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公开(公告)号：US20080255076A1
公开(公告)日：2008-10-16
申请号：US11571345
申请日：2005-06-29
申请人： Tobias Braxmeier , Kai Simons , Marino Zerial , Teymuras Kurzchalia , Tim Friedrichson , Wolfgang Frohner , Gary Jennings , Georg Schlechtingen , Cornelia Schroeder , Hans-Joachim Knolker
发明人： Tobias Braxmeier , Kai Simons , Marino Zerial , Teymuras Kurzchalia , Tim Friedrichson , Wolfgang Frohner , Gary Jennings , Georg Schlechtingen , Cornelia Schroeder , Hans-Joachim Knolker
IPC分类号： A61K31/57 , A61K31/575 , A61K31/565 , A61P35/00 , A61P25/28 , A61P31/12 , A61P31/04 , A61P33/00
CPC分类号： A61K31/56 , A61K31/565 , A61K31/57 , A61K31/575 , Y02A50/475
摘要： The present invention relates to the use of specific steroid derivatives in the preparation of medicaments for the treatment or prevention and/or amelioration of disorders relating to pathological processes in lipid rafts.
摘要翻译： 本发明涉及特定类固醇衍生物在制备用于治疗或预防和/或改善与脂筏病理过程有关的疾病的药物中的用途。
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公开(公告)号：US20080090913A1
公开(公告)日：2008-04-17
申请号：US11571354
申请日：2005-06-29
申请人： Tobias Braxmeier , Tim Friedrichson , Wolfgang Frohner , Gary Jennings , Georg Schlechtingen , Cornelia Schroeder , Hans-Joachim Knolker , Kai Simons , Marino Zerial , Teymuras Kurzchalia
发明人： Tobias Braxmeier , Tim Friedrichson , Wolfgang Frohner , Gary Jennings , Georg Schlechtingen , Cornelia Schroeder , Hans-Joachim Knolker , Kai Simons , Marino Zerial , Teymuras Kurzchalia
IPC分类号： A61P3/10 , A61K31/131 , A61K31/133 , A61P31/00 , A61P37/00 , C07C217/46 , C07C233/57 , C07C233/17 , C07C215/24 , A61P35/00 , A61K31/16 , A61P25/00
CPC分类号： A61K31/133 , Y02A50/475
摘要： The present invention relates to specific sphingolipids/sphingolipid derivatives as pharmaceutical compositions as well as their use in the preparation of medicaments for the treatment, prevention and/or amelioration of disorders relating to pathological processes in lipid rafts.
摘要翻译： 本发明涉及作为药物组合物的特定鞘脂/鞘脂衍生物及其在制备用于治疗，预防和/或改善与脂筏中的病理过程有关的疾病的药物中的用途。
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公开(公告)号：US20080317767A1
公开(公告)日：2008-12-25
申请号：US11547853
申请日：2005-04-08
申请人： Tobias Braxmeier , Tim Friedrichson , Wolfgang Frohner , Gary Jennings , Michael Munick , Georg Schlechtingen , Cornelia Schroeder , Hans-Joachim Knolker , Kai Simons , Marino Zerial , Teymuras Kurzchalia
发明人： Tobias Braxmeier , Tim Friedrichson , Wolfgang Frohner , Gary Jennings , Michael Munick , Georg Schlechtingen , Cornelia Schroeder , Hans-Joachim Knolker , Kai Simons , Marino Zerial , Teymuras Kurzchalia
CPC分类号： A61K47/554 , A61K47/543
摘要： The present invention relates to a compound comprising a tripartite structure in the format C-B-A or C′-B′-A′ wherein moiety A and moiety A′ is a raftophile, moiety B and moiety B′ is a linker, moiety C and moiety C′ is a pharmacophore; and wherein moiety B and B′ is a linker which has a backbone of at least 8 carbon atoms and wherein one or more of said carbon atoms may be replaced by nitrogen, oxygen or sulfur. Furthermore, specific medical and pharmaceutical uses of the compounds of the invention are disclosed.
