要： A method is disclosed for reversing fixation-induced cross-linking in tissue specimens that have been preserved for histological examination. The method involves placing the fixed tissue in a liquid under elevated temperature and pressure conditions that are sufficient to reverse the fixation-induced cross-linking, restore antigenicity to proteins, and permit improved molecular and proteomic analysis of the preserved tissue specimen. Methods are also disclosed for processing tissues for histological examination under elevated pressure conditions that enhance the perfusion of liquid reagents into the tissue and reduce overall processing times.
摘要翻译： 公开了一种用于逆转已经保留用于组织学检查的组织标本中固定诱导交联的方法。 该方法包括将固定组织置于液体中，该温度和压力条件足以逆转固定诱导的交联，恢复对蛋白质的抗原性，并允许改进保藏组织标本的分子和蛋白质组学分析。 还公开了用于处理在升高的压力条件下进行组织学检查的组织的方法，其增强液体试剂灌注到组织中并减少总体加工时间。
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2.发明授权Pressure-assisted molecular recovery (PAMR) of biomolecules, pressure-assisted antigen retrieval (PAAR), and pressure-assisted tissue histology (PATH) 有权生物分子的压力辅助分子回收（PAMR），压力辅助抗原回收（PAAR）和压力辅助组织组织学（PATH）公开(公告)号：US08481283B2
公开(公告)日：2013-07-09
申请号：US13613618
申请日：2012-09-13
IPC分类号： G01N1/30
CPC分类号： A01N1/0231 , G01N1/30
摘要： A method is disclosed for reversing fixation-induced cross-linking in tissue specimens that have been preserved for histological examination. The method involves placing the fixed tissue in a liquid under elevated temperature and pressure conditions that are sufficient to reverse the fixation-induced cross-linking, restore antigenicity to proteins, and permit improved molecular and proteomic analysis of the preserved tissue specimen. Methods are also disclosed for processing tissues for histological examination under elevated pressure conditions that enhance the perfusion of liquid reagents into the tissue and reduce overall processing times.
摘要翻译： 公开了一种用于逆转已经保留用于组织学检查的组织标本中固定诱导交联的方法。 该方法包括将固定组织置于液体中，该温度和压力条件足以逆转固定诱导的交联，恢复对蛋白质的抗原性，并允许改进保藏组织标本的分子和蛋白质组学分析。 还公开了用于处理在升高的压力条件下进行组织学检查的组织的方法，其增强液体试剂灌注到组织中并减少总体加工时间。
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3.发明申请PRESSURE-ASSISTED MOLECULAR RECOVERY (PAMR) OF BIOMOLECULES, PRESSURE-ASSISTED ANTIGEN RETRIEVAL (PAAR), AND PRESSURE-ASSISTED TISSUE HISTOLOGY (PATH) 有权生物分子的压力辅助分子恢复（PAMR），压力辅助抗体检索（PAAR）和压力协助组织学（PATH）公开(公告)号：US20130011854A1
公开(公告)日：2013-01-10
申请号：US13613618
申请日：2012-09-13
IPC分类号： G01N1/30
CPC分类号： A01N1/0231 , G01N1/30
摘要： A method is disclosed for reversing fixation-induced cross-linking in tissue specimens that have been preserved for histological examination. The method involves placing the fixed tissue in a liquid under elevated temperature and pressure conditions that are sufficient to reverse the fixation-induced cross-linking, restore antigenicity to proteins, and permit improved molecular and proteomic analysis of the preserved tissue specimen. Methods are also disclosed for processing tissues for histological examination under elevated pressure conditions that enhance the perfusion of liquid reagents into the tissue and reduce overall processing times.
摘要翻译： 公开了一种用于逆转已经保留用于组织学检查的组织标本中固定诱导交联的方法。 该方法包括将固定组织置于液体中，该温度和压力条件足以逆转固定诱导的交联，恢复对蛋白质的抗原性，并允许改进保藏组织标本的分子和蛋白质组学分析。 还公开了用于处理在升高的压力条件下进行组织学检查的组织的方法，其增强液体试剂灌注到组织中并减少总体加工时间。
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4.发明授权Pressure-assisted molecular recovery (PAMR) of biomolecules, pressure-assisted antigen retrieval (PAAR), and pressure-assisted tissue histology (PATH) 有权生物分子的压力辅助分子回收（PAMR），压力辅助抗原回收（PAAR）和压力辅助组织组织学（PATH）公开(公告)号：US08288122B2
公开(公告)日：2012-10-16
申请号：US12630746
申请日：2009-12-03
IPC分类号： G01N1/30
CPC分类号： A01N1/0231 , G01N1/30
摘要： A method is disclosed for reversing fixation-induced cross-linking in tissue specimens that have been preserved for histological examination. The method involves placing the fixed tissue in a liquid under elevated temperature and pressure conditions that are sufficient to reverse the fixation-induced cross-linking, restore antigenicity to proteins, and permit improved molecular and proteomic analysis of the preserved tissue specimen. Methods are also disclosed for processing tissues for histological examination under elevated pressure conditions that enhance the perfusion of liquid reagents into the tissue and reduce overall processing times.
摘要翻译： 公开了一种用于逆转已经保留用于组织学检查的组织标本中固定诱导交联的方法。 该方法包括将固定组织置于液体中，该温度和压力条件足以逆转固定诱导的交联，恢复对蛋白质的抗原性，并允许改进保藏组织标本的分子和蛋白质组学分析。 还公开了用于处理在升高的压力条件下进行组织学检查的组织的方法，其增强液体试剂灌注到组织中并减少总体加工时间。
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