摘要翻译： 本发明涉及一种化合物，其包含CBA或C'-B'-A'形式的三方结构，其中部分A和部分A'为拉夫方，部分B和部分B'为连接体，部分C和部分C “是药效团; 并且其中部分B和B'是具有至少8个碳原子的主链的连接体，并且其中一个或多个所述碳原子可被氮，氧或硫代替。 此外，公开了本发明化合物的具体医药用途。
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公开(公告)号：US07629385B2
公开(公告)日：2009-12-08
申请号：US11571354
申请日：2005-06-29
申请人： Tobias Braxmeier , Tim Friedrichson , Wolfgang Fröhner , Gary Jennings , Georg Schlechtingen , Cornelia Schroeder , Hans-Joachim Knölker , Kai Simons , Marino Zerial , Teymuras Kurzchalia
发明人： Tobias Braxmeier , Tim Friedrichson , Wolfgang Fröhner , Gary Jennings , Georg Schlechtingen , Cornelia Schroeder , Hans-Joachim Knölker , Kai Simons , Marino Zerial , Teymuras Kurzchalia
CPC分类号： A61K31/133 , Y02A50/475
摘要： The present invention relates to specific sphingolipids/sphingolipid derivatives as pharmaceutical compositions as well as their use in the preparation of medicaments for the treatment, prevention and/or amelioration of disorders relating to pathological processes in lipid rafts.
摘要翻译： 本发明涉及作为药物组合物的特定鞘脂/鞘脂衍生物及其在制备用于治疗，预防和/或改善与脂筏中的病理过程有关的疾病的药物中的用途。
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公开(公告)号：US20100063126A1
公开(公告)日：2010-03-11
申请号：US11571351
申请日：2005-06-29
申请人： Tobias Braxmeier , Tim Friedrichson , Wolfgang Fröhner , Gary Jennings , Georg Schlechtingen , Cornella Schroeder , Hans-Joachim Knölker , Kai Simons , Marino Zerial , Teymuras Kurzchalia
发明人： Tobias Braxmeier , Tim Friedrichson , Wolfgang Fröhner , Gary Jennings , Georg Schlechtingen , Cornella Schroeder , Hans-Joachim Knölker , Kai Simons , Marino Zerial , Teymuras Kurzchalia
IPC分类号： A61K31/403
CPC分类号： A61K31/40 , Y02A50/475
摘要： The present invention relates to the use of specific carbazole derivatives in the preparation of medicaments for the treatment, prevention and/or amelioration of disorders relating to pathological processes in lipid rafts.
摘要翻译： 本发明涉及特定咔唑衍生物在制备用于治疗，预防和/或改善与脂筏病理过程有关的疾病的药物中的用途。
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6.发明授权公开(公告)号：US09573886B2
公开(公告)日：2017-02-21
申请号：US14403166
申请日：2012-05-25
申请人： Georg Schlechtingen , Hans-Joachim Knolker , Tim Friedrichson , Gary Jennings , Tobias Braxmeier
发明人： Georg Schlechtingen , Hans-Joachim Knolker , Tim Friedrichson , Gary Jennings , Tobias Braxmeier
IPC分类号： C07C237/08 , A61K31/164 , A61K45/06
CPC分类号： A61K31/164 , A61K45/06 , C07C237/08
摘要： The present invention relates to hydroxy-substituted amino and ammonium derivatives, in particular the compounds of formula (1) or (2), and their medical use, including their use in the treatment, prevention or amelioration of an inflammatory, autoimmune and/or allergic disorder, or a proliferative, neoplastic or dysplastic disease or disorder.
摘要翻译： 本发明涉及羟基取代的氨基和铵衍生物，特别是式（1）或（2）的化合物及其医疗用途，包括其用于治疗，预防或改善炎症，自身免疫和/或 过敏性疾病或增殖性，肿瘤性或发育异常性疾病或病症。
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7.发明申请公开(公告)号：US20150232418A1
公开(公告)日：2015-08-20
申请号：US14403166
申请日：2012-05-25
申请人： Georg Schlechtingen , Hans-Joachim Knolker , Tim Friedrichson , Gary Jennings , Tobias Braxmeier
发明人： Georg Schlechtingen , Hans-Joachim Knolker , Tim Friedrichson , Gary Jennings , Tobias Braxmeier
IPC分类号： C07C237/08 , A61K45/06 , A61K31/164
CPC分类号： A61K31/164 , A61K45/06 , C07C237/08
摘要： The present invention relates to hydroxy-substituted amino and ammonium derivatives, in particular the compounds of formula (1) or (2), and their medical use, including their use in the treatment, prevention or amelioration of an inflammatory, autoimmune and/or allergic disorder, or a proliferative, neoplastic or dysplastic disease or disorder.
摘要翻译： 本发明涉及羟基取代的氨基和铵衍生物，特别是式（1）或（2）的化合物及其医疗用途，包括其用于治疗，预防或改善炎症，自身免疫和/或 过敏性疾病或增殖性，肿瘤性或发育异常性疾病或病症。
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公开(公告)号：US09850265B2
公开(公告)日：2017-12-26
申请号：US14403167
申请日：2012-05-25
申请人： Georg Schlechtingen , Hans-Joachim Knölker , Tim Friedrichson , Gary Jennings , Tobias Braxmeier
发明人： Georg Schlechtingen , Hans-Joachim Knölker , Tim Friedrichson , Gary Jennings , Tobias Braxmeier
IPC分类号： C07F9/40 , C07D211/62 , C07D211/46 , C07D295/037 , C07C229/12 , A61K31/205 , C07F9/38 , C07C309/14 , A61K31/662 , A61K31/4425
CPC分类号： C07F9/4006 , A61K31/205 , A61K31/4425 , A61K31/662 , C07C229/12 , C07C309/14 , C07D211/06 , C07D211/46 , C07D211/60 , C07D211/62 , C07D295/037 , C07F9/3808
摘要： The present invention relates to amino- or ammonium-containing sulfonic acid, phosphonic acid and carboxylic acid derivatives, in particular the compounds of formula 1, 2, 3, 4, 5 or 6, and their medical use, including their use in the treatment, prevention or amelioration of an inflammatory, autoimmune and/or allergic disorder.
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9.发明申请公开(公告)号：US20150284320A1
公开(公告)日：2015-10-08
申请号：US14403168
申请日：2012-05-25
申请人： Georg Schlechtingen , Hans-Joachim Knölker , Tim Friedrichson , Gary Jennings , Tobias Braxmeier
发明人： Georg Schlechtingen , Hans-Joachim Knölker , Tim Friedrichson , Gary Jennings , Tobias Braxmeier
IPC分类号： C07C309/14
CPC分类号： C07C309/14 , A61K31/205
摘要： The present invention relates to oxygenated amino or ammonium-containing sulfonic acid, phosphonic acid and carboxylic acid derivatives, in particular the compounds of formula 1, 2, 3, 4, 5 or 6, and their medical use, including their use in the treatment, prevention or amelioration of an inflammatory, autoimmune and/or allergic disorder, or a proliferative, neoplastic or dysplastic disease or disorder.
摘要翻译： 本发明涉及含氧氨基或铵的磺酸，膦酸和羧酸衍生物，特别是式1,2,3,4,5或6的化合物及其医疗用途，包括它们在治疗中的用途 ，预防或改善炎症，自身免疫和/或过敏性疾病，或增殖性，肿瘤性或发育异常性疾病或病症。
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公开(公告)号：US09751834B2
公开(公告)日：2017-09-05
申请号：US14403168
申请日：2012-05-25
申请人： Georg Schlechtingen , Hans-Joachim Knölker , Tim Friedrichson , Gary Jennings , Tobias Braxmeier
发明人： Georg Schlechtingen , Hans-Joachim Knölker , Tim Friedrichson , Gary Jennings , Tobias Braxmeier
IPC分类号： C07C309/14 , A61K31/205
CPC分类号： C07C309/14 , A61K31/205
摘要： The present invention relates to oxygenated amino or ammonium-containing sulfonic acid, phosphonic acid and carboxylic acid derivatives, in particular the compounds of formula 1, 2, 3, 4, 5 or 6, and their medical use, including their use in the treatment, prevention or amelioration of an inflammatory, autoimmune and/or allergic disorder, or a proliferative, neoplastic or dysplastic disease or disorder.
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